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Bofedal response to climate variability, local management, and water extraction: A case study of Chucuyo, Northern Chile

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Journal of Mountain Science 2022年第1期19卷 241-252页

作者： URIBE-ÁLVAREZ Monserrat C prieto manuel MESEGUER-RUIZ Oliver Departamento de Ciencias Históricas y Geográficas Universidad de TarapacáArica 1010069Chile Departamento de Ciencias Históricas y Geográficas Universidad de TarapacáIquique 1101783Chile

Andean high-altitude wetlands are important ecosystems that serve a range of socialecological functions. In the Andes, bofedales, a specific type of peat-producing wetland, are essential for the sustainability of mountain ecosystems and indigenous pastoralist communities. The Chucuyo bofedal in northern Chile is affected by climatic variability and water extraction for agricultural uses via the Lauca canal. Herders in the local community also actively manage this wetland according to their traditional ecological knowledge to ensure permanent fodder for their animals. In this article, we analyze the annual behavior of the Chucuyo bofedal after the wet season. Based on precipitation data, extracted water flows, vegetation vigor from satellite images, and an ethnographic approach, we determined that the bofedal’s productivity was negatively correlated with the amount of precipitation and positively correlated with the surface area of the wetland. However, water extraction via the Lauca channel had no significant relationship with either surface area or vegetation vigor. We identify community practices and traditional ecological knowledge as key elements in the maintenance of these ecosystems. This situation is critical in the context of an aging population and the current pattern of migration out of the region to urban areas. The results provide substantial empirical evidence for future decision-making regarding the conservation of these ecosystems.

关键词： Atacama Bofedales Indigenous people Lauca canal Normalized Difference Vegetation Index

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Effective prophylaxis with rFVIIa in young haemophiliacs with inhibitors using a schedule similar to FVIII prophylaxis in non-inhibitor patients

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Health 2013年第7期5卷 1151-1157页

作者： Maria Fernanda Lopez-Fernandez Carmen Altisent Victor Jimenez-Yuste Faustino Garcia-Candel Carmen Sedano Ana Cid Eva Mingot Ramiro Nunez Maria Jose Paloma Inmaculada Soto manuel prieto Haematology Complejo Hospitalario Universitario A CorunaA CorunaSpain Haemophilia Unit Hospital Universitario Vall d’HebronBarcelonaSpain Haemophilia Unit Hospital UniversitarioMadridSpain Haemophilia Unit Hospital Universitario Virgen de la ArreixacaMurciaSpain Haematology Complejo Hospitalario Universitario Marques de ValdecillaSantanderSpain Congenital Coagulophaties Unit Hospital Universitario La FeValenciaSpain Haematology Hospital Universitario Carlos HayaMalagaSpain Haematology Hospital Universitario Virgen del RocíoSevillaSpain Haematology Hospital Virgen del CaminoPamplonaSpain Haematology Hospital General de AsturiasOviedoSpain Haematology Hospital General YagüeBurgosSpain

Objective: To assess the role of early prophylaxis with recombinant activated factor VII (rFVIIa) in young haemophiliacs with inhibitors and to determine whether it can reduce bleeding episodes and prevent joint damage. Patients and Methods: Ten severe haemophiliacs, less of three years old, with up to four joint bleeds and inhibitors to FVIII who started early prophylaxis with rFVIIa, were included. A number of haemorrhages/year/patient and haemarthroses/ year/patient were compared before the start of prophylaxis, which include both the time before (initial period) and after inhibitor diagnosis (inhibitor period), with those during prophylaxis (prophylaxis period). Results: The mean time of inhibitor diagnosis was 15.6 months (range: 2.3-34.1). The mean time between inhibitor diagnosis and the start of prophylaxis was 7.1 months (range: 0-23.2), shorter than the time of rFVIIa prophylaxis (mean: 10.3 months;range: 4.1-32.0). Bleeding episodes for the three time periods were 45, 36 and 17, respectively, or 0.29 and 0.51 haemorrhages/year/patient in the two periods prior to prophylaxis compared to 0.17 during prophylaxis. Total haemarthroses for the three-time periods were 7, 5 and 5, respectively. The haemarthroses/year/patient in the pre-prophylaxis period were 0.032 and 0.070, compared to0.049 inthe prophylaxis period. rFVIIa schedules were either 90 μg/kg three times weekly or 90 μg/kg daily. Conclusions: Early prophylaxis with rFVIIa may be efficacious in young haemophiliacs with inhibitors, reducing joint bleeds. After the risky period of inhibitor presence, they are able to continue rFVIII prophylaxis with success assured to prevent arthropathy.

