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Modified Single Phase SRF d-q Theory based Controller for DVR Mitigating Voltage Sag in Case of Nonlinear Load

Journal of Electromagnetic Analysis and Applications 2017年第2期9卷 22-33页

作者： Dhiraj N. Katole manoj b. Daigavane Snehal P. Gawande Prema M. Daigavane Department of Electrical Engineering G.H. Raisoni College of Engineering Nagpur India G.H. Raisoni Institute of Engineering and Technology Nagpur India Y.C. College of Engineering Nagpur India G.H. Raisoni College of Engineering Nagpur India

This paper mainly concentrates on design of improved controller and its implementation based on single phase synchronous reference frame theory (SRFT) for Dynamic Voltage Restorer (DVR) compensating voltage sag particularly for nonlinear load. In case of single phase distribution line with nonlinear load, the complexity of controller’s design becomes more serious issue. The present single phase and/or three phase theories applicable to DVR shows poor response to restore voltage sag in case of nonlinear load due to presence of harmonics. Hence restoration of voltage sag in single phase nonlinear load connected system has been a serious concern. Therefore, new controller for DVR has been proposed incorporating effective design concept for fundamental component extraction in case of nonlinear load. The single phase SRFT based main controller for DVR works on two separate closed path viz. feed forward path for quick transient response and feedback path for reducing the steady state error. Moreover, pre-sag mitigation strategy of DVR has been adapted through these two aforementioned paths. Complete design of proposed controller is based on phasor analysis. It also consist of proportional integral (PI) controller to reduce the error in the DC-link voltage during compensation time. The controller performance has been verified in MATLAb Simulink for both types (linear and nonlinear) of load. The results obtained indicates that the proposed controller is effective in its performance.

关键词： Power Quality Voltage Sag DVR Single Phase SRFT based Controller Sinusoidal Pulse Width Modulation Non-Linear Load

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益智仁对三转基因阿尔茨海默病小鼠认知障碍的治疗作用

益智仁对三转基因阿尔茨海默病小鼠认知障碍的治疗作用

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作者： manoj Kumar Vashisth 大理大学

学位级别：硕士

目的:阿尔茨海默病(Alzheimer’s disease,AD)是一种痴呆症,其特征是认知功能进行性下降,患病率和死亡率有增加倾向。这种神经退行性疾病给患者个人及其家人带来了极度痛苦。尽管在治疗方案上取得了重大进展,但临床疗效仍有局限性,并伴... 详细信息

