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Fetal lung growth predicts the risk for early-life respiratory infections and childhood asthma

World Journal of Pediatrics 2024年第5期20卷 481-495页

作者： Dimitra E.Zazara Olympia Giannou Steven Schepanski Mirja Pagenkemper Anastasios D.Giannou Maike Pincus ioannis Belios Stefan Bonn Ania C.Muntau Kurt Hecher Anke Diemert Petra Clara Arck Division for Experimental Feto-Maternal Medicine Department of Obstetrics and Fetal MedicineUniversity Medical Center Hamburg-Eppendorf(UKE)Martinistraße 5220251HamburgGermany University Children’s Hospital UKEHamburgGermany Computer Engineering and Informatics Department Polytechnic SchoolUniversity of PatrasPatrasGreece Institute of Developmental Neurophysiology Center for Molecular Neurobiology Hamburg(ZMNH)UKEHamburgGermany Department of Obstetrics and Fetal Medicine UKEHamburgGermany Department of General Visceral and Thoracic SurgeryUKEHamburgGermany Section of Molecular Immunology and Gastroenterology Ⅰ.Department of MedicineUKEHamburgGermany Pediatrics and Pediatric Pneumology Practice BerlinGermany Institute of Medical Systems Biology ZMNHUKEHamburgGermany Hamburg Center for Translational Immunology UKEHamburgGermany

Background Early-life respiratory infections and asthma are major health burdens during *** predicting an increased risk for early-life respiratory diseases are ***,we identified the predictive value of ultrasound-monitored fetal lung growth for the risk of early-life respiratory infections and *** Fetal lung size was serially assessed at standardized time points by transabdominal ultrasound in pregnant women participating in a pregnancy *** between fetal lung growth and respiratory infections in infancy or early-onset asthma at five years were ***-learning models relying on extreme gradient boosting regressor or classifier algorithms were developed to predict respiratory infection or asthma risk based on fetal lung *** model development and validation,study participants were randomly divided into a training and a testing group,respectively,by the employed *** Enhanced fetal lung growth throughout pregnancy predicted a lower early-life respiratory infection *** sex was associated with a higher risk for respiratory infections in *** lung growth could also predict the risk of asthma at five years of *** designed three machine-learning models to predict the risk and number of infections in infancy as well as the risk of early-onset *** models’R2 values were 0.92,0.90 and 0.93,respectively,underscoring a high accuracy and agreement between the actual and predicted *** variables included known risk factors and novel predictors,such as ultrasound-monitored fetal lung *** Sonographic monitoring of fetal lung growth allows to predict the risk for early-life respiratory infections and asthma.

关键词： Asthma Child risk Early-life respiratory infections Prenatal lung development Sexual dimorphism

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Future clinical prospects of C-peptide testing in the early diagnosis of gestational diabetes

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World Journal of Experimental Medicine 2024年第1期14卷 13-21页

作者： Charalampos Milionis ioannis Ilias Anastasia Lekkou Evangelia Venaki Eftychia Koukkou Department of Endocrinology Diabetesand Metabolism‘Elena Venizelou’General HospitalAthens 11521Greece

Gestational diabetes is typically diagnosed in the late second or third trimester of *** is one of the most common metabolic disorders among expectant mothers,with potential serious short-and long-term complications for both maternal and offspring health.C-peptide is secreted from pancreatic beta-cells into circulation in equimolar amounts with *** is a useful biomarker to estimate the beta-cell function because it undergoes negligible hepatic clearance and consequently it has a longer half-life compared to *** induces increased insulin resistance due to physiological changes in hormonal and metabolic *** compensation by islet beta-cells results in *** standard oral glucose tolerance test at 24-28 wk of gestation sets the *** evidence from prospective studies indicates a link between early pregnancy C-peptide levels and the risk of subsequent gestational *** C-peptide levels and surrogate glycemic indices at the beginning of pregnancy could prompt appropriate strategies for secondary prevention.