关键词： rFVIIa Haemarthroses Haemophilia Inhibitors Prophylaxis

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太平洋深处的浮动生态城市设计

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工业设计 2023年第8期 16-16页

作者： Juan manuel prieto Clara Focaccia Maxi Araya 不详

随着地球温度的持续飙升,冰川融化加速,海平面急剧上升,许多国家已经开始对海洋进行城市化设计,以防止自己像“亚特兰蒂斯”一样被淹没在水中。Estudio Focaccia prieto提出了一个浮动城市的概念,围绕未受污染的海洋水域形成的潟湖,提... 详细信息

随着地球温度的持续飙升,冰川融化加速,海平面急剧上升,许多国家已经开始对海洋进行城市化设计,以防止自己像“亚特兰蒂斯”一样被淹没在水中。Estudio Focaccia prieto提出了一个浮动城市的概念,围绕未受污染的海洋水域形成的潟湖,提供了一个可持续的居住生态系统。该项目计划在太平洋深处通过回收的塑料创建一座大都市,从而净化污染严重的海洋垃圾场。Polimeropolis用一系列巨大的浮动岛屿来清理海洋,实现太平洋垃圾场的城市化,通过可再生系统现场产生清洁的电力和水。作为一个可扩展的城市阶段模型,这个概念项目包括一系列混合用途的城市“环”,每个环都容纳了一组栖息地,同时包围着一个巨大的海洋潟湖。围绕着这些岛屿,创建了一个由植被组成的废物收集边界网,限制了微塑料的通过,同时净化水源。

关键词：混合用途亚特兰蒂斯地球温度冰川融化阶段模型垃圾场微塑料生态系统

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*** binding properties of the C-terminal segment of retinol dehydrogenase 8

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Annals of Eye Science 2018年第1期 428-428页

作者： AndréHädicke Ana I.A.Coutinho François Otis Mustapha Lhor Line Cantin manuel prieto Normand Voyer Christian Salesse PROTEO and CUO-Recherche Centre de recherche du CHU de Québec-UniversitéLavalHôpital St-SacrementQuébecCanada Centro Química-Física Molecular Instituto Superior TécnicoUniversidade de LisboaLisboaPortugal PROTEO and Dépt.Chimie FacultéSciences et génieUniversitéLavalQuébecCanada

Background:Retinol dehydrogenase 8(RDH8)is a 312-amino acid(aa)protein involved in the visual *** to the outer segment disk membranes of photoreceptors,it reduces all-trans-retinal to all-trans-retinol1 as one of the rate-limiting steps of the visual ***8 is a member of the short-chain dehydrogenase/reductase *** C-terminal segment allows its membrane-anchoring through the postulated presence of an amphipathicα-helix and of 1 to 3 acyl groups at positions 299,302 and *** secondary structure and membrane binding characteristics of RDH8 and its C-terminal segment have not yet been ***:To evaluate the membrane binding of RDH8,the full-length protein(aa 1-312),a truncated form(aa 1-296),its C-terminal segment(aa 281-312 and 297-312)as well as different additional variants of this segment were *** truncated protein binds membranes less efficiently than the full-length ***,the C-terminal segment of RDH8 is essential for the binding and has thus been further *** intrinsic fluorescence of tryptophan residues at positions 289 and 310 of the wild-type C-terminal segment of RDH8 and the mutants W289F,W310F and W310R have thus been used to determine their extent of binding to lipid vesicles and to monitor their local *** lipid vesicles composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine(POPC)or a mixture of POPC and 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine(POPS)were used to mimic the phospholipid content of the outer segment disk membranes of ***:An increase in fluorescence intensity and in fluorescence lifetime is observed upon increasing the concentration of lipid *** data allowed calculating values of partition coefficient of the C-terminal segment of RDH8 varying between Kp=1.1 E6 to 1.7 *** is noteworthy that the observation of a more intense shift to lower wavelengths upon membrane binding of the mutant W310R and W310F indicates a deeper inco

