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Emotion and cognitive function assessment of patients with central neurocytoma resection through transcortical frontal approach： a 5-year postoperative follow-up study

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Chinese Medical Journal 2011年第17期124卷 2593-2598页

作者： SHI Zhi-feng SUN Da-liang SONG Jian-ping YAO Yu mao ying Department of Neurosurgery Huashan Hospital Fudan University Shanghai 200040 China Department of Psychiatry Huashan Hospital Fudan University Shanghai 200040 China

Background Central neurocytoma accounts for 0.1% of primary brain tumor that often occurs in young adults. Surgery is the main treatment for central neurocytoma and the rate of 5-year survival reaches up to over 90%. This study aimed to assess the effect of transcortical frontal approach to surgical resection of central neurocytoma on emotion and cognitive function 5 years after surgery. Methods Telephone following-up visits were used in this study. By means of neuropsychological testing, assayed emotion, memory and abstract thinking ability of 18 patients undergoing central neurocytoma resection by transcortical frontal approach for 5 years or more, with another 21 normal cases as control group were enrolled. The data were analyzed statisticaJly by paired t test with SPSS11.5. Results Patients whose central neurocytoma was removed by transcortical frontal approach were not affected on calculating ability 5 years after operation while ability of memory declined sharply （P=-0.000）, the older, the more sharply （P=0.036）. Ability of abstract thinking was significantly reduced （P=0.000）, the older, the more significantly as well （P=-0.012）; additionally, anxiety and depression occurred in patients rather more than those of control group （P=0.000）, especially cognitive impairment. Conclusions Transcortical frontal approach for surgical resection of central neurocytoma has certain long-term influence on patients＇ life quality, vulnerable to anxiety, depression and cognitive impairment, the severity of which was correlated to age. Therefore, imDrovina suroical aoDroach will be of value for better Iona-term life aualitv of oatients.

关键词： central neurocytoma transcortical frontal approach cognition emotions follow-up studies

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White Matter Deficits Underlying the Impaired Consciousness Level in Patients with Disorders of Consciousness

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Neuroscience Bulletin 2018年第4期34卷 668-678页

作者： Xuehai Wu Jiaying Zhang Zaixu Cui Weijun Tang Chunhong Shao Jin Hu Jianhong Zhu Yao Zhao Lu Lu Gang Chen Georg Northoff Gaolang Gong ying mao Yong He Neurosurgical Department Shanghai Huashan HospitalFudan University State Key Laboratory of Cognitive Neuroscience and Learning IDG/Mc Govern Institute for Brain ResearchBeijing Normal University Centre for Medical Image Computing Department of Computer Science University College London Radiological Department Shanghai Huashan Hospital Fudan University Psychiatry Department Shanghai Huashan Hospital Fudan University Huajia Hospital Shanghai Scientific and Statistical Computing Core National Institute of Mental Health National Institutes of Health Department of Health and Human Services Institute of Mental Health Research University of Ottawa

In this study, we aimed to （1） identify white matter （WM） deficits underlying the consciousness level in patients with disorders of consciousness （DOCs） using diffusion tensor imaging （DTI）, and （2） evaluate the relationship between DTI metrics and clinical measures of the consciousness level in DOC patients. With a cohort of 8 comatose, 8 unresponsive wakefulness syndrome/ vegetative state, and 14 minimally conscious state patients and 25 patient controls, we performed group comparisons of the DTI metrics in 48 core WM regions of interest （ROIs）, and examined the clinical relevance using correlation analysis. We identified multiple abnormal WM ROIs in DOC patients compared with normal controls, and the DTI metrics in these ROIs were significantly correlated with clinical measures of the consciousness level. Therefore, our findings suggested that multiple WM tracts are involved in the impaired consciousness levels in DOC patients and demonstrated the clinical relevance of DTI for DOC patients.

关键词： Disorder of consciousness White matter Diffusion tensor imaging Brain injury

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Construction of a DNA library from chromosome 4 of rice(Oryza sativa)by microdissection

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Cell Research 1998年第4期8卷 285-293页

作者： mao ying WEI SI YUAN LIANG WEN QIN SONG XIU LAN LI RUI YANG CHEN (Biology Department, Nankai University, Tianjin 300071,China) Biology Department Nankai University Tianjin China

A simple method to create a chromosome-specific DNA library of rice, including microdissection, amplification,characterization and cloning, is described. Rice chromosome 4 from a metaphase cell has been isolated and amplified by the Linker Adapter PCR (LA-PCR). The PCR products were labeled as probes with DIG-11-dUTP using the random priming *** blot analysis with rice genomic DNA and specific RFLP markers demonstrated that the PCR products were derived from rice chromosome 4. A large library comprising over 100,000recombinant plasmid microclones from rice chromosome 4was constructed. Colony hybridization showed that 58% of the clones contained single or low-copy sequences and 42%contained repetitive sequences. The size of inserts generated by PCR ranged from 140bp to *** method will facilitate cloning of the specific chromosome DNA markers and important genes of rice.

