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Treatment of Chronic Oxaliplatin-Induced Peripheral Neuropathy: A Systematic Review

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Journal of Cancer Therapy 2020年第9期11卷 519-534页

作者： Alda Tavares Ana Agrelo manuela Machado Department of Medical Oncology Hospital Pedro Hispano Matosinhos Local Health Unit Matosinhos Portugal Department of Anesthesiology Portuguese Institute of Oncology of Porto Porto Portugal Department of Medical Oncology Portuguese Institute of Oncology of Porto Porto Portugal

Introduction: Oxaliplatin is a platinum-derivative chemotherapeutic agent used in digestive tumours, in the adjuvant and metastatic setting. Oxaliplatin can cause a chronic peripheral sensory neuropathy which impacts the quality of life and is dose limiting. To date, no therapeutic strategies have proved effective in the treatment of oxaliplatin-induced peripheral neuropathy (OIPN). Methods: A computerized search of the literature on PubMed database was performed. Publisher original articles were included if they focused on treatment of peripheral neuropathy among patients submitted to oxaliplatin. Eleven out of 242 reviewed papers met our inclusion criteria and were subjected to a 19-item quality checklist. Results: The included studies differed with respect to study design, patient population and sample size, neuropathic symptoms assessment and efficacy measure. Most studies had an adequate quality. Ten trials tested one drug, and one pilot study tested a non-pharmacological treatment—the neurofeedback. Of these, 3 trials included only patients submitted to oxaliplatin-based chemotherapy. Duloxetine showed moderate efficacy in 3 trials. Topical treatment with capsaicin or 10% amitriptyline was promisors in 2 single-arm trials with a few samples.

关键词： Peripheral Neuropathy Oxaliplatin Chemotherapy-Induced Peripheral Neuropathy Pain Neurotoxicity Supportive Care

LA NEVOSIT IN LOMBARDIA NEL PERIODO 1964-1973

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Natural Disaster Reduction in China 1988年第1期 63-108页

作者： SEVERINO BELLONI e manuela PELFINI Dipartimento di Scienze della Terra dell'Università degli Studi di Milano

The snow fall in Lombardy benceen 1964 and *** article considers the snow precipitationsin Lombardy through the analysis of the snow cover thickness,the precipitation days and the stay-on-grounddays numbers registered in 110 stations between 1964 and *** the above mentioned parameters the an-nual maximum、medium and minimum trends are included into their respective *** diagrams of fourstation are given as *** thickness of the snow cover increases according to the *** maximum mo-ves from January to *** number of snow precipitation days increases unevenly according to the alti-tude,because of some local factors such as morphology and *** snow fall period of the low and me-dium altitude stations goes from October to *** that of the high altitude ones,above 1500 m a.s.l.,goes from October to *** annual stay of the snow cover is higher than the number of snow fall days.

关键词： OO La St OC ab LA NEVOSIT IN LOMBARDIA NEL PERIODO 1964-1973

Artistic Creativity: Implicit Theories of the Painters and Artists

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Artistic Creativity: Implicit Theories of the Painters and A...

Brazilian adolescents’lifestyle in the COVID‑19 pandemic:a mixed‑methods study

创造创新与可持续发展国际学术研讨会

作者： manuela Romo Global Correspondents:Ph.D.Professor of Psychology

＜正＞INTRODUCTIONThe study I present here analyzes implicit theories about artistic creativity. It was developed in three phases: an historiographic study, a representational one and the last with painters, where the implicit theories of artistic creativity defined previously in a sample of lay persons were compared with those of a painters group.

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World Journal of Pediatrics 2022年第8期18卷 553-557页

作者： Caroline Lima Fonseca Carolina Ferreira Peterle Bruna Hinnah Borges Martins de Freitas Maria Aparecida Munhoz Gaíva Paula manuela Jorge Diogo Juliano Bortolini Federal University of Mato Grosso 2367 Fernando Corrêa da Costa AvBoa EsperançaCuiabáMT 78060-900Brazil Lisbon College of Nursing LisbonPortugal

The COVID-19 pandemic has forced the health authorities and governments worldwide to engage in a battle against the disease,adopting several mitigation strategies[1].Since then,the world population has been afected by various changes in its *** imposed by the COVID-19 pandemic are believed to have had an impact on adolescents'lifestyle(LS)[2].The LS is determined by discernible behavior patterns that can trigger efects on adolescents'health and is related to countless aspects that refect attitudes,values and life opportunities[3].Therefore,LS can be observed from the habits,behaviors and activities performed by people in their daily lives[4].

