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Downregulation of TNFR2 decreases survival gene expression,promotes apoptosis and affects the cell cycle of gastric cancer cells

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World Journal of Gastroenterology 2022年第24期28卷 2689-2704页

作者： Ana Flávia Teixeira Rossi Fernanda da silva manoel-Caetano Joice Matos Biselli Ágata silva Cabral Marilia de Freitas Calmon Saiki Marcelo Lima Ribeiro Ana Elizabete silva Department of Biological Sciences Sao Paulo State University(UNESP)São Josédo Rio Preto 15054-000São PauloBrazil Clinical Pharmacology and Gastroenterology Unit São Francisco University(USF)Bragança Paulista 12916-900São PauloBrazil

BACKGROUND Chronic inflammation due to Helicobacter pylori(***)infection promotes gastric *** necrosis factor-α(TNF-α),a key mediator of inflammation,induces cell survival or apoptosis by binding to two receptors(TNFR1 and TNFR2).TNFR1 can induce both survival and apoptosis,while TNFR2 results only in cell *** dysregulation of these processes may contribute to *** To evaluate the effects of TNFR1 and TNFR2 downregulation in AGS cells treated with *** extract on the TNF-α*** AGS cell lines containing TNFR1 and TNFR2 receptors downregulated by specific shRNAs and nonsilenced AGS cells were treated with *** extract for 6 ***,quantitative polymerase chain reaction with TaqMan®assays was used for the relative quantification of the mRNAs(TNFA,TNFR1,TNFR2,TRADD,TRAF2,CFLIP,NFKB1,NFKB2,CASP8,CASP3)and miRNAs(miR-19a,miR-34a,miR-103a,miR-130a,miR-181c)related to the TNF-αsignalling *** cytometry was employed for cell cycle analysis and apoptosis *** In nonsilenced AGS cells,*** extract treatment increased the expression of genes involved in cell survival and inhibited both apoptosis(NFKB1,NFKB2 and CFLIP)and the TNFR1 ***1 downregulation significantly decreased the expression of the TRADD and CFLIP genes,although no change was observed in the cellular process or miRNA *** contrast,TNFR2 downregulation decreased the expression of the TRADD and TRAF2 genes,which are both important downstream mediators of the TNFR1-mediated pathway,as well as that of the NFKB1 and CFLIP genes,while upregulating the expression of miR-19a and ***,a reduction in the number of cells in the G0/G1 phase and an increase in the number of cells in the S phase were observed,as well as the promotion of early *** Our findings mainly highlight the important role of TNFR2 in the TNF-αpathway in gastric cancer,indicating that silencing it can reduce the

关键词： Gastric cancer Helicobacter pylori Tumour necrosis factor-αsignalling pathway TNFR1 TNFR2 miRNAs

Power Curve Modelling for Wind Turbine Using Artificial Intelligence Tools and Pre-established Inference Criteria

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Journal of Modern Power Systems and Clean Energy 2021年第3期9卷 526-533页

作者： Jonata C.de Albuquerque Ronaldo R.B.de Aquino Otoni Nobrega neto Milde M.S.Lira Aida A.Ferreira manoel Afonso de Carvalho Jr. the Department of Electrical Engineering Federal University of PernambucoRecifeBrazil DASE Federal Institute of PernambucoRecifeBrazil

We propose a new way to develop non-parametric models of power curves using artificial intelligence *** parametric model and eight non-parametric models are developed to emulate the behavior described by the power curve of the wind farms.A comparison between the power curve models based on artificial neural networks(ANNs)and those based on fuzzy logic are also *** of the power curve models based on ANNs and fuzzy inference systems(FISs)are used as well as two new FISs with the proposed new *** initial pre-training is proposed,resulting from the characteristics derived from the expert inference followed by a transformation of a fuzzy Mamdani system into a fuzzy Sugeno *** the presented values by the error indicators are comparable,the results show that the new pre-trained FIS models have better precision compared with the ANN and FIS *** comparative study is conducted in two wind farms located in northeastern *** proposed method is a relevant alternative to improve power curve approximation based on an FIS.

