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Intra-hepatic and extra-hepatic cholangiocarcinoma:New insight into epidemiology and risk factors

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World Journal of Gastrointestinal Oncology 2010年第11期2卷 407-416页

作者： Vincenzo Cardinale Rossella Semeraro Alessia Torrice manuela gatto Cristina Napoli Maria Consiglia Bragazzi Raffaele Gentile Domenico Alvaro Dipartimento di Scienze e Biotecnologie Medico-Chirurgiche Sapienza University of Rome00185 RomeItaly

Cholangiocarcinoma(CCA) is a malignant tumour that arises from biliary epithelium at any portion of the biliary *** is currently classified as intra-hepatic or extra-hepatic CCA(EH-CCA).Recent evidences suggest that intra-hepatic CCA(IH-CCA) and EH-CCA are biologically different cancers,giving further support to a number of recent epidemiological studies showing large differences in terms of incidence,mortality and risk *** purpose of this manuscript is to review recent literature dealing with the descriptive epidemiology and risk factors of CCA with a special effort to compare IH-with EH-CCA.

关键词： Liver flukes Viral hepatitis Liver stem cells Peribiliary glands Epidemiology Extra-hepatic cholangiocarcinoma Risk factors Primary sclerosing cholangitis Intra-hepatic cholangiocarcinoma Liver cirrhosis

设计研究实验室 2000—2002年成功超越我的边界

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世界建筑导报 2004年第1期19卷 146-151页

作者： Aljosa Dekleva manuela gatto Tina Gregoric Robert Sedlak Vasilis Stroumpakos Patrik Schumacher Christopher Hight 怡指导教师

成功超越我的边界！驱使我们走进4D建模技术的广阔空间之中，就像邻里或社区的建筑形式那样被正式注册。更重要的是，这项工程的地点是在伦敦的市中心，不像人们所期待的那样，就是说它处在被无情的城市大漩涡所冲击的地方，在那里，众... 详细信息

成功超越我的边界！驱使我们走进4D建模技术的广阔空间之中，就像邻里或社区的建筑形式那样被正式注册。更重要的是，这项工程的地点是在伦敦的市中心，不像人们所期待的那样，就是说它处在被无情的城市大漩涡所冲击的地方，在那里，众所周知社区在过去的100年中遭到毁灭。为了进步增加投资，最初提出这个挑战的目的并不是呼吁要在社会的“边缘”地带寻求避难所，

关键词：设计研究实验室 4D建模技术伦敦投资

Musculoskeletal disorders in nursing staff

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World Journal of Methodology 2025年第2期15卷 9-14页

作者： Agapi Kolovou Asterios N Gkougkoulias Nikolaos Stefanou Elena manuela Samaila Maria Tsekoura Marianna Vlychou Charalampos Matzaroglou Zoe H Dailiana Department of Orthopaedic Surgery Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500ThessaliaGreece Department of Radiology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500ThessaliaGreece Orthopaedic and Trauma Center University of VeronaVerona 37134Italy Department of Physiotherapy School of Health Rehabilitation SciencesUniversity of PatrasPatra 26504DytikíElládaGreece

Nursing staff provides patient care in an occupational environment that often imposes challenges that affect significantly the musculoskeletal ***-related musculoskeletal disorders are common in nursing stuff and have a negative impact in their professional and daily *** the current editorial,the duties of nursing staff,the types of musculoskeletal disorders,the predis-posing factors(including factors related to professional tasks/ergonomics and to working schedules,psychological,social and individual factors)and their impact on working ability and quality of life nursing staff are summarized and pre-ventive measures are proposed.

关键词： Musculoskeletal disorders Nursing staff Predisposing factors Ergonomics Prevention

Production Process and Properties of a Highly Porous Al Alloy Made Using NaCl Droplets as a Space Holder

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Acta Metallurgica Sinica(English Letters) 2015年第8期28卷 1034-1040页

作者： manuela Covaciu Andrew Richard Kennedy Faculty of Engineering University of Nottingham Faculty of Material Science and Engineering Universitatea Tehnica din Cluj-Napoca School of Engineering Pontificia Universidad Católica de Chile

Porous Al structures have been made using a porogen leaching method but with additional novel steps. In this way, Al-0.25Cu-0.6Si-1.0Mg alloys with interconnected, open cells have been made, with high levels of porosity（up to 89%）. The use of 4 to 5 mm diameter sodium chloride droplets combined with interspersion of the metal powder and droplets in the die and dissolution of the salt before sintering was found to enable easier interspersion of the two components, resulting in good connectivity of the beads via the formation of ‘‘windows＇＇ between the pores, and rapid elimination of salt from the structure. Porous Al with densities in the range of 0.28–0.86 g/cm3 exhibited compressive yield strengths in the range of 0.14 to 7.5 MPa, with no difference being observed between the samples made by this route and by more conventional dissolution of the salt after sintering. These novel steps widen the possibility for porous metal manufacture to other materials, not limited by the need to have a sintering temperature below that for the melting point of salt.

