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Sedimentary environment and major controlling factors of organic matter-rich shale from the Wufeng-Longmaxi formation in eastern Sichuan Basin,China

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Frontiers of Earth Science 2024年第3期18卷 649-670页

作者： Yang WANG Hanyu ZHANG Yanming ZHU Shangbin CHEN Qingshun CAO manli huang Jinghui YANG Yunsheng ZHANG Key Laboratory of Coalbed Methane Resources and Reservoir Formation Process(Ministry of Education) China University of Mining and TechnologyXuzhou 221008China School of Resources and Geoscience China University of Mining and TechnologyXuzhou 221116China

The major controlling factors of organic matter and its enrichment model of the black shale from the Wufeng-Longmaxi Formation were explored by investigating the vertical variation characteristics,as well as major element and trace element abundances in the Wuxi Bailu *** results show that the sedimentary tectonic setting of the Wufeng-Longmaxi Formation in the north-east margin of the upper Yangtze platform is located on the active continental margin,which is a passive continental margin and continental island *** parent rock in the source area is mainly felsic volcanic rocks mixed with small amounts of sedimentary recycling *** to increased plate activity and a drop in sea levels,terrigenous pyroclastic input *** palaeoclimate was semi-humid,and a robust dysoxic-reduction environment and a high level of palaeoproductivity,causing the formation of the organic-rich shale in the Wufeng *** the base of the Longmaxi Formation,the sedimentary water body was affected by global transgression,showing a strong anoxic-reductive environment,and the paleoclimate was a warm and humid *** palaeoproductivity level was high,resulting in the formation of organic *** to the sea level drop at the top of the Longmaxi Formation,the sedimentary water was in an oxic-reduced environment,but the input of terrigenous pyroclastic matter *** the paleoclimate was warm and humid and the palaeoproductivity level was high,organic-rich shale was *** findings demonstrate that terrigenous clastic input circumstances,palaeoproductivity conditions,and paleo-redox conditions had the greatest influence on the enrichment of organic matter in the Wufeng-Longmaxi ***,organic matter enrichment was controlled by multiple paleoenvironmental factors.

关键词： Wufeng-Longmaxi Formation organic-rich shale organic matter enrichment depositional palaeoenvironment eastern Sichuan Basin

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B-N covalent bond-involved π-extension of multiple resonance emitters enables high-performance narrowband electroluminescence

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National Science Review 2024年第6期11卷 243-253页

作者： Xingyu huang Jiahui Liu Yulin Xu Guohao Chen manli huang Mingxin Yu Xialei Lv Xiaojun Yin Yang Zou Jingsheng Miao Xiaosong Cao Chuluo Yang Shenzhen Key Laboratory of New Information Display and Storage Materials College of Materials Science and EngineeringShenzhen University College of Physics and Optoelectronic Engineering Shenzhen University

Multi-boron-embedded multiple resonance thermally activated delayed fluorescence（MR-TADF） emitters show promise for achieving both high color-purity emission and high exciton utilization ***, their development is often impeded by a limited synthetic scope and excessive molecular weights,which challenge material acquisition and organic light-emitting diode（OLED） fabrication by vacuum deposition. Herein, we put forward a B–N covalent bond-involved π-extension strategy via post-functionalization of MR frameworks, leading to the generation of high-order B/N-based motifs. The structurally and electronically extended π-system not only enhances molecular rigidity to narrow emission linewidth but also promotes reverse intersystem crossing to mitigate efficiency roll-off. As illustrated examples, ultra-narrowband sky-blue emitters（full-width at half-maximum as small as 8 nm in n-hexane）have been developed with multi-dimensional improvement in photophysical properties compared to their precursor emitters, which enables narrowband OLEDs with external quantum efficiencies(EQEmax) of up to 42.6%, in company with alleviated efficiency decline at high brightness, representing the best efficiency reported for single-host OLEDs. The success of these emitters highlights the effectiveness of our molecular design strategy for advanced MR-TADF emitters and confirms their extensive potential in high-performance optoelectronic devices.

关键词： narrowband electroluminescence thermally activated delayed fluorescence (TADF) multiple resonance emitters ultra-high external quantum efficiency

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Phosphorylated TDP-43 Staging of Primary Age-Related Tauopathy

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Neuroscience Bulletin 2019年第2期35卷 183-192页

作者： Xiaoling Zhang Bing Sun Xing Wang Hui Lu Fangjie Shao Annemieke J.M.Rozemuller Huazheng Liang Chong Liu Jiadong Chen manli huang Keqing Zhu China Brain Bank and Department of Neurology in Second Affiliated Hospital Key Laboratory of Medical Neurobiology of Zhejiang ProvinceDepartment of NeurobiologyZhejiang University School of Medicine Department of Pathology Zhejiang University School of Medicine Department of Pathology Amsterdam NeuroscienceVU University Medical Center Brain Structure and Function Group Neuroscience Research Australia Department of Psychiatry First Affiliated HospitalZhejiang University School of Medicine