关键词： Wind turbine pre-training artificial intelligence artificial neural network(ANN) fuzzy inference system(FIS)

Variation of the Thermal Properties of a Polyurethane-Polyethylene Composite

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Journal of Physical Science and Application 2015年第3期5卷 179-182页

作者： Jacques Cousteau da silva Borges manoel Leonel de Oliveira neto George Santos Marinho Physics Laboratory Instituto Federal de Educ. Ciencia e Tecnologia do Rio Grande do Norte-IFRN. Natal-RN 59015-000 Brazil Laboratory of Heat Transfer Universidade Federal do Rio Grande do Norte-UFRN. Natal-RN 59078-970 Brazil

This paper discusses the behavior of the thermal properties of polymer composites made of a natural polyurethane matrix and loads of different waste of HDPE （High density polyethylene） industry. This polymer is partially crystalline, having amorphous phases and crystalline phases, HDPE type is harder and tougher than other polyethylenes, having a wide range of applications that depend almost exclusively on the processes for obtaining final products. After the process, waste from the manufacture of these products are discarded daily as they are not found effective ways to use this material. In this study we seek to use this ＂factory floor＂ to act as filler in a polyurethane matrix derived from the castor oil, which is a natural biodegradable. The residue loads were separated according to the process that originated in this way have been the A residue from the process of cork and the B residue derived from the extrusion process. Specimens in mass proportions of 10%, 20% and 30% polyethylene both loads were prepared and their thermal properties were mediated, these being the thermal conductivity （k）, specific heat （c） and thermal diffusivity （~）. By adding such fillers to castor polyurethane matrix, different behaviors were observed, because of the residue contributed to a reduction in conductivity and specific heat of the composite material. Since the residue B on average 47% higher than residue, caused an increase in these same properties as before the spaces filled with air only into the polyurethane are now filled with polyethylene grains. We can see then that the particle size of the HDPE waste has a direct influence on the improvement of the thermal properties of the analyzed composite material.

关键词： Thermal properties polyethylene polyurethane reutilization.

The Difference of the Impact of Elective Cholecystectomy Surgery in the Immune Response

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Surgical Science 2018年第8期9卷 243-247页

作者： Rosamaria Rodrigues Gomes manoel Messias Lima neto Ayrton silva Alves Cristiane Monteiro da Cruz Medical School Centro Universitário Cesmac Maceió Brazil

Introduction: The inflammatory response is essential to initiate the healing process, and in this response there is an increase in white blood cells and pro-inflammatory compounds. Creactive proteins (CRP), together with the blood leukocyte count, have been used to study the immune response. Due to the risk of infection and exacerbated inflammatory response of the patients undergoing surgical procedure, it is relevant to investigate the pre and postoperative inflammatory response of those individuals. Objective: To determine the difference in the impact of elective cholecystectomy surgery on the patient’s immune response. Methods: The present study was cross-sectional, where a group included patients who underwent elective cholecystectomy procedure. Patients who were pregnant, under 18 years, of indigenous communities or with other conditions that depress the immune system, as well as those on immunosuppressive medications, were excluded. Results: CRP and leukocyte counts indicated a mean increase of 5.97-fold (95% CI 3.76 to 8.34, SD 6.98) and 1.97-fold (95% CI 1.71 to 2.24, SD 1.97) respectively, both being evaluated before and after surgery. Discussion: In the present study, to avoid a possible methodological bias, it was chosen to evaluate the patients submitted to videolaparoscopic cholecystectomy only and the hypothesis was confirmed that there is an increase in CRP and leukocyte count as a response to surgical trauma. Conclusion: There was an elevation of the inflammatory markers in patients submitted to surgical trauma when comparing the exams collected in the preoperative period and after the surgical aggression.

