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International Journal of Digital Earth 2022年第1期15卷 2223-2238页

作者： manuel ignacio perez Bruno Karelovic Roberto Molina Rodrigo Saavedra Pierluigi Cerulo Guillermo Cabrera Department of Computer Sciences Universidad de Concepcion Biblioteca CentralConcepcionChile Celulosa Arauco y Constitucion SA I&DSantiagoChile

The monitoring of trees is crucial for the management of large areas of forest cultivations,but this process may be ***,remotely sensed data offers a solution to automate this *** this work,we used two neural network methods named You Only Look Once(YOLO)and Mask R-CNN to overcome the challenging tasks of counting,detecting,and segmenting high dimensional Red–Green–Blue(RGB)images taken from unmanned aerial vehicles(UAVs).We present a processing framework,which is suitable to generate accurate predictions for the aforementioned tasks using a reasonable amount of labeled *** compared our method using forest stands of different ages and *** counting,YOLO overestimates 8.5%of the detected trees on average,whereas Mask R-CNN overestimates a 4.7%of the *** the detection task,YOLO obtains a precision of 0.72 and a recall of 0.68 on average,while Mask R-CNN obtains a precision of 0.82 and a recall of *** segmentation,YOLO overestimates a 13.5%of the predicted area on average,whereas Mask R-CNN overestimates a 9.2%.The proposed methods present a cost-effective solution for forest monitoring using RGB images and have been successfully used to monitor∼146,500 acres of pine cultivations.

关键词： Artificial intelligence tree identification forestry remote sensing

Aldynoglia cells and modulation of RhoGTPase activity as useful tools for spinal cord injury repair

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Neural Regeneration Research 2016年第7期11卷 1043-1045页

作者： Ernesto Doncel-perez manuel Nieto-Sampedro Grupo de Quimica Neuro-Regenerativa Hospital Nacional de Paraplejicos Servicio de Salud de Castilla La Mancha (SESCAM) Toledo Spain Grupo de Plasticidad Neural Instituto Cajal CSIC Madrid Spain

A combined approach in spinal cord injury （SCI） therapy is the modulation of the cellular and molecular processes involved in glial scarring. Aldaynoglial cells are neural cell precursors with a high capacity to differentiate into neurons, promote axonal growth, wrapping and myelination of resident neurons. These important characteristics of aldaynoglia can be combined with specific inhibition of the RhoGTPase activity in astroglia and microglia that cause reduction of glial proliferation, retraction of glial cell processes and myelin production by oligodendrocytes. Previously we used experimental central nervous system （CNS） injury models, like spinal cord contusion and striatal lacunar infarction and observed that administration of RhoGTPase glycolipid inhibitor or aldaynoglial cells, respectively, produced a significant gain of functional recovery in treated animals. The combined therapy with neuro-regenerative properties strategy is highly desirable to treat SCI for functional potentiation of neurons and oligodendrocytes, resulting in better locomotor recovery. Here we suggest that treatment of spinal lesions with aldaynoglia from new rospheres plus local administration of a RhoGTPase inhibitor could have an additive effect and promote recovery from SCI.

关键词： glial scar astrocyte microglia neurospheres aldaynoglia axonal growth myelination glycosideinhibitor

Description of a Propulsion Unit Used in Guiding a Walking Machine by Recognizing a Three-point Bordered Path

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Chinese Journal of Mechanical Engineering 2016年第6期29卷 1157-1166页

作者： NUNEZ-ALTAMIRANO Diego A JUAREZ-CAMPOS ignacio MARQUEZ-perez Lucia FLORES-DIAZ Ociel School of Mechanical Engineering Universidad Michoacana de San Nicolas de Hidalgo Morelia Michoacan Mexico

A reconfigurable propulsion unit based on the Peaucellier-Lipkin mechanism has the ability to describe exact straight or curved paths depending on the selected ratio between the lengths of two of its links. The Peaucellier-Lipkin mechanism with one degree of freedom is transformed into a more sophisticated parallel kinematic chain by including four more degrees of freedom. The resulting propulsion unit is able to adapt its kinematic structure and reach instant centers of rotation, in accordance with the presence of three points that border a geometric path. A laser sensor mounted on the body of the machine detects each point. Once the machine has detected the exact location of the border of the road, it walks along a curve parallel to that border. Although the proposed research describes only one propulsion unit or leg, the methodology can be applied to all the legs of the walking machine. The novel 5-DOF leg is able to reach different centers of rotation, providing either the concave or convex arcs that satisfy the basic principle of displacement of walking machines.

