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Journal of Energy Chemistry 2023年第3期78卷 283-293,I0009页

作者： Cheng Tang manni li Yaling Wang Yan Zhang Yinzhuo Yao Guolong Wang Jiamei liu Lei li State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049ShaanxiChina State Key Laboratory of Electrical Insulation and Power Equipment Xi’an Jiaotong UniversityXi’an 710049ShaanxiChina Instrument Analysis Center of Xi’an Jiaotong University Xi’an Jiaotong UniversityXi’an 710049ShaanxiChina

The advance of microelectronics requires the micropower of microsupercapacitors(MSCs) to possess wide temperature-and damage-tolerance beyond high areal energy density.The properties of electrolyte are crucial for MSCs to meet the above requirements.Here,an organohydrogel electrolyte,featured with high salt tolerance,ultralow freezing point,and strong self-healing ability,is experimentally realized via modulating its inner dynamic bonds.Spectroscopic and theoretical analysis reveal that dimethyl sulfoxide has the ability to reconstruct li^(+)solvation structure,and interact with free water and polyvinyl alcohol chains via forming hydrogen bonds.The organohydrogel electrolyte is employed to build MSCs,which show a boosted energy density,promising wide temperature range-and damage-tolerant ability.These attractive features make the designed organohydrogel electrolyte have great potential to advance MSCs.

关键词： Microsupercapacitor Organohydrogel Salt tolerance Anti-freezing Self-healing

Electrode structure enabling dendrite inhibition for high cycle stability quasi-solid-state lithium metal batteries

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Journal of Energy Chemistry 2023年第4期79卷 232-241页

作者： Kaiming Wang Ao Yu Zhiyi Zhou Fei Shen manni li liang Zhang Weichang Guo Yifei Chen Le Shi Xiaogang Han State Key Laboratory of Electrical Insulation and Power Equipment School of Electrical EngineeringXi’an Jiaotong UniversityXi’an 710049ShaanxiChina School of Future Technology Xi’an Jiaotong UniversityXi’an 710049ShaanxiChina National Innovation Platform(Center)for Industry-Education Integration of Energy Storage Technology Xi’an 710049ShaanxiChina

lithium(li)metal batteries(LMBs)are widely regarded as the ultimate choice for the next generation of high-energy–density batteries.However,the uncontrollable growth of li dendrites formed by inhomogeneous deposition seriously hinders its commercialization.Although many studies have achieved significant results in inhibiting the formation of li dendrites,it is still impossible to eradicate them completely.Therefore,regulating the deposition behavior,such as the growth direction of unevenly deposited li,is preferable to unilaterally suppressing them in some cases.Here we report a structured anode that can confine the deposited li within holes and tune it to become vertical-up/horizontal-centripetal mixed growth mode by optimizing the electric field/li^(+)concentration gradient.The li^(+) adsorbed by the poly(amic acid)(PAA)insulating layer coated on the anode surface can form the li^(+)concentration gradient pointing to the center of the hole.Combined with the special electric field formed by the hole structure,it is favorable for the li^(+)to move into the vertically arrayed holes and simultaneously deposit on the bottom and walls.Furthermore,both in-situ and ex-situ observations confirm that the growth mode is changed and the li deposition morphology is denser,which can greatly delay capacity fading and prolong cycle life in both liquid and quasi-solid-state LMBs.All the results show that the novel anode provides a new perspective for deep research into solid-state LMBs.

关键词： lithium metal batteries Structured anode Deposition behavior Quasi-solid-state

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技术转移与企业高质量创新

世界经济 2024年第3期47卷 66-93页

作者：郑曼妮黎文靖谭有超华南师范大学经济与管理学院暨南大学管理学院 510632

技术转移是科技创新的重要环节,企业具备承接科技成果的能力是创新驱动新旧动能转换的前提。本文基于国家技术转移中心设立事件,采用多期双重差分模型研究发现,在区域中心设立后,企业通过技术溢出、研发投入及研发补助等机制增加了发明... 详细信息

技术转移是科技创新的重要环节,企业具备承接科技成果的能力是创新驱动新旧动能转换的前提。本文基于国家技术转移中心设立事件,采用多期双重差分模型研究发现,在区域中心设立后,企业通过技术溢出、研发投入及研发补助等机制增加了发明专利申请和被引数量。技术合同交易额和技术交流交易活动较多、市场化程度较高地区,技术转移对企业创新的影响显著增强。技术转移推动了基础研发能力较强企业的创新,而企业实现高质量创新的前提是具备基础研发能力。“倍风而驰,易以远”,企业可借助技术转移的东风实现高质量创新。本文丰富了技术市场与科技创新文献,为完善技术转移机制以助力企业创新的议题提供了政策启示。

