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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn J.w.So Konstantin Feinberg Marina Manoraj Jenny Cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

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Models and observations of sunspot penumbrae

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Science China(Physics,Mechanics & Astronomy) 2009年第11期52卷 1670-1677页

作者： BORRERO Juan manuel Max Planck Institut fr Sonnensystemforschung Max Planck Strasse 2 D 37191 Katlenburg-Lindau Germany

The mysteries of sunspot penumbrae have been under an intense scrutiny for the past 10 years. During this time, some models have been proposed and refuted, while the surviving ones had to be modified, adapted and evolved to explain the ever-increasing array of observational constraints. In this contribution I will review two of the present models, emphasizing their contributions to this field, but also pinpointing some of their inadequacies to explain a number of recent observations at very high spatial resolution (0.32 ). To help explaining these new observations I propose some modifications to each of those models. These modifications bring those two seemingly opposite models closer together into a general picture that agrees well with recent 3D magneto-hydrodynamic simulations.

关键词： sunspots magnetic fields spectropolarimetry magnetohydrodynamics

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Sperm subpopulations in avian species： a comparative study between the rooster （Gallus domesticus） and Guinea fowl （Numida meleagris）

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Asian Journal of Andrology 2016年第6期18卷 889-894页

作者： manuel Garcia-Herreros National Secretariat of Higher Education Science Technology and Innovation (SENESCYT) Quito Ecuador

The main aims of this research were to study possible differences in objective morphometric sperm characteristics, establish normative sperm morphometry standards, and evaluate the presumed different subpopulation distribution of avian spermatozoa from the rooster （Gallus domesticus） and Guinea fowl （Numida meleagris） as model avian species. Seventy-two ejaculates （36 per species studied） were obtained manually, following a training period involving gently combined dorso-abdominal and *** massage of the birds. Ejaculates were processed for volume, sperm concentration, viability, motility, and morphology. Moreover, samples were submitted for sperm morphometric assessment using objective Computer-Assisted Semen Analysis for Morphometry （CASA-Morph） methods, with sperm morphometric descriptors evaluated by Principal Component Analysis （PCA） and multivariate clustering analyses. There were several differences observed between the avian species in values obtained for ejaculate volume and sperm concentration （P 〈 0.001）. Irrespective of species, PCA revealed two Principal Components （PCs） explaining more than 80% of the variance. In addition, the number of subpopulations differed with species （three and five subpopulations for rooster and Guinea fowl, respectively）. Moreover, the distribution of the sperm subpopulations was found to be structurally different between species. In conclusion, our findings from using CASA-Morph methods indicate pronounced sperm morphometric variation between these two avian species. Because of the strong differences observed in morphometric parameter values and their subpopulation distribution, these results suggest that application of objective analytical methods such as CASA-Morph could substantially improve the reliability of comparative studies and help establish valid normative sperm morphological values for avian species.

关键词： Gallus domesticus Numida meleaEris principal component analysis sperm morphometry sperm subpopulations

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Characterization of Gromov Hyperbolic Short Graphs

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Acta Mathematica Sinica,English Series 2014年第2期30卷 197-212页

作者： José manuel RODRIGUEZ Departamento de Matemticas Universidad Carlos III de MadridAvenida de la Universidad 30

To decide when a graph is Gromov hyperbolic is,in general,a very hard *** this paper,we solve this problem for the set of short graphs（in an informal way,a graph G is r-short if the shortcuts in the cycles of G have length less than r）：an r-short graph G is hyperbolic if and only if S9r（G）is finite,where SR（G）：=sup{L（C）：C is an R-isometric cycle in G}and we say that a cycle C is R-isometric if dC（x,y）≤dG（x,y）＋R for every x,y∈C.

关键词： Short graph Gromov hyperbolicity Gromov hyperbolic graph infinite graphs geodesics

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Verdier quotients of homotopy categories of rings and Gorenstein-projective precovers

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Science China Mathematics 2024年第12期67卷 2701-2712页

作者： manuel Cortes-Izurdiaga Departamento de Matematica Aplicada Universidad de MalagaMalaga 29071Spain

Let R be a ring, Proj be the class of all the projective right R-modules, K be the full subcategory of the homotopy category K(Proj) whose class of objects consists of all the totally acyclic complexes, and MorK be the class of all the morphisms in K(Proj) whose cones belong to K. we prove that if K(Proj) has enough MorK-injective objects, then the Verdier quotient K(Proj)/K has small Hom-sets, and this last condition implies the existence of Gorenstein-projective precovers in Mod-R and of totally acyclic precovers in C(Mod-R).

关键词： homotopy category Gorenstein-projective precover Verdier quotient small Hom-sets totally acyclic complex

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Genome-based nutrition:An intervention strategy for the prevention and treatment of obesity and nonalcoholic steatohepatitis

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world Journal of Gastroenterology 2015年第12期21卷 3449-3461页

作者： Sonia Roman Claudia ojeda-Granados Omar Ramos-Lopez Arturo Panduro Department of Molecular Biology in Medicine Civil Hospital of Guadalajara "Fray Antonio Alcalde"GuadalajaraJalisco Mexico and Health Sciences Center University of Guadalajara

Obesity and nonalcoholic steatohepatitis are increasing in westernized countries, regardless of their geographiclocation. In Latin America, most countries, including Mexico, have a heterogeneous admixture genome with Amerindian, European and African ancestries. However, certain high allelic frequencies of several nutrientrelated polymorphisms may have been achieved by past gene-nutrient interactions. Such interactions may have promoted the positive selection of variants adapted to regional food sources. At present, the unbalanced diet composition of the Mexicans has led the country to a 70% prevalence rate of overweightness and obesity due to substantial changes in food habits, among other factors. International guidelines and intervention strategies may not be adequate for all populations worldwide because they do not consider disparities in genetic and environmental factors, and thus there is a need for differential prevention and management strategies. Here, we provide the rationale for an intervention strategy for the prevention and management of obesity-related diseases such as nonalcoholic steatohepatitis based on a regionalized genome-based diet. The components required to design such a diet should focus on the specific ancestry of each population around the world and the convenience of consuming traditional ethnic food.