关键词： C-peptide Gestational diabetes Secondary prevention Pregnancy Clinical laboratory techniques

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Neoadjuvant treatment of pancreatic ductal adenocarcinoma:present and future

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 174-196页

作者： ioannis M.Koukourakis Dimitra Desse Marios Papadimitriou manousos Konstadoulakis Anna Zygogianni Christos Papadimitriou Oncology Unit Aretaieio University HospitalNational and Kapodistrian University of AthensAthens 11528Greece Radiation Oncology Unit Aretaieio University HospitalNational and Kapodistrian University of AthensAthens 11528Greece Second Department of Surgery Aretaieio University HospitalNational and Kapodistrian University of AthensAthens 11528Greece

Pancreatic ductal adenocarcinoma is a highly aggressive malignancy with a poor *** treatment with acceptable outcomes is yet to be found,with chemo-and radioresistance comprising major impediments towards this *** upfront surgery is the established therapeutic approach for resectable and borderline resectable disease,neoadjuvant treatment has recently monopolized the interest in clinical *** also applies to locally advanced pancreatic adenocarcinomas that could potentially be rendered *** and chemoradiotherapy are the most utilized therapeutic modalities in the neoadjuvant setting,while immunotherapy and targeting agents have been gaining significant *** critical review focuses on the clinical experience gained from retrospective and phase II/III randomized trials,reporting on the outcomes of neoadjuvant chemotherapy and chemoradiotherapy for pancreatic ***,the ongoing trials,including those that involve immunotherapy and targeting agents,are summarized.

关键词： Pancreatic cancer neoadjuvant treatment chemotherapy radiotherapy surgery immunotherapy

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Circadian rhythm disruption and endocrine-related tumors

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World Journal of Clinical Oncology 2024年第7期15卷 818-834页

作者： Christos Savvidis Efthymia Kallistrou Eleni Kouroglou Sofia Dionysopoulou Georgios Gavriiloglou Dimitra Ragia Vasiliki Tsiama Stella Proikaki Konstantinos Belis ioannis Ilias Department of Endocrinology Hippocration General HospitalAthens GR-11527Greece

This review delved into the intricate relationship between circadian clocks and physiological processes,emphasizing their critical role in maintaining *** by interlocked clock genes,the circadian timekeeping system regulates fundamental processes like the sleep-wake cycle,energy metabolism,immune function,and cell *** central oscillator in the hypothalamic suprachiasmatic nucleus synchronizes with light-dark cycles,while peripheral tissue clocks are influenced by cues such as feeding *** disruption,linked to modern lifestyle factors like night shift work,correlates with adverse health outcomes,including metabolic syndrome,cardiovascular diseases,infec-tions,and *** explored the molecular mechanisms of circadian clock genes and their impact on metabolic disorders and cancer *** associ-ations between circadian disruption and endocrine tumors,spanning breast,ovarian,testicular,prostate,thyroid,pituitary,and adrenal gland cancers,are *** work is associated with increased breast cancer risk,with PER genes influencing tumor progression and drug *** gene expression correlates with cisplatin resistance in ovarian cancer,while factors like aging and intermittent fasting affect prostate *** review underscored the intricate interplay between circadian rhythms and cancer,involving the regulation of the cell cycle,DNA repair,metabolism,immune function,and the tumor *** advocated for integrating biological timing into clinical consider-ations for personalized healthcare,proposing that understanding these connec-tions could lead to novel therapeutic *** supports circadian rhythm-focused therapies,particularly chronotherapy,for treating endocrine *** review called for further research to uncover detailed connections between circadian clocks and cancer,providing essential insights for targeted *** emphasized the importance of pub

关键词： Circadian rhythm Circadian disruption Shift work CLOCK gene Cancer Endocrine tumors Chronotherapy

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Effects of albumin/glutaraldehyde glue on healing of colonic anastomosis in rats

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World Journal of Gastroenterology 2017年第31期23卷 5680-5691页

作者： Kalliopi Despoudi ioannis Mantzoros Orestis Ioannidis Aggeliki Cheva Nikolaos Antoniou Dimitrios Konstantaras Savvas Symeonidis manousos George Pramateftakis Efstathios Kotidis Stamatis Angelopoulos Konstantinos Tsalis Fourth Surgical Department Medical SchoolAristotle University of Thessaloniki Department of Pathology General Hospital“G.Papanikolaou”57010 ThessalonikiGreece

