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中华风湿病学杂志 2024年第6期28卷 367-373页

作者：毛桐俊何倩贾兰兰赵心悦忻钰棋谈文峰皖南医学院第一附属医院风湿免疫科、安徽省危重症呼吸疾病临床医学研究中心芜湖241001 皖南医学院麻醉学院芜湖241002 南京医科大学第一附属医院风湿免疫科南京210029

目的探讨IL-18在抗黑色素瘤分化相关基因5(MDA5)抗体阳性皮肌炎(MDA5-DM)发病过程中的作用。方法本研究中纳入2018年8月至2020年12月南京医科大学第一附属医院与皖南医院第一附属医院风湿免疫科收治MDA5-DM患者28例, 其中合并快速进展... 详细信息

目的探讨IL-18在抗黑色素瘤分化相关基因5(MDA5)抗体阳性皮肌炎(MDA5-DM)发病过程中的作用。方法本研究中纳入2018年8月至2020年12月南京医科大学第一附属医院与皖南医院第一附属医院风湿免疫科收治MDA5-DM患者28例, 其中合并快速进展型间质性肺炎(RPILD)15例、非RPILD 13例, 同时纳入抗合成酶综合征(ASS)28例, 健康志愿者(HC)组28名, 分别收集MDA5-DM组、ASS组患者临床资料和实验室、影像学资料;应用ELISA法检测各组血清IL-18水平。采用独立t检验、Mann-WhitneyU检验、χ^(2)检验和Fisher确切概率法进行分析。结果 MDA5-DM组、ASS组及HC组在LDH、羟丁酸脱氢酶(HBDH)、ESR、CRP、血清铁蛋白(SFE)及IL-18等指标上差异有统计学意义(F=46.65, P<0.001;F=43.19, P<0.001;F=31.28, P<0.001;F=23.94, P<0.001;F=30.94, P<0.001;F=49.44, P<0.001)。3组间淋巴细胞计数、血红蛋白水平差异有统计学意义(F=35.26, P<0.001;F=18.59, P<0.001)。MDA5-DM患者Gottron征、向阳疹、甲周红斑、皮肤溃疡、RPILD发生率均高于ASS组患者(χ^(2)=20.96, P<0.001;χ^(2)=5.85, P=0.016;χ^(2)=13.69, P<0.001;χ^(2)=9.16, P=0.002;χ^(2)=4.79, P=0.029), 而技工手发生率低于ASS组患者(χ^(2)=3.90, P=0.048)。MDA5-DM治疗前IL-18水平为104.28(71.96, 151.10)pg/ml, 治疗后IL-18明显下降78.30(56.20, 94.80)pg/ml(Z=2.27, P=0.023);ASS组患者治疗前IL-18水平为72.30(61.39, 95.94)pg/ml, 治疗后IL-18明显下降45.30(29.00, 84.10)pg/ml(Z=2.69, P=0.007);而MDA5-DM合并RPILD组患者治疗前后IL-18水平变化差异无统计学意义[99.49(77.65, 130.87)pg/ml与89.40(54.80, 120.20)pg/ml, Z=0.65, P=0.515]。MDA5-DM存活组患者治疗后IL-18水平[59.45(53.58, 81.63)pg/ml]明显较治疗前[106.37(83.62, 152.07)pg/ml]下降(Z=2.80, P=0.005);而MDA5-DM死亡组患者治疗前后IL-18水平变化差异无统计学意义[99.49(56.70, 140.15)pg/ml与94.80(71.40, 155.45)pg/ml, Z=1.75, P=0.080]。结论 MDA5-DM组患者在临床表现及实验室检查方面有别于ASS患者;IL-18在MDA5-DM及ASS活动期表达水平升高, 并随着病情缓解而下降;可能与DM并发ILD中具有重要的作用。持续高水平IL-18与MDA5-DM发生RPILD及死亡相关, 可以作为预测MDA5-DM发生RPILD潜在性的生物标志物。

关键词：白细胞介素18 皮肌炎抗黑色素瘤分化相关基因5抗体间质性肺病快速进展型

Efficacy and safety of Xinfeng capsule in patients with rheumatoid arthritis:a multi-center parallel-group double-blind randomized controlled trial

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Journal of Traditional Chinese Medicine 2015年第5期35卷 487-498页

作者： Liu Jian Wang Yuan Huang Chuanbing Xu Jianhua Li Zhijun Xu Liang He Liyun Sun Yue Wang Yali Xu Shengqian Zhao Ping mao tongjun Tan Bin Zhu Fubing Zhang Pingheng Fang Li Department of Rheumatism Immunity The First Affiliated HospitalAnhui University of Chinese Medicine Department of Rheumatism Immunity The First Affiliated Hospital of Anhui Medical University Department of Rheumatism Immunity The First Affiliated Hospital of Bengbu Medical College Department of Rheumatism Immunity The First Affiliated Hospital of Wannan Medical College The Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences

