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Missed colorectal cancers in a fecal immunochemical test-based screening program: Molecular profiling of interval carcinomas

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World Journal of Gastrointestinal Oncology 2022年第11期14卷 2195-2207页

作者： manon van der Vlugt Beatriz Carvalho Joelle Fliers Nahid Montazeri Christian Rausch Esmée J Grobbee manon van engeland manon C W Spaander Gerrit A Meijer Evelien Dekker Department of Gastroenterology and Hepatology Amsterdam University Medical CenterAmsterdam 1105 AZNetherlands Department of Pathology Netherlands Cancer InstituteAmsterdam 1066 CXNetherlands Biostatistics Unit Department of Gastroenterology and HepatologyAmsterdam University Medical CenterAmsterdam 1105 AZNetherlands Department of Gastroenterology and Hepatology Erasmus MC University Medical CenterRotterdam 3015 CNNetherlands Department of Pathology GROW-School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastricht 6202 AZNetherlands

BACKGROUND For optimizing fecal immunochemical test(FIT)-based screening programs,reducing the rate of missed colorectal cancers(CRCs)by FIT(FIT-interval CRCs)is an important *** of the molecular make-up of these missed lesions could facilitate more accurate detection of all(precursor)*** To compare the molecular make-up of FIT-interval CRCs to lesions that are detected by FIT[screen-detected CRCs(SD-CRCs)].METHODS FIT-interval CRCs observed in a Dutch pilot-program of FIT-based screening were compared to a control group of SD-CRCs in a 1:2 ratio,resulting in 27 FIT-interval CRC and 54 *** analyses included microsatellite instability(MSI),CpG island methylator phenotype(CIMP),DNA sequence mutations and copy number alterations(CNAs).RESULTS Although no significant differences were reached,FIT-interval CRCs were more often CIMP positive and MSI positive(33%CIMP in FIT-interval CRCs vs 21%in SD-CRCs(P=0.274);19%MSI in FIT-interval CRCs vs 12%in SD-CRCs(P=0.469)),and showed more often serrated pathway associated features such as BRAF(30%vs 12%,P=0.090)and PTEN(15%vs 2.4%,P=0.063)*** mutations,a classic feature of the adenoma-carcinoma-sequence,were more abundant in SD-CRCs(68%vs 40%in FIT-interval CRCs P=0.035).Regarding CNAs differences between the two groups;FIT-interval CRCs less often showed gains at the regions 8p11.22-q24.3(P=0.009),and more often gains at 20p13-p12.1(P=0.039).CONCLUSION Serrated pathway associated molecular features seem to be more common in FIT-interval CRCs,while classic adenoma carcinoma pathway associated molecular features seem to be more common in *** indicates that proximal serrated lesions may be overrepresented among FITinterval CRCs.

关键词： Fecal immunochemical test-interval colorectal cancer Mutation analysis Colorectal cancer screening Serrated pathway Adenoma-carcinoma pathway

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Investigation of operational parameters for an industrial CFB combustor of coal,biomass and sludge

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China Particuology 2007年第4期5卷 247-254页

作者： manon van de Velden Jan Baeyens Bill Dougan Alan McMurdo Department of Chemical Engineering University of Birmingham B15 2TT Birmingham United Kingdom UPM-Kymmene Caledonian Paper Ltd.AyrUnited Kingdom

The combustion of coal and/or biomass （sludge, wood waste, RDF, etc.） in a circulating fluidized bed has been a commercial topper for over 20 years, and references to principles and applications are numerous and widespread although few data are presented concerning the operation of large scale CFB-units. The authors studied the CFB-combustion at UPM-Kymmene （Ayr）, a major paper mill relying for its steam production upon the combustion of coal （80-85 %）, wood bark （5-10%） and wastewater treatment sludge （5-10%）. The maximum capacity of the CFB is 58 MWth. A complete diagnostic of the operation was made, and additional tests were performed to assess the operating mode. The plant schematics, relevant dimensions and process data are given. To assess the operation of the UPM-CFB, it is important to review essential design parameters and principles of CFB combustors, which will be discussed in detail to include required data, heat balance and flowrates, operating versus transport velocity, kinetics and conversion （including the possible effect of the Bouduard reaction if carbon is present）. Since the residence time in the riser and the cyclone efficiency determine the burnout of circulating fuel-particles, the UPM-CFB was subjected to a stimulus response technique using nickel oxide as tracer. Results illustrate the efficiency of the cyclone separation and the number of recycle loops for particles of a given size. Results will also be used to assess the cyclone operation and efficiency and to comment upon expected and measured carbon conversion.