关键词： Rice chromosome 4 DNA library microdissection LA-PCR

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Neuronavigation surgery in China： reality and prospects

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Chinese Medical Journal 2012年第24期125卷 4497-4503页

作者： WU Jin-song LU Jun-feng GONG Xiu mao ying ZHOU Liang-fu Glioma Surgery Division Department of Neurosurgery Huashan Hospital Fudan University Shanghai 200040 China Shanghai Medical College Fudan University Shanghai 200040 China

Objective To review the history, development, and reality of neuronavigation surgery in China and to discuss the future of neuronavigation surgery. Data sources PubMed, the China Knowledge Resource Integrated Database, and the VIP Database for Chinese Technical Periodicals were searched for papers published from 1995 to the present with the key words ＂neuronavigation,＂＂functional navigation,＂＂image-guided,＂ and ＂stereotaxy.＂ Articles were reviewed for additional citations, and some information was gathered from Web searches. Study selection Articles related to neuronavigation surgery in China were selected, with special attention to application to brain tumors. Results Since the introduction of neurosurgical navigation to China in 1997, this core technique in minimally invasive neurosurgery has seen rapid development. This development has ranged from brain structural localization to functional brain mapping, from static digital models of the brain to dynamic brain-shift compensation models, and from preoperative image-guided surgery to intraoperative real-time image-guided surgery, and from application of imported equipment and technology to use of equipment and technology that possess Chinese independent intellectual property rights. Conclusions The development and application of neuronavigation techniques have made neurological surgeries in China more safe, precise and effective, and less invasive, and promoted the quality of Chinese neurosurgical practice to the rank of the most advance and excellence in the world.

关键词： neurosurgery neuronavigation medical image

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Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis

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Frontiers of Medicine 2024年第1期18卷 147-168页

作者： Weiwei Xian Mohammad Asad Shuai Wu Zhixin Bai Fengjiao Li Junfeng Lu Gaoyu Zu Erin Brintnell Hong Chen ying mao Guomin Zhou Bo Liao Jinsong Wu Edwin Wang Linya You Department of Human Anatomy&Histoembryology School of Basic Medical SciencesFudan UniversityShanghai200032China Cumming School of Medicine University of CalgaryCalgaryAlbertaT2N 4N1Canada Glioma Surgery Division Department of NeurosurgeryHuashan HospitalFudan UniversityShanghai200040China Department of Pathology Huashan HospitalFudan UniversityShanghai200040China Department of Neurosurgery Huashan HospitalFudan UniversityShanghai200040China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Fudan UniversityShanghai200040China School of Mathematics and Statistics Hainan Normal UniversityHaikou570100China

The association of neurogenesis and gliogenesis with glioma remains *** conducting single-cell RNA-seq analyses on 26 gliomas,we reported their classification into primitive oligodendrocyte precursor cell(pri-OPC)-like and radial glia(RG)-like tumors and validated it in a public cohort and TCGA *** RG-like tumors exhibited wild-type isocitrate dehydrogenase and tended to carry EGFR mutations,and the pri-OPC-like ones were prone to carrying TP53 *** subclones only in pri-OPC-like tumors showed substantially down-regulated MHC-I genes,suggesting their distinct immune evasion ***,the two subgroups appeared to extensively modulate glioma-infiltrating lymphocytes in distinct *** specific genes not expressed in normal immune cells were found in glioma-infiltrating *** example,glial/glioma stem cell markers OLIG1/PTPRZ1 and B cell-specific receptors IGLC2/IGKC were expressed in pri-OPC-like and RG-like glioma-infiltrating lymphocytes,*** expression was positively correlated with those of immune checkpoint genes(e.g.,LGALS33)and poor survivals as validated by the increased expression of LGALS3 upon IGKC overexpression in Jurkat *** finding indicated a potential inhibitory role in tumor-infiltrating lymphocytes and could provide a new way of cancer immune evasion.

关键词： single-cell RNA-seq glioma radial glia primitive oligodendrocyte precursor cell immune escape

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脑血管重建术的重新评价与应用

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中国脑血管病杂志 2007年第10期4卷 433-435页

作者：毛颖复旦大学附属华山医院神经外科上海200040

当我们把21世纪的显微神经外科技术和20世纪所做的手术进行比较,就会发现目前所能治疗的疾病已远多于上个世纪,用来诊断和判断疾病的手段已极大丰富,取得的临床疗效也好于以往,所以我们常自豪地宣称:我们能为前辈所不能为的事.但任何临... 详细信息

当我们把21世纪的显微神经外科技术和20世纪所做的手术进行比较,就会发现目前所能治疗的疾病已远多于上个世纪,用来诊断和判断疾病的手段已极大丰富,取得的临床疗效也好于以往,所以我们常自豪地宣称:我们能为前辈所不能为的事.但任何临床技术的革新都是建立在前人经验和教训基础上,任何创新都需要临床结果的支持和确凿的证据,以证明方法的先进性和有效性.因此,我们应深刻地意识到:我们能做的并不代表我们应该做.