Primary age-related tauopathy(PART) is characterized by tau neurofibrillary tangles(NFTs) in the absence of amyloid plaque pathology. In the present study,we analyzed the distribution patterns of phosphorylated43-kDa TAR DNA-binding protein(pTDP-43) in the brains of patients with PART. Immunohistochemistry and immunofluorescence double-labeling in multiple brain regions was performed on brain tissues from PART,Alzheimer's disease(AD), and aging control cases. We examined the regional distribution patterns of pTDP-43 intraneuronal inclusions in PART with Braak NFT stages[ 0 and B IV, and a Thal phase of 0(no beta-amyloid present). We found four stages which indicated potentially sequential dissemination of pTDP-43 in PART. Stage I was characterized by the presence of pTDP-43 lesions in the amygdala, stage II by such lesions in the hippocampus,stage III by spread of pTDP-43 to the neocortex, and stage IV by pTDP-43 lesions in the putamen, pallidum, and insular cortex. In general, the distribution pattern of pTDP-43 pathology in PART cases was similar to the early TDP-43 stages reported in AD, but tended to be more restricted to the limbic system. However, there were some differences in the distribution patterns of pTDP-43 between PART and AD, especially in the dentate gyrus of the hippocampus. Positive correlations were found in PART between the Braak NFT stage and the pTDP-43 stage and density.

关键词： TDP-43 Primary age-related tauopathy Alzheimer's disease Neurofibrillary tangle Hippocampus

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Melatonin changes in the pineal gland of sleep-deprived rats following habenular nucleus lesion

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Neural Regeneration Research 2011年第9期6卷 681-685页

作者： Huijuan Jin Meiying Song Min huang manli Wang Hua Zhao Department of Physiology Norman Bethune College of Medicine Jifin University Changchun 130021 Jilin Province China

The habenular nucleus （Hb） is an important structure that regulates the function of the pineal gland which may affect melatonin content in the pineal gland after sleep deprivation （SD）. In the present study, high performance liquid chromatography showed that the melatonin content in the pineal gland was significantly reduced, and y-aminobutyric acid content in the Hb was significantly increased after SD. Furthermore, the melatonin content in the pineal gland was markedly reduced after Hb lesion under normal sleep and SD conditions. Immunohistochemistry showed that the number of Fos-positive neurons was significantly decreased in the lateral and medial Hb after SD. The findings demonstrate that the reduction of melatonin in the pineal gland after SD is related to decreased activity of Hb neurons, and that the Hb can regulate sleep-wake rhythm by influencing melatonin secretion in the pineal gland.

关键词： Habenular nucleus melatonin pineal gland sleep deprivation neural regeneration

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Aberrant single-subject morphological brain networks in first-episode,treatment-naive adolescents with major depressive disorder

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Psychoradiology 2023年第1期3卷 220-231页

作者： Xiaofan Qiu Junle Li Fen Pan Yuping Yang Weihua Zhou Jinkai Chen Ning Wei Shaojia Lu Xuchu Weng manli huang Jinhui Wang Institute for Brain Research and Rehabilitation South China Normnal UniversityGuangzhou 510631China Departnent of Psychiatry First Affliated HospitalCollge of MedicineZhejiang UniversityHangzhou 310013China The Key Laboratory of Mental Disorder's Management of Zhejiang Province Hangzhou 310013China Key Laboratory of Brain Cognition and Education SciencesMinistry of EducationGuangzhou 510631China Center for Studies of Psychological Application South China Normal UniversityGuangzhou 510631China Guangdong Key Laboratory of Mental Health and Cognitive Science Guangzhou 510631China Zhejiang Engineering Center for Mathematical Mental Health Hangzhou 310003China

Background:Neuroimaging-based connectome studies have indicated that major depressive disorder(MDD)is associated with dis-rupted topological organization of large-scale brain ***,the disruptions and their clinical and cognitive relevance are not well established for morphological brain networks in adolescent ***:To investigate the topological alterations of single-subject morphological brain networks in adolescent ***:Twenty-five first-episode,treatment-naive adolescents with MDD and 19 healthy controls(HCs)underwent T1-weighted magnetic resonance imaging and a battery of neuropsychological ***-subject morphological brain networks were constructed separately based on cortical thickness,fractal dimension,gyrification index,and sulcus depth,and topologically characterized by graph-based ***-group differences were inferred by permutation *** significant alterations,partial correla-tions were used to examine their associations with clinical and neuropsychological variables in the ***,a support vector machine was used to classify the patients from ***:Compared with the HCs,the patients exhibited topological alterations only in cortical thickness-based networks character-ized by higher nodal centralities in parietal(left primary sensory cortex)but lower nodal centralities in temporal(left parabelt complex,right perirhinal ectorhinal cortex,right area PHT and right ventral visual complex)***,decreased nodal centralities of some temporal regions were correlated with cognitive dysfunction and clinical characteristics of the *** results were largely reproducible for binary and weighted network ***,topological properties of the cortical thickness-based net-works were able to distinguish the MDD adolescents from HCs with 87.6%***:Adolescent MDD is associated with disrupted topological organization of morphological brain networks,and the d

