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Numerical analysis of anisotropic stiffness and strength for geomaterials

Journal of Rock Mechanics and Geotechnical Engineering 2023年第2期15卷 323-338页

作者： Fei Song manuel a.gonzález-fernández Alfonso Rodriguez-Dono Leandro R.Alejano Department of Civil and Environmental Engineering Universitat Politècnica de Catalunya(UPC)Barcelona08034Spain CINTECX GESSMin GroupDepartment of Natural Resources and Environmental EngineeringUniversity of VigoVigo36310Spain International Centre for Numerical Methods in Engineering(CIMNE) Barcelona08034Spain

In numerical modelling,selection of the constitutive model is a critical factor in predicting the actual response of a *** use of oversimplified or inadequate models may not be sufficient to reproduce the actual geomaterial *** selection is especially relevant in the case of aniso-tropic rocks,and particularly for shales and slates,whose behaviour may be affected,*** stability in geothermal or oil and gas production *** this paper,an alternative anisotropic constitutive model has been implemented in the finite element method software CODE_BRIGHT,which is able to account for the anisotropy of shales and slates in terms of both deformability and *** this purpose,a transversely isotropic version of the generalised Hooke’s law is adopted to represent the stiffness anisotropy,while a nonuniform scaling of the stress tensor is introduced in the plastic model to represent the strength ***,a detailed approach has been proposed to determine the model parameters based on the stressestrain results of laboratory ***,numerical analyses are performed to model uniaxial and triaxial tests on Vaca Muerta shale,Bossier shale and slate from the northwest of Spain(NW Spain slate).The experimental data have been recovered from the literature in the case of the shale and,in the case of the slate,performed by the authors in terms of stress-strain curves and strengths.A good agreement can be generally observed between numerical and experi-mental results,hence showing the potential applicability of the approach to actual case ***,the presented constitutive model may be a promising approach for analysing the anisotropic behaviour of rocks and its impact on well stability or other relevant geomechanical problems in aniso-tropic rocks.

关键词： Rock mechanics Anisotropy Numerical modelling CODE_BRIGHT Shale Slate

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Size effects on the tensile strength and fracture toughness of granitic rock in different tests

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第9期15卷 2179-2192页

作者： Ignacio Pérez-Rey Andrea Muñoz-Ibáñez manuel a.gonzález-fernández Mauro Muñiz-Menéndez Miguel Herbón Penabad Xian Estévez-Ventosa Jordi Delgado Leandro RAlejano Laboratorio de Geotecnia CEDEXMadridSpain CINTECX GESSMin GroupDepartment of Natural Resources and Environmental EngineeringUniversidade de VigoVigoSpain School of Civil Engineering Universidade da CoruñaA CoruñaSpain

This study investigates the tensile failure mechanisms in granitic rock samples at different scales by means of different types of *** do that,we have selected a granitic rock type and obtained samples of different sizes with the diameter ranging from 30 mm to 84 *** samples have been subjected to direct tensile strength(DTS)tests,indirect Brazilian tensile strength(BTS)tests and to two fracture toughness testing *** DTS and fracture toughness were found to consistently grow with sample size,this trend was not clearly identified for BTS,where after an initial grow,a plateau of results was *** is a rather complete database of tensile related properties of a single rock *** if similar databases are rare,the obtained trends are generally consistent with previous scatter and partial experimental ***,different observations apply to different types of rocks and experimental *** differences in variability and mean values of the measured parameters at different scales are critically analysed based on the heterogeneity,granular structure and fracture mechanics *** potential relations between parameters are revised and an indication is given on potential sample sizes for obtaining reliable *** this database with different types of rocks is thought to be convenient to advance towards a better understanding of the tensile strength of rock materials.

关键词： Size effect Tensile strength Fracture toughness Granite Finite fracture mechanics

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Beyond wrecking a wall:revisiting the concept of blood–brain barrier breakdown in ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 1944-1956页

作者： Julia Castillo-gonzález Elena.gonzález-Rey Institute of Parasitology and Biomedicine Lopez-Neyra(IPBLN) CSICPT SaludGranadaSpain