OBJECTIVE:To evaluate the efficacy and safety of Xinfeng capsule in patients suffering rheumatoid arthritis(RA).METHODS:A multi-center parallel-group designed,double-blind,randomized,controlled trial was *** 304 RA patients were assigned to two groups:one group was administered Xinfeng capsule(XFC) plus the placebo of leflunomide and the other given leflunomide(LEF) plus the placebo of XFC for twelve *** clinical and laboratory parameters were compared at baseline and fourth,eighth,and twelfth ***:After twelve-week treatment,patients in two groups all showed some trend of effectiveness when compared in terms of American Rheumatism Association(ACR) recommended 20%,50%,70%improvement criteria,but it was *** validity in ameliorate modified disease activity score(DAS28) and laboratory indexes as erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),rheumatoid factor(RF) were also found no *** score of health assessment questionnaire(HAQ),self-rating anxiety scale(SAS),self-rating depression scale(SDS) and quality of life questionnaire with rheumatoid arthritis(RAQOL)both lower than the first week and the changes showed no ***,the score of SDS dropped more in XFC group than in the other.A total of 147 adverse reaction cases were reported,which shows no difference between the two *** most common adverse reactions were hepatic impairment,anemia,leukocytopenia,epigastric discomfort and ***:XFC demonstrated better improvement in the scores of SDS and compared with those of LEF group.

关键词： Arthritis rheumatoid Xinfeng capsule Treatment outcome Multicenter study Double-blind method Randomized controlled trials

Simulation and evaluation study of atmospheric aerosol nonsphericity as a function of particle size

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Particuology 2024年第7期90卷 281-291页

作者： Qianjun mao Xin Nie School of Urban Construction Wuhan University of Science and TechnologyWuhan430065China College of New Energy and Materials Northeast Petroleum UniversityDaqing163318China

Aerosol nonsphericity causes great uncertainty in radiative forcing assessments and climate *** considerable studies have attempted to quantify this uncertainty,the relationship between aerosol nonsphericity and particle size is usually not considered,thus reducing the accuracy of the *** this study,a coupled inversion algorithm combining an improved stochastic particle swarm optimization algorithm and angular light scattering is used for the nonparametric estimation of aerosol nonsphericity variation with particle size,and the optimal sample selection method is employed to screen the *** on the verification of inversion accuracy,the variation of aerosol aspect ratio with particle size based on the ellipsoidal model in global regions has been obtained from Aerosol Robotic Network(AERONET)data,and the effect of nonsphericity on radiative forcing and dry deposition has been *** results show that the aspect ratio increases with particle size in all regions,with the maximum ranging from 1.4 to 1.8 in the desert,reflecting the differences in aerosol composition at different particle *** radiation calculations,considering aerosol nonsphericity makes the aerosol cooling effect weaker and surface radiative fluxes increase,but hardly changes the aerosol absorption,with maximum differences of 9.22%and 22.12%at the bottom and top of the atmosphere,***,the differences in radiative forcing between aspect ratios as a function of particle size and not varying with particle size are not significant,averaging less than 2%.Besides,the aspect ratio not varying with particle size underestimates the deposition velocity of small particles and overestimates that of large particles compared to that as a function of particle size,with maximum differences of 7%and 4%,respectively.

关键词： Aerosol nonsphericity Inversion Aspect ratio Radiative forcing Dry deposition velocity

Pressure-induced hydrogen-dominant high-temperature superconductors

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National Science Review 2024年第7期11卷 14-16页

作者： Ho-kwang mao Shanghai Advanced Research in Physical Sciences Center for High Pressure Science and Technology Advanced Research

Recent studies of hydrogen-dominant（superhydride） materials have led to putative discoveries of near-room temperature superconductivity at high pressures. The idea started more than half-a-century ago as a by-product of the quest for metallic hydrogen for which a natural consequence of its very high Debye temperature and phonon frequency due to the very low mass of the hydrogen atoms would lead to a high superconducting critical temperature （Tc） in weak coupling Bardeen-Cooper-Schrieffer（BCS） expression.

