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General Psychiatry 2020年第2期33卷 94-100页

作者： Eram Ansari Sudha Mishra Adarsh tripathi Sujita kumar Kar Pronob kumar Dalai College of Nursing King George's Medical UniversityLucknowIndia Departm ent of Psychiatry King George's Medical UniversityLucknowIndia

Background Patients suffering from psychiatric disorders tend to stigmatise themselves which had been linked to poor adherence to *** The aim of the present study was to study internalised stigma and medication adherence and to assess the relationship between them in patients with obsessive compulsive disorder(0CD).Methods A cross-sectional study was conducted on 112 patients diagnosed with 0CD who were attending the Out-patient's department at Department of Psychiatry of a tertiary care hospital in North *** stigma and current medication adherence were assessed with Internalized Stigma of Mental Illness Scale(ISMI)and Medication Adherence Rating Scale,***-Brown Obsessive Compulsive Scale was used to assess the current severity of OCD *** and clinical details were also obtained from the patients by using a semistructured sociodemographic *** Most of the patients reported moderate level of internalised stigma with a mean ISMI score of 77.98(10.82).Most of the patients were compliant while 41.96%reported poor medication *** stigma was negatively correlated with the current medication *** severity of OCD symptoms also showed a significant positive correlation with internalised stigma and a significant negative correlation with medication *** High levels of internalised stigma were associated with lower adherence to treatment which suggests that internalised stigma may be a very important factor influencing medication adherence in patients with OCD.

关键词： patients medication Internal

MicroRNA-99a mimics inhibit M1 macrophage phenotype and adipose tissue inflammation by targeting TNFα

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Cellular & Molecular Immunology 2019年第5期16卷 495-507页

作者： Anant Jaiswal Sukka Santosh Reddy Mohita Maurya Preeti Maurya manoj kumar Barthwal Division of Pharmacology Council of Scientific and Industrial Research-Central Drug Research Institute(CSIR-CDRI)Lucknow 226031 U.P.India Academy of Scientific and Innovative Research New Delhi 110025India

In human adipose tissue and obesity,miR-99a expression is negatively correlated with ***,the present study investigated the role of miR-99a in macrophage phenotype activation and adipose tissue inflammation.M2 BMDMs showed a significant increase in miR-99a expression when compared to the M0 and M1 ***-switching experiments established an association between upregulated miR-99a expression and the M2 *** of miR-99a prevented M1 phenotype activation and attenuated bactericidal ***,knockdown of miR-99a abolished M2 phenotype *** means of in silico target prediction tools and a luciferase reporter assay,TNFαwas identified as a direct target of *** of TNFαrecapitulated the effect of miR-99a overexpression in M1 *** a db/db mice model,miR-99a expression was reduced in eWAT and F4/80+*** overexpression of miR-99a in db/db mice attenuated adipocyte hypertrophy with increased CD301 and reduced CD86 *** cytometry analysis also showed an increased M2 and a reduced M1 macrophage *** of miR-99a also improved the diabetic dyslipidemia and insulin signaling in eWAT and liver,with an attenuated expression of gluconeogenesis and cholesterol metabolism genes in the ***,adoptive transfer of miR-99a-overexpressing macrophages in the db/db mice recapitulated in vivo miR-99a mimic effects with increased M2 and reduced M1 macrophage populations and improved systemic glucose,insulin sensitivity,and insulin signaling in the eWAT and *** present study demonstrates that miR-99a mimics can regulate macrophage M1 phenotype activation by targeting TNFα.miR-99a therapeutics in diabetic mice reduces the adipose tissue inflammation and improves insulin sensitivity.

关键词： inflammation macrophage CD86

An isolated duodenal perforation in pediatric blunt abdominal trauma:a rare but distinct possibility

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Burns & Trauma 2015年第1期3卷 50-53页

作者： Anjan kumar Dhua manoj Joshi Department of Pediatric Surgery Pondicherry Institute of Medical SciencesQuarter E7PIMS Hospital CampusPondicherry 605014India

Isolated duodenal perforation(IDP)in pediatric trauma is rarely *** most of the children with blunt trauma are managed expectantly,timely diagnosis is imperative to avoid morbidity and *** report a case of IDP and emphasize on certain specific clinical features indicating possibility of duodenal *** also stress upon the role of early contrast-enhanced computerized tomography(CECT)in such cases.

关键词： Blunt trauma abdomen Duodenorrhaphy Isolated duodenal perforation Pediatric trauma

Canonic Realizations of Voltage-Controlled Floating Inductors Using CFOAs and Analog Multipliers

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Circuits and Systems 2016年第11期7卷 3617-3625页

作者： Raj Senani Data Ram Bhaskar Munish Prasad tripathi manoj kumar Jain Division of Electronics and Communication Engineering Netaji Subhas Institute of Technology New Delhi India Department of Electronics and Communication Engineering Faculty of Engineering and Technology Jamia Millia Islamia New Delhi India Department of Electrical Engineering Delhi Technological University New Delhi India Department of Electronics and Communication Engineering National Institute of Technology Ashok Rajpath Bihar India Department of Electronics Engineering Institute of Engineering and Technology Lucknow India

New voltage-controlled floating inductors employing CFOAs and an analog multiplier have been presented which have the attractive features of using a canonic number of passive components (only two resistors and a capacitor) and not requiring any component-matching conditions and design constraints for the intended type of inductance realization. The workability and applications of the new circuits have been demonstrated by SPICE simulation and hardware experimental results based upon AD844-type CFOAs and AD633-type/MPY534 type analog multipliers.

