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Mechanism and its regulation of tumor-induced angiogenesis

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World Journal of Gastroenterology 2003年第6期9卷 1144-1155页

作者： manoj kumar gupta Department of Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030Hubei ProvinceChina

Tumor angiogenesis is the proliferation of a network of blood vessels that penetrates into cancerous growths, supplying nutrients and oxygen and removing waste products. The process of angiogenesis plays an important role in many physiological and pathological conditions. Solid tumors depend on angiogenesis for growth and metastasis in a hostile environment. In the prevascular phase, the tumor is rarely larger than 2 to 3 mm3 and may contain a million or more cells. Up to this size, tumor cells can obtain the necessary oxygen and nutrient supplies required for growth and survival by simple passive diffusion. The properties of tumors to release and induce several angiogenic and antiangiogenic factors which play crucial roles in regulating endothelial cell (EC) proliferation, migration, apoptosis or survival, cell-cell and cell-matrix adhesion through different intracellular signaling are thought to be the essential mechanisms during tumor-induced angiogenesis. Tumor angiogenesis actually starts with tumor cells releasing molecules that send signals to surrounding normal host tissue. This signaling activates certain genes in the host tissue that, in turn, make proteins to encourage growth of new blood vessels. In this review, we focus the mechanisms of tumor-induced angiogenesis, with an emphasis on the regulatory role of several angiogenic and anti-angiogenic agents during the angiogenic process in tumors. Advances in understanding the mechanisms of tumor angiogenesis have led to the development of several most effective antiangiogenic and anti-metastatic therapeutic agents and also have provided several techniques for the regulation of cancer's angiogenic switch. The suggestion is made that standard cytotoxic chemotherapy and angiogenesis inhibitors used in combination may produce complementary therapeutic benefits in the treatment of cancer.

关键词：肿瘤血管生成发病机理病因学治疗

Alteration of somatostatin receptor subtype 2 gene expression in pancreatic tumor angiogenesis

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World Journal of Gastroenterology 2004年第1期10卷 132-135页

作者： manoj kumar gupta Department of Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

AIM: To explore the difference of somatostatin receptor subtype 2 (SST2R) gene expression in pancreatic cancerous tissue and its adjacent tissue, and the relationship between the change of SST2R gene expression and pancreatic tumor angiogenesis related genes. METHODS: The expressions of SST2R, DPC4, p53 and ras genes in cancer tissues of 40 patients with primary pancreatic cancer, and the expression of SST2R gene in its adjacent tissue were determined by immunohistochemiscal LSAB method and EnVisionTM method. Chi-square test was used to analyze the difference in expression of SST2R in pancreatic cancer tissue and its adjacent tissue, and the correlation of SST2R gene expression with the expression of p53, ras and DPC4 ***: Of the tissue specimens from 40 patients with primary pancreatic cancer, 35 (87.5%) cancer tissues showeda negative expression of SST2R gene, whereas 34 (85%) a positive expression of SST2R gene in its adjacent tissues. Five (12.5%) cancer tissues and its adjacent tissues simultaneously expressed SST2R. The expression of SST2R gene was markedly higher in pancreatic tissues adjacent to cancer than in pancreatic cancer tissues (P0.05). CONCLUSION: There was a significant difference of SST2R gene expression in pancreatic cancer tissues and its adjacent tissues, which might be one cause for the different therapeutic effects of somatostatin and its analogs on pancreatic cancer patients. There were abnormal expressions of SST2R, DPC4, p53 and ras genes in pancreatic carcinogenesis, and moreover, the loss or decrease of SST2R gene expression was significantly negatively correlated with the overexpression of tumor angiogenesis correlated p53 and ras genes, suggesting that SST2R gene togethe

关键词：胰腺癌肿瘤血管生成生长抑制素受体亚型2 免疫组织化学肿瘤病理学

Expression of TREM-1 mRNA in acute pancreatitis

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World Journal of Gastroenterology 2004年第18期10卷 2744-2746页

作者： manoj kumar gupta Department of Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030Hubei ProvinceChina

AIM: To explore the expression of triggering receptor expressed on myeloid cells (TREM-I) mRNA in acute pancreatitis (AP).METHODS: Using the reverse transcription polymerase chain reaction (RT-PCR), we examined the expression of TREM-1 mRNA in 10 cases of mild acute pancreatitis (MAP), 8 cases of severe acute pancreatitis (SAP), and 10 cases of healthy control subjects. And we also examined the expression of TREM-1 mRNA in 14 cases of AP (including 10 MAP and 4 SAP) before treatment, after successful therapy and clinically ***: The expression of TREM-1 mRNA in the groups of MAP, SAP patients and healthy control subjects was 0.771±0.274, 1.092±0.331 and 0.459±0.175, respectively;there was a significant difference among the three groups (P<0.05). And there was also a significant difference between the AP patients (0.914±0.341) and healthy control subjects (0.459+0.175) (P<0.05). Moreover, in the 14 cases of AP, before treatment, after successful therapy and clinically cured, the expression of TREM-1 mRNA was 0.905±0.226,0.739±0.169 and 0.633±0.140, respectively, and there was a significant difference among the three stages (P<0.05).CONCLUSION: The expression of TREM-1 mRNA in the patients with AP increases obviously, and correlates with the degree of AP. Furthermore, the expression of TREM-1 mRNA is distinctly different at the different stages of AP. It indicates TREM-1 may play an important role in the occurrence and development of AP.

