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Journal of Energy Chemistry 2025年第1期100卷 509-521页

作者： Xinyuan Wang Fan Zhang Xingyu Zhou Qian Wang Changyu liu Yangyang liu Hui Wang Xiaojie liu Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry & Materials Science Northwest University

Na3V2（PO4）2O2F （VP） is recognized as a promising cathode material for sodium-ion batteries due to its stable structural framework and high specific *** functional theory （DFT） and finite element simulations show that incorporating SO42-into VP decreases its band gap,lowers the migration energy barrier,and ensures a uniform Na+concentration gradient and stress distribution during charge and discharge ***,the average Na+diffusion coefficient of Na3V2（PO4）1.95（SO4）0.05O2F（VPS-1） is roughly double that of VP,leading to enhanced rate capability (80 C,75.5 mAh g-1) and cycling stability (111.0 mAh g-1capacity after 1000 cycles at 10 C current density) for ***-1 exhibits outstanding fast-charging capabilities,achieving an 80%state of charge in just 8.1 *** assembled VPS-1//SbSn/NPC full cell demonstrated stable cycling over 200 cycles at a high 5 C current,maintaining an average coulombic efficiency of 95.35%.

关键词： Anionic group modulation Polarization behavior Fast-charging Sodium-ion battery Fluorophosphate Cathode

Double [5]carbohelicene: facile synthesis, chiroptical properties,isomerization study, and lasing application

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Science China Chemistry 2025年第1期 233-240页

作者： Peipei liu Yantong Li Meng-Xiang Wu Hao Kang Xiao-Li Zhao Lin Xu Linlin liu Xiaodong Li Junfeng Fang Zhiwei Fang Ya cheng Hai-Bo Yang Huakang Yu Xueliang Shi State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University School of Physics and Optoelectronics South China University of Technology Institute of Polymer Optoelectronic Materials & Devices State Key Laboratory of Luminescent Materials & Devices South China University of Technology School of Physics and Electronic Science Engineering Research Center of Nanophotonics & Advanced Instrument Ministry of EducationEast China Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University

Double carbohelicenes have attracted considerable attention due to their aesthetic structures, distinct π-conjugation extension, inherent chirality, and intriguing optical and electronic properties. Herein, the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties, isomerization process and lasing application is presented. 1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key intermediate. It is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM, which were successfully isolated and unambiguously confirmed by Xray crystallography. The optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography（HPLC）, and 1-PP and 1-MM were characterized by circular dichroism. Interestingly, it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating, and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated. 1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%. Consequently, we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously, which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm-2. We believe that our studies, including the facile synthesis methodology, detailed isomerization studies, and lasing application, will shed some light on the design and synthesis of novel carbohelical systems with more functions.

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非肽类β-分泌酶1(BACE1)抑制剂的研究进展

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中国药物化学杂志 2016年第6期26卷 498-508页

作者：李慧宁李凤然程卯生刘洋沈阳药科大学基于靶点的药物设计与研究教育部重点实验室辽宁沈阳110016

β-分泌酶1(β-site APP cleaving enzyme 1,BACE1)是存在于中枢神经系统的天冬氨酸蛋白酶,能够催化β-淀粉样多肽(Aβ)形成中的第一步也是关键一步的反应,因而被认为是调节认知障碍、治疗阿尔兹海默症(AD)的关键靶点。自2000年BACE1的... 详细信息

β-分泌酶1(β-site APP cleaving enzyme 1,BACE1)是存在于中枢神经系统的天冬氨酸蛋白酶,能够催化β-淀粉样多肽(Aβ)形成中的第一步也是关键一步的反应,因而被认为是调节认知障碍、治疗阿尔兹海默症(AD)的关键靶点。自2000年BACE1的结构被解析出来后,其抑制剂的研究始终是药物化学领域的热点。随着高通量筛选和基于片段的药物发现等技术的广泛应用,大量非肽类小分子BACE1抑制剂被设计与合成,并且部分化合物已经进入了临床研究阶段。本文对近5年来非肽类BACE1抑制剂的研究进展进行综述。

关键词： β-分泌酶1 非肽类BACE1抑制剂 β-淀粉样多肽

The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan liu Wei Wu Xuejuan Li chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-cheng Ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

Recent Advances and Progress for the Fabrication and Surface Modification of AIE-active Organic-inorganic Luminescent Composites

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Chinese Journal of Polymer Science 2019年第4期37卷 340-351,I0005页

作者： liu-cheng mao Xiao-Yong Zhang Yen Wei Department of Chemistry Nanchang University Department of Chemistry and the Tsinghua Center for Frontier Polymer Research Tsinghua University Department of Chemistry and Center for Nanotechnology and Institute of Biomedical Technology Chung-Yuan Christian University

Organic dyes based hybrid organic-inorganic luminescent nanomaterials with high quantum efficiency, good physical or chemical stability, and favorable biocompatibility, have attracted growing attention recently because of their important applications in the areas of biomedical imaging, chemical sensors, and light-emitting diodes(LEDs). Nevertheless, conventional fluorescence molecules suffer from aggregation-caused quenching(ACQ) when they are doped into inorganic nanomaterials. Aggregation-induced emission(AIE) is an abnormal and intriguing fluorescent phenomenon that has aroused increasing interest for various applications especially in biomedical fields. Compared with conventional organic dyes, the AIE-active molecules will emit more intense fluorescence in their aggregates or solid states. It provides an elegant route to overcome the drawbacks of conventional organic molecules. Over the past few decades, the fabrication and surface modification of various organic-inorganic luminescent composites doped with AIE-active molecules have been reported. Therefore, it is highly desirable to summarize these advances. In this review, recent advances and progress in constructing various AIEgens-doped organic-inorganic hybrid nanocomposites and their subsequent surface modification were summarized. We hope this review could further promote the research of AIE-active functional materials.

