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Hepatitis B Surface Antigen Serum Level Is Correlated with Fibrosis Severity in Treatment-Naïve, Chronic Hepatitis B Patients in Côte d’Ivoire (West Africa)?

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Open Journal of Gastroenterology 2015年第11期5卷 164-172页

作者： Mamert Fulgence Yao Bathaix dramane Soro Aboubacar demba Bangoura Adjéka Stanislas doffou Siaka koné Ya Henriette kissy dimitri Hartrydt kouamé Aoudi Ousmane dé Mahassadi kouamé Alassane Attia koffi Alain Aya Thérèse N’dri Yoman department of Hepatology and Gastroenterology of the Centre Hospitalier Universitaire de Yopougon (CHU-Y) Abidjan Cote d’Ivoire department of Hepatology and Gastroenterology of the Centre Hospitalier Universitaire de Cocody (CHU-C) Abidjan Cote d’Ivoire

HBsAg serum level (quantification) may be useful for managing hepatitis B virus (HBV) infection patients. However few studies especially in Africa have evaluated the association between HBsAg serum level and liver fibrosis severity. The objective of this study was to estimate the correlation between HBsAg serum level and liver fibrosis severity with treatment naive chronic hepatitis B patients in Cote d’Ivoire. Methodology: It is a prospective study covering from February 1st, 2014 to April 30st, 2015 at Centre Hospitalier et Universitaire de Yopougon and a private medical office in Abidjan, Cote d’Ivoire. Inclusion criteria for patients were: HBsAg positive, known HBeAg status, serum HBsAg levels, serum HBV dNA levels, complex serum markers and absence of HCV, HdV, or HIV co-infection, drinking more than 30 g/day for men and 20 g/day in women over 10 years, metabolic disease and/or hepatic overload. Pearson’s Chi-square test (r2), Anova, Spearman, T-Student, Pearson’s (r) correlations and Mann Withney’s Test were carried out as appropriate. A p value ken as significant. Results: We recruited, 105 patients (77 men) of whom the medium age was 39.01 ± 9.72 years. Predominant hepatitis B viral genotype was E (93%). Less than 10% patients had an inactive HBV in HBeAg-negative. Patients had an average high HBsAg serum level (mean 12111.2 ± 10617.4 IU/ml) as well as the one viral load (mean 4.4 e7 ± 7.5 e7). Serum ALAT levels averaged at the upper limit of normal value. The average liver fibrosis score was 0.34 ± 0.22 and the degree of viral activity was 0.19 ± 0.20. Half of our patients had no fibrosis (35.24%) or had mild fibrosis (20.95%). No significant association was observed between HBsAg serum level and patient age (p = 0.3994), genre (p = 0.8075) or serum ALT levels (p = 0, 0787). In multivariate analysis, there’s a significant correlation (r = 0.239, p = 0.014) between HBV dNA levels and HBsAg serum level. There’s a significant correlation (r = 0.92

关键词： Hepatitis B Surface Antigen Serum Level Liver Fibrosis Chronic Hepatitis B Viral Africa

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用户知识与经验在云IOS人-机信任中的调节作用

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武汉理工大学学报（信息与管理工程版） 2015年第4期37卷 477-482页

作者：朱江陈利民 LAI Ivan ka-Wai 李妍北京师范大学珠海分校广东珠海519087 中国工业工程学会明爱专上学院华南理工大学广州学院广东广州510800

在CIOS(基于云的跨组织信息系统)的信任影响因素模型的基础上,利用来自中国大陆的256份有效样本数据进行实证分析,研究发现用户的受教育程度、全职工作年限,以及可控性对CIOS人-机信任的影响具有负向调节作用,用户所在企业的CIOS应用阶... 详细信息

在CIOS(基于云的跨组织信息系统)的信任影响因素模型的基础上,利用来自中国大陆的256份有效样本数据进行实证分析,研究发现用户的受教育程度、全职工作年限,以及可控性对CIOS人-机信任的影响具有负向调节作用,用户所在企业的CIOS应用阶段和可用性对CIOS人-机信任的影响具有负向调节作用。研究结果对CIOS的研发与应用有参考价值。

