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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第9期14卷 829-836页

作者： Ya-e ZHAO Jun-xian MA Li HU Li-ping WU manuel de rojas department of Immunology and Pathogen Biology Xi'an Jiaotong University College of Medicine department of Microbiology and Parasitology Faculty of PharmacyUniversity of Sevilla

For a long time,classification of demodex mites has been based mainly on their hosts and phenotypic characteristics.A new subspecies of demodex folliculorum has been proposed,but not ***,cox1 partial sequences of nine isolates of three demodex species from two geographical sources(China and Spain) were studied to conduct molecular identification of *** showed that the mitochondrial cox1 fragments of five *** isolates from the facial skin of Chinese individuals were 429 bp long and that their sequence identity was 97.4%.The average sequence divergence was 1.24% among the five Chinese isolates,0.94% between the two geographical isolate groups(China(5) and Spain(1)),and 2.15% between the two facial tissue sources(facial skin(6) and eyelids(1)).The genetic distance and rate of third-position nucleotide transition/transversion were 0.0125,2.7(3/1) among the five Chinese isolates,0.0094,3.1(3/1) between the two geographical isolate groups,and 0.0217,4.4(3/1) between the two facial tissue *** trees showed that *** from the two geographical isolate groups did not form sister clades,while those from different facial tissue sources *** to the molecular characteristics,it appears that subspecies differentiation might not have occurred and that *** isolates from the two geographical sources are of the same ***,population differentiation might be occurring between isolates from facial skin and eyelids.

关键词： demodex folliculorum cox1 partial sequences Divergence Genetic relationship Phylogenetic tree

Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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Neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia Michael J.Bannon Irma Alicia Martínez-Dávila Luis O.Soto-rojas David Reyes-Corona Lourdes Escobedo Minerva Maldonado-Berny ME Gutierrez-Castillo Armando J.Espadas-Alvarez manuel A.Fernandez-Parrilla Juan U.Mascotte-Cruz CP Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera Francisco E.Lopez-Salas Jaime Santoyo-Salazar Daniel Martinez-Fong departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogénesis Molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de Medicina para la Educación y desarrollo y la Investigación Científica de Iztacala(Red MEDICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle Therapy Institute AguascalientesMéxico departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Escuela Nacional de Medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico departamento de Biología Molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de Nanociencias y Nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-*** Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 *** study found that rNurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-D-glucoside-induced ***,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the *** addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** neurotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates

Venopulmonary ECMO Improved Hypoxemia and Supported the Right Ventricle in a Patient with decompensated Eisenmenger Syndrome

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World Journal of Cardiovascular Surgery 2024年第1期14卷 7-19页

作者： Daniel Manzur-Sandoval Gian manuel Jiménez-Rodríguez Edgar García-Cruz Ramón Espinosa-Soto Erika Yamali Ramirez-Marcano Yessenia Máyory Téllez-López José Luis Elizalde-Silva Gustavo rojas-Velasco Cardiovascular Critical Care Unit Ignacio Ch&#225vez National Institute of Cardiology Mexico City Mexico Adult Congenital Heart Disease Unit Ignacio Ch&#225vez National Institute of Cardiology Mexico City Mexico Cardiology department Ignacio Ch&#225vez National Institute of Cardiology Mexico City Mexico

Mechanical circulatory and/or respiratory assistance with extracorporeal membrane oxygenation (ECMO) has become a standard of care for patients with circulatory (venoarterial) and/or respiratory (venovenous) failure refractory to standard therapies. Adult patients with congenital heart disease are an increasingly recognized and growing population and include various groups, such as undiagnosed cases in childhood and palliated and/or corrected cases, which require subsequent care because of residual lesions, cardiac arrest/insufficiency, and arrhythmias, among other conditions. In addition, these patients are prone to developing pathologies that are typical of adulthood with a generally increased risk of morbidity and mortality because of their low reserves and organic damage associated with the underlying heart disease, which makes them candidates for ECMO. These patients represent an additional challenge in this therapy because malformations and the presence of a shunt can generally affect the usual cannulation methods and hemodynamic and oximetry monitoring. Thus, the configuration decision must be made on a case-by-case basis. Here, we present a cannulation method, venopulmonary artery ECMO, which provides hemodynamic and respiratory support, and may be ideal for patients with shunts and/or right ventricular dysfunction. To our knowledge, this is the first report of this configuration in patients with congenital heart diseases.

