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Hypoallergenic formula with Lactobacillus rhamnosus GGfor babies with colic:A pilot study of recruitment,retention,and fecal biomarkers

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World Journal of Gastrointestinal Pathophysiology 2016年第1期7卷 160-170页

作者： Nicole Y Fatheree Yuying Liu Michael Ferris Melissa Van Arsdall Valarie McMurtry Marcela Zozaya Chunyan Cai Mohammad H Rahbar manouchehr hessabi Ta Vu Christine Wong Juleen Min Dat Q Tran Fernando Navarro Wallace Gleason Sara Gonzalez J Marc Rhoads Department of Pediatrics the University of Texas Health Science Center at Houston Medical SchoolHoustonTX 77030United States Biostatistics/Epidemiology/Research Design Core Center for Clinical and Translational Sciencesthe University of Texas Health Science Center at HoustonHoustonTX 77030United States Division of Epidemiology Human Genetics and Environmental Sciencesthe University of Texas School of Public Health at HoustonHoustonTX 77030United States Department of Pediatrics Louisiana State University Health Science Center and the Research Institute for ChildrenNew OrleansLA 70112United States Investigational Drug Services Pharmacy Memorial Hermann HospitalHoustonTX 77030United States

AIM: To investigate recruitment, retention, and estimates for effects of formula supplementation with Lactobacillus rhamnosus GG(LGG) on inflammatory biomarkers and fecal microbial community in infants with colic. METHODS: A prospective, double-blind, placebocontrolled trial was conducted in otherwise healthy infants with colic. We screened 74 infants and randomized and analyzed results in 20 infants [9 receiving LGG(LGG+) and 11 not receiving LGG(LGG-)]. LGG was incorporated in the formula(Nutramigen~®)(minimum of 3 × 107 CFU/d) in the LGG+ group. Fecal microbiota and inflammatory biomarkers, including fecal calprotectin(FC), plasma cytokines, circulating regulatory T cells(Tregs), and crying + fussing time were analyzed to determine optimal time points and effect sizes for a larger trial. RESULTS: Recruitment in this population was slow, with about 66% of eligible infants willing to enroll; subject retention was better(75%). These rates were influenced by parents' reluctance to volunteer their infant for a clinical trial and by their tendency to change formulas. The maximal difference of crying + fussing time was observed at day 14, comparing the 2 groups, with a mean difference of-91(95%CI:-76, 259) min(P = NS). FC showed no significant difference, but the optimal time to determine a potential effect was at day 90 [with a mean difference of 121(95%CI:-48, 291) μg/g stool], observing a lower level of FC in the LGG+ group. The fecal microbial communities were chaotic, as determined by Shannon's diversity index and not apparently influenced by the probiotic. No significant change was observed in plasma inflammatory cytokines or Tregs, comparing LGG+ to LGG- groups. CONCLUSION: Designing future colic trials involving a probiotic-supplemented formula for infants in the United States will require consideration for difficult enrollment. Infants with colic have major variations in feal microbiota and calprotectin, both of which improve with time, with optimal time p

关键词： Barr diary Regulatory T cells Cytokines Crying Fussing Probiotic Inflammation Biomarker Newborn Intestine

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454例胎儿期有乙烯雌酚接触史妇女的产科结局:一项病例对照研究

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世界核心医学期刊文摘（妇产科学分册） 2005年第6期1卷 56-57页

作者： Papiernik E. Pons J.-C. hessabi M. 高雪莲 Univer-sité Joseph- Fourier Departement d’ Obstetrique Gynecol. et Med. de la Reproduction 38043 Grenoble Cedex 09 France

Objective. To analyze the predictive effect on obstetrical outcome in women with prenatal exposure to diethylstilbestrol (DES) of previous obstetrical history or the specific risk of DES exposure. Patients and methods. We included all in utero DES- exposed women (454 women) followed and delivered at one maternity unit in Paris and compared them with two control women matched for age, parity, number of late fetal losses, number of previous preterm births, number of singleton or twin fetuses, and follow- up, who were managed by the same team or referred for pregnancy complication. Results. DES women had a higher rate of preterm birth (19.2% ) than matched controls (10.5% ), even when considering women with a previous preterm birth or twin pregnancy. The rate of fetal or neonatal deaths were lower in DES- exposed women than in controls. DES women showed a higher rate of severe post partum bleeding (2.8% ) than matched controls (1.5% ) or the global population of women delivered in this maternity unit. Conclusion. A history of prenatal exposure to DESis a major predictor of preterm birth for primiparous women and for those with an adverse obstetrical history.

关键词：胎儿期乙烯雌酚双胎妊娠病例对照研究早产率早产史严重产后出血接触组医疗人员妊娠史

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