关键词：跨组织信息系统云计算用户知识与经验调节作用

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Extended Global Convergence Framework for Unconstrained Optimization

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Acta Mathematica Sinica,English Series 2004年第3期20卷 433-440页

作者： rpád BRMEN Franc BRATkOVI Janez PUHAN Iztok FAJFAR Tadej TUMA University of Ljubljana Faculty of Electrical EngineeringTr■aka Cesta 25SI-1000 LjubljanaSlovenia

An extension of the global convergence framework for unconstrained derivative-free op- timization methods is *** extension makes it possible for the framework to include opti- mization methods with varying cardinality of the ordered direction ***-based search methods are shown to be a special case of the more general extended global convergence ***, the required properties of the sequence of ordered direction sets listed in the definition of grid-based methods are relaxed and simplified by removing the requirement of structural equivalence.

关键词： derivative free optimization descent methods Convergence analysis Grid-based optimization

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Hydrologic and climatic implications of a multi-disciplinary study of the mid to late Holocene Lake Eastern Juyanze

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Chinese Science Bulletin 2003年第14期48卷 1411-1417页

作者： S.Mischke d.demske M.E.Schudack Institute of Geological Sciences Freie Universit8 BerlinInstitute of Geological Sciences Freie Universit8 BerlinInstitute of Geological Sciences Freie Universit8 Berlin Malteserstr. 74-100 12249 Berlin Germany Correspondence should be addressed to S. Mischke Malteserstr. 74-100 12249 Berlin Germany Correspondence should be addressed to S. Mischke Malteserstr.74-100 12249 Berlin Germany Correspondence should be addressed to S. Mischke

A mid to late Holocene exposure in a recently desiccated lake basin in western Inner Mongolia was investigated with regard to palaeoenvironmental changes and the overall climatic conditions in NW China between 2.7 and 5.4 cal. ka BP. High lake levels of Lake Eastern Juyanze were recorded by ostracod assemblages, shell geochemistry and sedimentology between 5.1 and 4.1 cal. ka BP. Relatively humid conditions and a relatively strong influence of the Asian monsoon are indicated by palynological data for the corresponding period. Lake levels decreased afterwards and short-term regressive events occurred at about 4.1, 3.8 and 3.4 cal. ka BP. The overall trend towards lower lake levels culminated in repeated episodes of desiccation of Lake Eastern Juyanze between 3.2 and 2.9 cal. ka BP, in phase with very arid conditions inferred from the palynological record. Individual regressive events as well as the rapid environmental fluctuations of Lake Eastern Juyanze at about 3.0 cal. ka BP were regarded as driven by mid to late Holocene summer monsoon fluctuations, supported by the dunde ice core record.

关键词：中国内蒙古晚全新世古气候水文学湖平面降低干旱东居延泽黑河

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Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics

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Stroke & Vascular Neurology 2023年第1期8卷 77-85页

作者： Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok ka Sing Wong Thomas W Leung Xinyi Leng department of Medicine and Therapeutics The Chinese UniversityHong KongChina department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina department of Neurology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina department of Imaging and Interventional The Chinese UniversityHong KongChina Research Centre of Intelligent Healthcare Faculty of Health and Life ScienceCoventry UniversityCoventryUK department of Neurology Nanjing University Medical School Affiliated Nanjing Drum Tower HospitalNanjingJiangsuChina department of Radiology Nanjing University Medical School Affiliated Nanjing Drum Tower HospitalNanjingJiangsuChina

Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical *** of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFd)models were associated with the risk of stroke *** aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these *** Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were *** vascular risk factors were *** of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFd modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical *** developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 *** Among 245 sICAS patients,20(8.2%)had *** d2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in *** analysis in patients with anterior-circulation sICAS showed similar *** The d2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS a

关键词： intracranial otherwise stratification

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富氧焙烧技术在109 m^(2)锌精矿流态化焙烧炉上的应用实践