关键词： Circulating fluidized bed Combustion Coal Biomass Operation Cyclone

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Spherical Tropical Geometry:a Survey of Recent Developments

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Acta Mathematica Sinica,English Series 2018年第3期34卷 454-465页

作者： Kiumars KAVEH Christopher manon Department of Mathematics University of PittsburghPittsburghPAUSA Department of Mathematics Univcrsity of KentuckyLexingtonKYUSA

This is a survey of some recent results on spherical tropical geometry.

关键词： Tropical geometry reductive group action spherical variety Grbner theory

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Spinal Analgesia with Intrathecal Morphine versus Conventional Analgesia after Laparoscopic Colectomy: A Retrospective Cohort Study

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Open Journal of Anesthesiology 2024年第7期14卷 159-174页

作者： Lionel Diyamona manon Colin Marc Léone Laurent Zieleskiewicz Joseph Nsiala Wilfrid Mbombo Rachel Mbala Bruno Pastene Chris Nsituavibidila Dan Kankonde Gracia Likinda Jean Claude Mubenga Khazy Anga Noelly Mukuna Christel Isengingo Department of Anaesthesia and Intensive Care University Clinics of Kinshasa University of Kinshasa Kinshasa Democratic Republic of the Congo Department of Anaesthesia and Intensive Care Marseilles Nord Hospital Marseille France General Hospital of Kinshasa ex Mama Yemo Kinshasa Democratic Republic of the Congo Department of Anaesthesia and Intensive Care Monkole Hospital Centre Kinshasa Democratic Republic of the Congo

Objective: Postoperative pain (POP) following abdominal surgery can vary from a few hours to several days. This acute, unrelieved pain can become chronic, requiring patients to take analgesics on an almost daily basis for comfort. Analgesia using general opioids has many side effects and intrathecal morphine is a good alternative. This study was conducted to evaluate the efficacy of intrathecal morphine (ITM) versus conventional analgesia in the management of postoperative pain in colectomy performed by laparoscopic surgery. Methods: Cohort study conducted at the Hôpital Nord in Marseille, from 01 January to 31 July 2021 in patients aged at least 18 years undergoing anaesthesia for scheduled colectomy by laparoscopic surgery. The primary endpoint was postoperative pain intensity and the secondary endpoints were morphine consumption, treatment side effects and length of hospital stay. Statistical analysis was performed using XLSTAT software. Results: We included 193 patients: 131 in the control group (conventional analgesia) and 62 in the ITM group. We observed: a significant decrease in pain (assessed by numerical scale) in favour of the ITM group in the post-anaesthetic care room, i.e. 3 (±4) vs 1 (±2), p 0 and H2: 2 (±2) vs. 1 (±2);p Conclusion: These results suggest that intrathecal morphine (ITM) in laparoscopic colectomy provides effective postoperative analgesia with low morphine consumption, and a reduction in morphine side-effects compared with conventional analgesia.

关键词： Intrathecal Morphine Colectomy Laparoscopy Conventional Analgesia

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Development and Evaluation of The Implementation of a Preceptorship Program for The Novice ICU Nurse Intensive Care Unit -A Secondary Publication

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Journal of Clinical and Nursing Research 2024年第3期8卷 158-175页

作者： Annie Perron manon Champagne Abir El-Haouly University of Quebec in Abitibi-Témiscamingue Rouyn-NorandaQC J9X 5E4Canada

This study focused on the development and evaluation of the implementation of a preceptorship program adapted to ICU practice in the Ab.-*** to provide preceptors with tools to support novice *** action research was made possible with the involvement of the centers,preceptors,and novice nurses throughout the development and implementation of the *** approach enabled participants to take ownership of the training content and fully utilize various *** program was implemented throughout the CISSS,where this study was subsequently carried *** novices mentioned that the program reinforced their sense of security and made them feel more equipped to handle complex care *** preceptors said they were better equipped to offer clinical support and novices were better prepared to work in the *** is important to evaluate the development of the novice nurses’skills following their participation in this program and the long-term impact of this preceptorship.

