Background:The administration of certain cannabinoids provides neuroprotection in models of neurodegenerative diseases by acting through various cellular and molecular *** cannabinoid actions in the nervous system are...
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Background:The administration of certain cannabinoids provides neuroprotection in models of neurodegenerative diseases by acting through various cellular and molecular *** cannabinoid actions in the nervous system are mediated by CB1 receptors,which can elicit psychotropic effects,but other targets devoid of psychotropic activity,including CB2 and nuclear PPARγreceptors,can also be the target of specific ***:We investigated the pro-neurogenic potential of the synthetic cannabigerol derivative,VCE-003.2,in striatal neurodegeneration by using adeno-associated viral expression of mutant huntingtin in vivo and mouse embryonic stem cell differentiation in ***:Oral administration of VCE-003.2 protected striatal medium spiny neurons from mutant huntingtin-induced damage,attenuated neuroinflammation and improved motor ***-003.2 bioavailability was characterized and the potential undesired side effects were evaluated by analyzing hepatotoxicity after chronic ***-003.2 promoted subventricular zone progenitor mobilization,increased doublecortin-positive migrating neuroblasts towards the injured area,and enhanced effective ***,we demonstrated the proneurogenic activity of VCE-003.2 in embryonic stem ***-003.2 was able to increase neuroblast formation and striatal-like CTIP2-mediated ***:The cannabigerol derivative VCE-003.2 improves subventricular zone-derived neurogenesis in response to mutant huntingtin-induced neurodegeneration,and is neuroprotective by oral administration.
A young patient was presented to the emergency department with chest pain and palpitations. A transthoracic echocardiogram showed a right atrial mass. Coronary angiography showed a right coronary artery with collatera...
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A young patient was presented to the emergency department with chest pain and palpitations. A transthoracic echocardiogram showed a right atrial mass. Coronary angiography showed a right coronary artery with collateral circulation to a large mass. The tumor could only be partially resected and the patient experienced persistent postoperative bleeding. We performed a new right coronary artery angiography which showed an important free extravasation of contrast into the pericardium through the collateral circulation. Using covered stents, the bleeding was controlled. The pathological examination performed later revealed a primary cardiac angiosarcoma. After asymptom-free survival of 14 months the patient presented bone metastases.
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