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Infectious Complications in Lupus Nephritis and Associated Factors: A Multicenter Study

Open Journal of Nephrology 2021年第4期11卷 506-515页

作者： mansour mbengue Myriam Mezouari Seynabou Diagne Abdou Niang Dalal Jamm Hospital Dakar Senegal Pikine Hospital Dakar Senegal

Introduction: The prevalence of infections in patients with systemic lupus erythematosus ranges from 26% to 78%. Patients with systemic lupus erythematosus are particularly susceptible to infections due to a dysfunction of immune response and the immunosuppressive therapy. Patients and method: We carried out this study with the aim of describing the prevalence of infections in lupus nephritis and determining the associated risk factors. This was a multi-center, observational, retrospective, descriptive and analytical study over a 10-year period from November 1, 2010 to October 31, 2020. The study was carried out in the nephrology departments of six hospitals in Dakar. Results: During the study period, 98 patients were included. The mean age was 32.32 ± 11.33 years with a sex ratio of 0.21. Among the included patients, fifty-four (55.1%) had at least one infectious episode, of which 53.7% had 1 infection, 24.1% had 2 infectious episodes and 22.2% had 3 infectious episodes. The overall incidence was 55.1 infections per 100 patient-years. 57.2% of these infectious episodes occurred within the first six months after the lupus was diagnosed. The main sites of infection were urinary (30.7%), gastrointestinal (22.0%) and pleuropulmonary (16.5%). The incriminated germ was a bacterium in 78.18% of cases, a virus in 5.46%, a parasite in 9.09 and a fungus in 7.27. The most frequently germ found was Escherichia coli (29.09%). The evolution was marked by recovery in 93.4% of cases. Deaths occurred in 15 patients of which 33.3% were related to infections. Factor significantly associated with the onset of infection in multivariate analysis was the presence of a proliferative class of lupus nephritis (p = 0.013). Conclusion: Infections were common during lupus nephritis. The presence of a proliferative class was risk factors for infection.

关键词： Lupus Nephritis Infection Proliferative Class

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Chronic Kidney Disease in Sub-Saharan Africans: A Study of 462 Patients

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Open Journal of Nephrology 2021年第1期11卷 114-122页

作者： mbengue mansour Ba Djenaba Lemrabott Tall Ahmed Cissé Mouhamadou Moustapha Niang Abdou Department of Nephrology Dalal Jamm University Hospital Dakar Senegal Department of Nephrology Aristide Le Dantec University Hospital Dakar Senegal Department of Nephrology El Hadji Amadou Sakhir Ndiéguéne Hospital Thiés Senegal

Chronic kidney disease is a global public health problem due to its increasing prevalence as well as its main risk factors such as hypertension and diabetes. However, in Africa, few studies have been done on chronic kidney disease. The aim of our study is to describe the epidemiological, clinical, paraclinical and therapeutic aspects of chronic kidney disease. It was a retrospective and descriptive study carried out from the first of January 2004 to the 31st of December 2013 at Principal hospital in Dakar. Records of any patient aged 18 and over with chronic kidney disease were included. Chronic kidney disease was defined according to the KDIGO 2012 recommendations. Among the 8873 patient records used during our study, 462 presented with chronic kidney disease, which was a hospital prevalence of 5.2%. The sex ratio was 1.61. The mean age of the patients was 58.37 ± 19.97 years. There were 75.32% of the patients who were aged 50 and over. The mean serum creatinine was 49.14 ± 56.83. The mean glomerular filtration rate was 27.47 ± 19.86 ml/min/1.73 m2. Chronic renal failure was diagnosed in 92% of patients, including 34.9% in the end-stage of the renal disease. The mean proteinuria was 3.07 ± 4.92 g/24 h. Leukocyturia was present in 34.17% of patients. Hematuria was present in 25% of patients. Hypertension and diabetes were the most common causes, found in 61.25% and 35.93% of patients, respectively. Hemodialysis was performed in 49 patients. Peritoneal dialysis was performed in 2 patients. One patient had undergone a kidney transplant. This study establishes the relatively high prevalence of chronic kidney disease and its risk factors including hypertension and diabetes. It also reveals the late diagnosis of chronic kidney disease in our pa

关键词： Chronic Kidney Disease Hypertension Diabetes

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Pulmonary Hypertension in Chronic Hemodialysis Patients at Aristide Le Dantec University Hospital

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Open Journal of Nephrology 2022年第1期12卷 93-100页

作者： Maria Faye Ahmed Tall Lemrabott Niakhaleen Keita Moustapha Faye Romina Ghassani mansour mbengue Bacary Ba Seynabou Diagne Abdou Niang El Hadj Fary Ka Nephrology Department Aristide Le Dantec University Hospital Dakar Senegal Cheikh Anta Diop University Dakar Senegal Nephrology Department Dalal Jamm Hospital Dakar Senegal