关键词： HYDRIDE LANTHANUM

Proof of Two Supercongruences of Truncated Hypergeometric Series_(4)F_(3)

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Acta Mathematica Sinica,English Series 2024年第4期40卷 1015-1028页

作者： Guo Shuai mao Department of Mathematics Nanjing University of Information Science and TechnologyNanjing 210044P.R.China

In this paper,we prove two supercongruences conjectured by Z.-*** via the Wilf-Zeilberger *** of them is,for any prime p>3,4F3[7/6 1/2 1/2 1/2 1/6 1 1]-1/8]-1/2≡p(-2/p)+p^(3)/4(2/p)Ep-3 (mod p^(4))where(·/p)stands f... 详细信息

关键词： Supercongruence truncated hypergeometric series Wilf–Zeilberger method Euler numbers Legendre symbol

One bird,multiple stones:The race to find a gene of dominant negative effect in wheat

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The Crop Journal 2024年第4期12卷 951-952页

作者： Long mao State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

In the current issue of The Crop Journal,Chen et al.[1]reports map-based cloning of a wheat gene that showed temperaturedependent pleiotropic effects on multiple traits including plant height,leaf shape,spike and grain morphology,and accordingly was named WPA1 for Wheat Plant Architecture *** mutant was first observed among EMS-treated plants and repeatedly appeared in multiple occasions.

关键词： Wheat bird repeatedly

Dynamic steric confinement effect expands the frontier of Cu-catalyzed asymmetric propargylic aminations

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Science China Chemistry 2024年第10期67卷 3181-3183页

作者： Peng Chen mao-mao Zhang Wen-Jing Xiao Liang-Qiu Lu Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction Ministry of EducationCollege of ChemistryCentral China Normal UniversityWuhan 430079China Wuhan Institute of Photochemistry and Technology Wuhan 430082China State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics(LICP)Chinese Academy of SciencesLanzhou 730000China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

Chiralα-tertiary amines and related azacycles are commonly found in many natural products,pharmaceuticals and agrochemicals[1].Copper-catalyzed asymmetric propargylic amination(APA)reactions have been established as a reliable method to access enantio-enriched propargylic amines,largely due to the seminal contribution of Nishibayashi et al.[2]and van Maarseveen et al.[3]in 2008.

关键词： catalyzed asymmetric amines

Heat Storage Performance of PCM in a Novel Vertical Pointer-Shaped Finned Latent Heat Tank

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Journal of Thermal Science 2024年第2期33卷 422-434页

作者： mao Qianjun ZHU Yuanyuan LI Tao School of Urban Construction Wuhan University of Science and TechnologyWuhan430065China

The heat storage performance of latent heat storage systems is not good due to the poor thermal conductivity of phase change *** this paper,a new type of pointer-shaped fins combining rectangular and triangular fins has been employed to numerically simulate the melting process in the heat storage tank,and the fin geometry parameter effects on heat storage performance have been *** results indicate that compared with the bare tube and the rectangular finned tank,the melting time of the phase change material in the pointer-shaped finned tank is reduced by 64.2%and 15.1%,*** closer the tip of the triangular fin is to the hot wall,the better the heat transfer *** optimal height of the triangular fin is about 8 *** the number of fins from 4 to 6 and from 6 to 8 reduces the melting time by 16.0%and 16.7%***,increasing the number of fins from 8 to 10 only reduces the melting time by 8.4%.When the fin dimensionless length is increased from 0.3 to 0.5 and from 0.5 to 0.7,the melting time is shortened by 17.5%and 13.0%.But the melting time is only reduced by 2.9%when the dimensionless fin length is increased from 0.7 to *** optimising the design of the thermal storage system,the results can provide a reference value.

关键词： thermal energy storage phase change material pointer-shaped fins heat storage performance

Equilibrium Strategy of the Pursuit-Evasion Game in Three-Dimensional Space

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 446-458页

作者： Nuo Chen Linjing Li Wenji mao School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049 Institute of Automation Chinese Academy of SciencesBeijing 100190China

The pursuit-evasion game models the strategic interaction among players, attracting attention in many realistic scenarios, such as missile guidance, unmanned aerial vehicles, and target defense. Existing studies mainly concentrate on the cooperative pursuit of multiple players in two-dimensional pursuit-evasion games. However, these approaches can hardly be applied to practical situations where players usually move in three-dimensional space with a three-degree-of-freedom control. In this paper,we make the first attempt to investigate the equilibrium strategy of the realistic pursuit-evasion game, in which the pursuer follows a three-degree-of-freedom control, and the evader moves freely. First, we describe the pursuer's three-degree-of-freedom control and the evader's relative coordinate. We then rigorously derive the equilibrium strategy by solving the retrogressive path equation according to the Hamilton-Jacobi-Bellman-Isaacs(HJBI) method, which divides the pursuit-evasion process into the navigation and acceleration phases. Besides, we analyze the maximum allowable speed for the pursuer to capture the evader successfully and provide the strategy with which the evader can escape when the pursuer's speed exceeds the threshold. We further conduct comparison tests with various unilateral deviations to verify that the proposed strategy forms a Nash equilibrium.

关键词： Differential game equilibrium strategy pursuit-evasion game threedegree-of-freedom control