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Towards an integrated risk analysis security framework according to a systematic analysis of existing proposals

Frontiers of Computer Science 2024年第3期18卷 199-216页

作者： Antonio SANTOS-OLMO Luis Enrique SÁNCHEZ David G.ROSADO manuel a.serrano Carlos BLANCO Haralambos MOURATIDIS Eduardo FERNÁNDEZ-MEDINA GSyA Research Group University of Castilla-La ManchaCiudad Real 13071Spain Institute for Analytics and Data Science University of EssexColchester CO43SQUK Alarcos Research Group University of Castilla-La ManchaCiudad Real 13071Spain ISTR Research group Department of Computer Science and ElectronicsUniversity of CantabriaSantander 39005Spain

The information society depends increasingly on risk assessment and management systems as means to adequately protect its key information *** availability of these systems is now vital for the protection and evolution of ***,several factors have led to an increasing need for more accurate risk analysis *** are:the speed at which technologies evolve,their global impact and the growing requirement for companies to *** analysis processes must consequently adapt to these new circumstances and new technological *** objective of this paper is,therefore,to present the results of an exhaustive analysis of the techniques and methods offered by the scientific community with the aim of identifying their main weaknesses and providing a new risk assessment and management *** analysis was carried out using the systematic review protocol and found that these proposals do not fully meet these new *** paper also presents a summary of MARISMA,the risk analysis and management framework designed by our research *** basis of our framework is the main existing risk standards and proposals,and it seeks to address the weaknesses found in these *** is in a process of continuous improvement,as is being applied by customers in several European and American *** consists of a risk data management module,a methodology for its systematic application and a tool that automates the process.

关键词： information security management security system security risk assessment and management

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Personality Trait Detection via Transfer Learning

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Computers, Materials & Continua 2024年第2期78卷 1933-1956页

作者： Bashar Alshouha Jesus serrano-Guerrero Francisco Chiclana Francisco P.Romero Jose A.Olivas Department of Information Technologies and Systems University of Castilla-La ManchaCiudad Real13071Spain Institute of Artificial Intelligence School of Computer Science and InformaticsDe Montfort UniversityThe GatewayLeicesterLE19BHUK

Personality recognition plays a pivotal role when developing user-centric solutions such as recommender systems or decision support systems across various domains,including education,e-commerce,or human ***-ditional machine learning techniques have been broadly employed for personality trait identification;nevertheless,the development of new technologies based on deep learning has led to new opportunities to improve their *** study focuses on the capabilities of pre-trained language models such as BERT,RoBERTa,ALBERT,ELECTRA,ERNIE,or XLNet,to deal with the task of personality *** models are able to capture structural features from textual content and comprehend a multitude of language facets and complex features such as hierarchical relationships or long-term *** makes them suitable to classify multi-label personality traits from reviews while mitigating computational *** focus of this approach centers on developing an architecture based on different layers able to capture the semantic context and structural features from ***,it is able to fine-tune the previous models using the MyPersonality dataset,which comprises 9,917 status updates contributed by 250 Facebook *** status updates are categorized according to the well-known Big Five personality model,setting the stage for a comprehensive exploration of personality *** test the proposal,a set of experiments have been performed using different metrics such as the exact match ratio,hamming loss,zero-one-loss,precision,recall,F1-score,and weighted *** results reveal ERNIE is the top-performing model,achieving an exact match ratio of 72.32%,an accuracy rate of 87.17%,and 84.41%of *** findings demonstrate that the tested models substantially outperform other state-of-the-art studies,enhancing the accuracy by at least 3%and confirming them as powerful tools for personality *** findings represent substantial a

关键词： Personality trait detection pre-trained language model big five model transfer learning

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CONSTANS alters the circadian clock in Arabidopsis thaliana

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Molecular Plant 2024年第8期17卷 1204-1220页

作者： Pedro de los Reyes Gloria.serrano-Bueno Francisco J.Romero-Campero He Gao Jose M.Romero Federico Valverde Plant Development Group-Institute for Plant Biochemistry and Photosynthesis Consejo Superior de Investigaciones CientificasUniversidad de SevillaSevilleSpain Department of Computer Science and Artificial Intelligence Universidad de SevillaSevilleSpain Department of Plant Developmental Biology Max Planck Institute for Plant Breeding ResearchCologneGermany Department of Plant Biochemistry and Molecular Biology Universidad de SevillaSevilleSpain