关键词： Aluminium alloy Sodium chloride Porous metal

Live-cell imaging:new avenues to investigate retinal regeneration

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Neural Regeneration Research 2017年第8期12卷 1210-1219页

作者： manuela Lahne David R.Hyde Department of Biological Sciences University of Notre Dame Notre Dame IN USA

Sensing and responding to our environment requires functional neurons that act in concert. Neuronal cell loss resulting from degenerative diseases cannot be replaced in humans, causing a functional impairment to integrate and/or respond to sensory cues. In contrast, zebrafish（Danio rerio） possess an endogenous capacity to regenerate lost neurons. Here, we will focus on the processes that lead to neuronal regeneration in the zebrafish retina. Dying retinal neurons release a damage signal, tumor necrosis factor α, which induces the resident radial glia, the Müller glia, to reprogram and re-enter the cell cycle. The Müller glia divide asymmetrically to produce a Müller glia that exits the cell cycle and a neuronal progenitor cell. The arising neuronal progenitor cells undergo several rounds of cell divisions before they migrate to the site of damage to differentiate into the neuronal cell types that were lost. Molecular and immunohistochemical studies have predominantly provided insight into the mechanisms that regulate retinal regeneration. However, many processes during retinal regeneration are dynamic and require live-cell imaging to fully discern the underlying mechanisms. Recently, a multiphoton imaging approach of adult zebrafish retinal cultures was developed. We will discuss the use of live-cell imaging, the currently available tools and those that need to be developed to advance our knowledge on major open questions in the field of retinal regeneration.

关键词： multiphoton microscopy live-cell imaging zebrafish interkinetic nuclear migration tissue culture retinal regeneration Miiller glia neuronal progenitor cell differentiation phagocytosis

Sarcopenic obesity:recent consensus and clinical implications in patients with chronic liver disease

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Hepatobiliary Surgery and Nutrition 2023年第3期12卷 417-420页

作者： manuela Merli Saniya Khan Department of Translational and Precision Medicine Sapienza University of RomeRomaItaly

Sarcopenia and obesity are two major public health concerns,particularly in the elderly *** conditions have a significant impact on both the individual’s health and quality of *** is defined as a loss of muscle mass,strength,and function physiologically present with aging,while obesity is an excessive accumulation of body *** these conditions are often considered separately,there is growing recognition that they frequently coexist,may synergistically enhance one another,leading to an increased risk of various chronic diseases and *** obesity(SO)is the term utilized to define the simultaneous occurrence of sarcopenia and obesity(1).Since recently,the lack of common diagnostic criteria for SO has made it difficult to diagnose and manage this condition effectively.

关键词： Sarcopenia obesity sarcopenic obesity liver disease

Analysis of the Vibrissa Parametric Resonance Causing a Signal Amplification during Whisking Behaviour

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Journal of Bionic Engineering 2016年第2期13卷 312-323页

作者： Tatiana Volkova Igor Zeidis Hartmut Witte manuela Schmidt Klaus Zimmermann Technische Universiat Ilmenau Technical Mechanics Group 98693 Max-Planck-Ring 12 Ilmenau Germany Technische Universitat Ilmenau Biomechatronics Group 98693 Max-Planck-Ring 12 Ilmenau Germany Friedrich-Schiller-Universitat Jena Institute of Systematic Zoology and Evolutionary Biology with Phyletic Museum 07743 Erbertstrafle 1 Jena Germany

The paper deals with the mechanical vibrational motion ofvibrissae during natural exploratory behaviour of mammals. The theoretical analysis is based on a mechanical model of a cylindrical beam with circular natural configuration under an applied periodic force at the tip, which corresponds to the surface roughness of an investigated object. The equation of motion of the beam is studied using the Euler-Bemoulli beam theory and asymptotic methods of mechanics. It is shown that from the me- chanical point of view the phenomenon of parametric resonance of the vibrissa is possible. It means that the amplitude of forced vibrations of a vibrissa increases exponentially with time, if it is stimulated within a specific resonance frequency range, which depends on biomechanical parameters of the vibrissa. The most intense parametric resonance occurs, when the excitation frequency is close to the doubled natural frequency of free vibrations. Thus, it may be used to distinguish and amplify specific periodic components of a complex roughness profile during texture discrimination.

