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Carcinoma bladder and sliding bladder hernia: Unusual association of paramount significance

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Asian Journal of Urology 2020年第2期7卷 186-187页

作者： Manav Agrawal Gaurav Garg Sunny Goel manoj kumar Department of Urology King George’s Medical UniversityLucknowUttar PradeshIndia

A 60-year-old man,a diagnosed case of inguinal hernia was referred for evaluation of voiding lower urinary tract symptoms(LUTS).There was no history of *** local examination,he had right-sided-direct inguinal hernia with right *** biochemical parameters were within normal *** routine microscopy revealed presence of field full of red blood *** uroflowmetry there was presence of decreased peak flow rate(12 mL/s)and average flow rate(8 mL/s).

关键词： bladder hernia Carcinoma

Heat and mass transfer effects on MHD viscoelastic fluid over a stretching sheet through porous medium in presence of chemical reaction

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Propulsion and Power Research 2016年第1期5卷 70-80页

作者： manoj kumar Nayak Gauranga Charan Dash Lambodar Prased Singh Department of Physics Radhakrishna Institute of Technology and EngineeringBijupatnaik University of TechnologyOdishaIndia Department of Mathematics I.T.E.R.Siksha‘O’Anusandhan UniversityOdishaIndia Department of Physics Utkal UniversityOdishaIndia

An attempt has been made to study the heat and mass transfcr effects in a boundary layer flow through porous medtium of an electrically conducting viscoelastic fluid subject to transverse magnetic field in the presence of heat sourcelsink and chemical *** has been considered the effects of radliation,viscous and Joule dissipations and intemal heat generation/*** form solutions for the boundary layer equations of viscoelastic,second-grxle and Walters'B’fluid models are *** method of solution involves similarity *** ransfommed equations of thermal and mass transport are solved by applying Kummer's *** solutions of temperature field for both prescribed surface temperature(PST)as well as prescribed surface heat flux(PHF)are *** is important to remark that the interaction of magnetic field is found to be counterproductive in enhancing velocity and concentration distibution whereas the presence of chemical reaction as well as porous matrix with moderate values of magnetic parameter reduces the temperature and concentration fields at all points of flow domain.

关键词： Stretching sheet Porous medium Viscoelastic Chemical reaction Kummer's function

Cyanobacteria,Lyngbya aestuarii and Aphanothece bullosa as antifungal and antileishmanial drug resources

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Asian Pacific Journal of Tropical Biomedicine 2013年第6期3卷 458-463页

作者： Maheep kumar manoj kumar Tripathi Akanksha Srivastava Jalaj kumar Gour Rakesh kumar Singh Ragini Tilak Ravi kumar Asthana Department of Botany Faculty of ScienceBanaras Hindu University Department of Biochemistry Faculty of ScienceBanaras Hindu University Department of Microbiology Institute of Medical SciencesBanaras Hindu University

Objective:To investigate two cyanobacteria isolated from different origins *** aestuarii(***)from brackish water and Aphanothece bullosa(***)from fresh water paddy fields for antifungal and antileishmanila activity taking Candida albicans and Leishmania donovain as ***:Biomass of *** and *** were harvested after 40 and60 d respectively and lyophilized twice in methanol(100%)and redissolved in methanol(5%)for *** bioassay was done by agar well diffusion method while antileishmanial,by counting cell numbers and flageller motility observation of promastigotes and amastigotes from *** and 5%methanol were used as ***:Both the cyanobacteria were found to be potent source of antifungal activity keeping fluconazole as positive control,however,methanolic crude extract(15 mg/mL)of *** was found more potent(larger inhibition zone)over that of methanolic crude extract of ***,Similarly antileishmanial activity of crude extract(24.0 mg/mL)of *** was superior over that of methanolic crude extract of ***(25.6 mg/mL).Conclusions:Antifungal and antileishmanial drugs are still limited in the *** of microbes possessing antifungal and antileishmanial activity drug is of prime *** are little explored in this context because most of the drugs in human therapy are derived from microorganisms,mainly bacterial,fungal and *** in the present study two cyanobacterial strains from different origins showed potent source of antifungal and antileishmanial biomolecules.

