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血清视黄醇结合蛋白、胱抑素C及载脂蛋白B/载脂蛋白A1联合检测对高血压早期肾损伤的诊断价值

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川北医学院学报 2024年第1期39卷 51-54页

作者：毛辉黄洁群欧志强宁亮忠钟敏贺州市中医医院医学检验科广西贺州542800

目的:探讨视黄醇结合蛋白(RBP)、胱抑素C(Cys-C)及载脂蛋白B/载脂蛋白A1(ApoB/ApoA1)检测对高血压早期肾损伤的诊断价值。方法:选取80例高血压患者为研究对象,根据早期肾损伤诊断标准将其分为单纯高血压组(n=47)及高血压合并早期肾损伤... 详细信息

目的:探讨视黄醇结合蛋白(RBP)、胱抑素C(Cys-C)及载脂蛋白B/载脂蛋白A1(ApoB/ApoA1)检测对高血压早期肾损伤的诊断价值。方法:选取80例高血压患者为研究对象,根据早期肾损伤诊断标准将其分为单纯高血压组(n=47)及高血压合并早期肾损伤组(n=33)。比较两组患者一般资料、血脂、RBP、Cys-C、ApoB/ApoA1水平,采用Logistic回归分析高血压患者早期肾损伤的危险因素。采用ROC曲线评估RBP、Cys-C、ApoB/ApoA1及其联合对高血压患者早期肾损伤的诊断效能。结果:早期肾损伤组患者RBP、Cys-C、ApoB/ApoA1水平均高于单纯高血压组,ApoA1水平低于单纯高血压组,差异均有统计学意义(P<0.05)。多因素Logistic回归分析显示,RBP、Cys-C、ApoB/ApoA1是原发性高血压患者合并早期肾损伤的危险因素(P<0.05)。ROC分析显示,当RBP≥3.475 mg/L时,诊断原发性高血压患者合并早期肾损伤的曲线下面积(AUC)为0.729,灵敏度为69.7%,特异度为72.3%;当Cys-C≥2.525 mg/L时,AUC为0.768,灵敏度为72.7%,特异度为74.5%;当ApoB/ApoA1≥0.870时,AUC为0.656,灵敏度为63.6%,特异度为68.1%;三者联合诊断的AUC为0.870,灵敏度为81.8%,特异度为80.9%。结论:高血压合并早期肾损伤患者RBP、Cys-C、ApoB/ApoA1水平升高,可将其联合用于高血压合并早期肾损伤的辅助诊断。

关键词：高血压早期肾损伤视黄醇结合蛋白胱抑素C 载脂蛋白B 载脂蛋白A1

供水管网水质化学稳定性分析及水质敏感区识别

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中国给水排水 2024年第7期40卷 45-50页

作者：刘志刚徐巧王亚超毛慧周正协何建荣王项荣韦学玉宁波市水务环境集团有限公司浙江宁波315041 安徽工程大学建筑工程学院安徽芜湖241000

针对南方某市多水源供水现状,研究了供水管网水质化学稳定性变化特征,并对该市供水管网水质敏感区进行识别。选取了该市不同水厂供水区域内20个管网采样点2019年3月—2021年3月的余氯、浊度及总铁数据,对不同区域不同季节的管网水质特... 详细信息

针对南方某市多水源供水现状,研究了供水管网水质化学稳定性变化特征,并对该市供水管网水质敏感区进行识别。选取了该市不同水厂供水区域内20个管网采样点2019年3月—2021年3月的余氯、浊度及总铁数据,对不同区域不同季节的管网水质特性进行分析。结果表明,该市供水管网水质整体较好,管网水质敏感区主要集中在供水管网末梢、老旧城区及部分供水分界点,在水源调度过程中需重点关注。管网水质中浊度与余氯具有一定的负相关性,而水体浊度的增加与管道内壁含铁污染物的释放有关。

关键词：供水管网水质化学稳定性水质敏感性余氯

Geant4 used in medical physics and hadrontherapy technique

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Nuclear Science and Techniques 2006年第5期17卷 276-279页

作者： TANG Shi-Biao YIN Ze-Jie HUANG Huan CHENG Yan CHENG Fu-hui mao Feng-Hua Department of Modern Physics University of Science and Technology of China Hefei 230026 China

This article mainly presents the application of Geant4 package (Geant4.7.0, 2005), developed by CERN (the Center of European Research of Nucleus), in medical physics and a novel technique, namely, hadrontherapy. The distribution of energy deposition in a water model by different radiation beams was also given. The results show that the distributions for proton beams are completely different from those for other radiation beams. Charged particles like protons exhibit little scattering when they penetrate the matter and give the highest energy deposition near the end of their range just before they reach the resting state. These characteristics permit very precise control of the shape of the energy distribution inside the patient’s body.