The blood–brain barrier constitutes a dynamic and interactive boundary separating the central nervous system and the peripheral *** tightly modulates the ion transport and nutrient influx,while restricting the entry of harmful factors,and selectively limiting the migration of immune cells,thereby maintaining brain *** the well-established association between blood–brain barrier disruption and most neurodegenerative/neuroinflammatory diseases,much remains unknown about the factors influencing its physiology and the mechanisms underlying its ***,the role of blood–brain barrier breakdown in the translational failure underlying therapies for brain disorders is just starting to be *** review aims to revisit this concept of“blood–brain barrier breakdown,”delving into the most controversial aspects,prevalent challenges,and knowledge gaps concerning the lack of blood–brain barrier *** moving beyond the oversimplistic dichotomy of an“open”/“bad”or a“closed”/“good”barrier,our objective is to provide a more comprehensive insight into blood–brain barrier dynamics,to identify novel targets and/or therapeutic approaches aimed at mitigating blood–brain barrier ***,in this review,we advocate for considering the diverse time-and location-dependent alterations in the blood–brain barrier,which go beyond tight-junction disruption or brain endothelial cell breakdown,illustrated through the dynamics of ischemic stroke as a case *** this exploration,we seek to underscore the complexity of blood–brain barrier dysfunction and its implications for the pathogenesis and therapy of brain diseases.

关键词： blood–brain barrier disruption drug delivery ischemic stroke neuroinflammation tight-junctions

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Tracking the change in Spanish greenhouse gas emissions through an LMDI decomposition model:A global and sectoral approach

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Journal of Environmental Sciences 2024年第5期139卷 114-122页

作者： Paula fernández gonzález María José Presno manuel Landajo Department of Applied Economics University of OviedoAuda del Cristos/n 33011 OviedoSpain

The reduction of GHG emissions to reverse the greenhouse effect is one of the main challenges in this *** this paper we pursue two ***,we analyze the evolution of GHG emissions in Spain in 2008–2018,at both the global and sectoral levels,with the variation in emissions decomposed into a set of determining ***,we propose several actions specifically oriented to more tightly controlling the level of *** results showed a remarkable reduction(18.44%)in GHG emissions,mainly due to the intensity effect,but also to the production-per-capita *** detected somewhat different patterns among the various sectors *** the intensity effect was the most influential one in the agricultural,transport,and others sectors,the production-per-capita effect was predominant in the case of *** carbonization effect was revealed as crucial in the commerce *** above findings highlight the importance of the energy efficiency measures taken in recent years in the Spanish economy,also pointing to the need to deepen those strategies and to propose new measures that entail greater efficiency in *** efforts in areas like innovation,R&D,diffusion of more eco-friendly technologies,and a greater use of greener energies all prove to be essential reduction actions to fight the greenhouse effect.

关键词： LMDI Decomposition Spain GHG emissions

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Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-Núñez María fernanda.gonzález Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and Notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

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A building energy models calibration methodology based on inverse modelling approach

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Building Simulation 2022年第11期15卷 1883-1898页

作者： Vicente Gutiérrez gonzález Carlos fernández Bandera Installations construction and structuresSchool of ArchitectureUniversity of NavarraCampus UniversitarioPamplona31009NavarraSpain

Nowadays,building energy models(BEMs)are widely used,particularly in the assessment of energy consumption in buildings to address the potential savings that can be *** realisation of a dynamic energy model based on high-fidelity physics(white-box models)requires a tuning process to fit the model to reality,due to many uncertainties *** some research trends try to reduce this performance gap by modulating different types of experimental parameters such as:capacitances or *** EnergyPlus simulation software,in its latest versions,has implemented an object:HybridModel:Zone that calculates the infiltration and internal mass of buildings using an inverse modelling approach that employs only the measured indoor temperature data to invert the heat balance equation for the zone under *** main objective of this paper is to reduce the execution time and uncertainties in the development of quality energy models by generating a new calibration methodology that implements this *** uses,as a starting point,a research created by the authors of this study,which was empirically and comparatively validated against the energy models developed by the participants in Annex *** is also worth highlighting the empirical validation of the HybridModel:Zone object,since it was activated in all scenarios where its execution is possible:periods of seven days or more of free oscillation and periods in which the building is under *** findings are *** data generated with the new methodology,if compared with those produced by the baseline model,improve their resemblance to the real ones by 22.9%.While those of its predecessor did it by 15.6%.For this study,the two dwellings foreseen in Annex 58 of the IEA ECB project have been modelled and their real monitoring data have been used.

关键词： internal thermal mass energy simulation EnergyPlus inverse model Annex 58 infiltration

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New insights into Wnt signaling alterations in amyotrophic lateral sclerosis: a potential therapeutic target?

