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Quality of Drugs Based on Ferrous Sulfate Dispensed in a Basic Health and Commercial Pharmacy in a City in the Amazon Region

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Pharmacology & Pharmacy 2022年第9期13卷 331-339页

作者： Amanda Gabryelle Nunes Cardoso Mello Marceonia Costa dos Santos Ana Gabriela Lisboa Santos danila Teresa Valeriano Alves daniella Paternostro de Araújo Grisolia Alan Barroso Araújo Grisólia Mariceli Baia Leão Barros Fabrícia de Jesus Paiva da Fonseca manoel samuel da cruz neto Faculty of Pharmacy FIBRA University Center Belém Brazil Faculty of Biotechnology Federal University of Pará Belém Brazil Biological Sciences Center Federal University of Pará Belém Brazil FACI WYDEN Faculty Belém Brazil

Background: For the WHO, anemia is a serious public health problem, with an emphasis on deprivation anemia, which has socioeconomic conditions as determining factors for its development. Among nutritional anemias, the most relevant is iron deficiency, whose main form of prevention and treatment is supplementation with ferrous sulfate dispensed in the public health system, with the need to periodically check whether the drug has the quality required by regulatory health agencies. Thus, the objective of this study was to analyze the quality of the ferrous sulfate medication, from the same laboratory, and dispensed in a basic health unit (BHU) and a commercial pharmacy (CF). Materials and Methods: An analytical, qualitative and quantitative study of ferrous sulfate heptahydrate (25 mg/mL in 100 mL syrup), carried out on 20 BHU and 10 from CF, both from the same laboratory, but in different batches. Samples were subjected to organoleptic analysis and verification of iron content, pH, volume and density. data were compared with values recommended by the Brazilian pharmacopoeia 5th edition. Results: Three batches were evaluated: 4659 of from the CF;4574 from the BHU1, and 4576 from the BHU2, stored in accordance with RDC 304/19 of ANVISA. All showed compliance with some organoleptic characteristics;and stable values in pH (3.61 - CF;3.67 - BHU1;3.65 - BHU2), density (1.079 - CF;1.088 - BHU1;1.086 - BHU2) and individual volume (not less than 95% of the declared value). However, it was not possible to detect the odor of herbs;the average volume of batch BHU1 was below the declared value, and the iron content of both BHUs was above the maximum value of pharmacopoeia standards. Conclusion: Samples did not show full compliance with the physical and chemical parameters evaluated, suggesting deviation in the quality of the medication.

关键词： Physical and Chemical Quality Control Ferrous Sulfate Heptahydrate Syrup

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Effect of drug therapies on self-reported chemosensory outcomes after COVID-19

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 88-96页

作者： Marco A.Fornazieri Bruno M.Cunha samuel P.Nicácio Lucas K.Anzolin JoséL.B.da Silva Aristides Fernandes neto Deusdedit Brandão neto Richard L.Voegels Fábio D.R.Pinna Department of Surgery Londrina State UniversityLondrinaBrazil Department of Medicine Pontifical Catholic University of ParanáLondrinaBrazil Department of Otorhinolaryngology University of São PauloSao PauloBrazil Department of Otorhinolaryngology:Head and Neck Surgery Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:The aim of this study was to assess the relative efficacy of medications used following severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection on self-reported alterations in taste and/or smell ***:Seven hundred and fourteen persons with self-reported postcoronavirus disease 2019(post-COVID-19)chemosensory disorders were personally interviewed regarding specific medications they were administered following the acute phase of the *** dependent measure—self-reported total recovery of chemosensory symptoms—was subjected to stepwise logistic *** predictors included demographic and clinical variables,in addition to specific medications used to mitigate disease symptoms(i.e.,systemic corticosteroids,oseltamivir,vitamin C,ibuprofen,hydroxychloroquine,azithromycin,ivermectin,nitazoxanide,anticoagulants,and zinc).Results:The median time between COVID-19 symptom onset and the interviews was 81 days(interquartile range:60-104).Of the 714 subjects,249(34.9%)reported total recovery of their chemosensory function;437(61.2%)had at least one treatment since the beginning of the *** and those with more comorbidities had undergone more *** recovery rates of the treated and nontreated groups did not differ ***,respondents who had used nitazoxanide tended to have a higher rate of self-reported taste or smell *** who took oral zinc were less likely to ***:No medication employed during the first months after SARS-CoV-2 infection had a clear positive effect on returning self-reported smell or taste function to normal,although nitrazoxide trended in a positive *** zinc had a negative effect on the reported recovery of these senses.

