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Journal of Modern Power Systems and Clean Energy 2021年第3期9卷 477-484页

作者： Ming Ni Manli Li Jun’e li Yingjun Wu Qi Wang the NARI Group Corporation(State Grid Electric Power Research Institute) NARI Technology Co.Ltd.and the State Key Laboratory of Smart Grid Protection and ControlNanjing 211106China the School of Cyber Science and Engineering Wuhan Universityand the Key Laboratory of Aerospace Information Security and Trusted Computing of the Ministry of EducationWuhan 430072China the College of Energy and Electrical Engineering Hohai UniversityNanjing 211100China the School of Electrical Engineering Southeast UniversityNanjing 210096China

Due to the tight coupling between the cyber and physical sides of a cyber-physical power system(CPPS),the safe and reliable operation of CPPSs is being increasingly impacted by cyber security.This situation poses a challenge to traditional security defense systems,which considers the threat from only one side,i.e.,cyber or physical.To cope with cyberattacks,this paper reaches beyond the traditional one-side security defense systems and proposes the concept of cyber-physical coordinated situation awareness and active defense to improve the ability of CPPSs.An example of a regional frequency control system is used to show the validness and potential of this concept.Then,the research framework is presented for studying and implementing this concept.Finally,key technologies for cyber-physical coordinated situation awareness and active defense against cyber-attacks are introduced.

关键词： Cyber-physical power system(CPPS) cyber security cyber-attack situation awareness active defense

The New Historical Divide of Online Education:Dialogues with Key Leaders During the Epidemic

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ECNU Review of Education 2020年第4期3卷 755-761页

作者： Xiaolei Zhang Xiaoxiao Wang Manli Li School of Education Tianjin University Office of lifelong Education Administration Undergraduate Academic AffairsTsinghua University Institute of Education Tsinghua UniversityBeijingChina

The Coronavirus epidemic has reached far deeper into people’s daily life across the world,with the sweeping shutdown of all schools and the educational upheaval of students globally.“The speed and scale of the educa... 详细信息

关键词： has globally shutdown

中国大学促进可持续发展的理念与实践:“关系健康发展模式”及其贡献

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中国高教研究 2024年第1期 50-57页

作者：李曼丽清华大学教育研究院北京100084

可持续发展是全球发展的原则。联合国已将可持续发展目标的重点从初等和中等教育扩大至高等教育。中国传统思想文化蕴含着渊源深厚的可持续发展理念。改革开放以来,中国高等教育发展迅猛,在冲突与转型之间始终坚持走中国特色之路,促进... 详细信息

可持续发展是全球发展的原则。联合国已将可持续发展目标的重点从初等和中等教育扩大至高等教育。中国传统思想文化蕴含着渊源深厚的可持续发展理念。改革开放以来,中国高等教育发展迅猛,在冲突与转型之间始终坚持走中国特色之路,促进可持续发展的相关理念与实践与西方大学有所不同,其政策和举措可以归纳为“关系健康发展模式”。通过对中国大学的“关系健康发展模式”之思想渊源、理论框架、实践范例的系统阐述,为世界高等教育提供来自中国的独特做法和经验。

关键词：中国高等教育全球可持续发展议程关系健康发展模式

Bioinformatics analysis of genes differentially expressed in autism and screening of hub genes in the occurrence and development of autism

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Journal of Translational Neuroscience 2022年第1期7卷 15-22页

作者： Manli Li Xiaoli Ma Chendi Mai Zhiru Fan Yankai Ren Department of Physiology Sanquan College of Xinxiang Medical UniversityXinxiang 453003China

Objective:to screen the genes differentially expressed in autism using bioinformatics methods,and to explore their functional enrichment,related signaling pathways and the tissue-specific expression of hub genes.Methods:the autism expression profile chip numbered GSE77103 in the Gene Expression Omnibus(GEO)database was selected for examination.R language and related R packages were used for the screening and visualization of the diflerentially expressed genes.Gene Ontology(GO)function enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG)signaling pathway analysis of the differential genes were carried out using the relevant R package of R language.The database STRING was used to construct the interaction network of the proteins encoded by the differentially expressed genes,and the software Cytoscape was used to screen the hub genes in the network.The selected hub genes were imported into the BioGPS database to analyze the tissue-specific expression of the hub genes.Results:six hundred and sixty diflerentially expressed genes were screened out.Three hundred and seventy-three up-regulated genes and 287 down-regulated genes in the peripheral blood mononuclear cells of autistic children were compared with the peripheral blood mononuclear cells of healthy children.GO functional enrichment results showed that biological processes(BP)were mainly involved in viral response,negative regulation of viral genome replication,negative regulation of multiple biological processes,negative reg ulation reg ulation of viral life cycle,and defense responses to viruses.Cell components(CC)were involved in vesicles,lysosomal membranes,lysosomal lumen,etc.;molecular functions(MF)were involved in regulating glutathione transferase activity peroxidase activity,oxidoreductase activity,Glutathione peroxidase and transferase activity,etc.The results of KEGG signaling pathway analysis showed that the differentially expressed genes were related to the lysosomal pathway,the glutathione metabolism pathway and the arachidonic acid metaboli