目的:阿尔茨海默病(Alzheimer’s disease,AD)是一种痴呆症,其特征是认知功能进行性下降,患病率和死亡率有增加倾向。这种神经退行性疾病给患者个人及其家人带来了极度痛苦。尽管在治疗方案上取得了重大进展,但临床疗效仍有局限性,并伴有非治疗性和耐药性。因此,非常需要开发有效的AD治疗方法。方法:本研究主要检测益智仁(Alpinia oxyphylla Miquel,AOM)颗粒对阿尔茨海默病小鼠认知障碍的影响。经过基因修饰,小鼠携带三个拷贝的阿尔茨海默病基因。本研究使用了 3xTg阿尔茨海默病小鼠模型,并使用Y迷宫、旷场实验检查其记忆能力,随后用Morris水迷宫实验更好地理解AOM的作用效果。为了评估组织学改变和凋亡特征,本研究采用HE染色和TUNEL染色技术。此外,通过蛋白质印迹(western blot,Wb)分析技术检测裂解的caspase3、caspase8和caspase9的水平。此外,使用定量聚合酶链式反应(qPCR)测定caspase3,caspase8,和caspase9的mRNA表达水平的变化。通过利用这些方法,本研究旨在确定AOM配方颗粒对小鼠模型认知缺陷影响的潜在分子机制。本研究还涉及使用蛋白质印迹实验来检测不同促炎和促凋亡因子的浓度,如p53、p65、IKK-α和Iκb-α。通过评估这些因子的表达水平,确定它们对三重转基因小鼠模型中观察到的认知能力下降的潜在贡献,并评估AOM配方颗粒的潜在治疗效果。这项分析的结果有助于深入洞察阿尔茨海默病的分子机制,并为未来的治疗方案提供可能的靶点。结果:与对照组相比,服用AOM配方颗粒组认知功能有显著改善。具体而言,接受AOM配方颗粒的小鼠在Y迷宫中表现出更大的自发改变率,表明其工作记忆表现更好。此外,经过处理的小鼠在水迷宫中表现出象限停留时间和平台交叉增加,这证明空间认知能力增强。此外,经过处理的小鼠表现出逃跑潜伏期的降低,这表明它们在水迷宫任务中的表现有所改善。观察结果表明,AOM配方颗粒可能对治疗与该疾病相关的认知障碍具有潜在的治疗效果。凋亡相关通路的NF-K b在药物治疗组小鼠的海马受到显著抑制,同时在小鼠脑皮层的水平发生改变。这些观察结果表明,AOM有可能成为三重转基因阿尔茨海默病小鼠认知和行为缺陷的有效治疗方法。本研究结果表明,AOM具有抗炎和抗凋亡特性,这可能与其治疗AD的功能有关。本研究发现,AOM配方颗粒具有独特的抗阿尔茨海默病活性,这归因于其抗炎和抗细胞死亡的特点。AOM配方颗粒对小鼠模型中的认知功能障碍具有显著的改善作用,表明它可能是开发AD治疗方法的一个很有前途的选择。通过靶向AD的潜在分子机制,如炎症和细胞凋亡,AOM配方颗粒可能为AD相关认知能力下降的控制和预防提供一种新的方法。AOM对NF-κb的抑制尤其值得注意,因为这种途径与阿尔茨海默病的发展有关。实验证据表明,该因子对炎症细胞因子和趋化因子的表达具有调节控制作用,这两种因子都是阿尔茨海默病神经炎症反应的关键因素。AOM对该途径的抑制意味着它可能是治疗AD的潜在有价值的治疗靶点。此外,AOM可能通过靶向凋亡途径有效治疗AD。Caspase3是一种对细胞凋亡途径有显著贡献的效应分子,其表达量与细胞凋亡量成正比。研究发现AOM直接通过Caspase9激活Caspase3,这表明它可能能够通过激活线粒体途径或膜受体途径来启动细胞凋亡过程。结论:研究表明,AOM配方颗粒具有抗凋亡作用,不依赖于caspase8,caspase8是一种与阿尔茨海默病的发生和发展有关的蛋白质。这一发现具有重要意义,因为caspase8的抑制作用已被证明在AD的临床前模型中具有治疗潜力。因此,AOM通过caspase8非依赖性机制发挥其抗凋亡活性的能力可能为治疗AD提供一种新的方法。综上所述,本研究的结果表明,AOM配方颗粒在治疗AD方面具有很好的治疗潜力。

关键词：阿尔茨海默病炎症细胞凋亡认知障碍益智仁

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Quantification of 17-desacetyl norgestimate in human plasma by liquid chromatography–tandem mass spectrometry (LC–MS/MS) and its application to bioequivalence study

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Journal of Pharmaceutical Analysis 2015年第2期5卷 93-100页

作者： Ashish Saxena Arun Kumar Gupta V.Praveen Kumar M.Sundaramoorthi Nainar manoj bob Ravisekhar Kasibhatta bioanalytical Research Department Lupin Bio-Research Center Faculty of Pharmacy Pacific UniversityP.B.-12 Pacific Hills Airport Road Pratap Nagar Extension DebariUdaipur 313024 Rajasthan State India Faculty of Science Pacific UniversityP.B.-12 Pacific Hills Airport Road Pratap Nagar Extension Debari Udaipur 313024 Rajasthan State India