To evaluate the effect of local surgical adhesive glue (albumin/glutaraldehyde-Bioglue) on the healing of colonic anastomoses in rats. METHODSForty Albino-Wistar male rats were randomly divided into two groups, with two subgroups of ten animals each. In the control group, an end-to-end colonic anastomosis was performed after segmental resection. In the Bioglue group, the anastomosis was protected with extraluminar application of adhesive glue containing albumin and glutaraldehyde. Half of the rats were sacrificed on the fourth and the rest on the eighth postoperative day. Anastomoses were resected and macroscopically examined. Bursting pressures were calculated and histological features were graded. Other parameters of healing, such as hydroxyproline and collagenase concentrations, were evaluated. The experimental data were summarized and computed from the results of a one-way ANOVA. Fisher’s exact test was applied to compare percentages. RESULTSBursting pressures, adhesion formation, inflammatory cell infiltration, and collagen deposition were significantly higher on the fourth postoperative day in the albumin/glutaraldehyde group than in the control group. Furthermore, albumin/glutaraldehyde significantly increased adhesion formation, inflammatory cell infiltration, neoangiogenesis, and collagen deposition on the eighth postoperative day. There was no difference in fibroblast activity or hydroxyproline and collagenase concentrations. CONCLUSIONAlbumin/glutaraldehyde, when applied on colonic anastomoses, promotes their healing in rats. Therefore, the application of protective local agents in colonic anastomoses leads to better outcomes.

关键词： Adhesions Bursting pressure Bioglue™ Albumin/glutaraldehyde Collagen Colonic anastomosis

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PD-1 inhibitors monotherapy in hepatocellular carcinoma: Meta-analysis and systematic review

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Hepatobiliary & Pancreatic Diseases International 2019年第6期18卷 505-510页

作者： ioannis A.Voutsadakis Algoma District Cancer Program Sault Area Hospital Section of Internal Medicine Division of Clinical Sciences Northern Ontario School of Medicine

Background:Immunity plays a major role in carcinogenesis and this is the case also for hepatocellular carcinomas(HCC).Checkpoint inhibitors,novel drugs that enhance the immune system’s ability to attack cancers,have been successfully introduced for the therapy of various malignancies including *** important target of these drugs is the PD-L1/PD-1 ligand/receptor pair and several clinically available inhibitors of this pair *** sources:A search of the literature until April 20,2019 was performed in the MEDLINE/PubMed database,the Embase database and the Cochrane Central Register of Controlled *** clinical studies describing treatment with PD-L1/PD-1 inhibitors as monotherapy in HCC patients were *** characteristics with relevance for treatment efficacy,such as liver function,disease extend and previous treatment,were extracted from identified *** and survival outcomes were the primary focus of the *** estimates of response rates and survival were calculated using a random or fixed effect model,depending on *** common adverse effects were also recorded and ***:Three studies(two on nivolumab and one on pembrolizumab)with a total of 400 patients were included in the *** summary response rate(RR)was 17.3%[95%confidence interval(CI):13.2%–21.4%].The summary disease control rate(DCR)was 56.6%(95%CI:44.7%–68.5%).Summary progression free survival(PFS)was 3.5 months(95%CI:2.8–4.2 months).Summary overall survival(OS)was 10.4 months(95%CI:3.5–17.2 months).Adverse effect rate was low and also consistent with the adverse effect profile of PD-L1/PD-1 inhibitors in other disease ***:Pembrolizumab and nivolumab are the only checkpoint inhibitors with data in *** of their effectiveness discloses rates not dissimilar to other systemic therapies available for this *** interest also are the observed long responses in a sub-set of ***

关键词： Hepatocellular carcinoma Immune checkpoint inhibitors Nivolumab Pembrolizumab Meta-analysis

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Thrombocytosis as a prognostic marker in gastrointestinal cancers

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World Journal of Gastrointestinal Oncology 2014年第2期6卷 34-40页

作者： ioannis A Voutsadakis Division of Medical Oncology Sault Area Hospital

Thrombocytosis is an adverse prognostic factor in many types of cancer. These include breast cancer, ovarian and other gynecologic cancers, renal cell carcinoma and lung cancers. In gastrointestinal cancers of various locations and histologic types, thrombocytosis has been reported in general to be associated with adverse clinical outcomes. Platelet count measurement is well standardized and available in every clinical laboratory, making its use as a prognostic marker practical. This paper will discuss the data on the prognostic value of thrombocytosis in gastrointestinal cancers as well as pathogenic aspects of the association that strengthen the case for its use in clinical prognostication.