关键词：企业创新技术转移国家技术转移中心技术溢出

Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.Cheng Carolyn A.Cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet Chung Tsun Ming Lau manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo C.H.Tsang Sara Chaothai Tsz Chun Kwan John K.C.li Karl C.K.Chan Leo L.H.Luk Jenson C.H.Ho Wing Yan li Amos M.T.Lee Jennifer H.Y.Lam Sau Man Chan Wilfred H.S.Wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is necessary.Fractional dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the full dose is unknown.This study(NCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in adolescents.Methods Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days later.Humoral and cellular immunogenicity outcomes were measured post-dose 2(IM-CC versus ID-CC)and post-dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,respectively.Results Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+CD4+,SNM-specific IL-2+CD8+,S-specific IL-2+CD8+,N-specific IL-2+CD4+,N-specific IL-2+CD8+and M-specific IL-2+CD4+responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC,whereas IgG avidity was inferior.For ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2+CD4+,interferon-γ+CD8+and IL-2+CD8+responses were superior and non-inferior to IM-CCC.The estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,respectively.The ID groups reported more local,mild adverse reactions.Conclusion This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research to improve the immunogenicity of inactivated vaccines.

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

T细胞表位模型和表达模型对非亲缘造血干细胞移植供受者HLA-DPB1基因错配风险的预测功能评估

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中华医学杂志 2024年第11期104卷 850-856页

作者：齐珺王天菊王满妮尚利侠陈乐王小芳李昱辉徐华马超锋陕西省血液中心西安710061

目的评估T细胞表位(TCE)模型和表达模型对人类白细胞抗原(HLA)相合非亲缘造血干细胞移植(MUD-HSCT)供受者HLA-DPB1基因错配风险的预测功能。方法回顾性分析2016至2019年陕西省血液中心进行HLA高分辨分型确认的MUD-HSCT供受者364例(182对... 详细信息

目的评估T细胞表位(TCE)模型和表达模型对人类白细胞抗原(HLA)相合非亲缘造血干细胞移植(MUD-HSCT)供受者HLA-DPB1基因错配风险的预测功能。方法回顾性分析2016至2019年陕西省血液中心进行HLA高分辨分型确认的MUD-HSCT供受者364例(182对)。182例受者中,男121例,女61例,年龄(26.3±14.2)岁;182例供者中,男148例,女34例,年龄(33.7±7.5)岁。应用聚合酶链反应-测序分型(PCR-SBT)、下一代测序(NGS)技术和基于LABScan^(■)3D平台的聚合酶链反应-序列特异寡核苷酸探针技术(PCR-SSO)等进行HLA-A、B、C、DRB1、DQB1、DPB1基因高分辨分型,采用PCR-SBT进行单核苷酸多态性(SNP)分型,运用TCE模型和表达模型评估MUD-HSCT供受者HLA-DPB1基因错配模式和急性移植物抗宿主病(aGVHD)风险。结果检出26种HLA-DPB1等位基因及其3′-UTR rs9277534 SNP基因型,发现并正式命名2个新等位基因HLA-DPB1^(*)1052∶01和HLA-DPB1^(*)1119∶01。HLA-DPB1基因总错配率达90.66%(165/182),TCE模型允许错配占47.80%(87/182),不允许错配占42.86%(78/182);移植物抗宿主(GvH)方向的不允许错配为13.73%(25/182),宿主抗移植物(HvG)方向的不允许错配为29.12%(53/182)。TCE模型中共有73对供受者符合表达模型评估标准,其中TCE允许错配组的受者DP5错配占34.25%(25/73),根据表达模型预测其移植后aGVHD风险为高风险;TCE不允许错配组的受者DP2错配占6.85%(5/73),受者DP5错配占10.86%(8/73),均被预测为aGVHD高风险。两种模型之间的整体一致性为27.27%,不一致性为16.97%。结论TCE模型和表达模型是预测MUD-HSCT供受者HLA-DPB1基因错配风险的有效工具,综合应用两种模型有助于移植风险分层评估。

关键词：人类白细胞抗原 T细胞表位表达水平单核苷酸多态性造血干细胞移植允许错配不允许错配

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依普黄酮促进人牙髓干细胞增殖和成骨分化

口腔医学研究 2024年第4期40卷 310-314页

作者：乐曼妮王小聪黄子璇张慧琳张晓月赵卿李明王基栋湖南中医药大学口腔医(学)院湖南长沙410208 长沙市口腔医院湖南长沙410004 中南大学湘雅医学院附属常德医院湖南常德415000