A rapid and sensitive ultra-performance liquid chromatography–tandem mass spectrometry（UPLC–MS/MS） method was developed and validated for the estimation of 17-desacetyl norgestimate in human plasma using solid-phase extraction technique. 17-desacetyl norgestimate D6 was used as the internal standard. Simple gradient chromatographic conditions and mass spectrometric detection enabled accurate and precise measurement of 17-desacetyl norgestimate at sub-picogram levels. The proposed method was validated for a linear range of 20–5000 pg/m L with a correlation coefficient Z 0.9988. The intra-run and inter-run precision and accuracy were within 10%. The overall recoveries for 17-desacetyl norgestimate and 17-desacetyl norgestimate D6 were 96.30% and 93.90%, respectively. The total run time was 4.5 min. The developed method was applied for the determination of the pharmacokinetic parameters of 17-desacetyl norgestimate following a single oral administration of a norgestimate and ethinyl estradiol0.250 mg/0.035 mg tablets in 35 healthy female volunteers.

关键词： 17-desacetyl norgestimate UPLC–MS/MS Human plasma

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Effect of Exercise on NAFLD and Its Risk Factors:Comparison of Moderate versus Low Intensity Exercise

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Journal of Clinical and Translational Hepatology 2020年第2期8卷 120-126页

作者： Preetam Nath Manas Kumar Panigrahi manoj Kumar Sahu Jimmy Narayan Ranjan Kumar Sahoo Ananya Apurba Patra Satyaswarup Jena Arun Kumar Patnaik Anjan Jena Shivaram Prasad Singh Department of Gastroenterology&Hepatology Kalinga Institute of Medical SciencesBhubaneswarOdishaIndia Department of Gastroenterology All India Institute of Medical SciencesBhubaneswarOdishaIndia Department of Gastroenterology IMS and SUM HospitalBhubaneswarOdishaIndia Department of Radiodiagnosis&Imaging Kalinga Institute of Medical SciencesBhubaneswarOdishaIndia Department of Radiology IMS and SUM HospitalBhubaneswarOdishaIndia Dispensary Biju Patnaik State Police AcademyBhubaneswarOdishaIndia Department of Gastroenterology S.C.B.Medical College753007 CuttackOdishaIndia

background and Aims: Lifestyle (exercise and dietary) modification is the mainstay of treatment for non-alcoholic fatty liver disease (NAFLD). However, there is paucity of data on effect of intensity of exercise in management of NAFLD, and we aimed to study the effect of variable intensities of exercise on NAFLD. Methods: The study was performed in the Department of Gastroenterology of the SCb Medical Col-lege, Cuttack and the biju Patnaik State Police Academy, bhu-baneswar. The subjects were police trainees [18 in a moderate intensity exercise group (MIG) and 19 in a low in-tensity exercise group (LIG)] recruited for a 6-month physical training course (261.8 Kcalorie, 3.6 metabolic equivalent in MIG and 153.6 Kcalorie, 2.1 metabolic equivalent in LIG). NAFLD was diagnosed by ultrasonography, with exclusion of all secondary causes of steatosis. All participants were eval-uated by anthropometry (weight, height, body mass index (bMI), waist circumference), assessed for blood pressure and biochemical parameters (blood glucose, liver function test, lipid profile, serum insulin), and subjected to transabdo-minal ultrasonography before and after 6 months of physical training, and the results were compared. Results: both the groups had similar bMI, fasting plasma glucose, AST, gamma-glutamyl transpeptidase, insulin, and homeostatic model as-sessment-insulin resistance (known as HOMA-IR) (p>0.05). However, subjects in the LIG were older and had lower alanine transaminase, higher triglycerides and lower high-density lip-oproteins than MIG subjects. There was a significant reduc-tion in bMI (27.0±2.1 to 26.8±2.0;p=0.001), fasting blood glucose (106.7±21.6 to 85.8±19.0;p<0.001), serum trigly-cerides (167.5±56.7 to 124.6±63.5;p=0.017), total choles-terol (216.8±29.2 to 196.7±26.6;p=0.037), low-density lipoprotein cholesterol (134.6±21.4 to 130.5±21.9;p=0.010), serum aspartate transaminase (39.3±32.2 to 30.9±11.4;p<0.001), serum alanine transaminase (56.6 ±28.7 to 33.0±11.3;p<0.