关键词： Eisenmenger Syndrome Venopulmonary Artery ECMO Refractory Hypoxemia Right Ventricular Dysfunction

Uremic Bleeding in 2 Patients with Dieulafoy’s Lesion: Case Report and Literature Review

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Open Journal of Gastroenterology 2024年第5期14卷 167-173页

作者： Gustavo Adolfo Hernández Valdez Diana Estefanía Ibarra García Juan Antonio Contreras Escamilla Janette Alejandra Gamiño Gutierrez Francisco manuel Tonatiuh Carrillo Beltran Ulises Solis Gomez Jocelyn Nataly Quintero Meléndez Ivan Alejandro Medina Jimenez Marco Antonio González Villar Jorge rojas Morales department of Internal Medicine ISSSTE APP General Hospital of Tepic Tepic Nayarit Mexico Hospital Civil de Guadalajara Fray Antonio Alcalde Guadalajara Jalisco M&#233xico

Dieulafoy’s lesions are rare vascular malformations of the gastrointestinal tract. A Dieulafoy’s lesion is an aberrant vessel that does not reduce in caliber when it extends from the submucosa to the mucosa. Damage to this artery can cause severe and intermittent arterial bleeding from small vascular stumps that are difficult to visualize. Furthermore, these catastrophic bleeding episodes frequently result in hemodynamic instability and the need for transfusion of multiple blood products. Recently, uremic syndrome has been identified as a risk factor for gastric mucosal lesions. We present two clinical cases of acute digestive bleeding due to Dielafoy lesion with chronic kidney disease as the main cause, where two different therapies were performed endoscopically. We concluded with the results of our patients that the best therapy was the application of the hemostatic hemoclip on the injury vs the injection with adrenaline on the wound site. Uremia is identified as a risk factor for upper gastrointestinal bleeding in patients with pre-existing Dieulafoy’s lesion, as well as a higher incidence of new bleeding.

关键词： Dieulafoy’s Lesion Gastrointestinal Bleeding Endoscopy Endoscopy Hemostatic Clips Kidney Disease Adrenaline Thermal Coagulation Dieulafoy

Entry of hepatitis C virus into the cell: A therapeutic target

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World Journal of Gastroenterology 2012年第33期18卷 4481-4485页

作者： José Antonio del Campo ngela rojas manuel Romero-Gómez Unit for Medical and Surgical Management of Digestive Diseases Center for Biomedical Research in Digestive and Liver Diseases Network (CIBERehd) Valme University Hospital University of Seville E-41014 Sevilla Spain

Several receptors have been identified as implicated on viral entry into the hepatocyte; and, this interaction between the virus and potential receptors could modulate infection, spontaneous viral clearance, persistence of the infection and the widespread of the virus as outbreak. Nevertheless, the playing role of each of them remains controversial. The NiemannPick type C1 like 1 gene (NPC1L1) receptor has been recently implicated on hepatitis C virus (HCV) entry into the cell and ezetimibe, an anti-cholesterol drug seems to block that, emerging the idea to control hepatitis C outbreak modulating lipid-related receptors. Hepatitis C infection seems to modulate lipid metabolism according to host genetic background. Indeed, it circulates like a lipoviroparticle. The main aim of this field of vision would be to discuss the role of hepatocyte receptors implicated on virus entry, especially NPC1L1 and the therapeutic options derived from the better knowledge about HCV-lipidsreceptors interaction.

关键词： Hepatitis C virus entry Niemann-Pick type C1 like 1 gene Lipid metabolism Ezetimibe

Guillain–Barré syndrome, transverse myelitis and infectious diseases

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Cellular & Molecular Immunology 2018年第6期15卷 547-562页

作者： Yhojan Rodríguez manuel rojas Yovana Pacheco Yeny Acosta-Ampudia Carolina Ramírez-Santana Diana M Monsalve M Eric Gershwin Juan-manuel Anaya Center for Autoimmune Diseases Research(CREA) School of Medicine and Health SciencesUniversidad del RosarioBogotaColombia Division of Rheumatology Allergy and Clinical ImmunologyUniversity of California DavisSchool of MedicineDavisCAUSA

