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中华医学会第14次全国皮肤性病学术年会

作者： Thomas Hancewicz manoj misra Unilever Research&Development

Skin forms an elegant layered structure that comprises epidermis, dermis and subcutaneous fat. The epidermis consists of the outermost surface of skin called stratum corneum (SC) and underlying living viable cells. The SC forms a unique structure which serves multiple functions and constitutes a dynamic and smart barrier that prevents exogenous materials from penetrating into the body and loss of vital components from inside the body. Hence, depth profiles of water can facilitate the understanding of skin composition and structure.

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A Predicted Region based Cache Replacement Policy for Location Dependent Data in Mobile Environment

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International Journal of Communications, Network and System Sciences 2008年第1期1卷 79-94页

作者： Ajey KUMAR manoj misra Anil K. SARJE Department of Electronics and Computer Engineering Indian Institute of Technology Roorkee Roorkee India Department of Electronics and Computer Engineering Indian Institute of Technology Roorkee Roorkee India

Caching frequently accessed data items on the mobile client is an effective technique to improve the system performance in mobile environment. Proper choice of cache replacement technique to find a suitable subset of items for eviction from cache is very important because of limited cache size. Available policies do not take into account the movement patterns of the client. In this paper, we propose a new cache replacement policy for location dependent data in mobile environment. The proposed policy uses a predicted region based cost function to select an item for eviction from cache. The policy selects the predicted region based on client’s movement and uses it to calculate the data distance of an item. This makes the policy adaptive to client’s movement pattern unlike earlier policies that consider the directional / non-directional data distance only. We call our policy the Prioritized Predicted Region based Cache Replacement Policy (PPRRP). Simulation results show that the proposed policy significantly improves the system performance in comparison to previous schemes in terms of cache hit ratio.

关键词： Mobile Computing Cache Replacement Location Dependent Data Valid Scope Location Dependent Information Services.

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A Consensus Modeling Approach for the Determination of Stratum Corneum Thickness Using In-Vivo Confocal Raman Spectroscopy

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Journal of Cosmetics, Dermatological Sciences and Applications 2012年第4期2卷 241-251页

作者： Thomas M. Hancewicz Chunhong Xiao Jesse Weissman Vickie Foy Shuliang Zhang manoj misra Advanced Measurement and Data Modeling Unilever Research & Development Trumbull USA Clinical Science Unilever Research & Development Trumbull USA Clinical Science Unilever Research & Development Trumbull USA.

The measurement of stratum corneum (SC) thickness from in-vivo Raman water concentration depth profiles is gaining in popularity and appeal due to the availability and ease of use of in-vivo confocal Raman measurement systems. The foundation of these measurements relies on high-quality confocal Raman spectroscopy of skin and the robust numerical analysis of water profiles, which allow for accurate determination of SC thickness. These measurements are useful for studying intrinsic skin hydration profiles at different body sites and for determining hydration properties of skin related to topically applied materials. While the use of high-quality in-vivo Raman instrumentation has become routine and its use for SC thickness measurement widely reported, there is lack of agreement as to the best method of computing SC thickness values from Raman water profiles. Several methods have been proposed and are currently in use for such computations, but none of these methods has been critically evaluated. The work reported in this paper describes a new method for the determination of stratum corneum thickness from in-vivo confocal Raman water profiles. The method represents a consensus approach to the problem, which was found necessary to apply in order to properly model and quantify the large diversity of water profile types encountered in typical in-vivo Raman water measurement. The methodology is evaluated for performance using three criteria: 1) frequency of minimum fitting error on modeling to a standard numerical function;2) frequency of minimum model error for consensus vs. individual SC thickness values;and 3) correlation with reflectance confocal microscopy (RCM) values for SC thickness. The correlation study shows this approach to be a reasonable replacement for the more tedious and time-consuming RCM method with R2 = 0.68 and RMS error = 3.7 microns over the three body sites tested (cheek, forearm and leg).

关键词： In-Vivo Raman Spectroscopy Confocal Raman Spectroscopy Reflectance Confocal Microscopy Stratum Corneum Thickness

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