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Polycytosine RNA-binding protein 1 regulates osteoblast function via a ferroptosis pathway in type 2 diabetic osteoporosis

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World Journal of Diabetes 2024年第5期15卷 977-987页

作者： Hong-Dong Ma Lei Shi Hai-Tian Li Xin-Dong Wang mao-Wei yang Department of Orthopedics The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Orthopedics The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

BACKGROUND Recently,type 2 diabetic osteoporosis(T2DOP)has become a research hotspot for the complications of diabetes,but the specific mechanism of its occurrence and development remains unknown.Ferroptosis caused by iron overload is con-sidered an important cause of T2DOP.Polycytosine RNA-binding protein 1(PCBP1),an iron ion chaperone,is considered a protector of ferroptosis.AIM To investigate the existence of ferroptosis and specific role of PCBP1 in the development of type 2 diabetes.METHODS A cell counting kit-8 assay was used to detect changes in osteoblast viability under high glucose(HG)and/or ferroptosis inhibitors at different concentrations and times.Transmission electron microscopy was used to examine the morpho-logical changes in the mitochondria of osteoblasts under HG,and western blotting was used to detect the expression levels of PCBP1,ferritin,and the ferroptosis-related protein glutathione peroxidase 4(GPX4).A lentivirus silenced and overex-pressed PCBP1.Western blotting was used to detect the expression levels of the osteoblast functional proteins osteoprotegerin(OPG)and osteocalcin(OCN),whereas flow cytometry was used to detect changes in reactive oxygen species(ROS)levels in each group.RESULTS Under HG,the viability of osteoblasts was considerably decreased,the number of mitochondria undergoing atrophy was considerably increased,PCBP1 and ferritin expression levels were increased,and GPX4 expression was decreased.Western blotting results demonstrated that infection with lentivirus overexpressing PCBP1,increased the expression levels of ferritin,GPX4,OPG,and OCN,compared with the HG group.Flow cytometry results showed a reduction in ROS,and an opposite result was obtained after silencing PCBP1.CONCLUSION PCBP1 may protect osteoblasts and reduce the harm caused by ferroptosis by promoting ferritin expression under a HG environment.Moreover,PCBP1 may be a potential therapeutic target for T2DOP.

关键词： Polycytosine RNA-binding protein 1 Ferroptosis Reactive oxygen species Ferritin Osteoblast Type 2 diabetic osteoporosis

Nanoindentation behavior and creep-induced cracking of long-term crept austenitic steel at 650℃

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Journal of Iron and Steel Research(International) 2024年第2期31卷 464-474页

作者： Zhen Zhang Yu-hang Duan Shuai Wang Jin-shan Chen An-zhe Wang Xiang-yang mao Yuan-ji Shi Jie Zhang Ming Liu Zheng-fei Hu School of Materials Science and Engineering Nanjing Institute of TechnologyNanjing211167JiangsuChina Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology Nanjing211167JiangsuChina Jiangsu Wind Power Engineering Technology Center Nanjing210023JiangsuChina Nanjing Vocational University of Industry Technology Nanjing210023JiangsuChina Baoshan Iron&Steel Co. Ltd.Shanghai201900China Fujian Provincial Key Laboratory of Terahertz Functional Devices and Intelligent Sensing School of Mechanical Engineering and AutomationFuzhou UniversityFuzhou350116FujianChina School of Materials Science and Engineering Tongji UniversityShanghai201804China

The grain boundary(GB)damage of long-term crept HR3C(25Cr–20Ni–Nb–N)austenitic steel with solid solution state was investigated by nanoindentation test accompanied with in-situ electron back-scattered diffraction.The corresponding microstructure was characterized by scanning electron microscopy and transmission electron microscopy.Results show that the increase in nanoindentation hardness at the GBs and triple grain junctions may be related to the dislocation accumulation and carbide growth during the creep.Coarsened M23C6 and dislocations piling-up at the GB accelerate the nucleation and coalescence of creep cavity along the GB.The nanoindentation hardness in grains varies with orientation of the stress axis.The orientation difference of neighbor grains may induce local high geometrically necessary dislocation densities and strain gradients near the GB,consequently causing stress concentration and subsequent crack growth at specific GBs.

关键词： Austenitic steel Creep Nanoindentation Grain orientation Creep-induced cracking

基于因果正则化极限学习机的风电功率短期预测方法

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电力系统保护与控制 2024年第11期52卷 127-136页

作者：杨茂张书天王勃现代电力系统仿真控制与绿色电能新技术教育部重点实验室(东北电力大学) 吉林吉林132012 新能源与储能运行控制国家重点实验室(中国电力科学研究院有限公司) 北京100192

随着风电并网比例的逐年提高,电力系统对风电功率预测的准确性和稳定性提出了更高要求。对于同一风电场而言,为了避免不同特征选择方法所选择的风电场特征子集不同,从因果关系的角度出发,提出了一种基于因果正则化极限学习机(causal reg... 详细信息

