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Recent Advances in Dissecting Stress-Regulatory Crosstalk.in Rice

Molecular Plant 2013年第2期6卷 250-260页

作者： Rita sharma David De Vleesschauwer manoj k. sharma Pamela C. Ronald Department of Plant Pathology and Genome Center University of California Davis CA 95616 USA Joint BioEnergy Institute Emeryville CA 94710 USA Laboratory of Phytopathology Faculty of Bioscience Engineering Ghent University B-9000 Ghent Belgium Department of Plant Molecular Systems Biotechnology and Crop Biotech Institute Kyung Hee University Yongin 446-701 Korea

Biotic and abiotic stresses impose a serious limitation on crop productivity worldwide. Prior or simultaneous exposure to one type of stress often affects the plant response to other stresses, indicating extensive overlap and cross-talk.between stress-response signaling pathways. Systems biology approaches that integrate large genomic and prot-eomic data sets have facilitated identification of candidate genes that govern this stress-regulatory crosstalk. Recently, we constructed a yeast two-hybrid map around three rice proteins that control the response to biotic and abiotic stresses, namely the immune receptor XA21, which confers resistance to the Gram-negative bacterium, Xanthomonas oryzae pv. oryzae; NH1, the rice ortholog of NPR1, a k.y regulator of systemic acquired resistance; and the ethylene-responsive transcription factor, SUBIA, which confers tolerance to submergence stress. These studies coupled with transcriptional profiling and co-expression analyses identified a suite of proteins that are positioned at the interface of biotic and abiotic stress responses, including mitogen-activated protein k.nase 5 （OsMPk.）, wall-associated k.nase 25 （WAk.5）, sucrose non-fermenting-l-related protein k.nase-1 （SnRk.）, SUBIA binding protein 23 （SAB23）, and several WRk. family tran- scription factors. Emerging evidence suggests that these genes orchestrate crosstalk.between biotic and abiotic stresses through a variety of mechanisms, including regulation of cellular energy homeostasis and modification of synergistic and/or antagonistic interactions between the stress hormones salicylic acid, ethylene, jasmonic acid, and abscisic acid.

关键词： abiotic biotic crosstalk defense response hormone systems biology stress.

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Long-term follow-up result of short metaphyseal femoral stem in primary total hip arthroplasty:A retrospective study

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World Journal of Orthopedics 2025年第1期16卷 40-45页

作者： manoj k.mar Ayush sharma Vivek.P k.heerasagar Ak.sh k.Ghosh Muk.nd Lal Department of Orthopaedics Indira Gandhi Medical College and HospitalShimla 171001Himāchal PradeshIndia Department of Orthopaedics Post Graduate Institute of Medical Education and ResearchChandigarh 160012ChandīgarhIndia

BACk.ROUND Total hip arthroplasty(THA)has increased along with an increasing demand for improved quality of *** with prolonged life expectancy,the number of revision surgeries is expected to *** shielding is a significant issue with traditional femoral stems used in THA,mak.ng revision surgeries particularly challenging in younger *** has spark.d renewed interest in studying safety and functional outcomes of short metaphyseal femoral stems,which have the potential to alleviate these challenges and simplify revision *** To evaluate the long-term outcomes of short-stem *** A total of 124 hips that underwent THA using the short femoral stem(TRILOCk.Depuy)between May 2006 and November 2008 were included in this *** were followed for a period of 15 *** were assessed in terms of pain relief,hip joint range of motion,improvement in mobility,and functional outcomes using the modified Harris Hip Score,Oxford hip score,and Western Ontario and McMaster Universities Osteoarthritis index *** A total of 124 hips in 98 patients were *** improvements in functional outcomes were observed over the 15-year follow-up period,with no cases of subsidence,implant loosening,or complications necessitating revision *** only complication reported was heterotopic ossification in 1 *** Short metaphyseal stems provide better functional outcomes with early mobilization,and its long-term follow-up without subsidence,implant loosening,or proximal femoral bone loss simplifies revision surgery in younger patients.