关键词：医学物理学强子治疗技术辐射能分布能量沉积欧洲核物理研究中心

In situ Growing PtCo Bimetallic Catalyst on Plant Tannin-grafted Collagen Fiber for Catalytic Hydrogenation of Cinnamaldehyde with Desirable Performance

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Chemical Research in Chinese Universities 2018年第2期34卷 285-289页

作者： LIAO Ziyi LAN Yang WANG Kai LEI Miao LIAO Yang mao hui MA Jun ZHAO Shilin Department of Scienttfic Research Sichuan Normal University Chengdu 610068 P. R. China College of Chemistry and Materials Science Sichuan Normal University Chengdu 610068 P. R. China Engineering Research Center for the Development of Farmland Ecosystem Service Functions Sichuan Province Institutions of Higher Education Chengdu 610068 P. R. China

PtCox bimetallic nanoparticles（NPs） supported on tannin-grafted collagen fiber（CF-BT） have been pre- pared via a novel synthetic strategy, and applied for catalytic hydrogenation of cinnamaldehyde（CAL）, a typic unsa- turated aldehyde. The catalysts were systematically artd specifically characterized by means of XRD, XPS, TEM-EDX and SEM to clarify the structure-property correlation. It was found that the PtCox/CF-BT catalysts exhi- bited significantly enhanced catalytic activity and desirable stability in catalytic hydrogenation of CAL, which is ascribed to the synergistic interaction between bimetallic components, the effective dispersion, the anchoring role of CF-BT matrix on bimetallic NPs, as well as the lower mass transfer resistance of the matrix.

关键词： Heterogeneous PtCox bimetallic catalyst Tannin-grafted collagen fiber Cinnamaldehyde Liquid-phase hydrogenation

Specific regulator of eosinophil apoptosis： Siglec-8 new hope for bronchial asthma treatment

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Chinese Medical Journal 2012年第11期125卷 2048-2052页

作者： FENG Yin-he mao hui Department of Respiratory Medicine West China Hospital of Sichuan UniversityChengduSichuan 610041China

Objective It is known that Siglec-8 is selectively expressed on human eosinophils at a high level and mediates eosinophil apoptosis when crosslinked with its antibody. The aim of our review is to elucidate the molecular and biological characteristic of Siglec-8 and then discuss the function and possible mechanisms of Siglec-8 in eosinophils. Thereby, we will expand our understanding to the regulation of eosinophil apoptosis, and provide important clues to the treatment of asthma and other hyper-eosinophilic diseases. Data sources Most articles were identified by searching of PubMed online resources using the key term Siglecs. Study selection Mainly original milestone articles and critical reviews written by major pioneer investigators in the field were selected. Results Siglec-8 is selectively expressed on human eosinophil and can specifically induce eosinophil apoptosis. Conclusion The restricted expression of Siglec-8 on human eosinophil and the rapid progress in understanding its role as cell signaling and activation of death receptors have made it an attractive target for treatment of asthma and other hyper-eosinophilic diseases.

关键词： asthma, eosinophil apotosis Siglec-8

Anthraquinone Covalently Modified Carbon Nanotubes for Efficient and Steady Electrocatalytic H2O2 Generation

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Chemical Research in Chinese Universities 2020年第6期36卷 1332-1338页

作者： YU Fangyuan WANG Kai WANG Chuan HE Xinxia LIAO Yang ZHAO Shilin mao hui LI Xiaoting MA Jun College of Chemistry and Materials Science Sichuan Normal UniversityChengdu 610068P.R.China Engineering Research Center for Development of Farmland Ecosystem Service Functions Sichuan Province Institutions of Higher EducationChengdu 610068P.R.China

Anthraquinone(AQ)modified carbon materials could be endowed with significantly improved oxygen re-duction reaction(ORR)***,the application of these materials in the generation of hydrogen peroxide(H2O2)has been rarely *** this motivation,AQ covalently modified carbon nanotube(AQ-CNT)was pur-posely synthesized for H2O2 *** was found that the cumulative H2O2 concentration reached up to 187.18 mg(Lh)over AQ(40)-CNT catalyst,nearly 2.0 times higher than that over CNT,and being superior to those over most carbon materials *** enhanced activity stemmed from the improved mass transfer fficiency of oxygen and the enhanced electrocatalytic ***,the AQ(40)-CNT material exhibited satisfactory stability for H2O2 generation,which was ascribed to the strong interaction force of C-N covalent *** present work could provide a vital idea for designing electrode material with simultancously improved activity and stability for H2O2 gencration.

关键词： Anthraquinone Covalently modified carbon nanotube Oxygen reduction reaction Generation of hydrogen peroxide

Induction chemotherapy with albumin-bound paclitaxel plus lobaplatin followed by concurrent radiochemotherapy for locally advanced esophageal cancer

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World Journal of Gastrointestinal Oncology 2021年第11期13卷 1781-1790页

作者： mao-hui Yan Fang Liu Bao-Lin Qu Bo-Ning Cai Wei Yu Xiang-Kun Dai Department of Radiotherapy The First Medical Center of the Chinese People's Liberation Army(PLA)General HospitalBeijing 100853China