关键词： Cholecystectomy Inflammation Leukocytes C-Reactive Protein

The influence of soil on vegetation structure and plant diversity in different tropical savannic and forest habitats

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Journal of Plant Ecology 2018年第2期11卷 226-236页

作者： Priscyla Maria silva Rodrigues Carlos Ernesto Gonçalves Reynaud Schaefer Jhonathan de Oliveira silva Walnir Gomes Ferreira Júnior Rubens manoel dos Santos Andreza Viana Neri Universidade Federal do Vale do São Francisco Campus Senhor do BonfimColegiado de EcologiaAv.Tomaz GuimarãesS/NBairro Santos DumontSenhor do BonfimBACEP 48.970-000Brazil Universidade Federal de Viçosa Departamento de SolosCampus UniversitárioViçosaMGCEP 36570-900Brazil Instituto Federal de Educação Ciência e Tecnologia do Sul de Minas GeraisRodovia Machado-ParaguaçuKm 3MachadoMGCEP 37750-000Brazil Universidade Federal de Lavras Departamento de Ciências FlorestaisLaboratório de Conservação e Manejo da BiodiversidadeCampus UniversitárioLavrasMGCEP 37200-000Brazil Universidade Federal de Viçosa Departamento de Biologia VegetalLaboratório de Ecologia e Evolução de PlantasCampus UniversitárioViçosaMGCEP 36570-900Brazil

Aims Soil plays an important role in the formation and heterogene-ity of habitats and thus can cause changes in vegetation struc-ture and plant *** differentiation between Cerrado/savanna and forest is well known,but the relationship between soil and habitats from savannic or forest formations still needs to be better understood,particularly in tropical ecotonal *** studied the association between attributes of plant com-munities,namely structure and diversity,and physicochemical characteristics of soils in the Caatinga domain at the transition to Cerrado in *** Chemical and physical analyses of soils were performed in samples of 38 plots from savannic formations and 30 plots from forest *** was characterized floristically and structurally in all plots,five habitats being assessed in each plant *** features and vegetation parameters were highly distinct among the different *** Findingsin general,forest habitats were more nutrient rich than savannic ***,soil variables showed effects both on vegetation structure and on its species diversity,more pronouncedly in the savannic *** were structurally distinct,and diversity differed between savannic and forest communities;however,a higher differentiation occurred when the savannic formation habitats were compared among *** plant diversity did not differ among forest formation habitats,soil attributes showed a close relationship with edaphic factors and can contribute for similar *** soil-vegetation relationship in highly diverse ecotonal landscapes is important from the conservation biology point of view and aid in the execution of proactive plans for the maintenance of ***,we noticed that diversity and soil behaves distinctly between savannic and forest communities.

关键词： Cerrado dry forest edaphic variation vegetation-soil relationship ecotone

Diversity of the Formicidae (Hymenoptera) carrion communities in Lisbon (Portugal): preliminary approach as seasonal and geographic indicators

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Forensic Sciences Research 2018年第1期3卷 65-73页

作者： António neto-silva Ricardo Jorge Dinis-Oliveira Catarina Prado e Castro Department of Public Health Forensic Sciences and Medical EducationFaculty of MedicineUniversity of PortoPortoPortugal Department of Sciences IINFACTS-Institute of Research and Advanced Training in Health Sciences and TechnologiesUniversity Institute of Health Sciences(IUCS)CESPUCRLGandraPortugal UCIBIO REQUIMTE-Laboratory of ToxicologyDepartment of Biological SciencesFaculty of PharmacyUniversity of PortoPortoPortugal Department of Life Sciences Centre for Functional EcologyUniversity of CoimbraCoimbraPortugal

The value of the Formicidae (Insecta,Hymenoptera) community in forensic investigations is poorly studied in *** order to better understand the structure and dynamics of this group of insects in cadavers and their putative value in forensic investigations,studies were carried out in Lisbon area during one *** carcasses were used as a model of human *** entomofauna attracted to the carcasses was collected over a period of about 2 months in each season of the *** collection of ants was performed at regular intervals,daily in the first 23 days and then with intervals of 2,3 or 5 days until the end of the *** stages of cadaveric decomposition were recognized with the ants being present in all of *** hundred and nine specimens were captured: 7 in autumn,6 in winter,90 in spring and 206 in *** specimens belong to three subfamilies and seven different *** of them had never been mentioned before as being associated to cadavers in this geographical *** and summer had the greater diversity of species and a larger number of *** luteus was the dominant species in spring and Tapinoma nigerrimum in *** the information of other similar studies carried out in the Iberian Peninsula,the sarcosaprophagous Formicidae community found in Lisbon is unique and different from other studied locations,which supports the need to perform regional *** results shown that ants do not present a definite pattern of succession,but some species have the potential to be seasonal or geographic indicators.