Introduction: Pulmonary hypertension (PH) is defined as high blood pressure in the lungs. It is recently described as a vascular disease entity in chronic kidney disease, particularly for chronic hemodialysis patients. The aims of this study were to determine the prevalence of PH, to describe clinico-biological and morphological characteristics and to identify risk factors associated with PH in hemodialysis patients. Patients and methods: This is a cross-sectional, descriptive, and analytical study during a period of 8 months from January 1, 2019, to August 31, 2019, in the hemodialysis center of nephrology department of Aristide Le Dantec Hospital. All chronic hemodialysis patients for more than 3 months and with PH confirmed by cardiac doppler ultrasound were included. Results: During the study period, 25/94 patients on chronic hemodialysis, presented with pulmonary hypertension (26.6%). The mean age was 49.3 ± 12.9 years. The sex ratio (M/F) was 0.92. Exertional dyspnea was found in 18 patients (72%). Cardiac auscultation revealed an arrhythmia in 3 patients (12%), augmented second heart sound in 12 patients (48%). On transthoracic doppler ultrasound, pulmonary systolic arterial pressure was on average 51.4 ± 13.2 mmHg. PH was moderate in 13 patients (52%), mild in 9 patients (36%) and severe in 3 patients (12%). The left ventricular ejection fraction was altered in 9 patients (36%). Three patients (12%) had valve calcifications. They were mainly located at aortic valve (8%) and mitral valve (4%). The major risk factors associated to PH in our patients are pathological fractures (p = 0.023), aortic calcifications (p = 0.023), ischemic heart disease (p = 0.023). The duration of hemodialysis represents another favoring factor (p = 0.042). Also implicated are arrhythmias (p = 0.004), high cardiac index (p = 0.043), ventricular dilatation (p = 0.034) and left atrial dilation (p = 0.015), as well as dilation of the inferior vena cava (p = 0.048).

关键词： Pulmonary Hypertension Chronic Hemodialysis Patients Transthoracic Doppler Ultrasound Dakar

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Pathological Fractures in Chronic Hemodialysis Patients in a Teaching Hospital in Senegal: Prevalence and Associated Risk Factors

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Open Journal of Nephrology 2023年第3期13卷 211-219页

作者： Ahmed Tall Lemrabott Baratou Coundoul Niakhaleen Keita Maria Faye Moustapha Faye mansour mbengue Bacary Ba Seynabou Diagne Abdou Niang El Hadji Fary Ka Department of Nephrology Aristide Le Dantec University Hospital Dakar Senegal Department of Nephrology Dalal Jamm National Hospital Center Dakar Senegal Dialysis Center National Hospital Center of Pikine Pikine Senegal

Introduction: The lack of follow-up and adequate management of chronic kidney disease-mineral and bone disorder (CKD-MBD) in chronic hemodialysis patients is associated with pathological fractures. Few studies are available on the subject in sub-Saharan Africa. The objective of this work was to evaluate the prevalence of pathological fractures in our chronic hemodialysis patients, to analyze their clinical aspects and to determine the factors associated with their occurrence. Patients and Methods: We conducted a retrospective, descriptive and analytical study over 9 years (January 1, 2011, to December 31, 2020) based on the medical records of chronic hemodialysis patients at the CHU Aristide Le Dantec. The diagnosis of pathological fracture was retained in front of any fracture occurring spontaneously or following minimal trauma and confirmed by X-ray. Results: Nineteen cases of pathological fractures were collected with a hospital prevalence of 19.39%. The mean age was 53.32 ± 13.94 years with a sex ratio of 0.36. The average seniority in dialysis was 84.16 ± 29.88 months. Among these patients, one had had 3 episodes of fractures and another 6 episodes. The circumstances of occurrence of the fractures were the fall in 63% of the cases, spontaneously in 37% of the cases. The predominant site of fractures was the femoral neck (47.38% cases). Female gender (p 5 years (p = 0.049), gait disturbances prior to the fracture (p = 0.001), positive CRP (p = 0.028) and the presence of vascular calcifications (p = 0.002) were significantly associated with the occurrence of pathological fractures. Conclusion: This study has identified the factors associated with the occurrence of pathological invoices in hemodialysis patients in our context. These fractures are often associated with the lack of regular biological follow-up due to the low socioeconomic level of our patients.