关键词： Preceptorship program Intensive care unit Novice ICU nurses

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几何竞赛,AI逼近人类天才

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环球科学 2024年第9期 44-49页

作者：玛农·比肖夫陶兆巍(译) 不详

国际数学奥林匹克竞赛可能是最高难度的高中数学竞赛,所有参赛者都是中的夜夜者。最近,一位“硅基”44“碳基生命”AI选手在几何题上的表现似乎已逼近人类天才。国际数学奥林匹克竞赛(IMO)可能是世界上最著名的高中数学竞赛。每年,世界... 详细信息

国际数学奥林匹克竞赛可能是最高难度的高中数学竞赛,所有参赛者都是中的夜夜者。最近,一位“硅基”44“碳基生命”AI选手在几何题上的表现似乎已逼近人类天才。国际数学奥林匹克竞赛(IMO)可能是世界上最著名的高中数学竞赛。每年,世界各地的学生都会竞争他们梦寐以求的IMO奖牌。

关键词：高中数学竞赛 IMO 几何题 AI 参赛者国际数学奥林匹克竞赛奖牌逼近

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Cabozantinib and the moving field of systemic treatments in advanced hepatocellular carcinoma

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Hepatobiliary Surgery and Nutrition 2019年第1期8卷 53-55页

作者： manon Allaire Jean Charles Nault Service d’hépato-gastroentérologie et de nutrition CHU Cote de NacreCaenFrance UMR 1149 Centre de Recherche sur l’inflammationFacultéde Médecine BichatParisFrance Service d’hépatologie CHU de jean VerdierBondyFrance UMR 1162 Génomique Fonctionnelle des Tumeurs SolidesInstitut National de la Santéet de la Recherche MédicaleParisFrance

Most of patients with hepatocellular carcinoma(HCC),are diagnosed at an advanced-stage explaining the poor prognosis of this cancer with a median survival without treatment around 8 months(1-3).Currently,two systemic multi-kinase inhibitors with anti-proliferative and antiangiogenic effects are available as first line treatments in advanced *** first one,Sorafenib,was the only available systemic treatment available during one decade and was associated with an improvement of overall survival of around 3 months compared to placebo(4,5).The second one,lenvatinib,showed a similar median overall survival compared to Sorafenib in a non-inferiority phase-3 trial(6).No second line was available during several years due to toxicity or absence of efficacy of the different drugs tested in multicentric phase 3 randomized controlled trials.

关键词： hepatocellular treatment drugs

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Hemostasis testing in patients with liver dysfunction: Advantages and caveats

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World Journal of Gastroenterology 2021年第42期27卷 7285-7298页

作者： Guillaume Nguyen manon Lejeune Benjamin Crichi Corinne Frere Department of Hematology Trousseau HospitalAssistance Publique Hôpitaux de ParisParis 75012France Department of Hematology Pitié-Salpêtrière HospitalAssistance Publique Hôpitaux de ParisParis 75013France Department of Internal Medicine Saint-Louis HospitalAssistance Publique Hôpitaux de ParisParis 75010France Inserm UMRS_1166 Institute of Cardiometabolism and NutritionSorbonne UniversitéParis 75013France

Due to concomitant changes in pro-and anti-coagulant mechanisms,patients with liver dysfunction have a“rebalanced hemostasis”,which can easily be tipped toward either a hypo-or a hypercoagulable *** are often faced with the question whether patients with chronic liver disease undergoing invasive procedures or surgery and those having active bleeding require correction of the hemostasis *** coagulation screening tests,such as the prothrombin time/international normalized ratio and the activated partial thromboplastin time have been demonstrated to have numerous limitations in these patients and do not predict the risk of bleeding prior to high-risk *** introduction of global coagulation assays,such as viscoelastic testing(VET),has been an important step forward in the assessment of the overall hemostasis profile.A growing body of evidence now suggests that the use of VET might be of significant clinical utility to prevent unnecessary infusion of blood products and to improve outcomes in numerous *** present review discusses the advantages and caveats of both conventional and global coagulation assays to assess the risk of bleeding in patients with chronic liver disease as well as the current role of transfusion and hemostatic agents to prevent or manage bleeding.