关键词： Propulsion unit Peaucellier-Lipkin walking machine straight line mechanism.

Anticoagulation in elderly patients at high risk of atrial fibrillation without documented arrhythmias

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Journal of Geriatric Cardiology 2017年第3期14卷 166-168页

作者： manuel Martinez-Selles Eusebio Garcia-Izquierdo Jaen ignacio Fernandez Lozano Servicio de Cardiologia Hospital General Universitario Gregorio Maranon Universidad Complutense CIBERCV Madrid Spain Servieio de Cardiologia Hospital Universitario Puerta de Hierro Majadahonda Madrid Spain

Recent studies have suggested that patients with high CHA2DS2VASc-score [Congestive Heart failure, hyperten- sion, Age ≥ 75 years （doubled）, Diabetes, Stroke （doubled）, Vascular disease, Age 65-74 years, Sex category （female sex）] thromboembolic complications occurred irrespective of the presence of atrial fibrillation （AF） and anticoagulant therapy may be initiated irrespective of documented AF.

关键词： Anticoagulation Atrial fibrillation Interatrial block Prognosis

2-Cys Peroxiredoxins Participate in the Oxidation of Chloroplast Enzymes in the Dark

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Molecular Plant 2018年第11期11卷 1377-1388页

作者： Valle Ojeda Juan manuel perez-Ruiz Francisco Javier Cejudo Instituto de Bioquimica Vegetaly Fotosintesis Universidad de Sevilla and Consejo Superior de lnvestigaciones CientificasAvenida Americo Vespucio 4941092SevillaSpain

Most redox-regulated chloroplast enzymes are reduced during the day and oxidized during the *** the reduction mechanism of light-dependent enzymes is well known,the mechanism mediating their oxidation in the dark remains *** thiol-dependent peroxidases,2-Cys peroxiredoxins (Prxs),play a key role in light-dependent reduction of chloroplast *** transfer reducing equivalents of thiols to hydrogen peroxide,suggesting the participation of these peroxidases in enzyme oxidation in the ***,we have addressed this issue by analyzing the redox state of well-known redox-regulated chloroplast enzymes in response to darkness in Arabidopsis thaliana mutants deficient in chloroplastlocalized Prxs (2-Cys Prxs A and B,Prx ⅡE,and Prx Q).Mutant plants lacking 2-Cys Prxs A and B,and plants overexpressing NADPH-dependent thioredoxin (Trx) reductase C showed delayed oxidation of chloroplast enzymes in the *** contrast,the deficiencies of Prx ⅡE or Prx Q exerted no *** vitro assays allowed the reconstitution of the pathway of reducing equivalents from reduced fructose 1,6-bisphosphatase to hydrogen peroxide mediated by Trxs and 2-Cys *** together,these results suggest that 2-Cys Prxs participate in the short-term oxidation of chloroplast enzymes in the dark.

关键词： chloroplast enzyme oxidation peroxiredoxin thioredoxin hydrogen peroxide darkness

Removing contaminants from tannery wastewater by chemical precipitation using CaO and Ca(OH)2

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Chinese Journal of Chemical Engineering 2020年第4期28卷 1107-1111页

作者： Adriana Reyes-Serrano Joel ELópez-Alejo manuel AHernández-Cortázar ignacio Elizalde Instituto Politécnico Nacional Centro Mexicano para la Producción más LimpiaCiudad de México 07340Mexico