关键词： Aggregation-induced emission Organic-inorganic luminescent composites Surface modification Biomedical applications

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan cheng Zhaoli Han Bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

A NEW METHOD OF CHANNEL FRICTION INVERSION BASED ON KALMAN FILTER WITH UNKNOWN PARAMETER VECTOR

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Journal of Hydrodynamics 2005年第6期17卷 693-698页

作者： cheng Wei-ping mao Gen-hai liu Guo-hua College of Civil Engineering and Architecture Zhejiang University Hangzhou 310027 China

Channel friction is an important parameter in hydraulic analysis. A channel friction parameter inversion method based on Kalman Filter with unknown parameter vector is proposed. Numerical simulations indicate that when the number of monitoring stations exceeds a critical value, the so lution is hardly affected. In addition, Kalman Filter with unknown parameter vector is effective only at unsteady state. For the nonlinear equations, computations of sensitivity matrices are time-costly. Two simplified measures can reduce computing time, but not influence the results. One is to reduce sensitivity matrix analysis time, the other is to substitute for sensitivity matrix.

关键词： channel inversion Kalman Filter with unknown parameter vector friction

Optimal Design Criteria of Tandem Configuration for High-Load Compressor Cascades

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Journal of Thermal Science 2024年第6期33卷 2047-2058页

作者： mao Xiaochen JIAO Yingchen cheng Hao ZHANG Botao liu Bo School of Power and Energy Northwestern Polytechnical UniversityXi'an 710129China The National Key Laboratory of Science and Technology on Aerodynamic Design and Research Xi'an 710129China Xi'an Thermal Power Research Institute Co. Ltd.Xi'an 710072China

Axial overlap(AO)and percent pitch(PP)are considered as key position configuration parameters that affect the tandem cascade *** objective of the current study is to investigate the optimal design criteria for these two parameters in tandem cascades of subsonic highly-loaded two-dimensional *** that,the influence mechanisms of AO and PP are explored *** results show that higher PP is beneficial for decreasing rear blade(RB)load,but an invalidity of gap flow occurs when it approaches *** change in AO has an influence on the adverse pressure gradient of the front blade(FB),and it also affects the gap flow strength and FB wake ***,the optimal design criteria for AO and PP are obtained in a large design space,which clarifies the matching relationship of the two parameters at different operating *** best global range of AO is about-0.05 to 0.05 while PP is between 0.85 to 0.92,and PP should be smaller to avoid performance degradation as AO *** to the fault tolerance in practical applications,PP should be closer to the lower bound to ensure that the deterioration boundary is wide enough.

关键词： axial compressor tandem cascade axial overlap percent pitch optimal design criteria

Design strategy and relevant flow mechanisms of highly loaded 3D compressor tandem cascades

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Chinese Journal of Aeronautics 2024年第7期37卷 220-235页

作者： Xiaochen mao Yunyu WANG Zhihua DING Hao cheng Bo liu School of Power and Energy Northwestern Polytechnical UniversityXi’an 710129China The National Key Laboratory of Science and Technology on Aerodynamic Design and Research Xi’an 710129China Xi’an Thermal Power Research Institute Co.Ltd Xi’an 710072China

To investigate the design strategy of highly loaded tandem cascades at both the midspan and endwall,the overall performance and flow mechanisms of four typical tandem cascades based on the optimization were analyzed from multiple perspectives *** results show that the interference effects on the Front Blade(FB)and Rear Blade(RB)should not be overlooked during the design phase,and the design strategies at the midspan and endwall are completely *** the midspan,the optimization aims to increase the interference effects and the strength of the gap jet while maintaining the same load on the FB and ***,the endwall optimal airfoil exhibits weakening interference effects,advancement of the gap jet location,and load transfer from the FB to *** further analysis of flow characteristics,the midspan optimal airfoil is beneficial for inhibiting the low-energy fluid from interacting with the suction surface of RB under the design condition,but results in earlier occurrence of corner *** endwall optimal airfoil helps suppress the development of the secondary flow and delay the onset of corner ***,by combining the benefits of these two design approaches,additional forward sweep effects are achieved,further enhancing the performance of the tandem cascade.

关键词： Tandem cascade Interference effect Vortex structure Load split Compressor

Role of the Greenland Sea ice anomaly in the late-spring drought over Northwest China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 1-5页

作者： Yang liu Huopo Chen Nansen-Zhu International Research Centre Institute of Atmospheric Physics Chinese Academy of SciencesBeijingChina Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University for Information Science and TechnologyNanjingChina

Drought across Northwest China in late spring has exerted a vital effect on the local climate and agricultural production,and has been alleviated during the past *** study explored the influence of the preceding Arctic sea ice on the May drought in Northwest China caused by the precipitation *** analysis indicated that when the Greenland Sea ice concentration is abnormally high during February to April,the dry conditions in Northwest China tend to be *** increase of sea ice in the Greenland Sea can excite a meridional circulation,which causes sea surface temperature(SST)anomalies in the North Atlantic via the sea-air interaction,manifested as significant warm SST anomalies over the south of Greenland and the subtropical North Atlantic,but negative SST anomalies over the west of the *** abnormal SST pattern maintains to May and triggers a zonal wave train from the North Atlantic through Scandinavia and Central Asia to Northwest China,leading to abnormal cyclones in Northwest ***,Northwest China experiences a more humid climate than usual.

关键词： Arctic sea ice Greenland Sea North Atlantic SST Drought Northwest China