关键词： autism diflFerentially expressed genes bioinformatics hub genes

Current Situation and Development Proposals of Agricultural Facilities(Planting)Application in Beijing

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Journal of Beijing Institute of Technology 2023年第3期32卷 275-284页

作者： Xihong Lei Wei li Yanfang Wang manli Niu Fudong Wang Dong An liguo Yang Beijing Agricultural Technology Extension Station Beijing 100029China College of Information and Electrical Engineering China Agricultural UniversityBeijing 100083China

Facility agriculture is an essential carrier for promoting stable production and supply.In2020,the planting area of facility agriculture in Beijing(290098000 m2)accounted for 29.06%of the total planting area of crops(998078000 m2),and the output value accounted for 46.56%.In2022,Beijing Agricultural Technology Extension Station organized relevant departments to summarize and evaluate the agricultural facilities in Beijing through consultation materials,interviews,questionnaires,and field trips,combining survey data and statistical data to draw the following conclusions.Facilities play a major supporting role in stabilizing production and ensuring supply.The number of traditional greenhouses is extensive and covers a large area,so special planning and classification upgrades are urgently needed.Facilities are rich in scientific and technological resources,but the mode of production is out of date.It is of great significance to improve the comprehensive production capacity of facility agriculture and promote the healthy and stable development of facility industry in Beijing to increase the utilization rate of facility agriculture land,strengthen the support of facility science and technology,and cultivate the socialized service organization of facility.

关键词： facility agriculture stable production and supply cost benefit technical support

国外一流大学高等教育学学术博士培养方案研究

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中国高教研究 2020年第6期 3-8页

作者：李曼丽清华大学教育研究院北京100084

随着我国高等教育快速发展,亟需高质量的高等教育学专业人才从事高校工作和相关研究,如何提高高等教育学博士的培养质量成为现实问题。从高等教育教学学术博士的培养方案入手,选取斯坦福大学、宾夕法尼亚大学、加州大学洛杉矶分校、威... 详细信息

随着我国高等教育快速发展,亟需高质量的高等教育学专业人才从事高校工作和相关研究,如何提高高等教育学博士的培养质量成为现实问题。从高等教育教学学术博士的培养方案入手,选取斯坦福大学、宾夕法尼亚大学、加州大学洛杉矶分校、威斯康辛大学麦迪逊分校4所国外一流大学的高等教育学学术博士培养方案为研究对象,从培养目标、学制和培养过程安排、课程设置、评价考核方式4个方面,系统梳理其人才培养的规划,总结共同经验和突出特色。最后,从研讨课、方法课、跨学科课程和过程性考核等方面提出对我国高等教育学学术博士培养的启示。

关键词：高等教育学学术博士培养方案国外一流大学课程计划

Bamboo charcoal enhances cellulase and urease activities during chicken manure composting:Roles of the bacterial community and metabolic functions

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Journal of Environmental Sciences 2021年第10期33卷 84-95页

作者： Yanan Yin Chao Yang Jingrui Tang Jie Gu Haichao li manli Duan Xiaochang Wang Rong Chen Key Laboratory of Northwest Water Resource Environment and EcologyMOESchool of Environmental and Municipal EngineeringXi’an University of Architecture and TechnologyXi’an 710055China International S&T Cooperation Center for Urban Alternative Water Resources Development Xi’an University of Architecture and TechnologyXi’an 710055China College of Resources and Environmental Sciences Northwest A&F UniversityYanglingShaanxi 712100China Department of Environment Faculty of Bioscience EngineeringGhent University9000 GhentBelgium State Key Laboratory of Eco-hydraulics in Northwest Arid Region of China Xi’an University of TechnologyXi’an 710048China