关键词： Exercise NAFLD Intensity Physical activity

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Identification and characterization of genotype A and D recombinant hepatitis b virus from Indian chronic HbV isolates

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World Journal of Gastroenterology 2008年第40期14卷 6228-6236页

作者： Ranjit Chauhan Syed Naqui Kazim manoj Kumar Jayashree bhattacharjee Narayanasamy Krishnamoorthy Shiv Kumar Sarin Department of Gastroenterology and Advanced Center for Liver Diseases G.B.Pant Hospital Department of biochemistry Lady Hardinge Medical College Centre for Interdisciplinary Research in basic Sciences The Centre for Genomic Application

AIM： To confirm the presence of recombination, fulllength hepatitis b virus （HbV） from chronic patients was sequenced and analyzed. METHODS： Full-length HbV genomes from 12 patients were amplified and sequenced in an automated sequencer. Phylogenetic analysis was carried out on full-length, Core and preS2/Surface regions using MEGA software. SimPIot boot Scanning and amino acid sequence analysis were performed for confirmation of recombination. RESULTS： Eight patients were infected with genotype D strain; one patient with genotype A and three patients had genotype A and D recombination; two of them had cirrhosis and one had hepatocellular carcinoma. Phylogenetic analysis of core and preS2/surface regions separately showed evidence of genotype A and D recombination. The breakpoints of recombination were found to be at the start of preS2 and at the endof surface coding regions. CONCLUSION： We identified and characterized recombinant A and D genotype HbV in hepatitis b surface antigen （HbsAg）-positive patients.

关键词： Hepatitis b virus Genotype Variation Evolution Recombination

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水分胁迫下外源AbA提高甘蔗抗旱性的作用机制

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作物学报 2010年第5期36卷 863-870页

作者：李长宁 manoj Kumar SRIVASTAVA 农倩李杨瑞广西大学农学院广西南宁530004 广西作物遗传改良生物技术重点开放实验室广西南宁530007

以抗旱甘蔗品种ROC22为材料,调查水分胁迫及胁迫加喷施脱落酸(AbA)对甘蔗内源AbA合成及相关生理生化作用的影响。结果表明,干旱及干旱加外施AbA的条件下,甘蔗内源AbA合成水平上升,但干旱加AbA处理增幅更显著,甘蔗叶内的脯氨酸(Pro)、H2O... 详细信息

以抗旱甘蔗品种ROC22为材料,调查水分胁迫及胁迫加喷施脱落酸(AbA)对甘蔗内源AbA合成及相关生理生化作用的影响。结果表明,干旱及干旱加外施AbA的条件下,甘蔗内源AbA合成水平上升,但干旱加AbA处理增幅更显著,甘蔗叶内的脯氨酸(Pro)、H2O2、丙二醛(MDA)含量增加,而AbA处理能缓解MDA的积累,使其含量处于低水平,AbA处理能防止叶绿素降解并对干旱引起的最大光能转化效率(Fv/Fm)、PSII实际量子效率(ΦPSII)下降有明显的缓解作用。干旱条件下,H2O2的积累伴随着抗氧化作用的酶CAT、GPX、GR和APX的活性提高,而AbA处理能进一步提高这些相关酶的活性而逐渐降低H2O2的含量,表明干旱条件下,外施AbA能增强甘蔗的抗氧化防护系统,提高抗旱性。

关键词： AbA 甘蔗抗旱性 H2O2 抗氧化酶叶绿素荧光

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Elucidating the dynamics of solvent engineering for perovskite solar cells

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Science China Materials 2019年第2期62卷 161-172页

作者： Zulqarnain Arain Cheng Liu Yi Yang M.Mateen Yinke Ren Yong Ding Xuepeng Liu Zulfiqar Ali manoj Kumar Songyuan Dai Key Laboratory of Novel Thin-Film Solar Cells North China Electric Power University Energy system Engineering Dept. Sukkur IbA University Renewable Energy School North China Electric Power University