关键词： Peptide-membrane binding electrostatic interactions hydrophobic interactions fluorescence spectroscopy

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A Passive Repression Mechanism that Hinders Synergic Transcriptional Activation by Heat Shock Factors Involved in Sunflower Seed Longevity

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Molecular Plant 2014年第1期7卷 256-259页

作者： Javier Tejedor-Cano Rail Carranco Jose-Maria Personat Pilar prieto-Dapena Concepcion Almoguera Jose manuel Espinosa Juan Jordano Departamento de Biotecnologia Vegetal tnstituto de Recursos Naturalesy Agrobiologia de Sevilla Consejo Superior de Investigaciones Cientificas (CSiC) Seville Spain

Different genetic programs that are active during late stages of zygotic embryogenesis are involved in seed phenotypes as longevity, basal thermotolerance, and desiccation tolerance. In sunflower, Heat Shock Factor A9 （HaHSFA9） controls one of such programs： the HaHSFA9 program. Overexpression of HaHSFA9 in seeds of transgenic tobacco showed the involvement of this transcription factor in basal thermotolerance and longevity;

关键词： SUNFLOWERS -- Research SUNFLOWERS -- Seeds RESEARCH HEAT shock proteins PLANTS -- Heat shock proteins AUXIN -- Physiological effect

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Determining the need for a thoracoscopic approach to treat a giant hiatal hernia when abdominal access is poor

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World Journal of Gastrointestinal Surgery 2023年第12期15卷 2739-2746页

作者： Francisco Javier Pérez Lara Rogelio Zubizarreta Jimenez Tatiana prieto-Puga Arjona Pilar Gutierrez Delgado Juan manuel Hernández Carmona Jose manuel Hernández Gonzalez Maria Pitarch Martinez Department of Surgery Hopital de AntequeraAntequera 29200Spain DOXA MicrofluidicsRincon de la Victoria 29730Spain Department of Surgery HRU Carlos HayaUnidad Cirugia Hepatobiliopancreat&TrasplantesMalaga 29200Spain

BACKGROUND Giant hernias present a significant challenge for digestive *** approach taken(laparoscopic vs thoracoscopic)depends largely on the preferences and skills of each surgeon,although in most cases today the laparoscopic approach is *** To determine whether patients presenting inadequate laparoscopic access to the intrathoracic hernial sac obtain poorer postoperative results than those with no such problem,in order to assess the need for a thoracoscopic *** For the retrospective series of patients treated in our hospital for hiatal hernia(n=112),we calculated the laparoscopic field of view and the working area accessible to surgical instruments,by means of preoperative imaging tests,to assess the likely outcome for cases inaccessible to *** Patients with giant hiatal hernias for whom a preoperative calculation suggested that the laparoscopic route would not access all areas of the intrathoracic sac presented higher rates of perioperative complications and recurrence during follow-up than those for whom laparoscopy was *** difference was statistically ***,the insertion of mesh did not improve results for the non-accessible *** For patients with giant hiatal hernias,it is essential to conduct a preoperative evaluation of the angle of vision and the working area for *** parts of the intrathoracic sac are inaccessible laparoscopically,the thoracoscopic approach should be considered.