Microbial enzymes are crucial for material biotransformation during the composting process.In this study,we investigated the effects of adding bamboo charcoal(BC)(i.e.,at 5%,10%,and 20%corresponding to BC5,BC10,and BC20,respectively)on the enzyme activity levels during chicken manure composting.The results showed that BC10 could increase the cellulose and urease activities by 56%and 96%,respectively.The bacterial community structure in BC10 differed from those in the other treatments,and Luteivirga,Lactobacillus,Paenalcaligenes,Ulvibacter,Bacillus,Facklamia,Pelagibacterium,Sporosarcina,Cellvibrio,and Corynebacterium had the most important roles in composting.Compared with other treatments,BC10 significantly enhanced the average rates of degradation of carbohydrates(Dxylose(40%)andα-D-lactose(44%))and amino acids(L-arginine(16%),L-asparagine(14%),and L-threonine(52%)).We also explored the associations among the bacterial community and their metabolic functions with the changes in the activities of enzymes.Network analysis demonstrated that BC10 altered the co-occurrence patterns of the bacterial communities,where Ulvibacter and class Bacilli were the keystone bacterial taxa with high capacities for degrading carbon source,and they were related to increases in the activities of cellulase and urease,respectively.The results obtained in this study may help to further enhance the efficiency of composting.

关键词： Bacterial community Carbon utilization Cellulase Composting Urease

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哈佛大学新制通识教育方案及其实施效果辨惑

北京大学教育评论 2018年第2期16卷 104-115,189-190页

作者：李曼丽清华大学教育研究院北京100084

近十余年来,2007年颁布的哈佛大学通识教育改革方案一直是高等教育界热议的话题,国内学界有不少对新方案的合理性、先进性的讨论。本文回顾了方案修订过程中各种争议、妥协以及谨小慎微的创新,对目前该方案实施后的效果和动态等问题进... 详细信息

近十余年来,2007年颁布的哈佛大学通识教育改革方案一直是高等教育界热议的话题,国内学界有不少对新方案的合理性、先进性的讨论。本文回顾了方案修订过程中各种争议、妥协以及谨小慎微的创新,对目前该方案实施后的效果和动态等问题进行了回应;并结合哈佛历史上1945年、1978年两次通识教育改革,探讨了此次改革对我国高校通识教育改革的启示。

关键词：哈佛大学通识教育 “2007方案” 实施效果

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域外四国教育优质均衡的议题及政策旨趣

比较教育研究 2022年第10期44卷 13-21页

作者：李睿淼李曼丽清华大学教育研究院北京100084

依据经济合作与发展组织构建的优质均衡指标,选择芬兰、日本、韩国、美国四个国家分析其推进教育优质均衡过程中的核心议题及政策旨趣。研究发现:一是四国呈现出不同的政策工具选择特征,芬兰采取“高质量的全纳教育”,日本采用“政府主... 详细信息

依据经济合作与发展组织构建的优质均衡指标,选择芬兰、日本、韩国、美国四个国家分析其推进教育优质均衡过程中的核心议题及政策旨趣。研究发现:一是四国呈现出不同的政策工具选择特征,芬兰采取“高质量的全纳教育”,日本采用“政府主导下优质教育资源均衡配置”,韩国推行“教育平准化向多样化转型”,美国则将“资源配置市场化与政府问责相结合”;二是四国均经历了入学机会均等阶段、教育过程公平与优质资源均衡配置阶段、教育结果公平与个性化教育阶段;三是各国政策主要关注资源投入与配置方式、教师发展与教师流动、学校治理模式、弱势群体补偿四大议题。综合来看,四国教育优质均衡政策是在均衡本位和质量本位两种旨趣中不断调适,动态发展。

关键词：基础教育优质均衡芬兰日本韩国美国

Construction and characterization of a synthesized herpes simplex virus H129-Syn-G2

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Virologica Sinica 2023年第3期38卷 373-379页

作者： Han Xiao Hengrui Hu Yijia Guo Jiang li Le Wen Wen-Bo Zeng manli Wang Min-Hua Luo Zhihong Hu State Key Laboratory of Virology Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China

Herpes simplex virus type 1(HSV-1)causes lifelong infections worldwide,and currently there is no efficient cure or vaccine.HSV-1-derived tools,such as neuronal circuit tracers and oncolytic viruses,have been used exten-sively;however,further genetic engineering of HSV-1 is hindered by its complex genome structure.In the present study,we designed and constructed a synthetic platform for HSV-1 based on H129-G4.The complete genome was constructed from 10 fragments through 3 rounds of synthesis using transformation-associated recombination(TAR)in yeast,and was named H129-Syn-G2.The H129-Syn-G2 genome contained two copies of the gfp gene and was transfected into cells to rescue the virus.According to growth curve assay and electron microscopy results,the synthetic viruses exhibited more optimized growth properties and similar morphogenesis compared to the parental virus.This synthetic platform will facilitate further manipulation of the HSV-1 genome for the devel-opment of neuronal circuit tracers,oncolytic viruses,and vaccines.

关键词： Herpes simplex virus type 1(HSV-1) Neuronal circuit tracers H129-Syn-G2 H129-G4 Synthetic biology