关键词： Short stem total hip replacement Short metaphyseal stem Uncemented hip replacement Proximal femur osteolysis Proximal femur bone loss

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Capture and fission analysis of various superheavy isotopes with ACN=258-280

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Communications in Theoretical Physics 2020年第2期72卷 65-74页

作者： Gurjit k.ur manoj k.sharma School of Physics and Materials Science Thapar Institute of Engineering and TechnologyPatiala—147004PunjabIndia

The capture and fission analysis of heavy ion induced fusion reactions leading to the formation of Z=107-111 superheavy nuclei has been carried *** have been made to analyze the synthesis traits,such as excitation functions,formation probabilities,barrier characteristics *** l-summed Wong model provides a decent description of available data on capture(σCap)and fusion-fission(σff)cross-sections and hence is exploited to mak. relevant predictions for future *** capture and fusion-fission excitation functions are predicted for the least explored region of superheavy nuclei(SHN)i.e.Z=*** role of massasymmetry(η),Coulomb factor(ZPZT)deformation and orientations,Businari-Gallone massasymmetry(αBG)fission barrier(Bf)etc is duly *** present study concludes that the mass-asymmetric reactions involving 24Mg,30Si,and 36S projectiles are preferred for the synthesis of unk.own isotopes of Z=***,the doubly magic 48Ca-projectile also provides a competing alternative to produce neutron-rich isotopes of the abovementioned SHN.

关键词： Capture and fission cross-section compound nucleus formation probability quasi-fission

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Sequential decay analysis of^(235)U(n^(th),f)reaction using fragmentation approach

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Chinese Physics C 2024年第6期48卷 145-154页

作者： Nitin sharma Ashutosh k.ushik.manoj k.sharma School of Physics and Materials Science Thapar Institute of Engineering&TechnologyPatiala-147004PunjabIndia

Numerous experimental and theoretical observations have concluded that the probability of the three fragment emission(ternary fission)or binary fission increases when one proceeds towards the heavy mass region of nuclear periodic *** factors affect fragment emission,such as the shell effect,deformation,orientation,and fissility *** and ternary fissions are observed for both ground and excited states of the *** collinear cluster tripartition(CCT)channel of the^(235)U(n^(th),f)reaction is studied,and we observe that the CCT may be a sequential or simultaneous emission *** date,different approaches have been introduced to study the CCT process as a simultaneous or sequential process,but the decay dynamics of these modes have not been not fully *** the three fragments of the sequential process and exploring their related dynamics using an excitation energy dependent approach would be of further ***,in this study,we investigate the sequential decay mechanism of the^(235)U(n^(th),f)reaction using quantum mechanical fragmentation theory(QMFT).The decay mechanism is considered in two steps,where initially,the nucleus splits into an asymmetric *** the second step,the heavy fragment obtained in the first step divides into two *** I analysis is conducted by calculating the fragmentation potential and preformation probability for the spherical and deformed choices of the decaying *** most probable fragment combination of stage I are identified with respect to the dips in the fragmentation structure and the corresponding maxima of the preformation probability(P0).The light fragments of the identified decay channels(obtained in step I)agree closely with the experimentally observed *** excitation energy of the decay channel is calculated using an iteration *** excitation energy is shared using an excitation energy dependent level density *** obtained excitation

关键词： fission cluster radioactivity ternary fission spontaneous fission cluster model total k.netic energy preformation probability

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Prevalence of transfusion transmissible infections among various donor groups:A comparative analysis

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World Journal of Virology 2025年第1期14卷 108-117页