关键词： Hiatal hernia Abdominal surgery Laparoscopy Thoracoscopy surgery

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Review of incomplete macroscopic resections(R2)in rectal cancer:Treatment,prognosis and future perspectives

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World Journal of Gastrointestinal Oncology 2021年第9期13卷 1062-1072页

作者： Francisco Javier Pérez Lara Maria Luisa Hebrero Jimenez Francisco Javier Moya Donoso Jose manuel Hernández Gonzalez Maria Pitarch Martinez Tatiana prieto-Puga Arjona Department of Surgery Antequera HospitalMálaga 29200Spain Department of Oncologic Radiotherapy Hopital Regional de MálagaMálaga 29010Spain

Colorectal cancer is one of the most prevalent tumours,but with improved treatment and early detection,its prognosis has greatly improved in recent ***,when the tumour is locally advanced at diagnosis or if there is local recurrence,it is more difficult to perform a complete tumour resection,and there may be a residual macroscopic *** this paper,we review the literature on residual macroscopic tumour resections,concerning both locally advanced primary tumours and recurrences,evaluating the main problems encountered,the treatments applied,the prognosis and future perspectives in this field.

关键词： Rectal cancer Surgery Treatment Incomplete resection Local recurrence

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Tenofovir vs lamivudine plus adefovir in chronic hepatitis B:TENOSIMP-B study

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World Journal of Gastroenterology 2017年第41期23卷 7459-7469页

作者： manuel Rodríguez Juan manuel Pascasio Enrique Fraga Javier Fuentes Martín prieto Gloria Sánchez-Antolín Jose Luis Calleja Esther Molina María Luisa García-Buey María Angeles Blanco Javier Salmerón María Lucía Bonet Jose Antonio Pons Jose manuel González Miguel Angel Casado Francisco Jorquera 无 Division of Gastroenterology and Hepatology.Hospital Universitario Central de Asturias Unit for the Clinical Management of Digestive Diseases IBISHospital Universitario Virgen del Rocío Liver Transplantation and Hepatology Unit Gastroenterology ServiceHospital Universitario Reina Sofía Digestive Medicine Service Hospital Universitario Miguel Servet Hepatology Unit Digestive Medicine ServiceHospital Universitari i Politècnic La Fe Hepatology Unit Hospital Universitario Rio Hortega Liver Unit Hospital Universitario Puerta de Hierro de MajadahondaUniversidad Autónoma de Madrid Digestive Medicine Service Hospital Clínico de Santiago de Compostela Liver Unit Hospital Universitario de La Princesa Digestive Medicine Service Hospital General Universitario Gregorio Maranon Digestive Medicine Unit Complejo Hospitalario de Granada Digestive Medicine Service Hospital Universitario Son Espases Hepatology Unit IMIB Hospital Universitario Virgen de la Arrixaca Digestive Medicine Service Hospital Clínico Universitario de Valladolid Pharmacoeconomics and Outcomes Research Iberia Division of Gastroenterology and Hepatology Complejo Asistencial Universitario de León the TENOSIMP-B Research Group

AIM To demonstrate the non-inferiority(15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate(TDF) vs the combination of lamivudine(LAM) plus adefovir dipivoxil(ADV) in the maintenance of virologic response in patients with chronic hepatitis B(CHB) and prior failure with *** This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups(TDF and LAM+ADV) of adult patients with hepatitis B e antigen(HBe Ag)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 Spanish hospitals. The follow-up time for each patient was 48 wk after randomization, with quarterly visits in which the viral load, biochemical and serological parameters, adverse effects, adherence to treatment and consumption of hospital resources were *** Forty-six patients were evaluated [median age: 55.4 years(30.2-75.2); 84.8% male], including 22 patients with TDF and 24 with LAM+ADV. During study development, hepatitis B virus DNA(HBV-DNA) remained undetectable, all patients remained HBe Ag negative, and hepatitis B surface antigen(HBs Ag) positive. Alanine aminotransferase(ALT) values at the end of the study were similar in the 2 groups(25.1± 7.65, TDF vs 24.22 ± 8.38, LAM+ADV, P = 0.646). No significant changes were observed in creatinine or serum phosphorus values in either group. No significant differences between the 2 groups were noted in the identification of adverse effects(AEs)(53.8%, TDF vs 37.5%, LAM+ADV, P = 0.170), and none of the AEs which occurred were serious. Treatment adherence was 95.5% and 83.3% in the TDF and the LAM+ADV groups, respectively(P = 0.488). The costs associated with hospital resource consumption were significantly lower with the TDF treatment than the LAM+ADV treatment(€4943 ± 1059 vs €5811 ± 1538, respectively, P < 0.001).CONCLUSION TDF monotherapy proved to be safe