关键词： Antifungal Antileishmanial Secondary metabolite Cyanobacteria

Bile Cast Nephropathy in Patients with Acute Kidney Injury Due to Hepatorenal Syndrome:A Postmortem Kidney Biopsy Study

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Journal of Clinical and Translational Hepatology 2017年第2期5卷 92-100页

作者： Suman Lata Nayak manoj kumar Chhagan Bihari Archana Rastogi Department of Nephrology Institute of Liver and Biliary Sciences New Delhi India Department of Hepatology and Liver Transplatation Institute of Liver and Biliary Sciences New Delhi India Department of Pathology Institute of Liver and Biliary Sciences New Delhi India

Background and Aims:The role of bile cast nephropathy (BCN) in pathogenesis of hepatorenal syndrome (HRS) in decompensated cirrhosis and acute on chronic liver failure (ACLF) is *** study aimed to determine the frequency of BCN detected on postmortem renal biopsy among patients with decompensated cirrhosis and ACLF who had been admitted with acute kidney injury due to HRS (HRAAKI) and expired during that ***:One-hundred-twenty-seven postmortem renal biopsies with adequate size (>1 cm in length) were included for *** were obtained from 84 patients with decompensated cirrhosis and 43 patients with ***:BCN was detected in 57 of the total 127 (44.8%) renal biopsy *** with BCN had significantly higher levels of serum total bilirubin,total leukocyte count and model for end-stage liver disease score,as compared to those without *** was detected in 32/43 (74.4%) of the patients with ACLF,as compared to 25/84 (29.7%) of the patients with decompensated cirrhosis (p < 0.001).On multivariate analysis,direct bilirubin (OR (95% CI):1.27 (1121-1.698);p < 0.001)and presence of ACLF (OR (95% CI):2.603 (1.054-7.111);p =0.041) were found to be significant predictors of BCN on postmortem renal ***:BCN was found in 72.1% of patients with ACLF and 27.4% patients with decompensated cirrhosis who had been hospitalized with an admitting diagnosis of HRS-AKI and who expired during that hospitalization and underwent postmortem renal *** serum bilirubin and presence of ACLF were found to be significant predictors of BCN on postmortem renal biopsy.

关键词： Bile cast nephropathy Acute kidney injury Hepatorenal syndrome

三元混合纳米流体(TiO_(2)-SiO_(2)-MoS_(2)/煤油)流过旋转圆盘时的二次热辐射和Cattaneo-Christov模型

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Journal of Central South University 2023年第4期30卷 1262-1278页

作者： SINGH Shiv Pratap kumar manoj YASEEN Moh RAWAT Sawan kumar Department of Mathematics Statistics and Computer ScienceGovind Ballabh Pant University of Agriculture and TechnologyPantnagar 263145UttarakhandIndia Department of Applied Science Meerut Institute of Engineering and TechnologyMeerut 250005Uttar PradeshIndia Department of Mathematics Graphic Era(Deemed to be University)Dehradun 248002UttarakhandIndia

本文研究了Cattaneo-Christov模型(C-C模型)和对流边界条件下的二次热辐射对三元混合纳米流体(TiO_(2)-SiO_(2)-MoS_(2)/煤油)流过旋转圆盘过程的影响,并研究了Darcy-Forchheimer多孔介质和吸入/注射的影响。比较分析了三元混合纳米流体... 详细信息

