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All roads go to Salubrinal:endoplasmic reticulum stress,neuroprotection and glial scar formation

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Neural Regeneration Research 2015年第12期10卷 1926-1927页

作者： Lorenzo Romero-Ramírez manuel nieto-sampedro M.Asunción Barreda-Manso Hospital Nacional de Parapléjicos SESCAM Instituto Cajal CSIC

Central nervous system（CNS）injuries caused by cerebrovascular pathologies（e.g.,stroke）or mechanical contusions（e.g.,traumatic brain injury）disrupt the blood-brain barrier（BBB）that protects the CNS microenviron... 详细信息

关键词： ER CNS TGF

Tauroursodeoxycholic acid:more than just a neuroprotective bile conjugate

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Neural Regeneration Research 2017年第1期12卷 62-63页

作者： Lorenzo Romero-Ramírez manuel nieto-sampedro Natalia Yanguas-Casás Hospital Nacional de Paraplejicos SESCAMToledoSpain Instituto Cajal CSICMadridSpain

Neurological diseases and the neuroinflammatory response：Neurological diseases are usually accompanied by dramatic changes in the tissue homeostasis,inducing a neuroinflammatory environment that leads to the progress... 详细信息

关键词： Tauroursodeoxycholic acid more than just a neuroprotective bile conjugate TGF CNS

Synthesis and properties of water-soluble 1,9-dialkyl-substituted BF2 azadipyrromethene fluorophores

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Frontiers of Chemical Science and Engineering 2020年第1期14卷 97-104页

作者： Dan Wu Gonzalo Duran-sampedro Donal F.O’Shea Department of Chemistry Royal College of Surgeons in Ireland(RCSI)Dublin 2Ireland

Bis-alkylsulfonic acid and polyethylene glycol(PEG)-substituted BF2 azadipyrromethenes have been synthesized by an adaptable and versatile *** four synthetic stages were required to produce the penultimate fluorophore compounds,containing either two alcohol or two terminal alkyne *** final synthetic step introduced either sulfonic acid or polyethylene glycol groups to impart aqueous *** acid groups were introduced by reaction of the bis-alcohol-substituted fluorophore with sulfur trioxide,and a double Cu(I)-catalyzed cycloaddition reaction between the bis-alkyne fluorophore and methoxypolyethylene glycol azide yielded a neutral bis-pegylated *** fluorophores exhibited excellent near-infrared(NIR)photophysical properties in methanol and aqueous *** cell microscopy imaging revealed efficient uptake and intracellular labelling of cells for both *** simple synthesis,with potential for last-step structural modifications,makes the present NIR-active azadipyrromethene derivatives potentially useful as NIR fluorescence imaging probes for live cells.

关键词： NIR-fluorophores live cell imaging NIRAZA

An Efficient Stacked Ensemble Model for Heart Disease Detection and Classification

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Computers, Materials & Continua 2023年第10期77卷 665-680页

作者： Sidra Abbas Gabriel Avelino sampedro Shtwai Alsubai Ahmad Almadhor Tai-hoon Kim Department of Computer Science COMSATS UniversityIslamabadPakistan College of Computer Studies De La Salle UniversityManila1004Philippines Faculty of Information and Communication Studies University of the Philippines Open UniversityLos Banos4031Philippines College of Computer Engineering and Sciences Prince Sattam bin Abdulaziz UniversityAlkharjSaudi Arabia Department of Computer Engineering and Networks College of Computer and Information SciencesJouf UniversitySakaka72388Saudi Arabia School of Electrical and Computer Engineering Yeosu CampusChonnam National UniversityYeosu-si59626Korea

Cardiac disease is a chronic condition that impairs the heart’s *** includes conditions such as coronary artery disease,heart failure,arrhythmias,and valvular heart *** conditions can lead to serious complications and even be life-threatening if not detected and managed in *** have utilized Machine Learning(ML)and Deep Learning(DL)to identify heart abnormalities swiftly and *** approaches have been applied to predict and treat heart disease utilizing ML and *** paper proposes a Machine and Deep Learning-based Stacked Model(MDLSM)to predict heart disease *** approaches such as eXtreme Gradient Boosting(XGB),Random Forest(RF),Naive Bayes(NB),Decision Tree(DT),and KNearest Neighbor(KNN),along with two DL models:Deep Neural Network(DNN)and Fine Tuned Deep Neural Network(FT-DNN)are used to detect heart *** models rely on electronic medical data that increases the likelihood of correctly identifying and diagnosing heart ***-known evaluation measures(i.e.,accuracy,precision,recall,F1-score,confusion matrix,and area under the Receiver Operating Characteristic(ROC)curve)are employed to check the efficacy of the proposed *** reveal that the MDLSM achieves 94.14%prediction accuracy,which is 8.30%better than the results from the baseline experiments recommending our proposed approach for identifying and diagnosing heart disease.