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Neural Regeneration Research 2020年第9期15卷 1580-1589页

作者： Carlos gonzález-fernández Pau gonzález Francisco Javier Rodríguez Laboratory of Molecular Neurology Hospital Nacional de Parapléjicos (HNP)

Amyotrophic lateral sclerosis is a fatal neurodegenerative disorder characterized by upper and lower motor neuron degeneration, which leads to progressive paralysis of skeletal muscles and, ultimately, respiratory failure between 2–5 years after symptom onset. Unfortunately, currently accepted treatments for amyotrophic lateral sclerosis are extremely scarce and only provide modest benefit. As a consequence, a great effort is being done by the scientific community in order to achieve a better understanding of the different molecular and cellular processes that influence the progression and/or outcome of this neuropathological condition and, therefore, unravel new potential targets for therapeutic intervention. Interestingly, a growing number of experimental evidences have recently shown that, besides its well-known physiological roles in the developing and adult central nervous system, the Wnt family of proteins is involved in different neuropathologica conditions, including amyotrophic lateral sclerosis. These proteins are able to modulate, at least, three different signaling pathways, usually known as canonical(β-catenin dependent) and non-canonical(β-catenin independent) signaling pathways. In the present review, we aim to provide a general overview of the current knowledge that supports the relationship between the Wnt family of proteins and its associated signaling pathways and amyotrophic lateral sclerosis pathology, as well as their possible mechanisms of action. Altogether, the currently available knowledge suggests that Wnt signaling modulation might be a promising therapeutic approach to ameliorate the histopathological and functional deficits associated to amyotrophic lateral sclerosis, and thus improve the progression and outcome of this neuropathology.

关键词： ALS astrocytes Frizzled human microglia motor neuron neurodegeneration neuroinflammation spinal cord Wnt

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Tolerance of Chrysantemum maximum to heavy metals:The potential for its use in the revegetation of tailings heaps

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Journal of Environmental Sciences 2013年第2期25卷 367-375页

作者： Ma.del Carmen a.gonzlez-Chvez Rogelio Carrillo-gonzlez Colegio de Postgraduados Programa de EdafologíaCarr.Mxico-Texcocokm 36.5MontecilloTexcoco estado de Mxico 56230Mxico

To find if ornamental plants are applicable to the remediation of metal-polluted areas, the tolerance of chrysanthemum plants （Chysanthemum maximum） var. Shasta to different metals under hydroponic conditions was studied. Their responses as influenced by the mycorrhizal fungus Glomus mosseae （Nicol. ＆ Gerd.） Gerdemann ＆ Trappe BEG25 on substrates containing mine residues were also investigated. Our results showed that chrysanthemum is a metal-tolerant plant under hydroponic conditions, plants behaving as Pb-excluders, whereas Cd, Cu and Ni were accumulated in roots. Low accumulation in flowers was observed for Cd and Cu but it was concentration-dependent. Ni and Pb were not translocated to flowers. Shoot biomass was not significantly affected by the different rates of mine residue addition for both mycorrhizal and non-mycorrhizal plants. Mycorrhizal plants accumulated less Pb and Cu in both shoots and roots than non-mycorrhizal plants. Chysanthemum could be a prospective plant for revegetation of tailings and the use of inoculation may decrease plant metal accumulation in polluted soils.

关键词： mine residues ornamental plants phytostabilization urban remediation

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Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés Mercedes Lachén-Montes Elena Anaya-Cubero Joaquín fernández-Irigoyen Enrique Santamaría Clinical Neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:Neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

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Crossed Products over Weak Hopf Algebras Related to Cleft Extensions and Cohomology

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Chinese Annals of Mathematics,Series B 2014年第2期35卷 161-190页

作者： José Nicanor Alonso áLVAREZ José manuel fernández VILABOA Ramón gonzález RODRíGUEZ Departamento de Matemáticas Universidad de VigoCampus Universitario Lagoas-Marcosende Departamento de álxebra Universidad de Santiago de Compostela Departamento de Matemática Aplicada II Universidad de VigoCampus Universitario Lagoas-Marcosende

The authors present the general theory of cleft extensions for a cocommutative weak Hopf algebra H. For a right H-comodule algebra, they obtain a bijective corre- spondence between the isomorphisms classes of H-cleft extensions AH → A, where AH is the subalgebra of coinvariants, and the equivalence classes of crossed systems for H over AH. Finally, they establish a bijection between the set of equivalence classes of crossed systems with a fixed weak H-module algebra structure and the second cohomology group H2φZ（AH）（H, Z（AH））, where Z（AH） is the center of AH.

关键词： Monoidal category Weak Hopf algebra Cleft extension Weak crossedproduct Sweedler cohomology for weak Hopf algebras

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