The removal of Cr,sulfates and Chemical Oxygen Demand(COD)from industrial tannery wastewater by chemical precipitation was carried out using Calcium oxide(CaO)and Calcium hydroxide(Ca(OH)2).Different doses of alkalis,ranging from deficiency to excess hydroxyl species over the stoichiometric necessary,were used to remove theoretically the 100%of Cr[0.3-3.2 g alkali·(g Cr^3+)^-1].The precipitation was carried out at room temperature,10 min of vigorous stirring,200 r·min^-1 and a settling time of 24 h,followed by separation and characterization of liquid *** result of addition of alkalis,pH underwent increase as did the alkali *** removal of Cr,and sulfates also increased as alkali concentration did,although for first species the changes at higher alkali contents were less *** removal on the other hand,did not follow a unique trend,instead exhibited a *** on our results,selection of a specific dose of alkali was carried out taking as reference the efficiency on total chromium removal,keeping the pH in the range 7 to 9 to ensure Cr precipitation as chromium *** those conditions,jar test was used to produce enough liquid product in order to determine the removal percent of several other *** removal percent of the species was as follows:Cr,SO4^2-,ZnSO4,FeSO4,CN^-1,NiSO4,Fe2[Fe(CN)6]at 99.8%,66.9%,99.6%,21.4%,70.9%,52.8%and 76.4%with CaO,and 99.8%,61.6%,99.9%,7.1%,84.0%,54.4%and 90.5%with Ca(OH)2,respectively.

关键词： Tannery wastewater Alkali Removal Chromium Sulfates Synergistic effect

Role of endoscopic ultrasound in the diagnosis of pancreatic cancer

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World Journal of Gastrointestinal Oncology 2014年第9期6卷 360-368页

作者： Juana Gonzalo-Marin Juan Jose Vila manuel perez-Miranda Unit of Endoscopy Department of GastroenterologyQuirón Hospital Unit of Endoscopy Department of GastroenterologyComplejo Hospitalario de Navarra Department of Gastroenterology Hospital Universitario Rio Hortega

Endoscopic ultrasonography(EUS) with or without fine needle aspiration has become the main technique for evaluating pancreatobiliary disorders and has proved to have a higher diagnostic yield than positron emission tomography,computed tomography(CT) and transabdominal ultrasound for recognising early pancreatic *** a diagnostic modality for pancreatic cancer,EUS has proved rates higher than 90%,especially for lesions less than 2-3 cm in size in which it reaches a sensitivity rate of 99% vs 55% for ***,EUS has a very high negative predictive value and thus EUS can reliably exclude pancreatic *** complication rate of EUS is as low as 1.1%-3.0%.New technical developments such as elastography and the use of contrast agents have recently been applied to EUS,improving its diagnostic *** has been found to be superior to the recent multidetector CT for T stagingwith less risk of overstaying in comparison to both CT and magnetic resonance imaging,so that patients are not being ruled out of a potentially beneficial *** accuracy for N staging with EUS is 64%-82%.In unresectable cancers,EUS also plays a therapeutic role by means of treating oncological pain through celiac plexus block,biliary drainage in obstructive jaundice in patients where endoscopic retrograde cholangiopancreatography is not affordable and aiding radiotherapy and chemotherapy.

关键词： Endosonography Pancreatic neoplasms Endoscopy Diagnosis Neoplasm Staging Therapeutics

A review of Helicobacter pylori diagnosis, treatment, and methods to detect eradication

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World Journal of Gastroenterology 2014年第6期20卷 1438-1449页

作者： Elvira Garza-González Guillermo ignacio perez-perez Héctor Jesús Maldonado-Garza Francisco Javier Bosques-Padilla Servicio de Gastroenterología y Departamento de Patología Clínica Hospital Universitario "Dr. José Eleuterio González" Universidad Autónoma de Nuevo León Departments of Medicine and Microbiology New York University School of Medicine

Helicobacter pylori (H. pylori) affects nearly half of the world’s population and, thus, is one of the most frequent and persistent bacterial infections worldwide. H. pylori is associated with peptic ulcer disease, gastric ulcers, mucosa-associated lymphoid tissue lymphoma, and gastric cancer. Various diagnostic methods exist to detect infection, and the choice of one method or another depends on several factors, such as accessibility, advantages and disadvantages of each method, cost, and the age of patients. Once H. pylori infection is diagnosed, the clinician decides whether treatment is necessity, according to the patient’s clinical condition. Typically, eradication of H. pylori is recommended for treatment and prevention of the infection. Cure rates with the standard triple therapy are acceptable, and effective quadruple therapies, sequential therapies, and concomitant therapies have been introduced as key alternatives to treat H. pylori infection. In this work, we review the main diagnostic methods used to identify H. pylori infection and to confirm eradication of infection. In addition, key factors related to treatment are reviewed.