关键词： chemosensory disorder coronavirus infections COVID-19 drug therapy SARS-CoV-2 smell loss taste loss

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The Difference of the Impact of Elective Cholecystectomy Surgery in the Immune Response

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Surgical Science 2018年第8期9卷 243-247页

作者： Rosamaria Rodrigues Gomes manoel Messias Lima neto Ayrton Silva Alves Cristiane Monteiro da cruz Medical School Centro Universitário Cesmac Maceió Brazil

Introduction: The inflammatory response is essential to initiate the healing process, and in this response there is an increase in white blood cells and pro-inflammatory compounds. Creactive proteins (CRP), together with the blood leukocyte count, have been used to study the immune response. Due to the risk of infection and exacerbated inflammatory response of the patients undergoing surgical procedure, it is relevant to investigate the pre and postoperative inflammatory response of those individuals. Objective: To determine the difference in the impact of elective cholecystectomy surgery on the patient’s immune response. Methods: The present study was cross-sectional, where a group included patients who underwent elective cholecystectomy procedure. Patients who were pregnant, under 18 years, of indigenous communities or with other conditions that depress the immune system, as well as those on immunosuppressive medications, were excluded. Results: CRP and leukocyte counts indicated a mean increase of 5.97-fold (95% CI 3.76 to 8.34, SD 6.98) and 1.97-fold (95% CI 1.71 to 2.24, SD 1.97) respectively, both being evaluated before and after surgery. Discussion: In the present study, to avoid a possible methodological bias, it was chosen to evaluate the patients submitted to videolaparoscopic cholecystectomy only and the hypothesis was confirmed that there is an increase in CRP and leukocyte count as a response to surgical trauma. Conclusion: There was an elevation of the inflammatory markers in patients submitted to surgical trauma when comparing the exams collected in the preoperative period and after the surgical aggression.

关键词： Cholecystectomy Inflammation Leukocytes C-Reactive Protein

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Endoscopic sleeve gastroplasty:a narrative review on historical evolution,physiology,outcomes,and future standpoints

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Chinese Medical Journal 2022年第7期135卷 774-778页

作者： Vitor Ottoboni Brunaldi manoel Galvao neto Center for Digestive Endoscopy Surgery and Anatomy DepartmentRibeirão Preto Faculty of MedicineUniversity of São Paulo14015-010 Ribeirão PretoBrazil Endovitta Institute 04102-001 São PauloBrazil ABC Faculty of Medicine 09060-870 Santo AndreBrazil

Since its first description in 2013,robust evidence supporting the efficacy and safety of the endoscopic sleeve gastroplasty(ESG)has been on the rise.A large case series and meta-analysis report supported results up to 24 months,while some other studies already described 5-year *** associated with pharmacotherapy,the ESG may help one to achieve weight loss similar to that of surgical sleeve *** the results of the ongoing randomized trials on ESG are awaited,currently available data support the clinical use of the ESG,especially for patients who are refusing or unfit for bariatric surgery.

关键词： Endoscopy Bariatric Obesity Overweight Sleeve Suturing

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Classification of the Juturnaíba dam: Potential Risk and damage

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Journal of Water Resource and Protection 2018年第1期10卷 1-19页

作者： Monica de Aquino Galeano da Hora Rocha manoel Isidro de Miranda neto Master’s Program in Civil Defense and Security Fluminense Federal University Niteroi Rio de Janeiro Brazil

A dam Safety Program aims to reduce the risks to human life, property, and the environment from dam related hazards. In Brazil, despite of the contemporary law about dam safety, there is still no cadastral information nor the classification of risk and associated potential damage to all dams. Besides that, the recent disaster caused by the failure of the Fund?o dam, located in Mariana city, Minas Gerais State, is an issue that aggravates the urgency of preventive measures and plans for disaster action. The present study proposes to classify the Juturnaíba dam, which maintains the largest reservoir for water supply in the state of Rio de Janeiro, Southeast region of Brazil. It was sought to analyze the risks and potential damage associated with the dam, in accordance with two classifications: one from the Brazilian dams Committee and the other from the National Water Resources Council. It was possible to conclude that the Juturnaíba dam potentially presents high risk and associated high rates of damage, both regarding losses of human lives and regarding environmental and socioeconomic impacts. This is mainly due to the poor state of conservation that it currently presents. It is recommended that future studies should assess the slope stability of the earth dam, and that repair work should be implemented on the degraded concrete structures, with recuperation or installation of instruments that would enable monitoring of possible movement of the earth dam.