关键词： Thrombocytosis Platelets Cancer Gastroin-testinal Prognosis

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Landscape of BRIP1 molecular lesions in gastrointestinal cancers from published genomic studies

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World Journal of Gastroenterology 2020年第11期26卷 1197-1207页

作者： ioannis A Voutsadakis Algoma District Cancer Program Sault Area HospitalSault Ste MarieON P6B 0A8Canada Section of Internal Medicine Division of Clinical SciencesNorthern Ontario School of MedicineSudburyON P0M 2Z0Canada

BACKGROUND BRIP1 is a helicase that partners with BRCA1 in the homologous recombination(HR) step in the repair of DNA inter-strand cross-link lesions. It is a rare cause of hereditary ovarian cancer in patients with no mutations of BRCA1 or BRCA2. The role of the protein in other cancers such as gastrointestinal(GI) carcinomas is less well characterized but given its role in DNA repair it could be a candidate tumor suppressor similarly to the two BRCA *** To analyze the role of helicase BRIP1(FANCJ) in GI cancers *** Publicly available data from genomic studies of esophageal, gastric, pancreatic,cholangiocarcinomas and colorectal cancers were interrogated to unveil the role of BRIP1 in these carcinomas and to discover associations of lesions in BRIP1 with other more common molecular defects in these *** Molecular lesions in BRIP1 were rare(3.6% of all samples) in GI cancers and consisted almost exclusively of mutations and amplifications. Among mutations,40% were possibly pathogenic according to the Onco KB database. A majority of BRIP1 mutated GI cancers were hyper-mutated due to concomitant mutations in mismatch repair or polymerase ε and δ1 genes. No associations were discovered between amplifications of BRIP1 and any mutated genes. In gastroesophageal cancers BRIP1 amplification commonly co-occurs with ERBB2 *** Overall BRIP1 molecular defects do not seem to play a major role in GI cancers whereas mutations frequently occur in hypermutated carcinomas and co-occur with other HR genes mutations. Despite their rarity, BRIP1 defects may present an opportunity for therapeutic interventions similar to other HR defects.

关键词： BRIP1 FANCJ BACH1 Gastrointestinal cancers Mutations Copy number alterations

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Striatum-specific mechanisms regulate neuronal cell cycle re-entry:the choice between life and death

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Neural Regeneration Research 2023年第3期18卷 523-524页

作者： Paula Dietrich ioannis Dragatsis Department of Physiology The University of TennesseeHealth Science CenterMemphisTNUSA

Mitochondria dysfunction occurs in the aging brain as well as in several neurodegenerative disorders and predisposes neuronal cells to enhanced sensitivity to *** particular,defects in any of the mitochondria respiratory chain complexes lead to impaired adenosine triphosphate production resulting in diseases that often affect the central nervous *** instance,innate deficits in succinate dehydrogenase(SDH)mitochondria respiratory chain complex II activity caused by genetic mutations in SDH subunits lead to early-onset neurodegeneration(Jain-Ghai et al.,2013),while several adult-onset genetic neurodegenerative disorders are associated with variable levels of complex II deficiency in the central nervous system(Túnez et al.,2010).Also,chemically induced complex II deficiency leads to neurodegeneration.

关键词： SDH impaired cycle

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On the Convergence of Broyden-Like Methods

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Acta Mathematica Sinica,English Series 2007年第11期23卷 2087-2096页

作者： ioannis K.ARGYROS Department of Mathematical Sciences Cameron UniversityLawtonOK 73505USA

The author provides a finer local as well as semilocM convergence analysis of a certain class of Broyden-like methods for solving equations containing a nondifferentiable term on the m-dimensional Euclidean space （m ... 详细信息

关键词： Broyden-like methods l2 norm Fréchet derivative radius of convergence local/semilocal convergence analysis

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