BACKGROUND Albumin-bound paclitaxel(ABP)has been used as second-and higher-line treatments for advanced esophageal cancer,and its efficacy and safety have been well ***(LBP)is a third-generation platinum antitumor agent;compared with the first two generations of platinum agents,it has lower toxicity and has been approved for the treatment of breast cancer,small cell lung cancer,and chronic granulocytic ***,its role in the treatment of esophageal cancer warrants further *** To investigate the efficacy and safety of induction chemotherapy with ABP plus LBP followed by concurrent radiochemotherapy(RCT)for locally advanced esophageal *** Patients with pathologically confirmed advanced esophageal squamous cell carcinoma(ESCC)at our hospital were enrolled in this *** patients were treated with two cycles of induction chemotherapy with ABP plus LBP followed by concurrent RCT:ABP 250 mg/m^(2),ivgtt,30 min,d1,every 3 wk;and LBP,30 mg/m^(2),ivgtt,2 h,d1,every 3 wk.A total of four cycles were *** dose of the concurrent radiotherapy was 56-60 Gy/28-30 fractions,1.8-2.0 Gy/fraction,and 5 fractions/*** A total of 29 patients were included,and 26 of them completed the treatment *** the induction chemotherapy,the objective response rate(ORR)was 61.54%,the disease control rate(DCR)was 88.46%,and the progressive disease(PD)rate was 11.54%;after the concurrent RCT,the ORR was 76.92%,the DCR was 88.46%,and the PD rate was 11.54%.The median progression-free survival was 11.1 mo and the median overall survival was 15.83 *** multivariate analysis revealed that two cycles of induction chemotherapy followed by concurrent RCT significantly reduced the risk of PD compared with two cycles of chemotherapy alone(P=0.0024).Non-hematologic toxicities were tolerable,and the only grade 3 non-hematologic toxicity was radiation-induced esophagitis(13.79%).The main hematologic toxicity was neutropenia,and no

关键词： Esophageal squamous cell carcinoma Esophagus cancer Induction chemotherapy Concurrent radiochemotherapy Radiotherapy Chemotherapy Albuminbound paclitaxel Lobaplatin

Effects of epidermal growth factor receptor inhibitor on proliferative cholangitis in hepatolithiasis

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Hepatobiliary & Pancreatic Diseases International 2015年第5期14卷 509-515页

作者： Qin Yang Yong Zhou Fu-Yu Li hui mao Anuj Shrestha Wen-Jie Ma Nan-Sheng Cheng Wei Zhang Department of Hepatobiliary Surgery West China Hospital of Sichuan University Department of Medicine The George Washington University

BACKGROUND： There is currently no effective medication to prevent stone recurrence after choledochoscopic lithotomy or to treat proliferative cholangitis（PC）, which is the pathologic basis of hepatolithiasis. This study aimed to investigate whether gefitinib, an epidermal growth factor receptor（EGFR） inhibitor, inhibited cholangio hyperplasia and lithogenesis in ***： After cholangioscopic lithotomy, indwelling catheters were placed in the diseased bile duct lumens in 94 patients with hepatolithiasis. Subsequently, 49 of the 94 patients were treated with 250 mg gefitinib solution via a catheter twice a week, and they were subjected to choledochoscopic biopsy at 6 and 12 weeks. The rest 45 hepatolithiasis patients without gefitinib treatment served as ***： The expressions of EGFR, PCNA and procollagen I were significantly reduced in the patients treated with gefitinib in 12 weeks compared with those in the control group. Patients in the gefitinib group had a much lower degree of hyperplasia of the biliary epithelium, submucosal glands and collagen fibers compared with those in the control group. Gefitinib treatment significantly decreased mucin 3 expression and β-glucuronidase ***： Postoperative gefitinib treatment could significantly inhibit PC-mediated hyperplasia and lithogenesis, which might provide a novel strategy for the prevention of biliary restenosis and stone recurrence in patients with hepatolithiasis.

关键词： hepatolithiasis proliferative cholangitis epidermal growth factor receptor blockade recurrence restenosis prevention

Single-Atom Protecting Group for on-Surface Synthesis of Graphdiyne Nanowires

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Chinese Journal of Chemical Physics 2019年第5期32卷 620-624页

作者： Huan Shan Ya-hui mao Ai-di Zhao Hefei National Laboratory for Physical Sciences at the Microscale Synergetic Innovation Center of Quantum Information & Quantum Physics Department of Chemical Physics University of Science and Technology of China Hefei 230026 China

On-surface synthesis of semiconducting graphdiyne nanowires usually suffer severe side reactions owing to the high reactivity of the butadiynylene units at noble metal surfaces,limiting the production of isolated nanowires. In this work, we report the high-yield synthesis of branchless graphdiyne nanowires [-C≡C-Ph2-C≡C-]nvia on-surface Ullmann coupling of 1,4-bis（4-bromophenyl）-1,3-butadiyne molecules with chemical vapor deposition ***-contact atomic force microscopy with single-bond resolution reveals that single gold adatoms act as effective protecting groups for butadiynylene units by forming Au-π ligand bonds, preventing unwanted branched coupling reactions and enabling the synthesis of ultralong isolated graphdiyne nanowires. This study will stimulate further investigation on the role of various surface adatoms in protecting on-surface reactions.

关键词： On-surface synthesis Graphdiyne Ullmann coupling Protecting group Atomic force microscopy