关键词： Latin America Mexico Gene-nutrient interactions Ev

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Effect of magnetic field orientation on fluidized beds of magnetic particles:Theory and experiment

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Particuology 2014年第1期12卷 54-63页

作者： Miguel ángel Sánchez Quintanilla manuel Jesús Espin José manuel Valverde Department of Electronics and Electromagnetism University of Seville Department of Applied PhysicsⅡ University of Seville

Geldart-A fluidized beds of fine particles experience a jamming transition between a fluid-like state and a solid-like state at a certain superficial gas velocity, that depends on the relative strength of interparticle attractive forces with respect to particle weight, lnterparticle forces provide the bed with a certain tensile strength in the jammed state. In the work presented here we analyze the behavior of a fluidized bed of magnetic particles subjected to an externally applied magnetic field, which contributes to enhance interparticle forces. The importance of the magnetic contribution to interparticle forces is measured by the changes in the tensile strength and the superficial gas velocity at the jamming transition. The link of the field orientation with the microstructure of the bed is discussed,

关键词： Magneto-fluidization Jamming transition Fluidization Fine powders Cohesion Magnetization

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Hyperbolic Moment Equations in Kinetic Gas Theory Based on Multi-Variate Pearson-IV-Distributions

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Communications in Computational Physics 2010年第4期7卷 639-673页

作者： manuel Torrilhon Seminar for Applied Mathematics ETH ZurichSwitzerland

In this paper we develop a new closure theory for moment approximationsin kinetic gas theory and derive hyperbolic moment equations for 13 fluid variablesincluding stress and heat flux. Classical equations have either restricted hyperbolicity regions like Grad’s moment equations or fail to include higher moments in apractical way like the entropy maximization approach. The new closure is based onPearson-Type-IV distributions which reduce to Maxwellians in equilibrium, but allowanisotropies and skewness in non-equilibrium. The closure relations are essentiallyexplicit and easy to evaluate. Hyperbolicity is shown numerically for a large range ofvalues. Numerical solutions of Riemann problems demonstrate the capability of thenew equations to handle strong non-equilibrium.

关键词： Kinetic gas theory moment approximations hyperbolic partial differential equations.

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The complex Maxwell stress tensor theorem:The imaginary stress tensor and the reactive strength of orbital momentum.A novel scenery underlying electromagnetic optical forces

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Light(Science & Applications) 2022年第11期11卷 2655-2675页

作者： manuel Nieto-Vesperinas Xiaohao Xu Instituto de Ciencia de Materiales de Madrid Consejo Superior de Investigaciones Cintificas.Campus de CantoblancoMadrid 28049Spain State Key Laboratory of Transient Optics and Photonics Xi'an Institute of Optics and Precision MechanicsChinese Academy of SciencesXi'an 710119China Institute of Nanophotonics Jinan UniversityGuangzhou 511443China

we uncover the existence of a universal phenomenon concerning the electromagnetic optical force exerted by light or other electromagnetic waves on a distribution of charges and currents in general,and of particles in *** conveys the appearence of underlying reactive quantities that hinder radiation pressure and currently observed timeaveraged *** constitutes a novel paradigm of the mechanical effciency of light on matter,and completes the landscape of the optical,and generally electromagnetic,force in photonics and classical electrodynamics;widening our understanding in the design of both llumination and particles in optical manipulation without the need of increasing the illuminating power,and thus lowering dissipation and *** show that this may be accomplished through the minimization of what we establish as the reactive strength of orbital(or canonical)momentum,which plays against the optical force a role analogous to that of the reactive power versus the radiation effciency of an *** long time overlooked quantity,important for current progress of optical manipulation,and that stems from the complex Maxwell theorem of conservation of complex momentum that we put forward,as well as its alternating flow associated to the imaginary part of the complex Maxwell stress tensor,conform the imaginary Lorentz force that we introduce in this work,and that like the reactive strength of orbital momentum,is antagonistic to the well-known time-averaged force;thus making this reactive Lorentz force indirectly observable near wavelengths at which the time-averaged force is *** Minkowski and Abraham momenta are also addressed.

关键词： imaginary tensor orbital

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Coherent States for the Two-Dimensional Dirac-Moshinsky Oscillator Coupled to an External Magnetic Field

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Communications in Theoretical Physics 2015年第3期63卷 271-274页

作者： D.ojeda-Guillen R.D.Mota V.D.Granados Escuela Superior de Física y Matemáticas Instituto Politécnico NacionalEd.9Unidad Profesional Adolfo López MateosC.P.07738México D.F.Mexico Escuela Superior de Ingeniería Mecánica y Eléctrica Unidad CulhuacánInstituto Politécnico NacionalAv.Santa Ana No.1000Col.San Francisco CulhuacánDelegación CoyoacánC.P.04430Mexico D.F.Mexico

we show that the（2＋1）-dimensional Dirac-Moshinsky oscillator coupled to an externa/ magnetic field can be treated algebraically with the SU（1,1） group theory and its group *** use the su（1,1） irreducible representation theory to find the energy spectrum and the ***,with the su（1,1） group basis we construct the relativistic coherent states in a closed form for this problem.

关键词： Lie algebras coherent states Dirac equation Dirac-Moshinsky oscillator

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