关键词： Tenofovir Lamivudine+Adefovir Efficacy Safety Adherence Costs Hepatitis B

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Preoperative calculation of angles of vision and working area in laparoscopic surgery to treat a giant hiatal hernia

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World Journal of Gastrointestinal Surgery 2021年第12期13卷 1638-1650页

作者： Francisco Javier Perez Lara Rogelio Zubizarreta Jimenez Francisco Javier Moya Donoso Jose manuel Hernández Gonzalez Tatiana prieto-Puga Arjona Arturo del Rey Moreno Maria Pitarch Martinez Surgery Service Antequera HospitalRincón de la Victoria 29730MálagaSpain DOXA Microfluidics Rincon de la Victoria 29738MálagaSpain

BACKGROUND Giant hiatal hernias still pose a major challenge to digestive surgeons,and their repair is sometimes a highly complex *** is usually performed by laparoscopy,while the role of the thoracoscopic approach has yet to be clearly *** To preoperatively detect patients with a giant hiatal hernia in whom it would not be safe to perform laparoscopic surgery and who,therefore,would be candidates for a thoracoscopic *** In the present study,using imaging test we preoperatively simulate the field of vision of the camera and the working area(instrumental access)that can be obtained in each patient when the laparoscopic approach is *** From data obtained,we can calculate the access angles that will be obtained in a preoperative computerised axial tomography coronal section,according to the location of the *** also provide the formula for performing the angle calculations If the trocars are placed in loss common situations,thus enabling us to determine the visibility and manoeuvrability for any position of the *** The working area determines the cases in which we can operate safely and those in which certain areas of the hernia cannot be accessed,which is when the thoracoscopic approach would be safer.

关键词： Hiatal hernia Angles Approach Laparoscopy Thoracoscopy

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Laser Wavelength Estimation Method Based on a High-Birefringence Fiber Loop Mirror

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Photonic Sensors 2019年第1期9卷 89-96页

作者： Ricardo I.ALVAREZ-TAMAYO Patricia prieto-CORTES manuel DURAN-SANCHEZ Baldemar IBARRA-ESCAMILLA Antonio BARCELATA-PINZON Evgeny A.KUZIN Faculty of Physical-Mathematical Sciences CONACYT-Universidad Autonoma de Nuevo LeonSan Nicolas de los Garza 66451Mexico Faculty of Physical-Mathematical Sciences Universidad Autonoma de Nuevo LednSan Nicolas de los Garza 66451 Mexico Optics department CONA CYT-Instituto Nacional de AstrofisieaOptica y EleetronieaTonantzintla 72480Mexico Optics department Instituto Nacional de AstrofisicaOptica y ElectronicaTonantzintla 72480Mexico Mechatronics division Universidad Tecnologica de PueblaPuebla 72300Mexico

A simple method for the estimation of the wavelength of a fiber laser system is proposed. The method is based on the use of a high-birefringence-fiber loop mirror(HBFLM).The HBFLM exhibits a periodic transmission/reflection spectrum whose spectral characteristics are determined by the length and temperature of the high-birefringence fiber(HBF).Then,by the previous characterization of the HBFLM spectral transmission response,the central wavelength of the generated laser line can be *** using a photodetector,the *** of the laser line is estimated during an HBF temperature scanning by measuring the temperature at which the maximum transmitted power of the HBFLM is *** proposed method is demonstrated in a linear cavity tunable Er/Yb fiber *** method is a reliable and low-cost alternative for laser wavelength determination in short wavelength ranges without the use of specialized and expensive equipment.

关键词： Wavelength meter fiber lasers fiber optical loop mirror high-birefringence fiber

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