关键词： dam Safety Disaster Hydrology

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Measurement Module for Young for Thermal Insulation Composite Polymeric

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Journal of Mechanics Engineering and Automation 2014年第12期4卷 969-974页

作者： Jacques Cousteau da Silva Borges manoel Leonel de Oliveira neto George Santos Marinho Physics Laboratory IFRN (Instituto Federal de Educ. Cieneia e Teenologia do Rio Grande do Norte) Natal-RN 59015-000 Brazil Laboratory of Heat Transfer UFRN (Universidade Federal do Rio Grande do Norte) Natal-RN 59078-970 Brazil

To analyze the feasibility of application of composite material as the insulating material, it is necessary to have knowledge of some of its mechanical properties. An insulating material may suffer from the most different efforts, but the major applications suggest mechanical bending and compression tests because the insulation can be applied on roofs of homes, liners similar to, in the form of plates. Thus, the product is continually flexed. When the material is used on a floor, it suffers constant compressions over its use. For tests performed in this study, we used the ASTM D695-96 for compression, an example of literature. Using such a standard test, specimens were produced for compression test, with specimens made of cylindrical shapes, respecting the condition that the height of the specimen corresponds to twice the diameter of the base. Polyurethane castor without charge vermiculite and mass loads of 10%, 15% and 20% matrix： four specimens for each type of material were produced. The composites were tested in a universal testing machine at a speed of 2 mm/s. The results are average values of four test samples, and initially show the behavior of castor oil polyurethane during the compression test, which is detailed in the stress versus strain curve. The achieved results are promising, and detailed in this paper.

关键词： Thermal properties mechanical properties composite polymeric.

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Power Curve Modelling for Wind Turbine Using Artificial Intelligence Tools and Pre-established Inference Criteria

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Journal of Modern Power Systems and Clean Energy 2021年第3期9卷 526-533页

作者： Jonata C.de Albuquerque Ronaldo R.B.de Aquino Otoni Nobrega neto Milde M.S.Lira Aida A.Ferreira manoel Afonso de Carvalho Jr. the Department of Electrical Engineering Federal University of PernambucoRecifeBrazil daSE Federal Institute of PernambucoRecifeBrazil

We propose a new way to develop non-parametric models of power curves using artificial intelligence *** parametric model and eight non-parametric models are developed to emulate the behavior described by the power curve of the wind farms.A comparison between the power curve models based on artificial neural networks(ANNs)and those based on fuzzy logic are also *** of the power curve models based on ANNs and fuzzy inference systems(FISs)are used as well as two new FISs with the proposed new *** initial pre-training is proposed,resulting from the characteristics derived from the expert inference followed by a transformation of a fuzzy Mamdani system into a fuzzy Sugeno *** the presented values by the error indicators are comparable,the results show that the new pre-trained FIS models have better precision compared with the ANN and FIS *** comparative study is conducted in two wind farms located in northeastern *** proposed method is a relevant alternative to improve power curve approximation based on an FIS.

关键词： Wind turbine pre-training artificial intelligence artificial neural network(ANN) fuzzy inference system(FIS)

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Variation of the Thermal Properties of a Polyurethane-Polyethylene Composite

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Journal of Physical Science and Application 2015年第3期5卷 179-182页

作者： Jacques Cousteau da Silva Borges manoel Leonel de Oliveira neto George Santos Marinho Physics Laboratory Instituto Federal de Educ. Ciencia e Tecnologia do Rio Grande do Norte-IFRN. Natal-RN 59015-000 Brazil Laboratory of Heat Transfer Universidade Federal do Rio Grande do Norte-UFRN. Natal-RN 59078-970 Brazil