关键词： Deep neural network heart disease healthcare machine learning stacking

TML:a language to specify aerial robotic missions for the framework Aerostack

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International Journal of Intelligent Computing and Cybernetics 2017年第4期10卷 491-512页

作者： Martin Molina Ramon A.Suarez-Fernandez Carlos sampedro Jose Luis Sanchez-Lopez Pascual Campoy Department of Artificial Intelligence Technical University of Madrid(UPM)MadridSpain Centre for Automation and Robotics Technical University of MadridMadridSpain

Purpose–The purpose of this paper is to describe the specification language TML for adaptive mission plans that the authors designed and implemented for the open-source framework Aerostack for aerial ***/methodology/approach–The TML language combines a task-based hierarchical approach together with a more flexible representation,rule-based reactive planning,to facilitate *** approach includes additional notions that abstract programming *** authors built an interpreter integrated in the software framework *** interpreter was validated with flight experiments for multi-robot missions in dynamic ***–The experiments proved that the TML language is easy to use and expressive enough to formulate adaptive missions in dynamic *** experiments also showed that the TML interpreter is efficient to execute multi-robot aerial missions and reusable for different *** TML interpreter is able to verify the mission plan before its execution,which increases robustness and safety,avoiding the execution of certain plans that are not ***/value–One of the main contributions of this work is the availability of a reliable solution to specify aerial mission plans,integrated in an active open-source project with periodic *** the best knowledge of the authors,there are not solutions similar to this in other active open-source *** additional contributions,TML uses an original combination of representations for adaptive mission plans(*** trees with original abstract notions and rule-based reactive planning)together with the demonstration of its adequacy for aerial robotics.

关键词： Adaptive mission plans Aerial robotic systems Autonomous aerial systems Mission plan specification

Variations of OCT measurements corrected for the magnification effect according to axial length and refractive error in children

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Journal of Innovative Optical Health Sciences 2018年第1期11卷 123-137页

作者： Inmaculada Bueno-Gimeno Enrique España-Gregori Andres Gene-sampedro Juan Carlos Ondategui-Parra Carlos J.Zapata-Rodriguez Department of Optics and Optometry and Vision Science University of Valencia Spain Department of Surgery University of Valencia University Hospital La FeSpain Faculty of Optics and Optometry University Vision Centre Polytechnic University of CataloniaSpain

Purpose:The aim of this paper was to examine the distribution of macular,retinal nerve fiber layer(RNFL)thickness and optic disc parameters of myopic and hyperopic eyes in comparison withemmetropic control eyes and to investigate their variation according to axial length(AL)andspherical equivalent(SE)in healthy ***:This study included 293 pairs of eyes of 293children(145 boys and 148 girks),ranging in age from 6 to 17 years,Subjects were dividedaccording to SE in control(emmetropia,99 children),myopia(100 children)and hyperopia(94children)groups and according to axial AL in 68 short(25.00 mm,36).Macular parameters,RNFL thickness and opticdisc morphology were assessed by the Cirrus^(TM) *** was measured using the ***'s formula was used for calculating the corrected AL-related ocular *** Mean age(±SD)was 10.84±3.05 years;mean(±SD)SE was+0.14±0.51 D(range from8.75 to+8.25 D)and mean AL(±SD)was 23.12±*** RNFL thickness,averagemacular thickness and macular volume decreased as AL and myopia *** correlationsbetween AL/SE and optic disc parameters were found after correcting for magnification ***:AL and refractive error affect measurements of macular and RNFL thickness inhealthy *** make a correct interpretation of ocT measurements,ocular magnificationeffect should be taken into account by clinicians or OCT manufacturers.

关键词： Axial length refractive error children OCT measurements magnification fect

Valorization of Kraft Lignin as Thickener in Castor Oil for Lubricant Applications

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Journal of Renewable Materials 2018年第4期6卷 347-361页

作者： A.M.Borrero-Lopez F.J.Santiago-Medina C.Valencia M.E.Eugenio R.Martin-sampedro J.M.Franco Department of Chemical Engineering University of HuelvaEl Carmen CampusAgrifood Campus of International Excellence(ceiA3)21071 HuelvaSpain Pro2TecS-Chemical Process and Product Technology Research Center University of Huelva21071 HuelvaSpain INIA-CIFOR Ctra de la Coruñakm 7.5.28040MadridSpain