关键词： Hemostasis Bleeding risk Conventional tests Thrombin generation Viscoelastic tests Hemostatic agents

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Instrumented and Vickers Indentation for the Characterization of Stiffness,Hardness and Toughness of Zirconia Toughened Al_2O_3 and SiC Armor

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Journal of Materials Science & Technology 2015年第8期31卷 773-783页

作者： Aleksandra Nastic Ali Merati Mariusz Bielawski manon Bolduc Olaniyi Fakolujo Michel Nganbe Department of Mechanical Engineering University of Ottawa National Research Council Canada Defence R&D Canada(DRDC Valcartier)

Instrumented and Vickers indentation testing and microstructure analysis were used to investigate zirconia toughened alumina （ZTA） and silicon carbide （SIC）. Several equations were studied to relate the Vickers indentation hardness, Young＇s modulus and crack behavior to the fracture toughness. The frac- ture in SiC is unstable and occurs primarily by cleavage leading to a relatively low toughness of 3 MPa m1/2, which may be inappropriate for multi-hit capability. ZTA absorbs energy by plastic deformation, pore collapse, crack deviation and crack bridging and exhibits time dependent creep. With a relatively high toughness around 6.6 MPa m1/2, ZTA is promising for multi-hit capability. The higher accuracy of median equations in calculating the indentation fracture toughness and the relatively high c/a ratios above 2.5 suggest median type cracking for both SiC and ZTA. The Young＇s modulus of both ceramics was most accurately measured at lower indentation loads of about 0.5 kgf, while more accurate hardness and fracture toughness values were obtained at intermediate and at higher indentation loads beyond 5 kgf, respectively. A strong indentation size effect （ISE） was observed in both materials. The load independent hardness of SiC is 2563 HV, putting it far above the standard armor hardness requirement of 1500 HV that is barely met by ZTA.

关键词： Zirconia toughened alumina Silicon carbide Armor Vickers indentation fracture toughness Elastic modulus Vickers hardness

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The structure of natural microbial enemy-victim networks

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Ecological Processes 2013年第1期2卷 130-138页

作者： Timothée Poisot manon Lounnas Michael E Hochberg UniversitéMontpellier II Institut des Sciences de l'EvolutionUMR 5554Place Eugène Bataillon34095Montpellier CEDEX 05France Département de biologie chimie et géographieUniversitédu QuébecàRimouski300 Allée des UrsulinesRimouskiQC G5L 3A1Canada Québec Centre for Biodiversity Sciences Stewart Biological Sciences Building1205 Dr.Penfield AvenueMontréalQC H3A 1B1Canada Santa Fe Institute 1399 Hyde Park RoadSanta FeNM 87501USA MIVEGEC UMR IRD 224 CNRS5 290 UM1-UM2911Avenue AgropolisBP 6450134394 Montpellier Cedex 5France

Introduction:The persistence of generalists and specialists is a topical question in community ecology and results from both ecological and evolutionary *** fine taxonomical scales,ecological specialisation,*** preferentially exploiting a subset of available habitats,is thought to be a driver promoting niche *** is not clear,however,how different mechanisms interact to shape specialist-generalist ***:We reconstruct the structure of five bacteria-phage networks from soil isolates,and perform an analysis of the relationships between host phylogenetic diversity,parasite specialism,and parasite ***:We show that the co-occurrence of species on a continuum of specialism/generalism is influenced by niche overlap,phage impact on bacterial hosts,and host phylogenetic *** addition,using a null-model analysis we show that infection strategies of the phages have more explanatory power than bacterial defenses on key structural features of these antagonistic ***:We report that generalists have more impact on their hosts than specialists,even when the phylogenetic heterogeneity of hosts is controlled *** discuss our results in the light of their implications for the evolution of biotic interactions.

关键词： Pseudomonas fluorescens Bipartite networks Specialisation Phylogeny Food webs Species coexistence

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