目的:初步检测依普黄酮(IP)对人牙髓干细胞(human dental pulp stem cells,hDPSCs)的增殖和成骨向分化的影响。方法:在体外对hDPSCs进行培养鉴定,用含IP(10^(-9)~10^(-5) mol/L)的完全培养液培养hDPSCs,CCK-8法检测不同时间点(1、2、3 d... 详细信息

目的:初步检测依普黄酮(IP)对人牙髓干细胞(human dental pulp stem cells,hDPSCs)的增殖和成骨向分化的影响。方法:在体外对hDPSCs进行培养鉴定,用含IP(10^(-9)~10^(-5) mol/L)的完全培养液培养hDPSCs,CCK-8法检测不同时间点(1、2、3 d)的细胞活性;用含IP(10-8~10^(-5) mol/L)的矿化诱导液诱导hDPSCs 7 d,通过碱性磷酸酶活性测定、ALP染色、茜素红染色及RT-qPCR检测IP对hDPSCs成骨分化的影响。结果:CCK-8检测结果表明10^(-9)~10^(-5) mol/L IP均可促进hDPSCs增殖,其中10^(-6) mol/L IP组促进增殖效果最佳(P<0.05);10^(-6) mol/L IP组ALP染色加深,ALP活性增高(P<0.05),矿化结节增多(P<0.05);RT-qPCR检测结果显示10^(-6) mol/L IP组能够提高成骨分化相关基因骨钙素(osteocalcin,OCN)、碱性磷酸酶和矮小相关转录基因2的表达水平(P<0.05)。结论:10^(-6) mol/L IP能提高hDPSCs增殖和成骨向分化的能力。

关键词：牙髓干细胞增殖成骨分化依普黄酮

Robust and Flexible Multimaterial Aerogel Fabric Toward Outdoor Passive Heating

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Advanced Fiber Materials 2022年第6期4卷 1545-1555页

作者： Jiawei Wu manni Zhang Minyu Su Yuqi Zhang Jun liang Shaoning Zeng Baishun Chen li Cui Chong Hou Guangming Tao Wuhan National Laboratory for Optoelectronics and State Key Laboratory of Material Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiPeople’s Republic of China School of Optics and Electronic Information Huazhong University of Science and TechnologyWuhan 430074HubeiPeople’s Republic of China Department of Textile Garment and DesignChangshu Institute of TechnologySuzhou 215500JiangsuPeople’s Republic of China College of Materials and Textile Engineering Jiaxing UniversityJiaxing 314001ZhejiangPeople’s Republic of China

Outdoor passive heating to maintain a constant human body temperature is critical for human activities.However,most traditional energy-exhausted heating systems and inefficient passive heating technologies are incapable of dealing with the cold outdoor environment.Developing fabrics with low thermal radiation and conduction to passively heat the human body is a viable way to overcome the constraints of existing passive heating strategies.Herein,a multimaterial aerogel fabric was developed to realize passive personal heating without any energy input.The multimaterial aerogel fabric was fabricated by coating an Ag layer on an aerogel composite fabric.The lightweight aerogel composite fabric,woven from aerogel composite fibers with multi-scale porous structure,exhibits excellent thermal insulation,self-cleaning,mechanical and thermal stability.Furthermore,by coating with an Ag layer,the multimaterial aerogel fabric exhibits both low thermal conductivity and low infrared emissivity at 7–14μm,demonstrating superior thermal insulating performance.As a result,the proposed multimaterial aerogel fabric with a thickness of only 1.29 mm is capable of improving the human body temperarure of 5.7℃ in a cold environment without energy input.This strategy offers a potential energy-saving alternative for future outdoor passive heating.

关键词： Outdoor passive heating Aerogel fabric Thermal insulation Porous structure

Clonal replacement of novel T cells: a new phenomenon in the tumor microenvironment following PD-1 blockade

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Signal Transduction and Targeted Therapy 2019年第1期4卷 243-244页

作者： Xue li manni Wang Rong Xiang Department of Biotherapy State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityNo.17Block 3Southern Renmin Road610041 ChengduSichuanChina Department of Immunology School of MedicineNankai UniversityTianjinChina

In a recent study published in Nature Medicine,Yost et al.1 described the clonal replacement of tumor-specific T cells after treatment with PD-1 antibodies.This finding reveals the intrinsic ability of the tumor microenvironment to attract new T cells,which has crucial applications for the design of immune checkpoint blockade(ICB)therapies(Fig.1).Over the past few decades,ICB therapies have been successful in some patients with different types of cancer by blocking inhibitory checkpoint receptors on T cells,and thus restoring T cell-mediated immune responses as well as recruiting more T cells into the tumor environment.

