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Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease

Signal Transduction and Targeted Therapy 2023年第11期8卷 5159-5183页

作者： Vivek Panwar Aishwarya Singh Manini Bhatt Rajiv K.Tonk Shavkatjon Azizov Agha Saquib Raza Shinjinee Sengupta Deepak Kumar manoj garg Department of Pharmaceutical Chemistry School of Pharmaceutical SciencesShoolini UniversitySolanHimachal Pradesh173229India Amity Institute of Molecular Medicine and Stem Cell Research(AIMMSCR) Amity University Uttar PradeshSector-125NoidaUttar Pradesh201313India Department of Biomedical Engineering Indian Institute of TechnologyRoparPunjab140001India Department of Pharmaceutical Chemistry School of Pharmaceutical SciencesDelhi Pharmaceutical Sciences and Research University(DPSRU)New Delhi110017India Laboratory of Biological Active Macromolecular Systems Institute of Bioorganic ChemistryAcademy of Sciences UzbekistanTashkent100125Uzbekistan Faculty of Life Sciences Pharmaceutical Technical University100084TashkentUzbekistan Rajive Gandhi Super Speciality Hospital TahirpurNew Delhi110093India

The mammalian target of rapamycin(mTOR)is a protein kinase that controls cellular metabolism,catabolism,immune responses,autophagy,survival,proliferation,and migration,to maintain cellular *** mTOR signaling cascade consists of two distinct multi-subunit complexes named mTOR complex 1/2(mTORC1/2).mTOR catalyzes the phosphorylation of several critical proteins like AKT,protein kinase C,insulin growth factor receptor(IGF-1R),4E binding protein 1(4E-BP1),ribosomal protein S6 kinase(S6K),transcription factor EB(TFEB),sterol-responsive element-binding proteins(SREBPs),Lipin-1,and Unc-51-like autophagy-activating *** signaling plays a central role in regulating translation,lipid synthesis,nucleotide synthesis,biogenesis of lysosomes,nutrient sensing,and growth factor *** emerging pieces of evidence have revealed that the constitutive activation of the mTOR pathway due to mutations/amplification/deletion in either mTOR and its complexes(mTORC1 and mTORC2)or upstream targets is responsible for aging,neurological diseases,and human ***,we provide the detailed structure of mTOR,its complexes,and the comprehensive role of upstream regulators,as well as downstream effectors of mTOR signaling cascades in the metabolism,biogenesis of biomolecules,immune responses,and ***,we summarize the potential of long noncoding RNAs(lncRNAs)as an important modulator of mTOR ***,we have highlighted the potential of mTOR signaling in aging,neurological disorders,human cancers,cancer stem cells,and drug ***,we discuss the developments for the therapeutic targeting of mTOR signaling with improved anticancer efficacy for the benefit of cancer patients in clinics.

关键词： metabolism homeostasis mTOR

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The Effect of Water Absorption on Mechanical Properties of Wood Flour/Wheat Husk Polypropylene Hybrid Composites

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Materials Sciences and Applications 2012年第5期3卷 317-325页

作者： Pradeep Upadhyaya manoj garg Vijai Kumar Ajay K. Nema Central Institute of Plastic Engineering and Technology Bhopal India Central Institute of Plastic Engineering and Technology Lucknow India

The main objectives of this research were to study the effect of water absorption on mechanical properties of hybrid fiber reinforcement for polypropylene composites. The poor resistance towards water absorption is one of the draw- backs of natural fibers. Hybrid filler-polypropylene composites are subjected to water immersion tests in order to study the effects of water absorption on the mechanical properties. Composites specimens containing 30 phr and 40 phr fiber weight were prepared by melt blending process. Water absorption tests were conducted by immersion specimens in distilled water at room temperature for different time durations (24, 48, 72, 96, 120, 144, 168, 192 hours). The tensile, flexural and impact properties were investigated before and after water absorption. The percentage of moisture uptake increased as the increasing order of the filler loading due to the high cellulose content. The phase morphology of wood flour/wheat husk polypropylene hybrid composites were investigated by SEM, the dynamic mechanical properties of the composite are analyzed by DMA & wheat, wood filler interaction are analyzed by FT-IR.

关键词： Hybrid Polypropylene Composites Water Absorption Mechanical Properties

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Case Study of Evaluation RO Desalination Systems for Potable Water in Safwan, Iraq

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Journal of Geoscience and Environment Protection 2021年第2期9卷 158-181页

作者： Areej H. Taha Himanshu Joshi manoj C. garg Hazim Kareem Manhee Department of Hydrology Indian Institute of Technology Roorkee Roorkee India Amity Institute of Environmental Sciences Amity University Noida India General Commission of Ground Water Baghdad Iraq

Iraq faces water scarcity due to a shortage of surface water resources. People in Safwan (Basrah, Iraq) and its environs use brackish groundwater as alternative resource. To improve water quality, small reverse osmosis (RO) plants have been established. The water selling price is (1.3 $/m3)* which does not cover the product cost which is (2.4 $/m3)*. Data were collected from eight plants, and a techno-economic assessment was conducted to explore the ideal cost. The known effective factored considered in this case, recovery ratio, temperature and total dissolved solids (TDS). From the other side, membrane replacement and energy cost were significantly effect, when their portions of the total production cost were 30.98%* and 48.38%* respectively as shown in Figure 10. In addition, software analysis was used to predict the scaling potential in raw water samples. Its results showed a high inorganic fouling (scaling) potential. Scaling has a permanent influence on operations and maintenance costs. These identified major cost influencers will be incorporated into the experimental design of the next phase of this ongoing research programme.