关键词： has routine COV

Nutritional value of a partially defatted and a highly defatted black soldier fly larvae (Hermetia illucens L.) meal for broiler chickens: apparent nutrient digestibility,apparent metabolizable energy and apparent ileal amino acid digestibility

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Journal of Animal Science and Biotechnology 2017年第4期8卷 897-905页

作者： Achille Schiavone Michele De Marco Silvia Martínez Sihem Dabbou manuela Renna Josefa Madrid Fuensanta Hernandez Luca Rotolo Pierluca Costa Francesco Gai Laura Gasco Department of Veterinary Sciences University of Turin Largo Paolo Braccini 2 10095 Grugliasco TO Italy Department of Animal Production University of Murcia Campus de Espinardo 30071 Murcia Spain Department of Agricultural Forest and Food Sciences University of Turin Largo Paolo Braccini 2 10095 Grugliasco TO Italy Institute of Science of Food Production National Research Council Largo Paolo Braccini 2 10095 Grugliasco TO Italy

Background: The study aimed to determine the apparent total tract digestibility coefficients(ATTDC) of nutrients, the apparent metabolizable energy(AME and AMEn) and the amino acid(AA) apparent ileal digestibility coefficients(AIDC)of a partially defatted(BSFp) and a highly defatted(BSFh) black soldier fly larvae meal. The experimental diets were: a basal diet and two diets prepared by substituting 250 g/kg(w/w) of the basal diet with BSFp or BSFh, ***: Significant differences were found between BSFp and BSFh meals for ATTDC of the nutrients: BSFp resulted more digestible than BSFh, except for ATTDC of CP which did not differed between meals, while a statistical trend was observed for ATTDC of DM and EE. The AME and AMEn values were significantly(P < 0.05) different between the two BSF meals, with higher levels for BSFp(16.25 and 14.87 MJ/kg DM, respectively). The AIDC of the AA in BSFp ranged from 0.44 to 0.92, while in BSFh they ranged from 0.45 to 0.99. No significant differences were observed for the AA digestibility(0.77 and 0.80 for BSFp and BSFh, respectively), except for glutamic acid, proline and serine that were more digestible in the BSFh meal(P < 0.05).Conclusions: Defatted BSF meals can be considered as an excellent source of AME and digestible AA for broilers with a better efficient nutrient digestion. These considerations suggested the effective utilization of defatted BSF larvae meal in poultry feed formulation.

关键词： Amino acid Apparent digestibility Black soldier fly meal Broiler chicken Metabolizable energy

Experimental Evaluation of Thermal Properties of Grouting Materials

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Journal of Energy and Power Engineering 2013年第8期7卷 1457-1463页

作者： manuela Campanale Marta Deganello Lorenzo Moro Department of lndustrial Engineering University of Padova Padova 35131 Italy

This study is aimed at the thermal analysis of sealant mortar （usually a mixtures of bentonite and cemem with addition of sand） used in geothermal cooling and heating. In particular, thermal conductivity and diffusivity measurements were performed on differem sealant mixtures by using Hot Disk thermal constants analyzer in order to identify the interesting thermal properties of grouting materials. The grouting materials that we considered are of porous nature and, if used in the presence of groundwater, have different levels of imbibitions. It is important to know the thermal behavior of these materials at different water content. A first set of measurements was performed on a not-tinted material at room temperature; then the samples were led to saturation conditions by contact capillary imbibitions with a cotton wool layer moistened in water. The determination of thermal conductivity in these test conditions appears to be critical compared to the measuremems on non-timed sample. The thermal conductivity tests have revealed how the thermal behavior of the samples analyzed is essentially determined by the density and water content of the material： in fact, the thermal conductivity increases of two to three times the value of the not-tinted material.

关键词： Geothermal energy thermal conductivity sealant mortar hot disk grouting materials Portland cement mortar.