Guillain–Barrésyndrome(GBS)and transverse myelitis(TM)both represent immunologically mediated polyneuropathies of major clinical *** are thought to have a genetic predisposition,but as of yet no specific genetic risk loci have been clearly *** are considered autoimmune,but again the etiologies remain *** may be induced via molecular mimicry,particularly from infectious agents and vaccines,but clearly host factor and co-founding host responses will modulate disease susceptibility and natural *** is an acute inflammatory immune-mediated polyradiculoneuropathy characterized by tingling,progressive weakness,autonomic dysfunction,and *** injury specifically takes place at the myelin sheath and related Schwann-cell components in acute inflammatory demyelinating polyneuropathy,whereas in acute motor axonal neuropathy membranes on the nerve axon(the axolemma)are the primary target for immune-related *** of GBS have been reported,most frequently related to Campylobacter jejuni infection,however,other agents such as Zika Virus have been strongly *** with GBS related to infections frequently produce antibodies against human peripheral nerve *** contrast,TM is an inflammatory disorder characterized by acute or subacute motor,sensory,and autonomic spinal cord *** is interruption of ascending and descending neuroanatomical pathways on the transverse plane of the spinal cord similar to *** has been suggested to be triggered by infectious agents and molecular *** this review,we will focus on the putative role of infectious agents as triggering factors of GBS and TM.

关键词： bacterial infections disease outbreaks Guillain-Barrésyndrome transverse myelitis virus diseases Zika virus

Glutaminolysis-ammonia-urea Cycle Axis,Non-alcoholic Fatty Liver Disease Progression and development of Novel Therapies

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 356-362页

作者： Ángela rojas María Rosario García-Lozano Antonio Gil-Gómez manuel Romero-Gómez Javier Ampuero department of Unit of Digestive Diseases Virgen del Rocío University HospitalSevilleSpain SeLiver group at the Insti-tute of Biomedicine of Seville(IBIS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Center for the Study of Liver and Gastrointestinal Diseases(CIBERehd) Carlos III National Institute of HealthMadridSpain de-partment of Organic and Medicinal Chemistry Faculty of PharmacyUniversity of SevilleE-41071SevilleSpain

The prevalence of non-alcoholic fatty liver disease(NAFLD)is increasing worldwide,reflecting the current epidemics of obesity,insulin resistance,type 2 diabetes mellitus,and metabolic *** is characterized by the accumulation of fat in the liver,and is known to be a cause of *** many pathways have been proposed,the cause of NAFLD-linked fibrosis progression is still unclear,which posed challenges for the development of new therapies to prevent NASH-related cirrhosis and hepatocellular *** is associated with activation of hepatic stellate cells(HSC)and accumulation of excess extracellular matrix proteins,and inhibiting the activation of HSCs would be expected to slow the progression of *** molecular signals and pathways such as oxidative stress and glutaminolysis have been reported to promote HSC *** mechanisms are plausible antifibrotic targets in NASH,as the activation of HSCs the proliferation of myofibroblasts depend on those *** review summarizes the role of the glutaminolysis-ammonia-urea cycle axis in the context of NAFLD progression,and shows how the axis could be a novel therapeutic target.

关键词： Non-alcoholic fatty liver disease Cirrhosis Fibrosis Glutaminoly-sis Ammonia Urea

Alzheimer’s disease and type 2 diabetes mellitus:Pathophysiologic and pharmacotherapeutics links

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World Journal of Diabetes 2021年第6期12卷 745-766页

作者： Milagros rojas Mervin Chávez-Castillo Jordan Bautista Ángel Ortega manuel Nava Juan Salazar Edgar Díaz-Camargo Oscar Medina Joselyn rojas-Quintero Valmore Bermúdez Endocrine and Metabolic Diseases Research Center School of MedicineUniversity of ZuliaMaracaibo 4004Venezuela Universidad Simón Bolívar Facultad de Ciencias Jurídicas y SocialesCúcuta 540006Colombia Pulmonary and Critical Care Medicine department Brigham and Women's HospitalHarvard Medical SchoolBostonMA 02155United States Universidad Simón Bolívar Facultad de Ciencias de la SaludBarranquilla 080001Colombia

At present,Alzheimer’s disease(AD)and type 2 diabetes mellitus(T2DM)are two highly prevalent disorders worldwide,especially among elderly individuals.T2DM appears to be associated with cognitive dysfunction,with a higher risk of developing neurocognitive disorders,including *** diseases have been observed to share various pathophysiological mechanisms,including alterations in insulin signaling,defects in glucose transporters(GLUTs),and mitochondrial dysfunctions in the ***,the aim of this review is to summarize the current knowledge regarding the molecular mechanisms implicated in the association of these pathologies as well as recent therapeutic *** this context,the hyperphosphorylation of tau and the formation of neurofibrillary tangles have been associated with the dysfunction of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways in the nervous tissues as well as the decrease in the expression of GLUT-1 and GLUT-3 in the different areas of the brain,increase in reactive oxygen species,and production of mitochondrial alterations that occur in *** findings have contributed to the implementation of overlapping pharmacological interventions based on the use of insulin and antidiabetic drugs,or,more recently,azeliragon,amylin,among others,which have shown possible beneficial effects in diabetic patients diagnosed with AD.