Plants are sessile organisms that have acquired highly plastic developmental strategies to adapt to the *** these processes,the floral transition is essential to ensure reproductive success and is finelyregulated by several internal andexternal genetic *** photoperiodic pathway,which controls plant response to day length,is one of the most important pathways controlling *** Arabidopsis photoperiodic flowering,CONSTANS(CO)is the central gene activating the expression of the florigen FLOWERING LOCUS T(FT)in the leaves at the end of a long *** circadian clock strongly regulates Co ***,to date,no evidence has been reported regarding a feedbackloop from the photoperiod pathway back to the circadian *** transcriptional networks,we have identified relevant network motifs regulating the interplay between the circadian clock and the photoperiod *** expression,chromatin immunoprecipitation experiments,and phenotypic analysis allowed us to elucidate the role of Co over the circadian *** with altered cO expression showed a different internal clock period,measured by daily leaf rhythmic *** showed that co upregulates the expression of key genes related to the circadian clock,such as CCA1,LHY,PRR5,and Gl,at the end of a long day by bindingto specific sites on their ***,a high numberof PRR5-repressed target genes are upregulated by CO,and this could explain the phase transition promoted by *** CO-PRR5 complex interacts with the bZiP transcriptionfactor HY5andhelps to localize the complex in the promoters of clock *** together,our results indicate that there may be a feedback loop in which co communicates back to the circadian clock,providing seasonal information to the circadian system.

关键词： CONSTANS circadian clock photoperiod

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Beyond Green

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Beijing Review 2024年第36期67卷 22-23页

作者： Juan Enrique serrano-Moreno Institute of International Studies University of Chile

What role will Chinese trade and investment play in Latin America's climate and sustainability efforts,particularly in Chile?To address this question,let's explore an unconventional comparison through two recent science fiction films-one from China and one from the U.S.-which offer distinct visions of humanity's future relationship with nature.

关键词： investment Latin humanity

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Olfactory receptors in neural regeneration in the central nervous system

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Neural Regeneration Research 2025年第9期20卷 2480-2494页

作者： Rafael Franco Claudia Garrigós Toni Capó Joan serrano-Marín Rafael Rivas-Santisteban Jaume Lillo Molecular Neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain CiberNed Network Center for Biomedical Research in Neurodegenerative Diseases Spanish National Health Institute Carlos IIIMadridSpain School of Chemistry Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagnostics and environmental *** ability of the olfactory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechanisms underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compounds and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compounds that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

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Olfactory receptors in neural regeneration in the central nervous system

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Neural Regeneration Research 2025年第09期 2480-2494页

作者： Rafael Franco Claudia Garrigós Toni Capó Joan serrano-Marín Rafael Rivas-Santisteban Jaume Lillo Molecular Neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de Barcelona CiberNed Network Center for Biomedical Research in Neurodegenerative Diseases Spanish National Health Institute Carlos Ⅲ School of Chemistry Universitat de Barcelona Department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de Barcelona Laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of Barcelona

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Clear cell sarcoma of the pancreas,an unusual cancer with unusual metastatic site or unusual primary site?

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World Journal of Clinical Cases 2024年第25期12卷 5653-5656页

作者： Jhenyffer Carvalho Moreno Pedro Luiz serrano Uson Junior Universidade 9 de Julho Sao Paulo 01509120Brazil Center for Personalized Medicine Hospital Israelita Albert EinsteinSão Paulo 05652900Brazil Department of Oncology Hospital do CoraçãoSao Paulo 04004030Brazil

Clear cell sarcoma(CCS)is a type of malignant tumor that can arise from tendons and *** malignant proliferation of cells with melanocytic lineage normally occurs in young patients,and it is normally identified in ***,different sites including gastrointestinal organs are also *** difficulties in the molecular and histopathology evaluation,the diagnosis is often confused with malignant *** cases are treated with surgical resection,but overall,the prognosis is *** this editorial,we will discuss a very interesting case of CCS identified in the *** will discuss the literature and controversies in the management of this type of ***,we will address molecular strategies to be incorporated in those cases to better understand the primary location of the ***,future perspectives of the field and new strategies of treatment will be described.

关键词： Clear cell sarcoma Soft tissue sarcoma Metastatic cancer Pancreatic cancer Pancreatectomy

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A novel neuroprotective method against ischemic stroke by accelerating the drainage of brain interstitial fluid

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Science China(Life Sciences) 2024年第10期67卷 2213-2223页

作者： Jingge Lian Liu Yang Hanbo Tan Shaoyi Su Leonor serrano Lopes Fangxiao Cheng Junhao Yan Yu Fu Wanyi Fu Zhaoheng Xie Jianfei Sun Jicong Zhang Zhiqian Tong Yajuan Gao Hongbin Han Department of Radiology Peking University Third HospitalBeijing 100191China Beijing Key Laboratory of Magnetic Resonance Imaging Technology Beijing 100191China Institute of Medical Technology Peking University Health Science CenterBeijing 100191China Department of Informatics Technical University of MunichGarching 80539Germany Department of Anatomy and Histology School of Basic Medical SciencesPeking UniversityBeijing 100191China Department of Neurology Peking University Third HospitalBeijing 100191China Department of Electronic Engineering Tsinghua UniversityBeijing 100084China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China School of Biological Science and Medical Engineering Beihang UniversityBeijing 100191China Key Laboratory of Alzheimer’s Disease of Zhejiang Province Institute of AgingSchool of Mental HealthWenzhou Medical UniversityWenzhou 325035China NMPA Key Laboratory for Evaluation of Medical Imaging Equipment and Technique Beijing 100191China