关键词： Diagnosis Helicobacter pylori Treatment Hybrid therapy Concomitant therapy Sequential therapy

Interplay among cellular polarization,lipoprotein metabolism and hepatitis C virus entry

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World Journal of Gastroenterology 2011年第22期17卷 2683-2690页

作者： ignacio Benedicto Francisca Molina-Jiménez Ricardo Moreno-Otero manuel López-Cabrera Pedro L Majano Molecular Biology Unit Hospital Universitario de la Princesa Instituto de Investigación Sanitaria Princesa (IP) Madrid 28006 Spain CIBERehd Instituto de Salud Car- los Ⅲ Madrid 28029 Spain Liver Unit Hospital Universitario de la Princesa Instituto de Investigación Sanitaria Princesa (IP) Madrid 28006 Spain Centro de Biología Molecular Severo Ochoa CSIC-UAM Madrid 28049 Spain

Hepatitis C virus (HCV) infects more than three million new individuals worldwide each year. In a high percent age of patients, acute infections become chronic, eventually progressing to fibrosis, cirrhosis, and hepatocellular carcinoma. Given the lack of effective prophylactic or therapeutic vaccines, and the limited sustained virological response rates to current therapies, new approaches are needed to prevent, control, and clear HCV *** into the host cell, being the first step of the viral cycle, is a potential target for the design of new antiviral compounds. Despite the recent discovery of the tight junction-associated proteins claudin-1 and occludin as HCV co-receptors, which is an important step towards the understanding of HCV entry, the precise mechanisms are still largely unknown. In addition, increasing evidence indicates that tools that are broadly employed to study HCV infection do not accurately reflect the real process in terms of viral particle composition and host cell phenotype. Thus, systems that more closely mimic natural infection are urgently required to elucidate the mechanisms of HCV entry, which will in turn help to design antiviral strategies against this part of the infection process.

关键词： Cellular polarization Tight junctions Lipoprotein metabolism Hepatitis C virus

mRNA levels of TLR4 and TLR5 are independent of H pylori

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World Journal of Gastroenterology 2008年第34期14卷 5306-5310页

作者： Elvira Garza-González Virgilio Bocanegra-García Francisco Javier Bosques-Padilla Juan Pablo Flores-Gutiérrez Francisco Moreno Guillermo ignacio perez-perez Departmento de Microbiología Facultad de MedicinaUniversidad Autónoma de Nuevo León Departmento de Biología Molecular y Bioingeniería UAM Reynosa Aztlán Universidad Autónoma de Tamaulipas Hospital Universitario "Dr. José Eleuterio González" Universidad Autónoma de Nuevo León Department of Medicine and Microbiology New York University School of Medicine

AIM:To determine if the presence H pylori or its viru- lence affect toll-like receptor 4 (TLR4) and TLR5 mRNA expression levels. METHODS:For the in vivo assays, gastric biopsies were obtained from 40 patients and H pylori status was determined. For the in vitro assays, human gastric adenocarcinoma mucosal cells (AGS) were cultured in the presence or absence of twelve selected H pylori strains. H pylori strains isolated from culture-positive patients and selected strains were genotyped for cagA and vacA. The cDNA was obtained from mRNA extracted from biopsies and from infected AGS cells. TLR4 and TLR5 mRNA levels were examined by real-time PCR. RESULTS: The presence of H pylori did not affect the mRNA levels of TLR4 or TLR5 in gastric biopsies. The mRNA levels of both receptors were not influenced by the vacA status (P > 0.05 for both receptors) andthere were no differences in TLR4 or TLR5 mRNA levels among the different clinical presentations/histological fi ndings (P > 0.05). In the in vitro assay, the mRNA levels of TLR4 or TLR5 in AGS cells were not influenced by the vacAs1 status or the clinical condition as-sociated with the strains (P > 0.05 for both TLR4 and TLR5). CONCLUSION: The results of this study show that the mRNA levels of TLR4 and TLR5 in gastric cells, both in vivo and in vitro, are independent of H pylori colonization and suggest that vacA may not be a significant player in the first step of innate immune recognition mediated by TLR4 or TLR5.

关键词： H pylori Toll-like receptor 4 Toll-likereceptor 5 AGS cells mRNA