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世界核心医学期刊文摘（胃肠病学分册） 2005年第4期1卷 10-11页

作者： mannon p.j. Fuss I.j. Mayer L. 郝筱倩 Mucosal Immunity Secti on Laboratory of Host Defense Natl. Inst. of Allerg./Infect. Dis. 10 Center D r. Bethesda MD 20892 United StatesDr.

BACKGROUND:Crohn’s disease is associated with excess cytokine activity mediated by type 1 helper T (Th1) cells. Interleukin-12 is a key cytokine that initiates Th1-mediated inflammatory responses. METHODS: This double-blind trial evaluated the safety and efficacy of a human monoclonal antibody against interleukin-12 (anti-interleukin-12) in 79 patients with active Crohn’s disease. patients were randomly assigned to receive seven weekly subcutaneous injections of 1 mg or 3 mg of anti-interleukin-12 per kilogram of body weight or placebo, with either a four week interval between the first and second injection (Cohort 1) or no interruption between the two injections (Cohort 2). Safety was the primar y end point, and the rates of clinical response (defined by a reduction in the s core for the Crohn’s Disease Activity Index [AI] of at least 100 points) and re mission (defined by a CDAI score of 150 or less) were secondary end points. RESU LTS: Seven weeks of uninterrupted treatment with 3 mg of anti interleukin-12 p er kilogram resulted in higher response rates than did placebo administration (7 5 percent vs. 25 percent, p=0.03). At 18 weeks of follow up, the difference in response rates was no longer significant (69 percent vs. 25 percent, p=0.08). Di fferences in remission rates between the group given 3 mg of anti in terleukin -12 per kilogram and the placebo group in Cohort 2 were not significant at eith er the end of treatment or the end of follow up (38 percent and 0 percent, resp ectively, at both times; p=0.07). There were no significant differences in respo nse rates among the groups in Cohort 1. The rates of adverse events among patien ts receiving anti interleukin-12 were similar to those among patients given pl acebo, except for a higher rate of local reactions at injection sites in the for mer group. Decreases in the secretion of interleukin-12, interferon γ, and tu mor necrosis factor α.by mononuclear cells of the colonic lamina propria accomp anied clinica

关键词：克罗恩病治疗活动肠黏膜固有层细胞因子次要终点安慰剂双盲试验细胞介导间隔期活动指数

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Transient pressure Behavior of a Well Located between a Constant pressure Boundary and a Sealing Fault

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Natural Resources 2017年第10期8卷 646-656页

作者： R. Trabelsi F. Boukadi A. Seibi D. Allen F. Sebring T. mannon H. Trabelsi University of Louisiana Lafayette USA

pressure transient analysis has been used to evaluate performance of a well located between one sealing fault and one constant pressure boundary. Type curves were generated by determining 1) dimensionless pressure and 2) rate of change of dimensionless pressure drop with respect to dimensionless time. When the well is located closer to the no flow boundary, both sets of type curves have three distinct slopes. These slopes characterize: 1) flow in an infinite reservoir, 2) presence of the no flow, and 3) the constant-pressure boundaries. When the well is closer to the constant pressure boundary, the type curves show two distinct slopes. These correspond to: 1) flow in an infinite reservoir, and 2) the presence of a constant pressure boundary. The type curves can be used to match actual pressure drawdown data and determine the drainage area and relative well location with respect to physical boundaries.

关键词： pressure Transient principle of Superposition Infinite Reservoir No Flow Boundary Constant pressure Boundary Drawdown Drainage Area

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