Ischemic stroke is a leading cause of death and disability *** response after stroke determines the outcome of ischemic injury.A recent study has reported an efficient method,epidural arterial implantation(EAI),for accelerating interstitial fluid(ISF)drainage,which provides a promising strategy to clear pro-inflammatory cytokines in the brain extracellular space(ECS).In this study,the method of EAI was modified(m-EAI)to control its function of accelerating the ISF drainage at different time points following ischemic *** neuroprotective effect of m-EAI on ischemic stroke was evaluated with the transient middle cerebral artery occlusion(tMCAO)rat *** results demonstrated the accumulation of IL-1β,IL-6,and TNF-αwas significantly decreased by activating m-EAI at 7 d before and immediately after ischemic attack in tMCAO rats,accompanied with decreased infarct volume and improved neurological *** study consolidates the hypothesis of exacerbated ischemic damage by inflammatory response and provides a new perspective to treat encephalopathy via brain *** research is essential to investigate whether m-EAI combined with neuroprotective drugs could enhance the therapeutic effect on ischemic stroke.

关键词： ischemic stroke brain extracellular space interstitial fluid modified epidural arterial implantation

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The Iberian Roma Population Variant Server(IRPVS)

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Journal of Genetics and Genomics 2024年第7期51卷 769-773页

作者： Fabiola Mavillard Javier Perez-Florido Francisco M.Ortuño Amador Valladares Miren L.Álvarez-Villegas Gema Roldán Rosario Carmona manuel Soriano Santiago Susarte Pilar Fuentes Daniel López-López Ana María Nuñez-Negrillo Alejandra Carvajal Yolanda Morgado Daniel Arteaga Rosa Ufano Pablo Mir Juan F.Gamella Joaquín Dopazo Carmen Paradas Macarena Cabrera.serrano Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud CarlosⅢSevillaSpain Plataforma Andaluza de Medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica Funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática en Enfermedades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain Departamento de Ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain Centro de Servicios Sociales Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain Departamento de Enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain Departamento de Neurología Hospital Virgen de las NievesGranadaSpain Departamento de Neurología Hospital Virgen de ValmeSevillaSpain Centro de Salud Utrera Sur SevillaSpain Centro de Salud Polígono Sur SevillaSpain Unidad de Trastornos del Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain Departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain Departamento de Antropología Social Universidad de GranadaSpain Unidad Enfermedades Neuromusculares Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponentially grown due to the widespread adoption of cost-effective massive parallel *** identify new disease variants,especially in monogenic disorders,a frequen... 详细信息

关键词： Server filtering massive

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A Bioequivalence Study of Empagliflozin/Metformin Fixed-Dose Combination in Healthy Subjects under Fasting Conditions

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Journal of Biosciences and Medicines 2024年第9期12卷 235-250页

作者： Evelyn Pena Alfredo Inatti Anyoly Taly José Chacón Xenon serrano-Martin Department of Clinical Research Industrias Biocontrolled C.A. Grupo Leti S.A.V. Guarenas Venezuela Department of Research & Development Industrias Biocontrolled C.A. Grupo Leti S.A.V. Guarenas Venezuela Department of Medical Megat Laboratories Quito Ecuador

Background: This study evaluated the bioequivalence of empagliflozin 12.5 mg/metformin 1000 mg tablets compared to Synjardy® (Empagliflozin 12.5 mg/metformin 1000 mg) tablets in healthy male subjects under fasting conditions. Methods: This was a phase I, randomized, single-dose, two-period, two-sequence, crossover study to evaluate the bioequivalence (BE) profiles of two fixed-dose combinations (FDCs) of empagliflozin/metformin. Cmax, AUC0-t and AUC0-∞ from test and reference formulations were evaluated to access BE. The plasma concentrations were measured using a validated liquid chromatography-mass spectrometry (LC-MS/MS) method. Of the 24 subjects enrolled, 23 completed both periods of the study. The two formulations test and reference were considered bioequivalent if 90% confidence interval (CI) fell within 80.00% - 125.00% for Cmax, AUC0-t and AUC0-∞. Tolerability and safety were assessed throughout the study. Results: The pharmacokinetic (PK) parameters were similar between the test product (T) and reference product (R) Synjardy®. The 90% CI of the test/reference ratios of log-transformed PK parameters point estimates was Cmax: 89.87% (85.68% - 94.27%), AUC0-t: 87.91% (83.65% - 92.39%) and AUC0-∞: 87.16% (82.80% - 91.75%) to empagliflozin and Cmax: 92.19% (87.95% - 96.65%), AUC0-t: 91.38% (84.42% - 98.91%) and AUC0-∞: 93.78% (83.82% - 104.93%) to metformin respectively (90% CI for all PK parameters fell within 80.00% - 125.00%). Conclusion: Our results demonstrated BE between the test and reference formulations of oral tablets of empagliflozin 12.5 mg/metformin 1000 mg (FDC) in healthy male subjects under fasting conditions.

关键词： Bioequivalence Fix Dose Combinations Pharmacokinetic Empagliflozin

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