关键词： al. tumor Medicine

Nomograms based on HPV load for predicting survival in cervical squamous cell carcinoma: An observational study with a longterm follow-up

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Chinese Journal of Cancer Research 2019年第2期31卷 389-399页

作者： Jing Zuo Ying Huang Jusheng An Xi Yang Ning li manni Huang lingying Wu Department of Gynecologic Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Women's Health Integrated Research Center the Henry Jackson Foundation

Objective: To investigate the prognostic value of pretreatment human papillomavirus(HPV) viral load for cervical cancer, and to develop nomograms based on HPV load and other clinicopathological factors for long-term survival.Methods: We conducted a prospective study on cervical squamous cell carcinoma(SCC) patients diagnosed between January 2003 and December 2008. Cervical samples were tested for HPV viral load by the Hybrid Capture II(HCII) assay before treatment and 6 months after treatment. Clinical characteristics and follow-up information were also collected. A multivariable Cox proportional hazards model was used to adjust covariates in both the radical hysterectomy(RH) treatment group and concurrent chemoradiotherapy(CCRT) treatment group to identify relevant covariates, and then nomograms were constructed and used for internal validation.Results: A total of 520 SCC patients enrolled in this study with a median follow-up of 127 months, 360 patients received RH, whereas 160 patients received CCRT. The median HPV viral load in RH and CCRT groups was356.10 and 294.29, respectively. Tumor size was positively correlated with high pretreatment HPV load in both groups. In CCRT group, the advanced International Federation of Gynecology and Obstetrics(FIGO) stage and enlarged retroperitoneal lymph node status determined by computed tomography(LNSCT) were correlated with low HPV load group. Initial HPV viral load, FIGO stage and lymph node metastasis were prognostic factors for RH group, whereas HPV viral load, squamous cell carcinoma antigen(SCC-Ag) level and LNSCT were identified as prognostic factors for CCRT group. Nomograms incorporating these predictors for 10-year progression-free survival(PFS) were constructed [concordance index(C-index): 0.756, 0.749].Conclusions: A low pretreatment HPV viral load is an independent prognostic factor for poor prognosis of cervical SCC and is related to other clinicopathological factors. The survival nomogram based on HPV viral load could predict the long-term prognosis.

关键词： Cervical squamous cell carcinoma human papillomavirus viral load survival nomogram

Analysis of Prognosis and Prognostic Factors of Cervical Adenocarcinoma and Adenosqumous Carcinoma of the Cervix

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Chinese Journal of Clinical Oncology 2009年第2期6卷 133-137页

作者： Guangwen Yuan lingying Wu Xiaoguang li manni Huang Department of Gynecologic Oncology Cancer Hospital Chinese Academy of Medical Science & Peking Union Medical College Beijing 100021. China

OBJECTIVE To analyze clinical characteristics and treatmentmethods of the patients with adenocarcinoma of the uterine cervix(AUC) and adenosquamous carcinoma of the cervix (ASCC). Tocompare the survival time of the patients in 2 groups and analyzethe prognostic factors.METHODS Clinical data of both 123 patients with AUC and32 patients with ASCC treated at the Cancer Hospital, ChineseAcademy of Medical Science (CAMS) & Peking Union MedicalCollege (PUMC), were retrospectively analyzed.RESULTS The median age of the AUC patients was 50 years, andthat of the ASCC patients was 44, P = 0.019. Poorly-differentiated(grade 3) cases accounted for 59.5% of the total ASCC patients,while only 32.5% of the AUC patients were in grade 3, P = 0.002.In 123 AUC patients, relapse or failure of the treatment occurredin 63 of the patients (51.2%), and the median relapse time was6 months (0-59 months). In 32 ASCC patients, relapse or failureof the treatment occurred in 8 of these patients (51.2%), with amedian relapse time of 4.5 months (0-52 months). The overall5-year survival rate of the AUC patients was 49.8%, which wassignificantly lower than that of the ASCC patients (74.1%), P =0.015. The 5-year survival rates of the ASCC patients in Stage Ⅰ-Ⅲwere higher than that of the AUC patients with the same stages.However, statistical significant difference could only be foundamong the patients in Stage Ⅱ, P = 0.006. The 5-year survival ratesof the ASCC patients with various differential grade were higherthan those of the AUC patients with the same differential grade,but statistical significant difference could only be found amongthe patients in the two groups with moderately differentiation,P = 0.039. It was found by Cox regression analysis that onlyclinical stage (P linical stage and histological type were theindependent prognostic factors of the AUC and ASCC patients.The prognosis of ASCC patients is better than that of the AUCpatients.

关键词：子宫颈腺癌预后因素预后分析 5年生存率北京协和医学院中国医学科学院 Cox回归分析哥伦比亚