关键词： Forensic science forensic entomology Formicidae sarcosaprophagous community decomposition process postmortem interval seasonal study

Bariatric endoscopy: treatment of obesity and bariatric surgery complications

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中华肥胖与代谢病电子杂志 2016年第4期2卷 185-190页

作者： Natan Zundel Josemberg Marins Campos Lyz Bezerra silva Maíra Gomes manoel Galvao neto Department of Surgery Florida International University USA Department of Surgery Federal University of Pernambuco Brazil

The fast increase in the number of patients undergoing bariatric surgery has led to the emergence of bariatric endoscopy as a therapeutic interface for minimally invasive treatment of complications. These techniques have the potential to be safer, reversible and cost-effective, with decreased morbidity, because of their less invasive nature.

关键词： Bariatric endoscopy Treatment of obesity Complication

CFD predictions for hazardous area classification

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Chinese Journal of Chemical Engineering 2019年第1期27卷 21-31页

作者： Andrey Oliveira de Souza Aurélio Moreira Luiz Ant?nio Tavernard Pereira neto Ant?nio Carlos Brandao de Araujo Heleno Bispo da silva Sidinei Kebler da silva Jose Jailson Nicacio Alves Federal Institute of Education Science and Technology of Paraiba Petrobras-Petróleo Brasileiro S.A. Federal University of Campina Grande

This study aimed to describe a Computational Fluid Dynamics(CFD) procedure using the ANSYS CFX software 16.1 and Design of Experiments for the determination of volume and extension of explosive atmospheres due to fugitive emissions of flammable *** multidimensional statistical sampling technique Latin Hypercube was used, which defined 100 simulations of random methane gas leak *** CFD model proved to be robust in predicting the extension and volume of the explosive atmosphere for orifice diameters from 0.1 to2.5 mm, pressure from 0.1 MPa to 12 MPa and temperatures from 0 ℃ to 400 ℃.It was found that the calculation domain must be parameterized 8 m in length for each millimeter of the diameter of the source of release to ensure the *** order not to lose precision for very small diameters, the mesh was parameterized with 50 elements along the orifice *** was proved that gravity does not influence the extension and volume of the explosive atmosphere at sonic *** deviation from the ideal gas behavior in the reservoir,achieved by applying the Soave–Redlich–Kwong equation of state, also has not significantly influenced the extension and volume of the explosive *** results showed that the size of the explosive atmosphere varies directly with the diameter of the source emission and reservoir pressure, and inversely with the temperature of the *** diameter of the source is the parameter that has the major effect on the extension of the explosive atmosphere, followed by the pressure and lastly the temperature of the reservoir.

关键词： Computational Fluid Dynamics Computer simulation Safety Fugitive emissions Classified area Flammable gas cloud

Encephalic hemodynamic phases in subarachnoid hemorrhage:how to improve the protective effect in patient prognoses

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Neural Regeneration Research 2015年第5期10卷 748-752页

作者： Marcelo de Lima Oliveira Daniel silva de Azevedo Milena Krajnyk de Azevedo Ricardo de Carvalho Nogueira manoel Jacobsen Teixeira Edson Bor-Seng-Shu Division of Neurological Surgery Hospital das ClinicasSchool of MedicineUniversity of Sao Paulo

Subarachnoid hemorrhage is frequently associated with poor prognoses. Three different hemo- dynamic phases were identified during subarachnoid hemorrhage： oligemia, hyperemia, and vasospasm. Each phase is associated with brain metabolic changes. In this review, we correlated the hemodynamic phases with brain metabolism and potential treatment options in the hopes of improving patient prognoses.

关键词： hemodynamic phases cerebral subarachnoid hemorrhage metabolic crises