关键词：基因表达 TREM-1 mRNA 急性胰腺炎消化系统

IL-1 β genesis: the art of regulating the regulator

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Cellular & Molecular Immunology 2018年第11期15卷 998-1000页

作者： Priya gupta manoj k.Barthwal Pharmacology Division CSIR-Central Drug Research InstituteLucknow226031UPIndia

In a study published in Cellular and Molecular Immunology,Singh et *** a new mechanism of monocyte IL-1βproduction.1 It was observed that TLR-4-and TLR-2-induced IRAk-ERk pathway cross-talk with p67phox-Nox-2 for reactive oxygen species(ROS)generation,thus regulating IL-1βtranscription and processing in *** study not only establishes a direct link between IRAk and ERk,but also demonstrates the regulation of p67phox-Nox-2 by ERk for ROS and IL-1βproduction(Fig.1).This study shows that the IRAk-ERk axis can regulate both IL-βtranscription and processing through ROS.

关键词： al. Immunology Singh

Optimal design of hybrid renewable-energy microgrid system:a techno-economic-environment-social-reliability perspective

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Clean Energy 2024年第1期8卷 66-83页

作者： manoj gupta Annapurna Bhargava Electrical Engineering Department Rajasthan Technical UniversityKotaRajasthan 324010India Electrical and Electronics Engineering Department IPS Academy Institute of Engineering and Science IndoreMadhya Pradesh 452012India

The main objective of this paper is to select the optimal model of a hybrid renewable-energy microgrid(MG)system for a village in *** MG comprises solar photovoltaic(PV)modules,a wind turbine generator,a biomass generator,a battery bank,a diesel generator and an electric *** optimal model selection is based on technical,economic,environmental,social and reliability parameters.A novel spoonbill swarm optimization algorithm is proposed to select the best hybrid MG *** optimization results are compared with particle swarm optimization,the genetic algorithm and the grasshopper optimization *** number or size of components of the optimized MG system is 215 PV modules,92 kW of wind turbine generation,25 kW of biomass generation,267 batteries,22 kW of electric vehicles and 30 kW of diesel *** optimized system was selected based on technical factors such as renewable dispersion(93.5%),the duty factor(5.85)and excess energy(15975 kWh/year)as well as eco-nomic considerations including the net present cost(Rs.34686622)and the cost of energy(9.3 Rs./kWh).Furthermore,environ-mental factors such as carbon emissions(396348 kg/year)and atmospheric particulate matter(22.686 kg/year);social factors such as the human progress index(0.68411),the employment generation factor(0.0389)and local employment generation(15.64643);and reliability parameters including loss of power supply probability(0.01%)and availability index(99.99%)were considered during the selection *** spoonbill swarm optimization algorithm has reduced the convergence time by 1.2 times and decreased the number of iterations by 0.83 times compared with other *** performance of the MG system is validated in the MATLAB®*** results show that the MG system is the optimal system considering technical,economic,environmental,social and reliability ***,the spoonbill swarm optimization algorithm is found to be more efficient than the other

关键词： cost of electricity microgrid reliability spoonbill techno-economic

Investigation of point defect evolution and Voronoi cluster analysis for magnesium during nanoindentation

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Journal of Magnesium and Alloys 2023年第3期11卷 1029-1042页

作者： Pragyan Goswami Snehanshu Pal manoj gupta Department of Metallurgical and Materials Engineering National Institute of TechnologyRourkelaOdisha 769008India Department of Mechanical Engineering National University of SingaporeSingapore 117575Singapore

The present study investigates the effect of nanoindentation on single-crystal magnesium specimens using the embedded-atom method potential in molecular dynamics *** are done under dynamic loading where the load-bearing capacity and change in the structural configuration are studied on the basal(Z-direction)and two prismatic planes(X-and Y-directions)with varying indenter *** investigation of structural evolution is done using atomic displacement analyses to measure the net magnitude of displacement,atomic strain analyses to evaluate the shear strain developed in the process,and Wigner-Seitz defect analyses to calculate the total vacancies at varied ***,Voronoi analyses are done when indented on the basal plane to identify the cluster distribution at different planar depths of the *** the analyses,it has been observed that the load-bearing capacity of the specimen varies with the indentation velocity and the direction of indentation on the ***,it is seen that the observed shear and total atomic displacement in the Z-direction is the least in comparison to the other two *** partial dislocation 1/3is seen to be majorly present and the population of dislocation loops is more abundant for lower indenter ***,clustersandare the major indices developed during nanoindentation on the basal plane where they exhibit symmetrical distribution as observed from the Z-direction.