关键词： Alzheimer’s disease Type 2 diabetes mellitus Oxidative stress Islet amyloid polypeptide Glucagon-like peptide 1 Cognitive dysfunction Hypoglycemic agents

Antifungal Activity of Crude Extracts of Tectona grandis L.f. against Wood decayFungi

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Phyton-International Journal of Experimental Botany 2022年第8期91卷 1795-1808页

作者： Enrique Cárcamo-Ibarra Mauro manuel Martínez-Pacheco Abril Munro-rojas Jorge Enrique Ambriz-Parra Crisanto Velázquez-Becerra Facultad de Ingeniería en Tecnología de la Madera Universidad Michoacana de San Nicolás de HidalgoMorelia58030México Instituto de Investigaciones Químico-Biológicas Universidad Michoacana de San Nicolás de HidalgoMorelia58030México

Wood is mainly made up of cellulose, hemicelluloses, lignin polymers and other organic and inorganic substances, making it susceptible to deteriorate by various biological agents. Tectona grandis L.f. (Teak) is a timberspecies with high resistance to biological deterioration, valued for its durability, beauty, and mechanical *** purpose of this work was to evaluate the antifungal activity of crude extracts from teak on various fungi thatcause wood deterioration. For this, Teak heartwood was obtained, then fragmented and pulverized until obtaininga flour which was used for compounds extraction using the Soxhlet technique coupled to a rotary evaporatorthrough solvents of increasing polarity (hexane, dichloromethane, tetrahydrofuran, and acetone). The extractsobtained were tested against fungal organisms collected in the field, and the LC50 was determined using teak crudeextracts on Artemia salina as a biological model. The results obtained showed that a high flour yield was obtainedwith hexane (0.951 g), followed by tetrahydrofuran (0.446 g), dichloromethane (0.348 g), and acetone (0.152 g). Byusing nine fungal organisms that predominantly correspond to the genus Aspergillus, the extractable compoundswere tested, inhibiting 25% of mycelial growth with tetrahydrofuran (T. versicolor), and 40.9% with dichloromethane(G. trabeum). Likewise, the biological model of A. salina showed an LC50 of 84.9 μg/mL with hexane, 43.3 μg/mLwith dichloromethane, 59.6 μg/mL with tetrahydrofuran, and 54.7 μg/mL with acetone. For this reason, it is concluded that Teak wood contains many extractable compounds in relation to its weight, besides having antimicrobialactivity when extracted through polar compounds such as dichloromethane and tetrahydrofuran.

关键词： Tectona grandis wood deterioration naphthoquinone antifungal activity wood protection

Contralateral trapezius transfer to treat scapular winging: A case report and review of literature

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World Journal of Orthopedics 2019年第1期10卷 33-44页

作者： Juan José Gil-álvarez Pablo García-Parra manuel Anaya-rojas María del Pilar Martínez-Fuentes department of Orthopedics and Traumatology Hospital Universitario Virgen del Rocío department of Rehabilitation Hospital Universitario Virgen del Rocío

BACKGROUND No dynamic technique, such as tendon transfer, has been described for scapular winging due to levator scapulae or rhomboid major and minor palsies resulting from an isolated dorsal scapular nerve injury. Thus, we evaluated how the contralateral trapezius compound osteomuscular flap transfer would work in stabilizing lateral scapular winging, and the case is reported here. A literature review was also conducted, and articles relevant to the case are *** SUMMARY A 37-year-old male patient who had sustained an isolated dorsal scapular nerve injury underwent reconstructive surgery using the contralateral trapezius compound osteomuscular flap transfer technique to treat scapular winging and the consequent pain, and to restore function from the shoulder impairment. As a result, the involved shoulder showed an improved Constant-Murley score, from19.5% to 81.88%.CONCLUSION Contralateral trapezius osteomuscular flap transfer succeeded in stabilizing scapular winging in this case, improving shoulder function and affording pain relief.

关键词： Trapezoid muscle Osteomuscular flap Scapular winging Rhomboid muscles Nerve paralysis Dorsal scapular nerve Case report