关键词： Voltage Controlled Inductors Floating Inductors Inductance Simulation Current Feedback Op-Amps Analog Multipliers Analog Circuits

Designing a Mini-Core Collection Effectively Representing 3004 Diverse Rice Accessions

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Plant Communications 2020年第5期1卷 141-154页

作者： Angad kumar Shivendra kumar Kajol B.M.Singh manoj Prasad Jitendra K.Thakur Plant Mediator Lab National Institute of Plant Genome ResearchAruna Asaf Ali MargNew Delhi 110067India

Genetic diversity provides the foundation for plant breeding and genetic *** 3000 rice genomes were recently sequenced as part of the 3K Rice Genome(3KRG)*** added four additional Indian rice accessions to create a panel of 3004 ***,such a large collection of germplasm is difficult to preserve and *** construction of core and mini-core collections is an efficient method for the management of genetic *** this study,we developed a mini-core comprising 520 accessions that captured most of the SNPs and represented all of the phenotypes and geographic regions from the original *** mini-core was validated using different statistical analyses and contained representatives from all major rice groups,including japonica,indica,aus/boro,and aromatic/*** association analyses of the mini-core panel efficiently reproduced the marker–trait associations identified in the original *** analysis validated the utility of the mini-core *** the current era with many ongoing large-scale sequencing projects,such a strategy for mini-core design should be useful in many *** rice mini-core collection developed in this study would be valuable for agronomic trait evaluation and useful for rice improvement via marker-assisted molecular breeding.

关键词： rice mini-core SNPs GWAS 3KRG agronomic trait

Mechanical Properties and Microstructural Evolution of Bulk UFG Al 2014 Alloy Processed Through Cryorolling and Warm Rolling

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Acta Metallurgica Sinica(English Letters) 2019年第7期32卷 845-856页

作者： manoj kumar Pathak Amit Joshi K. K. S. Mer R. Jayaganthan Department of Mechanical Engineering G. B. Pant Institute of Engineering and Technology Pauri-Garhwal 246194 India Department of Engineering Design. Indian Institute of Technology Madras Chennai 600036 India

Tensile properties, microstructural evolution and fracture toughness of Al 2014 alloy subjected to cryorolling followed by warm rolling (CR + WR) have been investigated in the present study. The solution-treated (ST) Al 2014 alloy is cryorolled followed by warm rolling process at different temperatures (110, 170 and 210 ℃). The mechanical properties and microstructural features of deformed and undeformed Al 2014 alloys were characterised by optical microscopy, transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The CR + WR samples at 170 ℃ showed an improved hardness (179 HV), tensile (UTS 499 MPa, YS 457 MPa) and fracture toughness (KQ = 37.49 MPa y/m, Kee = 37.39 MPa √m and J integral = 33.25 kJ/mm^2) with respect to ST alloy as measured from the tensile and fracture toughness test. The improved mechanical properties of CR + WR alloy are attributed to grain boundary strengthening, combined recovery and recrystallisation, precipitation hardening and dynamic ageing effect during the deformation. The precipitation of metastable spherical phase Al2Cu was responsible for the improved tensile and fracture properties of finegrained Al 2014 alloy observed in the present work.

关键词： Al alloys Ultrafine grains Fracture toughness

Assessment of Genetic Diversity of Drought Tolerant and Susceptible Rice Genotypes Using Microsatellite Markers

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Rice science 2019年第4期26卷 239-247,I0005,I0010-I0014页

作者： Ravindra DONDE Jitendra kumar Gayatri GOUDA manoj kumar GUPTA Mitadru MUKHERJEE Sk Yasin BAKSH Pradosh MAHADANI Khirod kumar SAHOO Lambodar BEHERA Sushanta kumar DASH Crop Improvement Division Indian Council of Agricultural Research-National Rice Research Institute/Formerly-Central Rice Research Institute Cuttack Pin-753006.OdishaIndia Ravenshaw University Department of Biotechnology Cuttack Pin-753003Odisha India Department of Biotechnology & Bioinformatics Yogi Vemana University KadapaPin-516003 OdishaIndia

The introgression of wild chromosomal segments into popular rice varieties is one of the potential approaches for developing varieties for drought stress condition. Sixteen genotypes, including nine indica, two tropical japonica and five chromosome segments substitution lines (CSSLs) with different levels of tolerance/susceptibility to drought stress, were selected for diversity study. Sixty-three microsatellite markers were utilized for assessing genetic diversity. A total of 95 alleles were amplified, and out of them, 60 were polymorphic. Six unique alleles, amplified by the microsatellite loci RM276, RM472, RM488, RM537, RM541 and RM28089, were identified in six genotypes, namely FR13A, Brahamanakhi, RUF44, Swarna-sub1, Brahamanakhi and Satyabhama. The highest genetic similarity was found among CSSLs. Polymorphism information content (PIC) value varied from 0 to 1.00 with an average of 0.66 per locus. Twenty-eight microsatellites were found to be polymorphic, which could be used in marker-assisted selection programme. All the sixteen genotypes were grouped into two major clusters at genetic similarity of 0.64. In the cluster I, five CSSLs identified as diverse genotypes had wild ancestor segments responsible for drought tolerance, and hence they could be utilized as potential donors. The popular Indian varieties, Swarna-sub1 and IR64-sub1, could be used as recurrent parents in the future breeding program for developing varieties for abiotic stresses such as submergence and drought.