关键词： Reverse Osmosis Recovery Ratio Total Dissolved Solids Energy Consumption Scaling

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Publish/subscribe based information dissemination over VANET utilizing DHT

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Frontiers of Computer Science 2012年第6期6卷 713-724页

作者： Tulika PANDEY Deepak garg manoj Madhav GORE Department of Computer Science and IT Sam Higginbotom Institute of AgricultureTechnology and SciencesAllahabad 211007India Department of Computer Science and Engineering Thapar UniversityPatiala 147004India Department of Computer Science and Engineering Motilal Nehru National Institute of TechnologyAllahabad 211004India

A vehicular ad-hoc network （VANET） can be visualized as a network of moving vehicles communicating in an asynchronous and autonomous fashion. Efficient and scalable information dissemination in VANET applications is a major challenge due to the movement of vehicles which causes unpredictable changes in network topology. The publish/subscribe communication paradigm provides decoupling in time, space, and synchronization between communicating entities, and presents itself as an elegant solution for information dissemination for VANET like environments. In this paper, we propose our approach for information dissemination which utilizes publish/subscribe and distributed hash table （DHT） based overlay networks. In our approach, we assume a hybrid VANET consisting of stationary info-stations and moving vehicles. These info-stations are installed at every major intersection of the city and vehicles can take the role of publisher, subscriber, or broker depending upon the context. The info-stations form a DHT based broker overlay among themselves and act as rendezvous points for related publications and subscriptions. Further, info-stations also assist in locating vehicles that have subscribed to information items. We consider different possible deployments of this hybrid VANET with respect to the number of info-stations and their physical connectivity with each other. We perform simulations to assess the performance of our approach in these different deployment scenarios and discuss their applicability in urban and semi-urban areas.

关键词： vehicular ad-hoc network (VANET) peer-to- peer overlay network publish/subscribe communication paradigm distributed hash table (DHT)

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Carcinoma bladder and sliding bladder hernia: Unusual association of paramount significance

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Asian Journal of Urology 2020年第2期7卷 186-187页

作者： Manav Agrawal Gaurav garg Sunny Goel manoj Kumar Department of Urology King George’s Medical UniversityLucknowUttar PradeshIndia

A 60-year-old man,a diagnosed case of inguinal hernia was referred for evaluation of voiding lower urinary tract symptoms(LUTS).There was no history of *** local examination,he had right-sided-direct inguinal hernia with right *** biochemical parameters were within normal *** routine microscopy revealed presence of field full of red blood *** uroflowmetry there was presence of decreased peak flow rate(12 mL/s)and average flow rate(8 mL/s).

关键词： bladder hernia Carcinoma

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Removal of chromium from water effluent by adsorption onto <i>Vetiveria zizanioides</i>and <i>Anabaena</i>species

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Natural Science 2013年第3期5卷 341-348页

作者： manoj Kumar Abhradip Pal Joginder Singh Shashank garg Madhu Bala Ashish Vyas Yogender Pal Khasa Umesh C. Pachouri Aarupadai Veedu Institute of Technology Tamilnadu India Department of Biotechnology and Biosciences Lovely Professional University Phagwara India Department of Microbiology South Campus University of Delhi New Delhi-110021 India Institute of Nuclear Medicine & Allied Sciences Defence Research and Development Organisation New Delhi India

Bioadsorption phenomenon is more or less like a chemical reaction and several parameters are bound to affect the process. The pH, amount of adsorbent and agitation time influence the biosorptive potentiality. Hence, the present study on adsorption of Cr(VI) by activated Vetivera roots and Blue green algae Anabaena supports that it is an effective low cost adsorbent for the removal of Cr(VI) from plating effluent. Langmuir and Freundlich adsorption isotherm correlate the equilibrium adsorption data. In batch experiments both Vetiveria and Anabaena species were found to be cost effective biosorbent for the efficient removal of Cr(VI) from the effluent and comparatively Anabaena species was found to adsorb maximum Cr(VI) (88.86%) at a low contact time of 60 min. The data obtained from the experiments and modeling would prove useful in designing and fabricating an efficient treatment plant for Cr(VI) rich effluent.

关键词： Bioadsorption Vetiveria Anabaena Adsorption Isotherm Chromium

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