关键词： adolescent major depressive disorder structural MRI morphological brain network cortical thickness support vector machine

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Is ecstasy-induced protracted symptom of motion perception associated with altered regional homogeneity of brain？

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Chinese Medical Journal 2014年第17期127卷 3189-3191页

作者： Wei Ning Lai Jianbo Xu Dongrong Qi Hongli Wang Qidong Zhang Minming huang manli Xu Yi Hu Shaohua Department of Mental Health First Affiliated Hospital Zhejiang University School of Medicine HangzhouZhejiang 310003 China Center for Developmental Neuropsychiatry Department of Psychiatry Columbia University and New York State Psychiatric Institute New York 10032 USA Department of Radiology First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310003 China Department of Radiology Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310003 China

The synthetic hallucinogen 3,4-methylenedioxymet hamphetamine （MDMA） is the main psychoactive constituent of the popular recreational drug ＂ecstasy.＂ Whether its neurotoxic effects are fully reversible is unknown.... 详细信息

关键词： ecstasy regional homogeneity functional magnetic resonance imaging repetitive transcranial magnetic stimulation duloxetine

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折衷范式内涵的演化及其内在逻辑研究

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管理学报 2016年第4期13卷 516-523,604页

作者：黄嫚丽赵妙荻华南理工大学工商管理学院

通过回顾折衷范式的起源与发展,对其演变的路径和主要特征做出归纳与总结,并梳理了资产优势、交易优势和制度优势3类所有权优势的内涵,以及上述三者分别与内部化优势的关系,明晰了折衷范式当前的内在逻辑。基于此,提出了折衷范式未来的... 详细信息

通过回顾折衷范式的起源与发展,对其演变的路径和主要特征做出归纳与总结,并梳理了资产优势、交易优势和制度优势3类所有权优势的内涵,以及上述三者分别与内部化优势的关系,明晰了折衷范式当前的内在逻辑。基于此,提出了折衷范式未来的修正方向,并在中国情境下对折衷范式开展进一步讨论,给出了中国情境下制度优势(Oi)概念的一种具体化定义过程,以及提出基于中国情境的制度优势(Oi)形成机制的命题。

关键词：折衷范式所有权优势制度优势中国情境具体化

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Increased ratio of mature BDNF to precursor-BDNF in patients with major depressive disorder with severe anhedonia

Increased ratio of mature BDNF to precursor-BDNF in patients...

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2020年浙江省医学会精神病学学术大会浙江省医师协会精神科医师分会第十三届年会

作者： Congchong Wu Jing Lu Shaojia Lu manli huang Yi Xu

Background:Although studies have shown that severe anhedonia in patients with major depressive disorder(MDD) is associated with poor treatment outcomes,the biological mechanism of this feature is *** aimof this study ...

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基于时间过程视角的连续并购研究综述

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管理学报 2020年第9期17卷 1412-1422页

作者：黄嫚丽张钺李静华南理工大学工商管理学院广州市510640 华南理工大学中国企业战略管理研究中心

通过文献计量梳理现有连续并购相关的文献,对连续并购的概念及内涵进行了界定。鉴于连续并购是一个在时间上具有持续性、行为上具有重复性、影响上具有动态性的概念,故以时间过程为视角,对连续并购发生的前因后果及其内部作用机制的研... 详细信息

通过文献计量梳理现有连续并购相关的文献,对连续并购的概念及内涵进行了界定。鉴于连续并购是一个在时间上具有持续性、行为上具有重复性、影响上具有动态性的概念,故以时间过程为视角,对连续并购发生的前因后果及其内部作用机制的研究成果进行综述,着重梳理连续并购的4个时间属性,即并购频数、并购节奏、并购经验及次序模式。从决策影响因素、并购效应的影响因素及其作用机制等方面厘清了现有研究成果,构建了研究现状的逻辑关系图,并指出现有研究的不足和未来的研究方向。

关键词：连续并购时间过程视角时间属性并购绩效

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基于吸收能力的联盟企业组织学习研究

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科技管理研究 2005年第10期25卷 89-91,105页

作者：黄嫚丽蓝海林华南理工大学工商管理学院广东广州510640

战略联盟是企业建立竞争优势的重要战略选择之一,特别是通过联盟进行组织学习更是企业提高核心竞争力的重要方式。本文以企业的吸收能力为视角,研究联盟一方企业在联盟中的组织学习过程模式与实现框架。首先,本文对吸收能力的概念进行... 详细信息

战略联盟是企业建立竞争优势的重要战略选择之一,特别是通过联盟进行组织学习更是企业提高核心竞争力的重要方式。本文以企业的吸收能力为视角,研究联盟一方企业在联盟中的组织学习过程模式与实现框架。首先,本文对吸收能力的概念进行了文献回顾和界定,对企业吸收能力的影响因素作了进一步的分析。在此基础上,本文提出联盟企业基于吸收能力的组织学习过程概念模型,以及探讨在组织学习的各个阶段中吸收能力的作用机制。

关键词：联盟企业组织学习吸收能力

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