本文研究了Cattaneo-Christov模型(C-C模型)和对流边界条件下的二次热辐射对三元混合纳米流体(TiO_(2)-SiO_(2)-MoS_(2)/煤油)流过旋转圆盘过程的影响,并研究了Darcy-Forchheimer多孔介质和吸入/注射的影响。比较分析了三元混合纳米流体(TiO_(2)-SiO_(2)-MoS_(2)/煤油)与混合纳米流体(TiO2-SiO2/煤油)。通过von Karman转换将偏微分方程集合转变为常微分方程,并通过MATLAB中的bvp4c函数对其求解。图表结果反映了径向、切向速度和传热速度的变化。讨论了各种参数的影响,包括磁场、Forchheimer数、孔隙率参数、滑移参数、辐射参数、热弛豫、混合对流、吸入/注射、Biot数、发热/热吸收、体积分数。发现较高的辐射值和热弛豫参数可以提高传热速率。本研究将对使用纳米流体的学科领域具有一定的参考价值,如运输过程、旋转的机械系统、协同旋转的涡轮系统、增强型油回收系统、医疗等。

关键词：三元混合纳米流体 Darcy-Forchheimer 多孔介质混合对流吸入/注射二次热辐射发热/吸收滑移效应

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扭带式换热器水热关联的机器学习辅助建模

Acta Mechanica Sinica 2023年第1期39卷 148-157页

作者： Jyoti Prakash Panda Bipin kumar Anil kumar Patil manoj kumar Ravi kumar Department of Mechanical Engineering DIT UniversityDehradunUttarakhandIndia

本文介绍了机器学习(ML)算法在带扭带插件的换热器传热关联(如努塞尔数和摩擦系数)建模中的应用.采用换热器在不同雷诺数(Re)、扭转比(t)、穿孔率(p)和不同扭带数(n)下的实验数据进行相关建模.在数据驱动的代理建模中使用了三种机器学... 详细信息

本文介绍了机器学习(ML)算法在带扭带插件的换热器传热关联(如努塞尔数和摩擦系数)建模中的应用.采用换热器在不同雷诺数(Re)、扭转比(t)、穿孔率(p)和不同扭带数(n)下的实验数据进行相关建模.在数据驱动的代理建模中使用了三种机器学习算法:多项式回归(PR)、随机森林(RF)和人工神经网络(ANN).为了保证模型的通用性,对ML模型的超参数进行了优化,分析了不同ML算法的性能参数(如R 2和MAE).结果表明,在不同的测试数据集上,人工神经网络对传热系数的预测优于PR和RF的预测.基于本文分析内容,对未来数据驱动的传热关联建模工作和类似研究提出了建议.

关键词：机器学习数据驱动测试数据集辅助建模多项式回归超参数穿孔率

Cylindrical gate all around Schottky barrier MOSFET with insulated shallow extensions at source/drain for removal of ambipolarity:a novel approach

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Journal of Semiconductors 2017年第12期38卷 42-47页

作者： manoj kumar Yogesh Pratap Subhasis Haldar Mridula Gupta R.S.Gupta Semiconductor Device Research Laboratory Department of Electronic ScienceUniversity of Delhi South CampusNew Delhi 110021India Department of Electronics Shaheed Rajguru College for Applied Sciences for Women University of DelhiNew Delhi 110021India Department of Physics Motilal Nehru CollegeUniversity of DelhiNew Delhi 110021India Department of Electronics and Communication Engineering Maharaja Agrasen Institute of TechnologyNew Delhi 110086India

In this paper TCAD-based simulation of a novel insulated shallow extension （ISE） cylindrical gate all around （CGAA） Schottky barrier （SB） MOSFET has been reported, to eliminate the suicidal ambipolar behavior （bias-dependent OFF state leakage current） of conventional SB-CGAA MOSFET by blocking the metal-induced gap states as well as unwanted charge sharing between source/channel and drain/channel regions. This novel structure offers low barrier height at the source and offers high ON-state current. The IoN/Iovr： of ISE-CGAA-SB-MOS- FET increases by 1177 times and offers steeper subthreshold slope （-60 mV/decade）. However a little reduction in peak cut off frequency is observed and to further improve the cut-off frequency dual metal gate architecture has been employed and a comparative assessment of single metal gate, dual metal gate, single metal gate with ISE, and dual metal gate with ISE has been presented. The improved performance of Schottky barrier CGAA MOSFET by the incorporation of ISE makes it an attractive candidate for CMOS digital circuit design. The numerical simulation is performed using the ATLAS-3D device simulator.