关键词： Pathological Fractures CKD-MBD Hyperparathyroidism Osteomalacia Adynamic Bone Disease Chronic Hemodialysis

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Accidental Migration of a Guide Wire during Femoral Venous Catheterization for Hemodialysis: A Case Report

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Open Journal of Nephrology 2018年第2期8卷 38-41页

作者： Faye Moustapha Cisse Mouhamadou Moustapha Faye Maria Daher Abdoul Karim Omar Lemrabott Ahmed Tall Fall Khodia Sakho Binta Keita Alex mbengue mansour Niang Abdou Diouf Boucar Ka Elhadji Fary Department of Nephrology Aristide Le Dantec Cheikh Anta Diop University Dakar Senegal

Femoral venous catheterization is the most used technic in emergency he-modialysis. Some uncommon mechanical complications can occur during a catheterization. We report the case of an accidental migration of a guide wire during the placement of a hemodialysis femoral catheter. The case of a patient admitted in the nephrology department at Aristide Le Dantec University Hospital for malignant hypertension was investigated. Emergency hemodialysis was indicated. Surgical extraction of the metal guide has been performed and the outcome was favorable.

关键词： Hemodialysis Catheter Complication Guide Wire Migration

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Cognitive-emotional feasibility of the effect of visual quality of building form on promoting the sense of place attachment(Case study:Cultural iconic buildings of Iran’s contemporary architecture)

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Frontiers of Architectural Research 2024年第1期13卷 37-56页

作者： Narmin Ariannia Negar Naseri mansour Yeganeh Digital Architecture and Artificial Intelligence Lab Department of ArchitectureTarbiat Modares UniversityTehranIran Architectural Design Modeling and Fabrication LabDepartment of ArchitectureTarbiat Modares UniversityTehranIran

The present research studies the relationship between place attachment and the perception of form’s visual quality in fifteen outstanding contemporary Iranian architectural cultural *** study puts forward the hypothesis that there is a correlation between the quality of building form and the sense of place attachment,in the sense that creating high visual quality through enhancing the quality of building form increases citizens’initial satisfaction with and subsequent attachment to the *** visual quality influences people’s experience of the environment and improves the quality of *** attachment highlights how people,on a personal level,recreate a sense of place for *** present study adopts the descriptive-analytical method as its theoretical framework and the survey as the empirical *** were developed using the Likert scale and distributed among experts and ordinary *** analysis using SPSS and the adoption of descriptive-analytical statistics,correlation analysis,and regression showed the relationship among the characteristics of *** results show a positive correlation between form and place attachment mediated through visual quality,and they are causal conditions for one *** addition,only some of the buildings under study evoke the same level of place attachment.

关键词： Visual preferences Environmental quality Environmental psychology Mental schemas Contemporary architecture

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Multiple Myeloma Secondary to HIV Infection, Revealed by Renal Failure: About a Case

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Open Journal of Nephrology 2019年第1期9卷 20-25页

作者： mbengue mansour Cissé Mouhamadou Moustapha Faye Maria Lemrabott Tall Ahmed Fall Khodia Keita Alex Faye Moustapha Ba Bakary Diagne Seynabou Keita Niakhaleen Ba Mamadou Aw Dieng Ameth Niang Abdou Ka El Hadji Fary Diouf Boucar Department of Nephrology Regional Hospital Thies Senegal Department of Nephrology Aristide Le Dantec University Hospital Dakar Senegal

Multiple myeloma is on the list of neoplasia that may be associated with human immunodeficiency virus infection. It is an affection that aggravates the prognosis in these particular patients. We present the case of a patient with multiple myeloma and HIV infection, revealed by renal failure. This was a 59-year-old patient who was received to the Department of nephrology for renal failure associated with severe aregenerative pancytopenia. In etiological investigations, multiple myeloma associated with HIV1 infection was found. The evolution was unfavorable, marked by the death of the patient caused by digestive haemorrhage before the start of antiretroviral treatment and chemotherapy.

关键词： Multiple Myeloma HIV Renal Failure

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Improved combustion stability of biogas at different CO_(2) concentrations using inhomogeneous partially premixed stratified flames

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Global Energy Interconnection 2024年第4期7卷 486-502页

作者： Mohy Saad mansour Maged Kiriakos Lili Hao Mohamed Amr Serag-Eldin Mechanical Power Engineering Department Cairo University1 Gamaa StreetCairo Governorate 12613Egypt Mechanical Engineering Department The American University in CairoAUC AveCairo Governorate 11835Egypt College of Electrical Engineering and Control Science Nanjing Tech UniversityNanjing 211816P.R.China