关键词： Magnesium Molecular dynamics Nanoindentation Voronoi analysis Wigner-Seitz defect analysis

SEQUENCING DELIVERIES TO MINIMIZE INVENTORY HOLDING COST WITH DOMINANT UPSTREAM SUPPLY CHAIN PARTNER

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Journal of Systems Science and Systems Engineering 2009年第2期18卷 159-183页

作者： Sushil gupta manoj VANAJAkUMARI Chelliah SRISkANDARAJAH Florida International University USA Texas A&M University USA The University of Texas at Dallas USA

This paper studies a two stage supply chain with a dominant upstream partner. Manufacturer is the dominant partner and operates in a Just-in-Time environment. Production is done in a single manufacturing line capable of producing two products without stopping the production for switching from one product to the other. The manufacturer imposes constraints on the distributor by adhering to his favorable production schedule which minimizes his manufacturing cost. Distributor on the other hand caters to retailers＇ orders without incurring any shortages and is responsible for managing the inventory of finished goods. Adhering to manufacturer＇s schedule may lead to high inventory carrying costs for the distributor. Distributor＇s problem, which is to find an optimal distribution sequence which minimizes the distributor＇s inventory cost under the constraint imposed by the manufacturer is proved NP-Hard by manoj et al. （2008）. Therefore, solving large size problems require efficient heuristics. We develop algorithms for the distribution problem by exploiting its structural properties. We propose two heuristics and use their solutions in the initial population of a genetic algorithm to arrive at solutions with an average deviation of less than 3.5% from the optimal solution for practical size problems.

关键词： Supply chain scheduling production and distribution system logistics genetic algorithm optimized cross over

Chemical and physical studies of metallic alloy-based old Indian coins with LIBS coupled with multivariate analysis

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Plasma Science and Technology 2023年第9期25卷 91-103页

作者： Vikas gupta Abhishekh kumar RAI Tejmani kUMAR Rajendhar JUNJURI G manoj kUMAR A k RAI Laser Spectroscopy Research Laboratory Department of PhysicsUniversity of AllahabadPrayagraj 211002India Department of Earth and Planetary Sciences University of AllahabadPrayagraj 211002India Advanced Centre of Research in High Energy Materials University of HyderabadHyderabad 500046 India Leibniz Institute of Photonic Technology Jena D-07745Germany

The present work aims to demonstrate the capabilities of Laser-induced Breakdown Spectroscopy(LIBS)coupled with a multivariate technique for rapid quantification and classification of old Indian coins made of various *** old Indian coins in different years of circulation,(1922–1986)were selected for the *** concentrations were determined by Calibration free LIBS(CF-LIBS)*** concentration of cuprum(Cu)is negligible,and aluminum(Al)is maximum in the first five coins,and vice-versa in the remaining eight *** different multivariate methods,Principal Component Analysis(PCA)and Soft Independent Modelling of Class Analogy(SIMCA)have been used to classify and identify the *** classified all thirteen samples into four main alloy *** discernment of unknown samples to their probable class membership of alloy was performed using *** surface hardness(Brinell hardness number)is linearly correlated with the plasma temperature and LIBS intensity *** sample surface of the first and fifth coin belongs to Al-alloy,having the least surface hardness,and it became harder for Cu–Ni alloy,Ni-brass alloy,and bronze *** hardness of the surface is more for bronze sample *** is also observed that the plasma temperature increases monotonically with the Brinell hardness *** analysis provides valuable information on fabrication methodology and explains large diversification in the elementary composition of old coins.

关键词： LIBS metallic alloy stoichiometric ablation PCA SIMCA old indian coins surface hardness

A review of TiO_2 nanoparticles

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Chinese Science Bulletin 2011年第16期56卷 1639-1657页

作者： gupta Shipra Mital TRIPATHI manoj University School of Basic and Applied Sciences Guru Gobind Singh Indraprastha UniversitySector 16C DwarkaDelhi 110075India

Climate change and the consumption of non-renewable resources are considered as the greatest problems facing *** of this,photocatalysis research has been rapidly ***2 nanoparticles have been extensively investigated for photocatalytic applications including the decomposition of organic compounds and production of H2 as a fuel using solar energy. This article reviews the structure and electronic properties of TiO2,compares TiO2 with other common semiconductors used for photocatalytic applications and clarifies the advantages of using TiO2 ***2 is considered close to an ideal semi- conductor for photocatalysis but possesses certain limitations such as poor absorption of visible radiation and rapid recombination of photogenerated electron/hole *** this review article,various methods used to enhance the photocatalytic characteristics of TiO2 including dye sensitization,doping,coupling and capping are *** and energy applications of TiO2, including photocatalytic treatment of wastewater,pesticide degradation and water splitting to produce hydrogen have been summarized.

关键词：纳米二氧化钛光催化特性审查不可再生资源催化应用可见光辐射光催化处理气候变化