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Hurwitz定理的一个简单证明

数学译林 2007年第3期26卷 287-288页

作者： manuel benito J. Javier Escribano 王义东(译) 陆柱家(校)

我们利用Brocot序列给出著名的Hurwitz定理的一个简单证明．

关键词： Hurwitz 简单证明定理

Differential colorectal carcinogenesis:Molecular basis and clinical relevance

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World Journal of Gastrointestinal Oncology 2010年第3期2卷 151-158页

作者： Alberto Morán Paloma Ortega Carmen de Juan Tamara Fernández-Marcelo Cristina Frías Andrés Sánchez-Pernaute Antonio José Torres Eduardo Díaz-Rubio Pilar Iniesta manuel benito the second Department of Biochemistry and Molecular Biology School of PharmacyComplutense University Surgery Service Ⅱ Clínico San Carlos Hospital Oncology Service Clínico San Carlos Hospital

Colorectal cancer(CCR) is one of the most frequent cancers in developed *** poses a major public health problem and there is renewed interest in understanding the basic principles of the molecular biology of colorectal *** has been established that sporadic CCRs can arise from at least two different carcinogenic *** traditional pathway,also called the suppressor or chromosomal instability pathway,follows the Fearon and Vogelstein model and shows mutation in classical oncogenes and tumour suppressor genes,such as K-ras,adenomatous polyposis coli,deleted in colorectal cancer,or *** in the Wnt pathway are also very common in this type of *** second main colorectal carcinogenesis pathway is the mutator *** pathway is present in nearly 15% of all cases of sporadic colorectal *** is characterized by the presence of mutations in the microsatellite sequences caused by a defect in the DNA mismatch repair genes,mostly in hMLH1 or *** two pathways have clear molecular differences,which will be reviewed in this article,but they also present distinct histopathological *** strikingly,their clinical behaviours are completely different,having the "mutator" tumours a better outcome than the "suppressor" tumours.

关键词： Colorectal cancer Microsatellite instability Clinical outcome

Intravascular Foreign Bodies： A Single-Institution Experience and Description of a Novel Modified Percutaneous Retrieval Technique

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Chinese Medical Journal 2018年第4期131卷 484-485页

作者： Mario Enrique Baltazares-Lipp benito Sarabia-Ortega Juan Ignacio Soto-Gonzalez Carlos manuel Aboitiz-Rivera Hector A Carmona-Ruiz Ruben Blachman-Braun Department of Hemodynamics and Echocardiography National Institute of Respiratory Diseases "Ismael Cosio Villegas" 14080 Mexico City Mexico Centro de Investigacion en Ciencias de la Salud F-acultad de Ciencias de la Saludl Universidad Anahuac Mexico Campus Norte Estado de Mexico 52786 Mexico

To the Editor： Catheters are frequently used as diagnostic and therapeutic devices that are frequently placed in critically ill patients. In addition, with the advantage of radiologic technology, the number of minimally invasive endovascular procedures has increased, and consequently the reports of intravascular foreign bodies （IFBs） and the numerous described IFBs retrieval technique.

关键词： REMOVAL

Feature importance:Opening a soil-transmitted helminth machine learning model via SHAP

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Infectious Disease Modelling 2022年第1期7卷 262-276页

作者： Carlos Matias Scavuzzo Juan manuel Scavuzzo Micaela Natalia Campero Melaku Anegagrie Aranzazu Amor Aramendia Agustín benito Victoria Periago Instituto de Altos Estudios Espaciales Mario Gulich Univesidad Nacional de Cordoba-Comision Nacional de Actividades EspacialesArgentina Fundacion Mundo Sano MadridSpain National Centre for Tropical Medicine Institute of Health Carlos IIIMadridSpain Fundacion Mundo Sano Buenos AiresArgentina Consejo Nacional de Investigaciones Científicasy Tecnicas(CONICET) Buenos AiresArgentina

In the field of landscape epidemiology,the contribution of machine learning(ML)to modeling of epidemiological risk scenarios presents itself as a good *** study aims to break with the”black box”paradigm that underlies the application of automatic learning techniques by using SHAP to determine the contribution of each variable in ML models applied to geospatial health,using the prevalence of hookworms,intestinal parasites,in Ethiopia,where they are widely distributed;the country bears the third-highest burden of hookworm in Sub-Saharan *** software was used,a very popular ML model,to fit and analyze the *** Python SHAP library was used to understand the importance in the trained model,of the variables for *** description of the contribution of these variables on a particular prediction was obtained,using different types of plot *** results show that the ML models are superior to the classical statistical models;not only demonstrating similar results but also explaining,by using the SHAP package,the influence and interactions between the variables in the generated *** analysis provides information to help understand the epidemiological problem presented and provides a tool for similar studies.