作者： Sanjay k.Thak.r Anil k.Sinha Santosh k.sharma Aarzoo Jahan Dinesh k.Negi Ruchik. Gupta Sompal Singh Regional Blood Transfusion Centre Hindu Rao Hospital and NDMC Medical CollegeNorth Delhi 110007DelhiIndia Department of Zoology Veer Kunwar Singh UniversityAra 802301BiharIndia Regional Blood Transfusion Centre and Pathology Hindu Rao Hospital and NDMC Medical CollegeNorth Delhi 110007DelhiIndia Department of Cytopathology ICMR-National Institute of Cancer Prevention and ResearchNoida 201301Uttar PradeshIndia

BACk.ROUND Transfusion transmissible infections(TTIs)are illnesses spread through contaminated blood or blood *** India,screening for TTIs such as hepatitis B virus(HBV),hepatitis C virus(HCV),human immunodeficiency virus(HIV)-I/II,malaria,and syphilis is mandatory before blood ***,HCV,HBV,and HIV are the leading viruses causing mortality,affecting millions of people globally,including those with co-infections of HIV/HCV and HIV/*** highlight the impact of TTIs on life expectancy and health risk.,such as liver cirrhosis,cancer,and other diseases in individuals with chronic ***,millions of blood donations tak. place annually,emphasizing the importance of maintaining blood *** To study the prevalence of TTIs,viz.,HBV,HCV,HIV I/II,syphilis,and malaria parasite(MP),among different blood donor *** The study assessed the prevalence of TTIs among different blood donor groups in Delhi,*** included total donors,in-house donors,total camp donors,institutional camp donors,and community camp *** for HIV,HBV,and HCV were done using enzyme-link.d immunosorbent assay,while syphilis was tested with rapid plasma reagins and MP rapid card *** prevalence of HBV,HCV,HIV,and syphilis,expressed as *** in infection rates between the groups were analyzed usingχ²tests and P-values(less than 0.05).RESULTS The study evaluated TTIs among 42158 blood donors in *** overall cumulative frequency of TTIs in total blood donors was 2.071%,and the frequencies of HBV,HCV,HIV-I/II,venereal disease research laboratory,and MP were 1.048%,0.425%,0.221%,0.377%,and 0.0024%,***-house donors,representing 37656 donors,had the highest transfusion transmissible infection(TTI)prevalence at 2.167%.Among total camp donors(4502 donors),TTIs were identified in 1.266%of donors,while community camp donors(2439 donors)exhibited a prevalence of 1.558%.Institutional camp donors(2063 donors)had the l

关键词： Blood donors Transfusion transmissible infections Hepatitis B virus Human immunodeficiency virus Hepatitis C virus Malaria parasite Syphilis

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Internal hernia as a rare cause of small bowel obstruction:An insight from 13 years of experience

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World Journal of Clinical Cases 2025年第7期13卷 21-27页

作者： Payal k.w Anu Behari Supriya sharma Ashok.k.mar Rajneesh k.Singh Department of Surgical Gastroenterology Sanjay Gandhi Post Graduate Institute of Medical SciencesLucknow 226014UPIndia

BACk.ROUND Internal hernia(IH)is a rare culprit of small bowel obstruction(SBO)with an incidence of<1%.It poses a considerable diagnostic challenge requiring a high index of suspicion to prevent misdiagnosis,improper ... 详细信息

BACk.ROUND Internal hernia(IH)is a rare culprit of small bowel obstruction(SBO)with an incidence ofk.ow,India between September 2010 and August 2023 were *** Out of 586 patients,7(1.2%)were diagnosed with *** these,4 had congenital IH and 3 had acquired *** male-to-female ratio was 4:*** median age at presentation was 32 ***-enhanced computed tomography(CECT)was the most reliable investigation for preoperative identification,demonstrating mesenteric whirling and clumped-up bowel *** paraduodenal hernia and transmesenteric hernia occurred with an equal frequency(approximately 43%each).Intraoperatively,one patient was found to have bowel ischemia and one had associated malrotation of *** follow-up,no recurrences were *** IH,being a rare cause,must be considered as a differential diagnosis for SBO,especially in young patients in their 30s or with unexplained abdominal pain or discomfort post-surgery.A rapid imaging evaluation,preferably with CECT,is necessary to aid in an early diagnosis and prompt intervention,thereby reducing financial burden related to unnecessary investigations and preventing the morbidity and mortality associated with closed-loop obstruction and strangulation of the bowel.