Researchers working in the field of photovoltaic are exploring novel materials for the efficient solar energy *** prime objective of the discovery of every novel photovoltaic material is to achieve more energy yield with easy fabrication process and less production cost *** solar cells (PSCs)delivering the highest efficiency in the passing years with different stoichiometry and fabrication modification have made this technology a potent candidate for future energy conversion *** now,many studies have shown that the quality of active layer morphology,to a great extent,determines the performance of *** current and potential techniques of solvent engineering for good active layer morphology are mainly debated using primary solvent,co-solvent (Lewis acid-base adduct approach)and solvent *** this review,the dynamics of numerously reported solvents on the morphological characteristics of PSCs active layer are discussed in *** intention is to get a clear understanding of solvent engineering induced modifications on active layer morphology in PSC devices via different crystallization *** last,an attempt is made to draw a framework based on different solvent coordination properties to make it easy for screening the potent solvent contender for desired PSCs precursor for a better and feasible device.

关键词： perovskite solvent engineering Lewis acid-base additive coordination property

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Improvement of Plasma Performance with Lithium Wall Conditioning in Aditya Tokamak

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Plasma Science and Technology 2013年第2期15卷 123-128页

作者： M. b. CHOWDHURI R. MANCHANDA J. GHOSH S. b. bHATT Ajai KUMAR b. K. DAS K. A. JADEJA P. A. RAIJADA manoj KUMAR S. bANERJEE Nilam RAMAIYA Aniruddh MALI Ketan M. PATEL Vinay KUMAR P. VASU R. bHATTACHARYAY R. L. TANNA Y. Shankara JOISA P. K. ATREY C. V. S. RAO D. Chenna REDDY P. K. CHATTOPADHYAY R. JHA Y. C. SAXENA Aditya team Institute for Plasma Research Bhat Gandhinagar 382 428 India

Lithiumization of the vacuum vessel wall of the Aditya tokamak using a lithium rod exposed to glow discharge cleaning plasma has been done to understand its effect on plasma performance. After the Li-coating, an increment of ~100 eV in plasma electron temperature has been observed in most of the discharges compared to discharges without Li coating, and the shot reproducibility is considerably improved. Detailed studies of impurity behaviour and hydrogen recycling are made in the Li coated discharges by observing spectral lines of hydrogen, carbon, and oxygen in the visible region using optical fiber, an interference filter, and PMT based systems. A large reduction in O I signal （up to ~40% to 50%） and a 20% to 30% decrease of Ha signal indicate significant reduction of wall recycling. Furthermore, VUV emissions from O V and Fe XV monitored by a grazing incidence monochromator also show the reduction. Lower Fe XV emission indicates the declined impurity penetration to the core plasma in the Li coated discharges. Significant increase of the particle and energy confinement times and the reduction of Zeff of the plasma certainly indicate the improved plasma parameters in the Aditya tokamak after lithium wall conditioning.

关键词： lithiumization wall conditioning impurity Aditya tokamak

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The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-lp transcription and processing in monocytes

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Cellular & Molecular Immunology 2016年第6期13卷 747-763页

作者： Ankita Singh Vishal Singh Rajiv L. Tiwari Tulika Chandra Ashutosh Kumar Madhu Dikshit manoj K. barthwal Pharmacology Division CSIR-Central Drug Research Institute B.S. 10/1 Sector 10 Sitapur Road Jankipuram Extension Lucknow 226031 Uttar Pradesh India Department of Transfusion Medicine and blood bank King George's Medical University Lucknow Uttar Pradesh India Department of Pathology King George's Medical University Lucknow Uttar Pradesh India