随着风电并网比例的逐年提高,电力系统对风电功率预测的准确性和稳定性提出了更高要求。对于同一风电场而言,为了避免不同特征选择方法所选择的风电场特征子集不同,从因果关系的角度出发,提出了一种基于因果正则化极限学习机(causal regularized extreme learning machine, CRELM)的风电功率短期预测方法。首先将极限学习机(extreme learning machine, ELM)建模为结构因果模型(structural causal model, SCM),在此基础上计算隐藏层神经元与输出层神经元之间的平均因果效应向量。然后将该平均因果效应向量与输出层权重相结合构成因果正则化项,在最小化训练误差的同时最大化网络的因果关系,以进一步提升模型的预测准确性和预测稳定性。最后,以国内蒙西某风电场数据为例,与采用特征选择或不采用特征选择的预测模型相对比,验证了所提方法的有效性和适用性。

关键词：特征选择因果正则化结构因果模型平均因果效应向量极限学习机

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面向差异化业务保障的自适应信道预约多址接入协议

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西北工业大学学报 2024年第1期42卷 84-91页

作者：刘泽李波杨懋闫中江西北工业大学电子信息学院陕西西安710072

在无中心节点网络中可能存在不同类型的业务,部分高优先级业务具有严格的时延等服务质量(quality of service,QoS)需求。但当网络负载较重时,冲突概率明显提高,使得这些业务的需求难以得到保障,如何设计高效的多址接入协议以保证不同种... 详细信息

在无中心节点网络中可能存在不同类型的业务,部分高优先级业务具有严格的时延等服务质量(quality of service,QoS)需求。但当网络负载较重时,冲突概率明显提高,使得这些业务的需求难以得到保障,如何设计高效的多址接入协议以保证不同种类业务的服务质量是重要的研究方向。信道预约机制是保证QoS的重要方法,但现有信道预约机制对多种业务服务时,通常没有根据服务质量需求和网络状况精细调整预约参数。因此针对以上问题提出了一种面向差异化业务保障的信道预约MAC协议(differentiated service guarantee adaptive reservation mechanism,DSGARM),协议核心思想是针对每种业务的容忍时延需求和网络状况精细提供差异化服务,协议中通过建立的数学模型设计自适应算法,定量计算出满足时延需求的预约参数,能够根据网络状况自适应调整合适的预约参数以保障每一类业务的时延需求。仿真结果说明了提出协议的优势,具有较大的实际意义。

关键词： Ad Hoc网络信道预约机制差异化业务保障

Sorafenib Combined with Cryoablation to Treat Unresectable Hepatocellular Carcinoma

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Chinese Journal of Cancer Research 2011年第3期23卷 188-193页

作者： Hong Ni mao yang Zhi Guo Ti Zhang Department of Interventional Therapy Tianjin 300060China Department of Hepatobiliary Disease Cancer Institute ＆ HospitalTianjin Medical UniversityTianjin 300060China

Objective：To evaluate the efficacy and tolerability of sorafenib combined with cryoablation in treating unresectable hepatocellular carcinoma （HCC）.Methods：Patients with unresectable advanced HCC received cryoablation and sorafenib at a dose of 400 mg twice daily in 4-week cycles on the same day of the cryoablation.Tumor response,median overall survival and the median time to radiological progression were calculated and the toxicity was evaluated.Results：Seventy-eight patients with unresectable HCC were involved in this study.The median age was 52 years （range,22-81 years）.The Eastern Cooperative Oncology Group （ECOG） performance status scores were 0 （39.7%）,1 （55.1%）,and 2 （5.1%）.Nine （11.5%） patients were at Barcelona clinic liver cancer （BCLC） stage A,twenty-four （30.8%） patients were at stage B and 45 （57.7%） patients were at stage C.Five （6.4%） achieved partial responses,and 34 （43.6%） achieved stable disease.The median time to progression （TTP） for all enrolled patients was 6.6 months and the median overall survival （OS） was 12.2 months.Conclusion：Cryoablation combined with sorafenib demonstrates good efficacy and acceptable tolerability in treating unresectable advanced HCC patients.

关键词： Hepatocellular carcinoma Sorafenib Cryoablation Unresectable

考虑交通流量俘获的电动汽车充电负荷预测和充电站规划

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电力自动化设备 2024年第7期44卷 263-270页

作者：孙亮申畅朱童生杨格林杨茂孙艳学东北电力大学电气工程学院吉林吉林132000 国网东北分部绿源水力发电公司云峰发电厂吉林通化134299

针对电动汽车(EV)的充电需求,考虑路径的交通流量,以最大交通流量俘获、最小配电系统网络损耗和最小节点电压偏移为目标,构建了一个多目标决策模型对EV充电站进行规划。运用网络扩展技术确定交通流量俘获路径;运用蒙特卡罗模拟算法,确... 详细信息