关键词： ATLAS-3D cylindrical gate all around dual metal gate insulated shallow extension Schottky barrier

Elucidating the dynamics of solvent engineering for perovskite solar cells

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Science China Materials 2019年第2期62卷 161-172页

作者： Zulqarnain Arain Cheng Liu Yi Yang M.Mateen Yinke Ren Yong Ding Xuepeng Liu Zulfiqar Ali manoj kumar Songyuan Dai Key Laboratory of Novel Thin-Film Solar Cells North China Electric Power University Energy system Engineering Dept. Sukkur IBA University Renewable Energy School North China Electric Power University

Researchers working in the field of photovoltaic are exploring novel materials for the efficient solar energy *** prime objective of the discovery of every novel photovoltaic material is to achieve more energy yield with easy fabrication process and less production cost *** solar cells (PSCs)delivering the highest efficiency in the passing years with different stoichiometry and fabrication modification have made this technology a potent candidate for future energy conversion *** now,many studies have shown that the quality of active layer morphology,to a great extent,determines the performance of *** current and potential techniques of solvent engineering for good active layer morphology are mainly debated using primary solvent,co-solvent (Lewis acid-base adduct approach)and solvent *** this review,the dynamics of numerously reported solvents on the morphological characteristics of PSCs active layer are discussed in *** intention is to get a clear understanding of solvent engineering induced modifications on active layer morphology in PSC devices via different crystallization *** last,an attempt is made to draw a framework based on different solvent coordination properties to make it easy for screening the potent solvent contender for desired PSCs precursor for a better and feasible device.

关键词： perovskite solvent engineering Lewis acid-base additive coordination property

Mechanism and its regulation of tumor-induced angiogenesis

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World Journal of Gastroenterology 2003年第6期9卷 1144-1155页

作者： manoj kumar Gupta Department of Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030Hubei ProvinceChina

Tumor angiogenesis is the proliferation of a network of blood vessels that penetrates into cancerous growths, supplying nutrients and oxygen and removing waste products. The process of angiogenesis plays an important role in many physiological and pathological conditions. Solid tumors depend on angiogenesis for growth and metastasis in a hostile environment. In the prevascular phase, the tumor is rarely larger than 2 to 3 mm3 and may contain a million or more cells. Up to this size, tumor cells can obtain the necessary oxygen and nutrient supplies required for growth and survival by simple passive diffusion. The properties of tumors to release and induce several angiogenic and antiangiogenic factors which play crucial roles in regulating endothelial cell (EC) proliferation, migration, apoptosis or survival, cell-cell and cell-matrix adhesion through different intracellular signaling are thought to be the essential mechanisms during tumor-induced angiogenesis. Tumor angiogenesis actually starts with tumor cells releasing molecules that send signals to surrounding normal host tissue. This signaling activates certain genes in the host tissue that, in turn, make proteins to encourage growth of new blood vessels. In this review, we focus the mechanisms of tumor-induced angiogenesis, with an emphasis on the regulatory role of several angiogenic and anti-angiogenic agents during the angiogenic process in tumors. Advances in understanding the mechanisms of tumor angiogenesis have led to the development of several most effective antiangiogenic and anti-metastatic therapeutic agents and also have provided several techniques for the regulation of cancer's angiogenic switch. The suggestion is made that standard cytotoxic chemotherapy and angiogenesis inhibitors used in combination may produce complementary therapeutic benefits in the treatment of cancer.

关键词：肿瘤血管生成发病机理病因学治疗