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High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen Fang huang Lijie mao Zhimin Zhang Han Lin Qixin Yan Xiangyu Lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan huang Yi-De Zhang Jie Chen hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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下肢丹毒发病危险因素分析

中国医药 2017年第7期12卷 1090-1093页

作者：李文惠毛丽萍黄海柳国斌上海中医药大学附属曙光医院中医血管外科 201203

目的分析下肢丹毒发病危险因素。方法选择2015年1月至2016年4月于上海中医药大学附属曙光医院住院治疗的下肢丹毒患者120例作为观察组。选择同期于上海中医药大学附属曙光医院进行体格检查的健康受试者120例作为对照组。收集2组受试... 详细信息

目的分析下肢丹毒发病危险因素。方法选择2015年1月至2016年4月于上海中医药大学附属曙光医院住院治疗的下肢丹毒患者120例作为观察组。选择同期于上海中医药大学附属曙光医院进行体格检查的健康受试者120例作为对照组。收集2组受试者临床特点，采用Logistic回归方法分析下肢丹毒患者危险因素。结果除去资料不完整患者，最终纳入观察组111例及对照组109例。观察组主被动吸烟史、喜辛辣、荤腥比例高于对照组［57.7%（64/111）比38.5%（42/109）、64.9%（72/111）比37.6%（41/109）、60.4%（67/111）比34.9%（38/109）］，睡眠非常满意、目前生活非常满意比例低于对照组［8.1%（9/111）比33.9%（37/109）、5.4%（6/111）比10.1%（11/109）］，差异均有统计学意义（均P＜0.05）。观察组糖尿病、下肢静脉功能不全、浅静脉炎、足部破损、足部湿糜比例高于对照组［34.2%（38/111）比22.0%（24/109）、38.7%（43/111）比23.9%（26/109）、32.4%（36/111）比2.8%（3/109）、34.2%（38/111）比10.1%（11/109）、36.9%（41/111）比16.5%（18/109）］，差异均有统计学意义（均P＜0.05）。Logistic回归方法单因素分析显示，性别、年龄分段、居住地、职业、文化程度、体重指数、主被动吸烟史、喜辛辣、喜荤腥、睡眠满意程度、目前生活满意度、糖尿病、下肢静脉功能不全、浅静脉炎、足部破损、足趾湿糜与发病相关（P＜0.05）。Logistic回归方法多因素分析显示，男性、年龄≥66岁、从事体力劳动、高中以下学历、体重指数≥30 kg/m^2、有主被动吸烟史、喜辛辣、睡眠非常不满意、目前生活非常不满意、下肢静脉功能不全、浅静脉炎、足部破损和足趾湿糜13个因素是下肢丹毒发病的独立危险因素（P＜0.05）。结论男性、年龄≥66岁、从事体力劳动、高中以下学历、体重指数≥30 kg/m^2、有主被动吸烟史、喜辛辣、睡眠非常不满意、目前生活非常不满意、下肢静脉功能不全、浅静脉炎、足部破损和足趾湿糜是下肢丹毒发病的独立危险因素。

关键词：丹毒危险因素临床特点

Collimation of High Velocity Molecular Outflows

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Chinese Physics Letters 1998年第5期15卷 388-390页

作者： WU Yue-fang huang mao-hai Department of Geophysics Peking UniversityBeijing 100871 Department of Astronomy Boston UniversityBostonMA02215U.S.A.

Statistics of apparent collimation factors for molecular outflows catalogued is *** collimation factor is calculated with the project effects *** is collimation difference between high and low mass *** may concern the... 详细信息

关键词： Velocity removed apparent

Assessment of the induced radioactivity in the treatment room of the heavy-ion medical machine in Wuwei using PHITS

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Nuclear Science and Techniques 2023年第2期34卷 153-166页

作者： Ying Luo Sheng‑Cong huang Hui Zhang hai‑Jun mao Qiang Li Zhong‑Ying Dai Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Science Lanzhou 730000China Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine Lanzhou 730000China Lanzhou University Lanzhou 730000China

Carbon-ion radiotherapy(CIRT)offers unique physical and biological advantages over photon ***,some materials and devices in the CIRT treatment room become radioactive under bombardment by therapeutic carbon-ion beams due to nuclear reactions,thereby leading to possible radiation hazards to medical staff and additional and unwanted doses to *** study assessed the level of induced radioactivity in the treatment room of the Heavy-Ion Medical Machine(HIMM)in *** Carlo simulations using PHITS were performed for a conservative case under the conditions of maximum beam energy and intensity provided by the HIMM *** geometry and configuration of Treatment Room 2 of the HIMM facility in Wuwei were *** evaluated the activation of air,the phantom,and the components of the beamline,such as the primary collimator(PC),ridge filter(RF),and multileaf collimator(MLC).For air activation,we calculated the medical staff immersion external exposure and inhalation internal exposure caused by the corresponding *** phantom activation,we estimated the additional dose to the patient’s family members owing to secondary photons after *** addition,the exemption or non-exemption of the component material activation was *** results showed that external radiation caused by air activation was the main source of the annual effective dose at approximately 0.5 mSv/*** induced radioactivity exposure to family members of a patient after CIRT was approximately 40μSv,sufficiently lower than the public dose limit of 1 mSv/*** induced radioactivity of the PC,RF,and MLC was all above the exempt levels after the devices were retired,whereas the induced radioactivity of the RS and compensator could reach the exempt levels after one patient *** study indicated that medical staff engaged in CIRT should stay away from the high-dose-rate area of induced radioactivity along the beam direction,shorten the residence time in

