检索结果-南通市图书馆

重症肌无力特异性免疫治疗的展望

引用

生理科学进展 1991年第3期22卷 203-206页

作者： Steinman L mantegazza r 殷金珠朱文玉

重症肌无力是免疫系统对乙酰胆碱受体自身耐受破坏,产生乙酰胆碱受体抗体的一种自身免疫病。本文介绍重症肌无力发生的免疫机理,及近年来自身免疫病的实验性研究成果应用于重症肌无力临床治疗的可能性。

关键词：重症肌无力免疫疗法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

美国重症肌无力基金会关于重症肌无力临床试验的建议

引用

中国神经免疫学和神经病学杂志 2013年第1期20卷 74-74页

作者： Benatar M Sanders DB Burns TM Cutter Gr Guptill JT Baggi F Kaminski HJ mantegazza r Meriggioli MN Quan J Wolfe GI 李海峰(摘译) 高翔(摘译) 不详青岛大学医学院附属医院神经内科

由美国重症肌无力基金会（MGFA）的医学科学建议委员会（MSAB）组成工作组，于2010年在美国和2011年在意大利召开专家共识会议讨论重症肌无力（MG）临床试验的问题，与会代表包括来自美国和欧洲的神经科医生、统计学家、企业界代表、MG... 详细信息

由美国重症肌无力基金会（MGFA）的医学科学建议委员会（MSAB）组成工作组，于2010年在美国和2011年在意大利召开专家共识会议讨论重症肌无力（MG）临床试验的问题，与会代表包括来自美国和欧洲的神经科医生、统计学家、企业界代表、MG患者以及MGFA和欧洲重症肌无力协会的平民代表。

关键词：重症肌无力临床试验基金会美国科学建议工作组委员会意大利

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Surveying the Oligomeric State of Arabidopsis thaliana Chloroplasts

引用

Molecular Plant 2017年第1期10卷 197-211页

作者： Peter K. Lundquist Otho mantegazza Anja Stefanski Kai Stuhler Andreas P.M. Weber institute for Plant Biochemistry Molecular Proteomics La_boratory BMFZ Cluster of Excellence on Plant Sciences (CEPLAS) Heinrich-Heine-University UniversitatsstraBe 1 40225 Duseldorf Germany present address: Plant Biology Division The Samuel Roberts Noble Foundation Ardmore OK 73401 USA

Blue native-PAGE （BN-PAGE） resolves protein complexes in their native state. When combined with immu- noblotting, it can be used to identify the presence of high molecular weight complexes at high resolution for any protein, given a suitable antibody. To identify proteins in high molecular weight complexes on a large scale and to bypass the requirement for specific antibodies, we applied a tandem mass spectrometry （MS/MS） approach to BN-PAGE-resolved chloroplasts. Fractionation of the gel into six bands allowed iden- tification and label-free quantification of 1000 chloroplast proteins with native molecular weight separation. Significantly, this approach achieves a depth of identification comparable with traditional shotgun proteo- mic analyses of chloroplasts, indicating much of the known chloroplast proteome is amenable to MS/MS identification under our fractionation scheme. By limiting the number of fractionation bands to six, we facil- itate scaled-up comparative analyses, as we demonstrate with the reticulata chloroplast mutant displaying a reticulated leaf phenotype. Our comparative proteomics approach identified a candidate interacting protein of rETICULATA as well as effects on lipid remodeling proteins, amino acid metabolic enzymes, and plastid division machinery. We additionally highlight selected proteins from each sub-compartment of the chloroplast that provide novel insight on known or hypothesized protein complexes to further illus- trate the utility of this approach. Our results demonstrate the high sensitivity and reproducibility of this technique, which is anticipated to be widely adaptable to other sub-cellular compartments.

关键词： chloroplast blue native-PAGE comparative proteomics protein complex oligomeric state,rETICULATA

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The role of immunoenzymatic therapy in the management of vestibulodynia associated with painful bladder syndrome

引用

Open Journal of Obstetrics and Gynecology 2013年第4期3卷 16-19页

作者： Filippo Murina raffaele Felice Stefania Di Francesco Valeria mantegazza Outpatient Department of Vulvar Disease V. Buzzi Hospital-University of Milan Milan Italy

Background: Vestibulodynia (VBD) and painful bladder syndrome (PBS) are two common and often concomitant conditions. Objective: To assess the effectiveness of an enzymatic combination of papain, bromelain, trypsin, chymotrypsin and quercetin in the supportive treatment of VBD/PBS, patients underwent TENS + amitriptyline and pregabalin therapy as a multimodal treatment strategy. Method: 40 patients were randomly assigned to receive a systemic therapy: amitriptyline + pregabalin (Group A) versus amitriptyline + Pregabalin plus a systemic enzyme preparation (Group B). All patients received a transcutaneous electric nerve stimulation (TENS) therapy in a self-administered domiciliary protocol. results: The VAS and the dyspareunia score after the treatment showed a significant difference in the two groups (VAS: Group A difference of 4.3, Group B difference of 3.1, p = 0.005;dyspareunia: Group A and Group B 1.8 vs. 0.8, p = 0.005). Conclusion: The positive results of our study prove the utility effectiveness of an enzyme combination to decrease and normalize the biomarkers of inflammation in VBD and PBS patients in a multimodal approach.

关键词： Vulvodynia TENS Vulvar Vestibulitis Syndrome Painful Bladder Syndrome Immunoenzymatic Therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Type 1 diabetes and celiac disease:The effects of gluten free diet on metabolic control

引用

World Journal of Diabetes 2013年第4期4卷 130-134页

作者： Andrea E Scaramuzza Cecilia mantegazza Alessandra Bosetti Gian Vincenzo Zuccotti Department of Pediatrics Luigi Sacco Hospital University of Milano

Type 1 diabetes mellitus is associated with celiac disease,with a prevalence that varies between 0.6% and 16.4%,according to different *** a diagnosis of celiac disease is confirmed by small bowel biopsy,patients are advised to commence a gluten-free diet(GFD).This dietary restriction may be particularly difficult for the child with diabetes,but in Europe(and in Italy) many food stores have targeted this section of the market with better labeling of products and more availability of specific GFD *** with a GFD in symptomatic patients has been shown to improve the symptoms,signs and complications of celiac ***,the effects of a GFD on diabetic control are less well *** reports of improved hypoglycemic control were based on children who were diagnosed with celiac disease associated with malabsorption,but there have subsequently been reports of improvement in patients with type 1 diabetes with subclinical celiac *** are other studies reporting no effect,improved control and an improvement of hypoglycemic ***,in this review we wish to focus on low glycemic index foods,often suggested in people with type 1 diabetes,since they might reduce postprandial glycemic excursion and enhance longterm glycemic *** contrast,GFD may be rich in high glycemic index foods that can increase the risk of obesity,insulin resistance and cardiovascular disease,worsening the metabolic control of the child with ***,it is important to evaluate the impact of a GFD on metabolic control,growth and nutritional status in children with type 1 diabetes.

关键词： Adolescents Celiac disease Children Glycemic control Type 1 diabetes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：