关键词： vibrissa whisking vibration tactile sensor beam theory parametric resonance

Microstructure and Mechanical Performance of Ti-6Al-4V Lattice Structures Manufactured via Electron Beam Melting(EBM):A Review

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Acta Metallurgica Sinica(English Letters) 2020年第2期33卷 183-203页

作者： Giuseppe Del Guercio manuela Galati Abdollah Saboori Paolo Fino Luca Iuliano Department of Management and Production Engineering(DIGEP) Politecnico di TorinoCorso Duca Degli Abruzzi 2410129 TurinItaly Department of Applied Science and Technology(DISAT) Politecnico di TorinoCorso Duca Degli Abruzzi 2410129 TurinItaly Integrated Additive Manufacturing Center(IAM)@Polito Politecnico Di TorinoCorso Duca Degli Abruzzi 2410129 TurinItaly

Electron beam melting(EBM) process is an additive manufacturing process largely used to produce complex metallic components made of high-performance materials for aerospace and medical ***,lattice structures made by Ti-6A1-4V have represented a hot topic for the industrial sectors because of having a great potential to combine lower weights and higher performances that can also be tailored by subsequent heat ***,the little knowledge about the mechanical behaviour of the lattice structures is limiting their *** present work aims to provide a comprehensive review of the studies on the mechanical behaviour of the lattice structures made of *** main steps to produce an EBM part were considered as guidelines to review the literature on the lattice performance:(1) design,(2) process and(3) post-heat ***,the correlation between the geometrical features of the lattice structure and their mechanical behaviour is *** addition,the correlation among the mechanical performance of the lattice structures and the process precision,surface roughness and working temperature are also *** investigation on the studies about the properties of heat-treated lattice structure is also conducted.

关键词： Electron beam melting(EBM) Additive manufacturing(AM) Lattice structures Ti–6Al–4V Mechanical properties Heat treatment

Interaction of silver nanoparticles with mediterranean agricultural soils: Lab-controlled adsorption and desorption studies

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Journal of Environmental Sciences 2019年第9期31卷 205-216页

作者： Laura Torrent Eva Margui Ignasi Queralt manuela Hidalgo Monica Iglesias Department of Chemistry University of Girona C/M. Aurelia Capmany 69 17003 Girona Spain Institute of Environmental Assessment and Water Research (IDAEA-CSIC) C. Jordi Girona 28-26 08034 Barcelona Spain

The production of silver nanoparticles(AgNPs) has increased tremendously during recent years due to their antibacterial and physicochemical properties. As a consequence, these particles are released inevitably into the environment, with soil being the main sink of disposal. Soil interactions have an effect on AgNP mobility, transport and bioavailability. To understand AgNP adsorption processes, lab-controlled kinetic studies were *** tests performed with five different Mediterranean agricultural soils showed that cation exchange capacity and electrical conductivity are the main parameters controlling the adsorption processes. The adsorption kinetics of different sized(40, 75, 100 and 200 nm)and coated(citrate, polyvinylpyrrolidone and polyethyleneglycol(PEG)) AgNPs indicated that these nanoparticle properties have also an effect on the adsorption *** assess the mobility and bioavailability of AgNPs and to determine if their form is maintained during adsorption/desorption processes, loaded soils were submitted to leaching tests three weeks after batch adsorption studies. The DIN 38414-S4 extraction method indicated that AgNPs were strongly retained on soils, and single-particle inductively coupled plasma mass spectrometry confirmed that silver particles maintained their nanoform, except for 100 nm PEG-AgNPs and 40 nm citrate-coated AgNPs. The DTPA(diethylenetriaminepentaacetic acid) leaching test was more effective in extracting silver,but there was no presence of AgNPs in almost all of these leachates.

关键词： Silver nanoparticles Agricultural soils Sorption kinetics Leaching tests Single-particle inductively coupled plasma mass spectrometry