It is known that large amounts of residual lignin are generated in the pulp and paper industry.A new alternative for Kraft lignin valorization,which consists of first a chemical modification using a diisocyanate and then the efficient dispersion in castor oil to achieve stable gel-like systems,is proposed in this *** properties and microstructure of these materials were determined by means of small amplitude oscillatory shear tests and viscous flow measurements and atomic force microscopy observations,***,both standardized penetration tests and tribological assays,usually performed in the lubricant industry,were carried out to evaluate the performance characteristics as lubricating *** viscoelasticity functions are affected by the lignin/diisocyanate ratio and thickener *** thermorheological response evidenced a softening temperature of around 105°*** microstructure of these gel-like dispersions is composed of interconnected thin fibers,homogeneously distributed in castor ***,the NCO-functionalized lignin gel-like dispersions studied show lower friction coefficients than traditional lubricating greases.

关键词： Kraft lignin diisocyanate gel-like dispersion rheology thermal properties

Laparoscopic approach in gastrointestinal emergencies

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World Journal of Gastroenterology 2016年第9期22卷 2701-2710页

作者： Rosa M Jimenez Rodriguez Juan José Segura-sampedro Mercedes Flores-Cortés Francisco López-Bernal Cristobalina Martín Verónica Pino Diaz Felipe Pareja Ciuro Javier Padillo Ruiz Department of Surgery Hospital Universitario Virgen del Rocio 41013 Sevilla Spain Hospital Universitario Son Espases 07010 Palma de Mallorca Spain

This review focuses on the laparoscopic approach to gastrointestinal emergencies and its more recent indications. Laparoscopic surgery has a specific place in elective procedures, but that does not apply in emergency situations. In specific emergencies, there is a huge range of indications and different techniques to apply, and not all of them are equally settle. We consider that the most controversial points in minimally invasive procedures are indications in emergency situations due to technical difficulties. Some pathologies, such as oesophageal emergencies, obstruction due to colon cancer, abdominal hernias or incarcerated postsurgical hernias, are nearly always resolved by conventional surgery, that is, an open approach due to limited intraabdominal cavity space or due to the vulnerability of the bowel. These technical problems have been solved in many diseases, such as for perforated peptic ulcer or acute appendectomy for which a laparoscopic approach has become a wellknown and globally supported procedure. On the other hand, endoscopic procedures have acquired further indications, relegating surgical solutions to a second place; this happens in cholangitis or pancreatic abscess drainage. This endoluminal approach avoids the need for laparoscopic development in these diseases. Nevertheless, new instruments and new technologies could extend the laparoscopic approach to a broader array of potentials procedures. There remains, however, a long way to go.

关键词： Minimally invasive surgery Gastrointestinal surgery Emergency surgery Digestive emergencies Abdominal emergencies

Verbal Communication in HIV-1 Patients： A New Perspective on the Study of Cognitive Disorders

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Journal of Life Sciences 2012年第12期6卷 1396-1407页

作者： Valeria Abusamra Lorena Abusamra Barbara sampedro Maria Macaya Mercedes Guemes Micaela Difalcis Aldo Ferreres Philosophy and Art School University of Buenos Aires Buenos Aires C1225AAM Argentina Psychology School University of Buenos Aires Buenos Aires C1225AAM Argentina Neuropsychology Serviee Eva Peron Hospital Buenos Aires C1225AAM Argentina Diego Thompson Hospital Buenos Aires C1225AAM Argentina Nexo Buenos Aires C1225AAM Argentina Argentina's National Council for Scientific and Technical Research (CONICET) Buenos Aires C1225AAM Argentina

The aims were：（1） to study verbal communication skills presenting with verbal communication deficits by applying the MEC in HIV-1 patients, and （2） to analyze the proportion of patients Protocol. The authors evaluated 20 patients over 18 years of age HIV-1 positive; native speakers of Spanish; without alterations in language acquisition, reading, writing or history of neurological or psychiatric disease; patients undergoing antiretroviral treatment （not efavirenz） with viral load 〉 50 copies/mL, and patients not undergoing treatment. Their verbal communication abilities were evaluated with Protocol MEC. The results demonstrate that some of the skills evaluated are more vulnerable in HIV-1 patients. The tasks that showed the most frequent and systematic deficits among patients were discourse-level tasks and those that evaluate lexical semantic processing. The authors compared patients＇ performances with the ＂cut-off＇. The scores were turned into score Z. A hierarchic cluster analysis was carried out to identify subgroups with different profiles according to the areas that were affected. The detection of communication deficit profiles in HIV-1 patients would be the starting point for the identification of disorders and the admission of the patients to health care system. This research constitutes an initial approach towards the identification of clinical profiles among HIV-1 patients.

关键词： HIV-1 neuropsychology cognitive disorders language communication impairments.