针对电动汽车(EV)的充电需求,考虑路径的交通流量,以最大交通流量俘获、最小配电系统网络损耗和最小节点电压偏移为目标,构建了一个多目标决策模型对EV充电站进行规划。运用网络扩展技术确定交通流量俘获路径;运用蒙特卡罗模拟算法,确定规划区内EV的最大充电负荷,从而推算得到充电站的容量;运用超效率数据包络分析评价方法,确定经过归一化处理后各目标函数的权重系数,从而将多目标优化问题转化为单目标优化问题,并采用改进的二进制粒子群优化算法进行求解。以一个包含25个节点的交通网络耦合33节点配电系统为算例进行仿真,验证所建模型和所提方法的有效性,并进一步分析EV最大行驶里程、充电站负荷接入不同节点以及不同时刻对各目标函数的影响。

关键词：电动汽车充电站交通流量俘获网络扩展技术蒙特卡罗模拟算法超效率数据包络分析

Biomimetic Design of Oxidized Bacterial Cellulose-gelatin-hydroxyapatite Nanocomposites

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Journal of Bionic Engineering 2016年第4期13卷 631-640页

作者： mao yang Wenjuan Zhen Hui Chen Zhihua Shan National Engineering Laboratory for Clean Technology Leather Manufacture Sichuan University Chengdu 610065 China Department of sports medicine Chengdu Sport University Chengdu 610041 China

Oxidized Bacterial Cellulose （OBC）-hydroxyapatite （HAp）-gelatin （Gel） nanocomposites were prepared by a biomimetic process. HAp nanocrystals were precipitated in a mixed solution ofNa2HPO4 （pH 9.2） and Gel solution at 37 ℃, and OBC was used to generate a three-dimensional （3D） network stent. The tensile strength of OBC-HAp-G was higher than 0.3 MPa, and the complete degradation time was approximately 90 d in Simulated Body Fluid （SBF）. Fourier transform infrared spectroscopy demonstrated that a coordinate bond had formed possibly between HAp and the cellulose hydroxyl. X-ray diffraction showed that both the oxidation of bacterial cellulose and an increase in Gel content induced the formation of tiny HAp crystallites during composite fabrication. Specific surface area and porosity measurements indicated that a low Gel concentration contributed to retention of porous structure. The Ca and P contents on the surface of materials increased initially and then decreased with an increase in Gel content, as measured by energy dispersive spectroscopy. From the thermogravimetric data, the increase in decomposition temperature suggested the formation of chemical bonds among OBC, HAp, and Gel. The above results suggest that the OBC-HAp-G0.3 composite is a potential bone scaffold material.

关键词： bacterial cellulose hydroxyapatite nanocomposite gelatin scaffold material

城市污水处理厂的“水-能-碳”协调调度模型

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电网技术 2024年第5期48卷 1918-1928,I0028,I0029-I0031页

作者：赵霞石诗义毛杨武桢寓输变电装备技术全国重点实验室(重庆大学) 重庆市沙坪坝区400044

城市污水处理厂面临能量密集、碳排量大、运行成本高的突出问题。污水厂优化调度是实现“节能降碳增效”的重要途径,但现有调度方法还存在对处理设备控制特性利用不足、对处理过程的温室气体排放缺乏全面管控等局限。为此,该文提出一种... 详细信息

城市污水处理厂面临能量密集、碳排量大、运行成本高的突出问题。污水厂优化调度是实现“节能降碳增效”的重要途径,但现有调度方法还存在对处理设备控制特性利用不足、对处理过程的温室气体排放缺乏全面管控等局限。为此,该文提出一种面向污水厂“水-能-碳”协调调度的新模型。所提模型利用鼓风机启停/沼气池温度控制来挖掘节能空间、计入碳排放成本来提升低碳水平、引入污水分级处理与回用来促进资源回收利用,在满足污水处理工艺流程和各种设备运行约束及水质处理要求的条件下,实现污水厂的低碳经济运行。以某中小型城市污水厂为算例,验证了所提调度模型的有效性以及各调度要素对污水厂“节能降碳增效”的积极作用。

关键词：污水处理厂污水回用分级处理碳排放协调调度

针刺治疗功能性消化不良的神经影像学研究进展

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针刺研究 2024年第2期49卷 192-197页

作者：何雨杞张攀毛杨科李思扬曾芳尹涛成都中医药大学针灸推拿学院成都610075 成都中医药大学针灸脑科学研究中心成都611137 针灸与时间生物学四川省重点实验室成都610075

神经影像技术为研究针刺效应机制提供了客观、可视化的研究手段。本文在系统检索既往基于神经影像技术的针刺治疗功能性消化不良临床研究的基础上,从穴位效应特异性、效应影响因素、不同机体应答特征、针刺疗效预测4个方面对既往研究内... 详细信息

神经影像技术为研究针刺效应机制提供了客观、可视化的研究手段。本文在系统检索既往基于神经影像技术的针刺治疗功能性消化不良临床研究的基础上,从穴位效应特异性、效应影响因素、不同机体应答特征、针刺疗效预测4个方面对既往研究内容进行归纳总结,提出针刺治疗功能性消化不良中枢整合具有疾病靶向性、循经特异性和动态条件性特征。最后,结合当前研究现状,从研究对象、影响因素、结果验证3个方面对未来研究提出展望,以期为今后深入开展相关研究提供参考。

关键词：功能性消化不良针刺神经影像功能磁共振成像