Biogas is a renewable and clean energy source that plays an important role in the current environment of lowcarbon *** high-content CO_(2) in biogas can be separated,transformed,and utilized,it not only realizes high-value utilization of biogas but also promotes carbon reduction in the biogas *** improve the combustion stability of biogas,an inhomogeneous,partially premixed stratified(IPPS)combustion model was adopted in this *** thermal flame structure and stability were investigated for a wide range of mixture inhomogeneities,turbulence levels,CO_(2) concentrations,air-to-fuel velocity ratios,and combustion energies in a concentric flow slot burner(CFSB).A fine-wire thermocouple is used to resolve the thermal flame *** flame size was reduced by increasing the CO_(2) concentration and the flames became lighter *** flame temperature also decreased with increase in CO_(2) *** stability was reduced by increasing the CO_(2) ***,at a certain level of mixture inhomogeneity,the concentration of CO_(2) in the IPPS mode did not affect the ***,the IPPS mode of combustion should be suitable for the combustion and stabilization of *** should support the design of highly stabilized biogas turbulent flames independent of CO_(2) *** data show that the lower stability conditions are partially due to the change in fuel combustion energy,which is characterized by the Wobbe index(WI).In addition,at a certain level of mixture inhomogeneity,the effect of the WI on flame stability becomes dominant.

关键词： Biogas Renewable energy Effect of CO_(2) Combustion stability Burner design Renewable fuels Partial premixed

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Levisticum officinale extract protects against CCl4-induced hepatotoxicity through anti-inflammatory,anti-fibrotic,and antioxidant properties in rats

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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 331-340页

作者： Nahid Ghaedi Iran Pouraboli mansour Mirtadzadini Mohammad-mehdi Moeini-aghtaie Department of Biology Faculty of SciencesShahid Bahonar University of KermanKermanIran Department of Pathology Pathology and Stem Cell Research CenterAfzalipour Medical FacultyKerman University of Medical SciencesKermanIran

Objective:To investigate the hepatoprotective effects of Levisticum officinale extract on CCl4-induced ***:Different doses of Levisticum officinale extract were given orally to rats for 10 days,then rats received a single dose of CCl4(2.5 mL/kg,50%v/v in liquid paraffin).Biochemical and histopathological assays were performed to assess the effects of the extract on liver function and ***,antioxidant and oxidative markers as well as inflammatory and fibrotic indicators were ***:Pretreatment with Levisticum officinale extract significantly mitigated CCl4-induced damage to liver structure,improved serum levels of alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,urea,total bilirubin,and total protein,enhanced glutathione content and superoxide dismutase and catalase activities in the liver,as well as decreased plasma and hepatic malondialdehyde *** results demonstrated that the extract reduced Ki-67 andα-SMA expression and Masson’s trichrome staining revealed decreased liver collagen in rats treated with Levisticum officinale ***,Levisticum officinale extract markedly decreased the gene expressions of TNF-α,IL-6,TGF-β1,MCP-1,and ***:Levisticum officinale extract exerts hepatoprotective effects on CCl4-induced hepatotoxicity through antioxidant,anti-inflammatory,and anti-fibrotic activities.

关键词： Levisticum officinale CCl4 Inflammation Liver toxicity Antioxidant

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Facies development and sedimentology of the Middle Miocene carbonates of the Raghama Formation, northeastern Saudi Arabia

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Acta Geochimica 2024年第1期43卷 87-96页

作者： mansour H.Al-Hashim Abdelbaset S.El-Sorogy Meshal Wadani Department of Geology and Geophysics College of ScienceKing Saud University2455Riyadh 11451Saudi Arabia

Ragahama Formation comprises a siliciclastic continental deposits followed by marine carbonates, representing prograding alluvial fans from adjacent high hinterlands seaward into lagoons and fringing reef environments. The present work aimed to document the facies development and sedimentology of the Raghama carbonates exposed along the eastern coastal plain of the Red Sea, northwestern Saudi Arabia. Four stratigraphic sections were measured and sampled(D1–D4) and thin sections and major and trace element analyses were prepared and applied for petrographic and geochemical approaches. The carbonates were subdivided into three successive fore-reef, reef-core, and back-reef depositional facies. Sandy stromatolitic boundstone, microbial laminites, dolomitic ooidal grainstone, bioclastic coralline algal wackestone, sandy bioclastic wackestone, and coral boundstones were the reported microfacies types. Petrographic analysis reveals that the studied carbonates were affected by dissolution, dolomitization, and aggrading recrystallization, which affects both the original micrite matrix and grains or acts as fracture and veinlet filling leading to widespread vuggy and moldic porosity. No evidence of physical compaction, suggesting rapid lithification and recrystallization during early diagenesis and prior to substantial burial and intensive flushing by meteoric waters. Most of the original microstructure of corals were leached and destructed. This is indicated by the higher depletion in Sr and Ca levels and increase in Mg,Na, Fe, and Mn levels, especially in section D1, in comparison with the worldwide carbonates.

关键词： Raghama Formation Miocene Diagenesis Geochemistry Saudi Arabia

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