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中国有色冶金 2021年第5期50卷 44-48,53页

作者：皮忠斌张振国王卡卡柴伟许良云南驰宏锌锗股份有限公司会泽冶炼分公司云南会泽654211 中国恩菲工程技术有限公司北京100038

多年来,国内富氧焙烧技术在锌精矿焙烧炉上的应用始终停留在试验阶段,驰宏会冶首次实现了锌精矿富氧焙烧规模化生产。该公司通过在原鼓风系统管道上增加富氧分布装置,配套有高浓度氧气调节阀组及流量、压力监测仪表等设施,同时,配套改... 详细信息

多年来,国内富氧焙烧技术在锌精矿焙烧炉上的应用始终停留在试验阶段,驰宏会冶首次实现了锌精矿富氧焙烧规模化生产。该公司通过在原鼓风系统管道上增加富氧分布装置,配套有高浓度氧气调节阀组及流量、压力监测仪表等设施,同时,配套改进流态化冷却器、高温引风机和鼓风机等设备,实现了富氧焙烧技术在锌精矿焙烧炉上的应用。生产实践表明,在适当的工艺参数下,富氧焙烧技术可以充分释放产能,流态化焙烧炉床能率提升到8.03 t/m^(2)·d;焙烧矿质量得到有效改善,烟尘含硫下降至3.5%;生产吨锌能耗大幅降低,空压风单耗194.0 Nm^(3)/t,电单耗135.80 kW·h/t,高浓度氧气的单耗为81 Nm^(3)/t。综上,109 m^(2)焙烧炉采用富氧焙烧技术后获得了较好的经济效益,另外,还提高了焙烧系统、硫酸系统装置的利用率,降低了鼓风量,有效防止了烟尘的无组织排放,改善了现场生产环境。

关键词：锌精矿富氧焙烧 109 m^(2)流态化焙烧炉床能率焙烧矿质量吨锌能耗焙尘含硫生产环境

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地面三维激光扫描点云的多站数据无缝拼接

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中国矿业大学学报 2010年第2期39卷 233-237页

作者：盛业华张卡张凯王永波南京师范大学虚拟地理环境教育部重点实验室江苏南京210046 江苏省基础地理信息中心江苏南京210013 中国矿业大学环境与测绘学院江苏徐州221116

针对如何将多站分块扫描的点云无缝地拼接为一个整体以完整地表达扫描对象几何形态的问题,基于测量平差理论,提出了一种简单易行的多站扫描数据无缝拼接方法.首先根据与相邻前一扫描站相重叠的扫描区域内的同名标志点按附有限制条件的... 详细信息

针对如何将多站分块扫描的点云无缝地拼接为一个整体以完整地表达扫描对象几何形态的问题,基于测量平差理论,提出了一种简单易行的多站扫描数据无缝拼接方法.首先根据与相邻前一扫描站相重叠的扫描区域内的同名标志点按附有限制条件的间接平差模型求取坐标转换参数,再对序列坐标转换参数按闭合条件进行加权误差分配,得到各站扫描点云的最终坐标转换模型,并依此坐标转换模型对各站扫描点云进行坐标变换,将它们统一到项目坐标系下,最终得到多站扫描点云的无缝拼接结果.对多站扫描的建筑物点云数据进行整体拼接实验,证明了本方法的可行性和有效性.

关键词：三维激光扫描坐标变换点云拼接误差分配

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Evolutionary Transients in the Rice Transcriptome

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Genomics, Proteomics & Bioinformatics 2010年第4期8卷 211-228页