关键词： activation approximate thereby

Hybrid linear amplifier-involved detection for continuous variable quantum key distribution with thermal states

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Chinese Physics B 2020年第5期29卷 132-141页

作者： Yu-Qian He Yun mao hai Zhong Duang huang Ying Guo School of Automation Central South UniversityChangsha 410083China School of Computer Science and Engineering Central South UniversityChangsha 410083China

Continuous-variable quantum key distribution(CVQKD)can be integrated with thermal states for short-distance wireless quantum ***,its performance is usually restricted with the practical thermal *** propose a method to improve the security threshold of thermal-state(TS)CVQKD by employing a heralded hybrid linear amplifier(HLA)at the *** find the effect of thermal noise on the HLA-involved scheme in near-and-mid infrared band or terahertz band for direct and reverse *** simulations show that the HLA-involved scheme can compensate for the detriment of thermal noise and hence increase the security threshold of *** near-and-mid infrared band,security threshold can be extended by 2.1 dB in channel loss for direct reconciliation and 1.6 dB for reverse reconciliation,whereas in terahertz band,security threshold can be slightly enhanced for the gain parameter less than 1 due to the rise in thermal noise.

关键词： continuous-variable quantum key distribution thermal state hybrid linear amplifier

Monte Carlo study of the neutron ambient dose equivalent at the heavy ion medical machine in Wuwei

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Nuclear Science and Techniques 2022年第9期33卷 111-125页

作者： Sheng-Cong huang Hui Zhang Kai Bai Ying Luo hai-Jun mao Zhong-Ying Dai University of Chinese Academy of Sciences Beijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China

The use of carbon-ion radiotherapy(CIRT)is gradually *** to the generation of high-energy secondary neutrons during CIRT,its use presents new challenges in radiation ***,secondary neutron dose distributions must be explored and evaluated under clinical scenarios based on different treatment ***,neutron dose and energy spectrum measurements are often *** can be primarily attributed to the inherent limitations of most neutron detectors,such as their unsuitability for spectral measurements and inaccurate responses to neutrons with energies above 20 *** calculation methods based on probabilistic statistical theory are fast and convenient for neutron dose *** this study,external secondary neutron doses at the heavy ion medical machine in Wuwei,which is equipped with a passive beam delivery system,were calculated using the Monte Carlo *** dependence of neutron doses on various treatment parameters(incident carbon-ion beam energy,spatial location,field size,and spread-out Bragg peak(SOBP)width)was ***,the feasibility of applying an analytical model to predict the ambient dose equivalent was *** the combination involving an energy of 400 MeV=u and SOBP width of 6 cm,the ambient dose equivalent per therapeutic dose(H=D)at the isocenter was 79.87 mSv=Gy:The H=D value decreased rapidly with increasing spatial distance and slightly with increasing aperture size and SOBP *** H=D values derived from the Monte Carlo simulations were in good agreement with the results reported in the *** analytical model could be used to quickly predict the H=D value along the incidence direction of the beam with an error of less than 20%.Thus,our study contributes to the understanding of the relationship between neutron radiation and treatment configuration parameters,which establishes a basis for predicting non-therapeutic radiation doses in CIRT.

关键词： Carbon-ion radiotherapy Passive beam delivery Secondary neutrons Monte Carlo method

The future of carbon-neutrality science and technology from an industrial transformation perspective:an interview with Hou-Liang Dai

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National Science Review 2023年第9期10卷 113-115页

作者： hai-Xia huang the Science and Technology Department of the China National Petroleum Corporation

Since China announced that it will strive to achieve its carbon peak by 2030 and carbon neutrality by 2060, it has determined to take steps, which will establish low carbon development and a transition to carbon neutrality,as part of its long-term strategyfor sustainable development and *** will be both a huge challenge and an *** achieve the dual-carbon goals,the whole society must undergo a broad and profound systemic transformation, involving changes in energy,technology,economy, industry and lifestyle, ***-neutrality science and technology should be the foundation of the transformation.

关键词： Carbon

Clinical characteristics and treatment compounds of obesity-related kidney injury

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World Journal of Diabetes 2024年第6期15卷 1091-1110页

作者： Tuo-Hua mao Han-Qi huang Chuan-hai Zhang Department of Endocrinology Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina Department of Endocrinology Hubei No.3 People’s Hospital of Jianghan UniversityWuhan 430033Hubei ProvinceChina Department of Physiology UT Southwestern Medical CenterDallasTX 75390United States

Disorders in energy homeostasis can lead to various metabolic diseases,particularly *** obesity epidemic has led to an increased incidence of obesityrelated nephropathy(ORN),a distinct entity characterized by proteinuria,glomerulomegaly,progressive glomerulosclerosis,and renal function *** and its associated renal damage are common in clinical practice,and their incidence is increasing and attracting great *** is a great need to identify safe and effective therapeutic modalities,and therapeutics using chemical compounds and natural products are receiving increasing ***,the summary is lacking about the specific effects and mechanisms of action of compounds in the treatment of *** this review,we summarize the important clinical features and compound treatment strategies for obesity and obesityinduced kidney *** also summarize the pathologic and clinical features of ORN as well as its pathogenesis and potential therapeutics targeting renal inflammation,oxidative stress,insulin resistance,fibrosis,kidney lipid accumulation,and dysregulated *** addition,detailed information on natural and synthetic compounds used for the treatment of obesity-related kidney disease is *** synthesis of detailed information aims to contribute to a deeper understanding of the clinical treatment modalities for obesity-related kidney diseases,fostering the anticipation of novel insights in this domain.

关键词： Compounds Obesity Kidney injury Obesity-related nephropathy Clinical features and treatment