关键词： genetic diversity marker-assisted selection microsatellite marker rice drought stress submergence chromosome segment substitution line

Performance assessment of genetic programming(GP)and minimax probability machine regression(MPMR)for prediction of seismic ultrasonic attenuation

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Earthquake Science 2013年第2期26卷 147-150页

作者： manoj kumar Manav Mittal Pijush Samui National Institute of Rock Mechanics Kolar Gold Fields 563117 Karnataka India School of Mechanical and Building Science VIT University Centre for Disaster Mitigation and Management VIT University

The determination of seismic attenuation （s）（dB/cm） is a challenging task in earthquake science. This article employs genetic programming （GP） and minimax probability machine regression （MPMR） for prediction of s. GP is developed based on genetic algo- rithm. MPMR maximizes the minimum probability of future predictions being within some bound of the true regression function. Porosity （n）（%）, permeability （k）（millidarcy）, grain size （d）（μm）, and clay content （c）（%） have been considered as inputs of GP and MPMR. The output of GP and MPMR is s. The developed GP gives an equation for prediction of s. The results of GP and MPMR have been compared with the artificial neural net- work. This article gives robust models based on GP and MPMR for prediction of s.

关键词： Seismic attenuation Geneticprogramming Minimax probability machineregression Artificial neural network Prediction

Evolving utility of exosomes in pancreatic cancer management

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World Journal of Methodology 2023年第3期13卷 46-58页

作者： Thattungal Manoharan Anoop Palash kumar Basu K Chandramohan Ajai Thomas S manoj Department of Medical Oncology Regional Cancer CenterMedical College CampusThiruvananthapuram 695011KeralaIndia Department of Avionics Indian Institute of Space Science&Technology(IIST)Thiruvananthapuram 695547KeralaIndia Surgical Oncology Regional Cancer CenterThiruvananthapuram 695011KeralaIndia

Despite the development of newer oncological treatment,the survival of patients with pancreatic cancer(PC)remains *** studies have identified exosomes as essential mediators of intercellular communications and play a vital role in tumor initiation,metastasis and ***,the utility of liquid biopsies using exosomes in PC management can be used for early detection,diagnosis,monitoring as well as drug delivery vehicles for cancer *** review summarizes the function,and clinical applications of exosomes in cancers as minimally invasive liquid biomarker in diagnostic,prognostic and therapeutic roles.

关键词： Pancreatic cancer Exosomes Biomarker Liquid biopsy Clinical applications Circulating biomarkers

Circulatory and hepatic failure at admission predicts mortality of severe scrub typhus patients: A prospective cohort study

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Asian Pacific Journal of Tropical Medicine 2021年第5期14卷 209-213页

作者： Ashok kumar Pannu Atul Saroch Saurabh Chandrabhan Sharda manoj kumar Debnath Manisha Biswal Navneet Sharma Department of Internal Medicine Postgraduate Institute of Medical Education and ResearchChandigarhIndia Department of Medical Microbiology Postgraduate Institute of Medical Education and ResearchChandigarhIndia

Objective:To study the spectrum and outcome of severe scrub typhus in adult patients and to predict the hospital mortality by organ failure on ***:This was a prospective observational cohort study conducted between July 2017 and October 2020 at the medical emergency centre of PGIMER,Chandigarh,*** hundred and twenty-six patients aged≥13 years were diagnosed with scrub *** disease was defined as the presence of organ failure based on the Sequential Organ Failure Assessment(SOFA)score on ***:About two-thirds of the patients were from geographic regions outside the endemic sub-Himalayan ***(99.21%)and dyspnea(79.36%)were the most frequent *** failure(81.75%)was the most common organ failure,followed by hepatic(52.38%),coagulative(47.62%),circulatory(33.33%),renal(21.43%),and cerebral dysfunction(13.49%).The median(Q1,Q3)SOFA score was 8(6,9),and 48.41%of the patients had a quick-SOFA score≥*** supports with invasive ventilation(40.48%),vasopressors(36.51%),and renal replacement therapy(7.14%)were frequently *** in-hospital mortality was 11.90% and was independently predicted by circulatory and hepatic failures on multivariate logistic regression(OR 11.12,95%CI 1.73-71.31 and OR 8.49,95%CI 1.18-61.41,respectively).Conclusions:Most patients had pulmonary dysfunction;circulatory or hepatic failure on admission strongly predicts death.

关键词： Scrub typhus Orientia tsutsugamushi Organ failure Mortality Prognosis