关键词： Shap Shapley Machine learning Remote sensing Hookworm Ethiopia

Thoracic Unilateral Spinal Cord Syndrome Following Neuraxial Anaesthesia for Periprosthetic Knee Fracture: A Case Report

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Open Journal of Anesthesiology 2019年第11期9卷 197-202页

作者： Nahir Chalup Torija Á lvaro Ramiro Ruiz Rubén Rodriguez Salas Beatriz Fuentes benito Marina Nevado Villafruela manuel Cortés Guerrero Anaesthesia Critical Care Department and Pain Medicine Hospital Universitario 12 de Octubre Madrid Spain Hospital Universitario Fundación Alcorcón Alcorcón Spain Centro de Salud de Torrelodones Áreanoroeste Torrelodones Spain

Neuraxial anaesthesia is widely used in surgical procedures;overall, epidural and intrathecal techniques. Nevertheless, several outcomes should be considered. The incidence of neurologic complications after neuraxial anaesthesia is not perfectly clear (0% - 0.08%), although there are several described cases of spinal cord ischemia. We present a case of thoracic unilateral spinal cord syndrome following lumbar spinal anaesthesia for periprosthetic knee fracture. Our patient suffered monoparesis in her left lower limb as well as decreasing of muscle strength and loss of tendon reflexes. The MNR showed left hyperintense intra-cord images from T7 to T12 attributed to spinal cord oedema and a lineal hypointensity related to minimal haematic component. What made this case surprising was the fact that spinal anaesthesia was performed between L3 and L4 and the patient did not suffer paraesthesia associated with local anaesthetic injection. She was treated with glucocorticoids, gabapentin and amitriptyline. She also was checked by physical rehabilitators, neurologists and Pain Unit physicians. We have found another case reported in the literature about thoracic cord injury after lumbar spinal puncture. In this paper, we report possible aetiologies according to a review and neurological evolution of the patient seven months later.

关键词： Neuraxial Anaesthesia Regional Anaesthesia Neurologic Complications Spinal Cord Injury

Timely reperfusion for ST-segment elevation myocardial infarction:Effect of direct transfer to primary angioplasty on time delays and clinical outcomes

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World Journal of Cardiology 2014年第6期6卷 424-433页

作者： Rodrigo Estévez-Loureiro ángela López-Sainz Armo Pérez de Prado Carlos Cuellas Ramón Calvio Santos Norberto Alonso-Orcajo Jorge Salgado Fernández Jose manuel Vázquez-Rodríguez Maria López-benito Felipe Fernández-Vázquez Division of Cardiology Complejo Asistencial Universitario de León (CAULE)24071 LeonSpain Division of Cardiology Complejo Hospitalario Universitario A Coru?a (CHUAC)15006 La Coru?aSpain

Primary percutaneous coronary intervention(PPCI) is the preferred reperfusion therapy for patients presenting with ST-segment elevation myocardial infarction(STEMI) when it can be performed expeditiously and by experienced operators. In spite of excellent clinical results this technique is associated with longer delays than thrombolysis and this fact may nullify the benefit of selecting this therapeutic option. Several strategies have been proposed to decrease the temporal delays to deliver PPCI. Among them,prehospital diagnosis and direct transfer to the cath lab,by-passing the emergency department of hospitals,has emerged as anattractive way of diminishing delays. The purpose of this review is to address the effect of direct transfer on time delays and clinical events of patients with STEMI treated by PPCI.

关键词： Primary angioplasty Direct transfer STsegment elevation myocardial infarction network Primary percutaneous coronary intervention Myocardial infarction