作者： Jun Wang Jianguo Zhang Ruiqiang Li Hongkun Zheng Jun Li Yong Zhang Heng Li Peixiang Ni Songgang Li Shengting Li Jingqiang Wang dongyuan Liu Jason Mcdermott Ram Samudrala Siqi Liu Jian Wang Huanming Yang Jun Yu Gane ka-Shu Wong key Laboratory of Genome Sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences Beijing 100029 China Beijing Genomics Institute at Shenzhen Shenzhen 518083 China department of Biochemistry and Molecular Biology University of Southern Denmark DK-5230 Odense M Denmark Theoretical Life Research Center Fudan University Shanghai 200433 China Computational Genomics Group Department of Microbiology University of Washington Seattle WA 98195 USA Computational Biology and Bioinformatics Pacific Northwest National Laboratory Richland WA 99352 USA department of Biological Sciences and department of Medicine University of Alberta Edmonton AB T6G 2E9 Canada

In the canonical version of evolution by gene duplication, one copy is kept unaltered while the other is free to evolve. This process of evolutionary experimentation can persist for millions of years. Since it is so short lived in comparison to the lifetime of the core genes that make up the majority of most genomes, a substantial fraction of the genome and the transcriptome may—in principle—be attributable to what we will refer to as ＂evolutionary transients＂, referring here to both the process and the genes that have gone or are undergoing this process. Using the rice gene set as a test case, we argue that this phenomenon goes a long way towards explaining why there are so many more rice genes than Arabidopsis genes, and why most excess rice genes show low similarity to eudicots.

关键词： evolutionary transients rice gene duplication

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依鲁替尼治疗后的高血压和心血管事件

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中华高血压杂志 2020年第2期28卷 115-115页

作者：刘青(译) 叶鹏(摘、审校) dickerson T Wiczer T Waller A Philippon J Porter k Haddad d Guha A Rogers ka Bhatt S Byrd JC Woyach JA Awan F Addison d 不详

依鲁替尼对B细胞恶性肿瘤有显著疗效。然而,依鲁替尼与潜在的限制性心脏毒性有关,包括新出现的严重高血压。使用依鲁替尼对高血压的发病率、严重程度的影响尚不清楚。研究者在2009-2016年间连续使用依鲁替尼治疗B细胞恶性肿瘤的562例患... 详细信息

依鲁替尼对B细胞恶性肿瘤有显著疗效。然而,依鲁替尼与潜在的限制性心脏毒性有关,包括新出现的严重高血压。使用依鲁替尼对高血压的发病率、严重程度的影响尚不清楚。研究者在2009-2016年间连续使用依鲁替尼治疗B细胞恶性肿瘤的562例患者中,评估了新发高血压或高血压进展的发生率(收缩压临界值为130mm Hg,1mm Hg=0.133kPa)。所观察到的高血压发生率与通过Framingham心脏预测的高血压发生率进行比较。

关键词：高血压发生率依鲁替尼严重高血压心血管事件心脏毒性 B细胞恶性肿瘤新发高血压临界值

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基于数字近景立体摄影的三维表面模型构建

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数据采集与处理 2007年第3期22卷 309-314页

作者：张卡盛业华李永强韩冰梁诚南京师范大学虚拟地理环境教育部重点实验室南京210046

采用经过标定的数字近景立体摄影系统Z-System获取待建模对象的数字立体像对序列,探讨利用这些立体像对进行三维表面构建的方法。在构建三维目标表面模型时,首先根据数字近景立体摄影测量原理,提取目标表面的特征点和计算特征点的三维坐... 详细信息

采用经过标定的数字近景立体摄影系统Z-System获取待建模对象的数字立体像对序列,探讨利用这些立体像对进行三维表面构建的方法。在构建三维目标表面模型时,首先根据数字近景立体摄影测量原理,提取目标表面的特征点和计算特征点的三维坐标;然后利用各立体像对内特征点的像平面坐标,按二维空间TIN(tri-angulated irregular network)构建方法得到离散特征点在三维空间中的拓扑连接关系,进而构建单像对内目标的局部表面TIN模型;最后再利用序列像对间的公共连接点,进行坐标转换,从而在三维空间中将各单立体像对的表面模型拼接成一个完整的三维表面模型。实验结果表明,该方法具有快速灵活的特点且行之有效。

关键词：数字摄影测量立体摄影三维建模三维TIN 模型拼接

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