关键词：脑血管重建术显微神经外科技术临床疗效临床技术临床结果有效性疾病新都

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DEDUCING AND VERIFying THE FREQUENCY EQUATION SET OF DUAL-FREQUENCY PIEZOELECTRIC TRANSDUCER

DEDUCING AND VERIFYING THE FREQUENCY EQUATION SET OF DUAL-FR...

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2012全国压电和声波理论及器件技术研讨会

作者： Jia-he FU Han-ying mao Zhen-feng HUANG Han-ling mao School of Mechanical Engineering Guangxi University Dept.of Autos Guangxi University of Technology

Two different operating frequencies were required in dual-frequency piezoelectric transducers,a frequency equation set that satisfy with the requirement were deduced in this *** different dual-frequency piezoelectric transducers were designed;then modal analysis and frequency response analysis for these transducers model were completed with ANSYS software,the frequencies obtained by simulation were very close to the design *** the frequency equation set has been verified.

关键词： Piezoelectric Transducer Dual-frequency Frequency equation set ANSYS

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论国库集中收付的制度条件——预算会计改革

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财经论丛（浙江财经学院学报） 2005年第2期 52-56页

作者：茆英娥浙江财经学院财政与公共管理学院浙江杭州310012

实行国库集中收付制度,客观上需要有对财政资金收付过程进行核算、反映、监督的完善的预算会计制度。本文针对现行预算会计制度不能满足实行国库集中收付制度所引起的财政资金运动变化要求这一现实问题,从建立和完善政府与非营利组织会... 详细信息

实行国库集中收付制度,客观上需要有对财政资金收付过程进行核算、反映、监督的完善的预算会计制度。本文针对现行预算会计制度不能满足实行国库集中收付制度所引起的财政资金运动变化要求这一现实问题,从建立和完善政府与非营利组织会计核算体系和内容、采用修正的权责发生制计量基础等方面提出了预算会计的改革方向。

关键词：国库集中收付制度条件预算会计改革

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论中国证券市场课税的公平与效率

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预测 2012年第6期31卷 35-39页

作者：茆晓颖苏州大学东吴商学院江苏苏州215021

证券市场税收制度是指与证券市场的行为主体或其行为相关的税收政策及制度规定。总体来说,对证券市场课税公平与效率的认识和估计,可以分为赞成派和反对派。在发展中国家,实施公平必须与经济发展相联系,与资源的利用效率相联系。通过分... 详细信息

证券市场税收制度是指与证券市场的行为主体或其行为相关的税收政策及制度规定。总体来说,对证券市场课税公平与效率的认识和估计,可以分为赞成派和反对派。在发展中国家,实施公平必须与经济发展相联系,与资源的利用效率相联系。通过分析中国证券发行环节、交易环节、所得环节和遗赠环节课税的公平与效率,本文提出了优化我国证券市场税收制度的政策建议。

关键词：证券市场税收公平效率

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Connexin 36 Mediates Orofacial Pain Hypersensitivity Through GluK2 and TRPA1

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Neuroscience Bulletin 2020年第12期36卷 1484-1499页

作者： Qian Li Tian-Le Ma You-Qi Qiu Wen-Qiang Cui Teng Chen Wen-Wen Zhang Jing Wang Qi-Liang mao-ying Wen-Li Mi Yan-Qing Wang Yu-Xia Chu Department of Integrative Medicine and Neurobiology Institutes of Integrative MedicineSchool of Basic Medical SciencesInstitutes of Brain ScienceBrain Science Collaborative Innovation CenterState Key Laboratory of Medical Neurobiologyand MOE Frontiers Center for Brain ScienceFudan UniversityShanghai 200031China Department of Pain Management Shandong Provincial Qianfoshan HospitalThe First Hospital Affiliated with Shandong First Medical UniversityJinan 250000China Department of Nephropathy The Third Affiliated Hospital of Shenzhen UniversityLuohu Hospital GroupShenzhen 518001China

Trigeminal neuralgia is a debilitating condition,and the pain easily spreads to other parts of the ***,we established a mouse model of partial transection of the infraorbital nerve(pT-ION)and found that the Connexin 36(Cx36)inhibitor mefloquine caused greater alleviation of pT-ION-induced cold allodynia compared to the reduction of mechanical *** reversed the pT-IONinduced upregulation of Cx36,glutamate receptor ionotropic kainate 2(GluK2),transient receptor potential ankyrin 1(TRPA1),and phosphorylated extracellular signal regulated kinase(p-ERK)in the trigeminal *** allodynia but not mechanic al allodynia induced by pT-ION or by virusmediated overexpression of Cx36 in the trigeminal ganglion was reversed by the GluK2 antagonist NS 102,and knocking down Cx36 expression in Nav1.8-expressing nociceptors by injecting virus into the orofacial skin area of Nav1.8-Cre mice attenuated cold allodynia but not mechanic al *** conclusion,we show that Cx36 contributes greatly to the development of orofacial pain hypersensitivity through GluK2,TRPA1,and p-ERK signaling.

关键词： Orofacial pain Gap junction Glutamate receptor ionotropic kainate 2 Transient receptor potential A1

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