苹果品质检测的可见-近红外激光漫反射光谱图像法的方法研究

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光谱学与光谱分析 2008年第6期28卷 1273-1277页

作者：庆兆坤籍保平史波林朱大洲屠振华 ZUDE manuela 中国农业大学食品科学与营养工程学院北京100083 德国农业工程研究所德国波茨坦14469

利用可见-近红外激光漫反射光谱图像法及化学计量学方法检测了苹果的可溶性固形物含量和硬度。为了消除苹果形状对品质检测的影响,分析了5个不同波长的激光(680,780,880,940和980 nm)照射在富士苹果果面形成的光斑图像,并通过一系列图... 详细信息

利用可见-近红外激光漫反射光谱图像法及化学计量学方法检测了苹果的可溶性固形物含量和硬度。为了消除苹果形状对品质检测的影响,分析了5个不同波长的激光(680,780,880,940和980 nm)照射在富士苹果果面形成的光斑图像,并通过一系列图像处理方法得出了的苹果形状修正算法。分别利用修正前后的光谱图像参数建立苹果可溶性固形物含量和硬度的偏最小二乘回归(PLSR)模型,模型预测值和真实值之间的相关系数从0.78和0.80分别提高到0.87和0.89。为了消除果面镜面反射对苹果内部品质检测的影响,文章提出了象素强度频率检测法,并比较了利用果面光斑图像中光强均值和不同强度对应的象素强度频率建立的苹果硬度和可溶性固形物含量的PLSR模型效果,得出象素强度频率的模型效果更好。苹果可溶性固形物含量和硬度PLSR模型中预测均方根误差(RMSEP)分别从1.28°Brix和8.23 ***-2降低到0.84°Brix和6.17 ***-2。

关键词：可见-近红外激光漫反射光谱图像法象素强度频率可溶性固形物含量硬度富士苹果修正算法

Zinc Oxide Nanoparticles in Bacterial Growth Medium: Optimized Dispersion and Growth Inhibition of <i>Pseudomonas putida</i>

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Advances in Nanoparticles 2013年第4期2卷 287-293页

作者： manuela Vielkind Ingo Kampen Arno Kwade Institute for Particle Technology Braunschweig University of Technology Braunschweig Germany

The majority of nanoparticles tend to agglomerate in bacterial growth media. Thus, nanoparticle-specific characteristics can get lost. To investigate the influence of nanoparticles on bacteria, these particles should remain in their nanoparticulate state. The present study demonstrates the stabilization of commercially available zinc oxide (ZnO) with sodiumhexametaphosphate (SHMP) in bacterial growth medium (LB) to avoid agglomeration of these particles after the addition to LB. This established method is appropriate to stabilize ZnO agglomerates as small as 43 nm. The method of fractionated centrifugation was used to obtain stable agglomerates (also stable in the presence of bacteria) with different mean diameters. The SHMP-stabilized ZnO inhibits the growth of Pseudomonas putida with increasing concentration (up to 500 mg/L) and decreasing agglomerate size (43 - 450 nm).

关键词： Bacterial Growth Medium Optimized Dispersion Pseudomonas putida Zinc Oxide Nanoparticles

Multiple Synchronous Tumours:A Peculiar Clinical Case

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Journal of Cancer Therapy 2019年第7期10卷 602-608页

作者： Maria Leitao Tiago Alpoim manuela Machado Medical Oncology Department IPOPortoPortugal

Background: Due to improvements in diagnosis, the better outcomes of oncological patients and the increase in the average age, the incidence of synchronous tumours is likely to increase. Aim: To reflect on the challenges of a case with multiple integrated diagnostic and therapeutic approaches and to bring to consideration the increasing prevalence of similar situations. Case Presentation: In this clinical case, the authors describe the evolution of an asymptomatic patient with several synchronous tumours (a GEJ primary adenocarcinoma, a low grade urothelial carcinoma in situ, a localized squamous cell lung carcinoma and 2 IPMNs). Conclusion: The challenge of this case lies in the difficult diagnostic approach, the assembly of a multidisciplinary and time-sensitive treatment plan and the individualized follow-up, due to lack of guidelines. More research is needed in this area.

关键词： Gastric Cancer Multiple Primary Neoplasms Synchronous