关键词： Paraduodenal hernia Internal hernia Mesenteric whirling Bowel obstruction Computed tomography

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Study of various ground state decay mechanisms of Actinide nuclei

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Chinese Physics C 2023年第10期47卷 197-212页

作者： Chahat Jindal Nitin sharma manoj k.sharma School of Physics and Materials Science Thapar Institute of Engineering&TechnologyPatiala-147004PunjabIndia

The special property of the actinide mass region is that nuclei belonging to this group are radioactive and undergo different ground state processes,such as alpha decay,cluster radioactivity(CR),heavy particle radioactivity(HPR),and spontaneous fission(SF).In this study,the probable radioactive decay modes of the heavy mass region(Z=89−102)are studied within the framework.of the preformed cluster model(PCM).In the PCM,the radioactive decay modes are explored in terms of the preformation probability(P0)and penetration probability(P)at the turning point Ra,where the penetration of fragments is initiated[Ra=RT(touching state)+ΔR(neck.length parameter)].First,the alpha decay half-lives are calculated for light and heavy nuclei,and Ra points are obtained by optimizing the neck.length *** Ra points are further employed to fix the Q-value dependent turning point(Ra(Q)).Then,using the(Ra(Q))relation,the decay half-lives are computed,and the calculated results are compared with the available theoretical and experimental *** isotopical trend of P0 and P is studied with respect to the mass number of the parent and daughter nucleus,*** CR and HPR channels are also explored,and a comparison of calculated data is conducted with the available *** analysis of the fragmentation potential and preformation probability is carried out for alpha decay and *** mass distribution of the nuclei is studied as a function of fragment mass(A2)by considering the spherical and hot-compact deformation of the decaying ***,the most probable fission fragments are identified using the fragmentation structure,and the corresponding fission fragment total k.netic energy of the identified fragments is calculated and compared with available data,wherever applicable.

关键词： Alpha decay cluster radioactivity spontaneous fission heavy particle radioactivity ground state decay

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Fusion of spherical-octupole pairs of colliding nuclei for compact and elongated configurations

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Chinese Physics C 2022年第1期46卷 146-156页

作者： Shivani Jain manoj k.sharma Raj k.mar School of Physics and Materials Science Thapar Institute of Engineering&TechnologyPatiala-147004PunjabIndia

The deformation and associated optimum/uniquely fixed orientations play an important role in the syn-thesis of compound nuclei via cold and hot fusion reactions,respectively,at the lowest and highest barrier *** choice of optimum orientation(0_(op))for the'cold or elongated'and hot or cormpact'fusion configurations of quadrupole(β_(2))deformed nuclei depends only on the+/-signs ofβ_(2)-deformation[***.G:***.31,631-644(2005)].In our recent study[***.C 101,051601(R)2020],we proposed a new sct of Oopt(iferent from the values reported for quadrupole deformed nuclei)after the inclusion of octupole deformation(up to B3)*** the respective 0op1 of B3-deformed nuclei for cold and hot optimum orientations,we analyzed the im-pact of the soft-and rigid-pear shapes of octupole deformed nuclei on the fusion barrier characterstics(barrier height Vg and barrier position RB).This analysis is applied to approximately 200 spherical-plus B3 deformed nucle-ar partners,that is,^(16)O,^(18)Cat octupole deformed *** with the compact configuration,the elongated fu-sion configuration has a relatively larger impact on the fusion barrier and cross sections ow ing to the inclusion of de-formations up to *** agreement with available experimental data for the^(16)O+^(150)Sm reaction(β_(22)-0.205,β_(32)=0.055)also improves when the optimum orientation degree of freedom is fixed in view of octupole *** reinforces the fact that nuclear structure effects play an important role in the nuclear fusion ***,octu-pole deformed nuclei can be used for the synthesis of heavy and superheavy nuclei.