This paper discusses the behavior of the thermal properties of polymer composites made of a natural polyurethane matrix and loads of different waste of HDPE （High density polyethylene） industry. This polymer is partially crystalline, having amorphous phases and crystalline phases, HDPE type is harder and tougher than other polyethylenes, having a wide range of applications that depend almost exclusively on the processes for obtaining final products. After the process, waste from the manufacture of these products are discarded daily as they are not found effective ways to use this material. In this study we seek to use this ＂factory floor＂ to act as filler in a polyurethane matrix derived from the castor oil, which is a natural biodegradable. The residue loads were separated according to the process that originated in this way have been the A residue from the process of cork and the B residue derived from the extrusion process. Specimens in mass proportions of 10%, 20% and 30% polyethylene both loads were prepared and their thermal properties were mediated, these being the thermal conductivity （k）, specific heat （c） and thermal diffusivity （~）. By adding such fillers to castor polyurethane matrix, different behaviors were observed, because of the residue contributed to a reduction in conductivity and specific heat of the composite material. Since the residue B on average 47% higher than residue, caused an increase in these same properties as before the spaces filled with air only into the polyurethane are now filled with polyethylene grains. We can see then that the particle size of the HDPE waste has a direct influence on the improvement of the thermal properties of the analyzed composite material.

关键词： Thermal properties polyethylene polyurethane reutilization.

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Ecophysiology and multivariate analysis for production of Tachigali vulgaris in Brazil:Influence of rainfall seasonality and fertilization

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林业研究:英文版 2023年第5期34卷 1289-1305页

作者： Pedro Henrique Oliveira Simoes Candido Ferreira de Oliveira neto manoel Tavares de Paula Dênmora Gomes de Araújo Rodrigo Silva do Vale Joao Olegário Pereira de Carvalho Universidade Federal de Mato Grosso Campus Universitario de SinopSinop 78550728Mato GrossoBrazil Universidade Federal Rural da Amazonia Campus BelemBelem 66077830ParaBrazil Universidade do Estado do Para Centro de Ciencias Naturais e TecnologiaBelem 66095015ParaBrazil Universidade Federal Rural da Amazonia Campus Capitao-PocoCapitao Poco 68650000ParaBrazil

Studies on fertilization management of species native to the Amazon for energy plantations contribute to the diversity of species use and reduce biological risk due to the excessive use of clones or hybrids of *** study evaluates the effect of precipitation seasonality and phosphorus and potassium fertilization on gas exchange in a Tachigali vulgaris *** levels of P(zero,65.2,130.4 kg ha^(-1))and three of K(zero,100.0,200.0 kg ha^(-1))were applied in a 3×3 factorial randomized block *** exchange measurements were conducted in April and November *** low rainfall,high irradiance period,photo synthetic rates were up to four times higher than in the high rainfall period,reaching 20.3μmol m^(-2)s^(-1)in the treatment with 130.4 g kg^(-1)of P and 100.0 g kg^(-1)of *** analysis and principal component analysis reduced the initial eight gas exchange variables to two and three principal components in periods of high and low rainfall,*** multivariate method used in this study readily identified variations in the variables as a function of rainfall,with high reliability in explaining the data set.

关键词： Photosynthesis rate Stomatal conductance Principal component analysis Factor analysis Tachigali vulgaris

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Physicians and Conflicts of Interest

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International Journal of Clinical Medicine 2014年第16期5卷 956-965页

作者： Deborah Pimentel Maria-Jesia Vieira Joao Pedro Declerc FSNeves manoel Juvenal da Costa-neto Lais Costa Souza Oliveira Department of Medicine Universidade Federal de SergipeAracajuBrazil Universidade Tiradentes AracajuBrazil Postgraduate Program in Health Sciences Universidade Federal de SergipeAracajuBrazil Universidade Federal de Sergipe AracajuBrazil

In medical practice, the most commonly observed conflicts of interest are the ones existing in the relations between professionals and industries linked to health or between the former and health services. These relations are no longer a partnership in search of the best to be offered to patients and tend to take up a commercial role, in a seduction game where, each one, in their own manner, seeks benefits. The purpose of this study is to analyze the existence of these conflicts of interest, in an exploratory and qualitative study, with physician focal groups. The results were grouped in two categories: benefits received by physicians and the justifications provided by them for the establishment of these partnerships. The most common benefits are: percentages over orthoses and prosthetics received by the industry;discounts and credits on rent or condominium fees for exam indications and procedures;rewards offered by the pharmaceutical industry for the indication of their products. Physicians have pointed out as main determinants for ethical missteps that involve conflicts of interest, the character and family formation as well as the lack of denunciations. The fact that efficient and widespread laws for resolution of conflicts of interest do not exist makes it necessary to recognize their existence with mechanisms of management and transparency, perhaps as the only way to avoid negative interference in physician behavior.

关键词： Ethics Physicians Conflicts of Interest

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