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Malignant hyperthermia as a rare complication of local lidocaine injection:A case report

World Journal of Anesthesiology 2023年第1期12卷 1-7页

作者： Mukosolu Florence Obi manveer ubhi Vikhyath Namireddy Chelsea Noel Manjari Sharma Frederick N.Campos Yash Garg Department of Internal Medicine Wyckoff Heights Medical CenterNew YorkNY 11237United States Department of Medicine St.Georges University School of MedicineTrue Blue 38902Grenada

BACKGROUND Malignant hyperthermia(MH)is a hypermetabolic disorder of skeletal muscles triggered by exposure to volatile anesthetics and depolarizing muscular *** manifests with clinical presentations such as tachycardia,muscle rigidity,hyperpyrexia,and rhabdomyolysis in genetically predisposed individuals with ryanodine receptor or calcium voltage-gated channel subunit alpha1 S *** anesthetics,such as lidocaine,are generally considered safe;however,complications can arise,albeit *** administration has been reported to induce hypermetabolic reactions resembling MH in susceptible *** exact mechanism by which lidocaine might trigger MH is not fully *** some mechanisms are postulated,further research is needed for a better understanding of *** SUMMARY We present the case of MH in a 43-year-old male patient with an unknown genetic predisposition following a lidocaine injection during a dental *** case serves as a reminder that while the occurrence of lidocaine-induced MH is rare,lidocaine can still trigger this life-threatening ***,caution should be exercised when administering lidocaine to individuals who may be susceptible to *** is important to note that prompt intervention played a crucial role in managing the patient’s *** recognizing the early signs of MH,aggressive measures were initiated,including vigorous intravenous normal saline administration and *** to the effectiveness of these interventions,the administration of dantrolene sodium,a specific antidote for MH,was *** This case highlighted the significance of vigilant monitoring and swift action in mitigating the detrimental effects of lidocaine-induced *** should be exercised when administering lidocaine to individuals who may be predisposed to *** is very important to be aware and vigilant of the signs and symptoms of MH as early recognition and treatment intervention

关键词： Malignant hyperthermia Tachyarrhythmia Lidocaine Local anesthesia Dantrolene sodium Genetic mutation Case report

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