关键词： nuclear fusion reactions fusion barrier heavy-ion reactions

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Decay Analysis of Ge Isotopes Formed in Reactions Induced by Tightly and Loosely Bound Projectiles

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Communications in Theoretical Physics 2018年第11期69卷 565-577页

作者： Amandeep k.ur k.randeep Sandhu manoj k.sharma School of Physics and Materials Science Thapar Institute of Engineering and Technology Patiala 147004PunjabIndia Department of Physics GSSDGS Khalsa CollegePatiala 147001PunjabIndia

The dynamical cluster-decay model (DCM) is employed to investigate the decay of ^(6870)Ge~* compound nuclei formed respectively via tightly (~4He) and loosely (~6He) bound projectiles, using ^(64)Zn target. The study is carried out over a wide energy range (E_(c.m.)～5 MeV to 16 MeV) by including the quadrupole deformations (β_(2i)) and optimum orientations (θ_i^(opt)) of the decaying fragments. The fusion cross-sections, obtained by adding various evaporation channels show nice agreement with the experimental data for ~4He+^(64)Zn reaction. The contribution from competing compound inelastic scattering channel is also analyzed particularly for ^(68)Ge~* nucleus at above barrier energies. On the other hand,the decrement in the fusion cross-sections of ^(70)Ge~* nuclear system is addressed by presuming that ^(65)Zn ER is formed via two different modes:(i) the αn evaporation of ^(70Ge)~* nucleus, and(ii) 1n-evaporation of ^(66)Zn~*nuclear system,formed via break.p and 2n-transfer channels due to halo structure of the ~6He projectile. Besides this, the suppression in2 np evaporation cross-sections suggests the contribution of another break.p and transfer process of ~6He i.e. ~4He+ ^(64)*** contribution of break.p+transfer channels for ~6He+^(64)Zn reaction is duly addressed by applying relevant energy corrections due to the break.p of "~6He" projectile into 2n and ~4He. In addition to this, the barrier lowering, angular momentum and energy dependence effects are also explored in view of the dynamics of chosen reactions.

关键词： tightly and loosely bound projectiles evaporation residue break.p and transfer

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Study of Cold Fusion Reactions Using Collective Clusterization Approach

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Communications in Theoretical Physics 2017年第10期67卷 505-517页

作者： Gurjit k.ur k.randeep Sandhu manoj k.sharma School of Physics and Materials Science Thapar University

Within the framework.of the dynamical cluster decay model （DCM）, the in evaporation cross-sections （σ1n） of cold fusion reactions （Pb and Bi targets） are calculated for ZCN = 104-113 superheavy nuclei. The calculations are carried out in the fixed range of excitation energy ECN = 15 ± 1 MeV, so that the comparative analysis of reaction dynamics can be work.d out. First of all, the fission barriers （Bf ） and neutron separation energies （S1n） are estimated to account the decreasing cross-sections of cold fusion reactions. In addition to this, the importance of hot optimum orientations of β24-deformed nuclei over cold one is explored at fixed angular momentum and neck.length parameters. The hot optimum orientations support all the target-projectile （t,p） combinations, which are explored experimentally in the cold fusion reactions. Some new target-projectile combinations are also predicted for future exploration. Further, the In cross-sections are addressed for ZCN = 104-113 superheavy nuclei at comparable excitation energies which show the decent agrement with experimental data upto ZCN = 109 nuclei. Finally, to understand the dynamics of higher-Z superheavy nuclei, the cross-sections are also calculated at maximum available energies around the Coulomb barrier and the effect of non-stick.ng moment of inertia （INS） is also investigated at these energies.

关键词： cold fusion reactions ln-decay cross-sections fragment mass distribution

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