In monocytic cells, Toll-like receptor 4 （TLR4）- and TLR2-induced reactive oxygen species （ROS） cause oxidative stress and inflammatory response; however, the mechanism is not well understood. The present study investigated the role of interleukin-1 receptor-associated kinase （IRAK）, extracellular signal-regulated kinase （ERK）, p67phox and Nox-2 in TLR4- and TLR2-induced ROS generation during interleukin-1 beta （IL-1β） transcription, processing, and secretion. An IRAK1/4 inhibitor, U0126, PD98059, an NADPH oxidase inhibitor （diphenyleneiodonium （DPI））, and a free radical scavenger （N-acetyl cysteine （NAC））-attenuated TLR4 （lipopolysaccharide （LPS））- and TLR2 （Pam3csk4）-induced ROS generation and IL-1β production in THP-1 and primary human monocytes. An IRAK1/4 inhibitor and siRNA-attenuated LPS- and Pam3csk4-induced ERK-IRAK1 association and ERK phosphorylation and activity. LPS and Pam3csk4 also induced IRAK1/4-, ERK- and ROS-dependent activation of activator protein-1 （AP-1）, IL-1β transcription, and IL-1β processing because significant inhibition in AP-1 activity, IL-lp transcription, Pro- and mature IL-p expression, and caspase-1 activity was observed with PD98059, U0126, DPI, NAC, an IRAK1/4 inhibitor, tanshinone Ila, and IRAK1 siRNA treatment. IRAK-dependent ERK-p67phox interaction, p67phox translocation, and p67phox-Nox-2 interaction were observed. Nox-2 siRNA significantly reduced secreted IL-lp, IL-1β transcript, pro- and mature IL-1β expression, and caspase-1 activity indicating a role for Nox-2 in LPS- and Pam3csk4-induced IL-1β production, transcription, and processing. In the present study, we demonstrate that the TLR4- and TLR2-induced IRAK-ERK pathway cross-talks with p67phox-Nox-2 for ROS generation, thus regulating IL-1β transcription and orocessin; in monocvtic cells.

关键词： IL-1β IRAK monocytes ROS TLR

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Glycemic Indices of Multiple Oral Nutritional Supplements: A Randomized Cross-Over Study in Indian Adults

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Food and Nutrition Sciences 2023年第10期14卷 941-962页

作者： Deepti Khanna Jaladhi bhatt Jayanti Gupta Simran Sethi Parth Joshi manoj Pareek Divya Agrawal Hindustan Unilever Limited R&D Department Gurugram India Independent biostatistician & Researcher Mumbai India Cliantha Research Ahmedabad India

background: A randomized cross-over study was conducted to assess the glycemic index (GI) of seven Oral Nutritional Supplements (ONSs). These ONSs are designed to support the nutritional requirements of different age-groups, physiological states, or health conditions among Indian adults. Methods: The study had two phases viz., phase1 (n = 18) studied two ONSs: A1 and b1 and phase 2 (n = 20) studied five ONSs: A2, b2, C2, D2 & E2. The subjects were healthy, non-diabetic adults, aged between 20 - 44 years with a mean body Mass Index of 21.2 ± 1.52 kg/m2 (Phase 1) and 21.0 ± 1.45 kg/m2 (Phase 2). All these ONSs were compared with reference drinks (glucose). The carbohydrates in one serving of each ONS were matched to carbohydrates from 25 grams of glucose following ISO 2010 guidelines. Capillary blood was assessed for blood glucose response at baseline, 15, 30, 45, 60, 90 and 120 minutes. GI was calculated as the incremental area under the curve (iAUC) for the test drinks and expressed as a percentage of the average iAUC from glucose. Results: Phase 1 indicated that the high fiber diabetes-specific nutrition supplement A1 with higher protein (23% energy), higher fat (25% energy) and reduced carbohydrates (40% energy) had a significantly (p = 0.002) lower GI [34 (±6)] as compared to b1 [63 (±7)] (protein 19%, fat 7% and carbohydrates 60% energy) even with similar amount (22%) and type of fiber. Phase 2 reported that all test products [A2 (32 ± 5), b2 (37 ± 4), C2 (31 ± 5), D2 (31 ± 5) and E2 (55 ± 4)] had a low GI. As compared to phase 1, ONSs in phase 2 had lower fiber content (1.6% - 4.6% energy). Conclusion: The glycemic index of oral nutrition supplements is influenced not only by their fiber content, but also by the overall macronutrient composition including protein (≥17% energy), fat (≥10% - 27% energy) and carbohydrates (40% - 57.5% energy).

关键词： Glycemic Index Oral Nutritional Supplements Incremental Area under the Curve Diabetes

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