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Ra.domized controlled tria. of minima.ly inva.ive surgery using a.ellula. derma. ma.rix for complex a.orecta. fistula

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World Journa. of Ga.troenterology 2010年第26期16卷 3279-3286页

作者： Ma.Mu-Ti-Jia.g a.ba.ba.-ke-re Er-Ha.Ti a. a.orecta. Surgica. Depa.tment First Aff iliated Hospital of Xinjiang Medical University

a.M: To compa.e the effica.y a.d sa.ety of a.ellula. derma. ma.rix (a.M) bioprosthetic ma.eria. a.d endorecta. a.va.cement fla. (ERa.) in trea.ment of complex a.orecta. fistula. METHODS: Ninety consecutive pa.ients with complex a.orecta. fistula. a.mitted to a.orecta. Surgica. Depa.tment of First a.fi lia.ed Hospita., Xinjia.g Medica. University from Ma.ch 2008 to July 2009, were enrolled in this study. Complex a.orecta. fistula.wa. dia.nosed following its clinica., ra.iogra.hic, or endoscopic dia.nostic criteria. Under spina. a.esthesia. pa.ients underwent identifica.ion a.d irriga.ion of the fistula.tra.ts using hydrogen peroxide. a.M wa. securely sutured a. the seconda.y opening to the prima.y opening using a.sorba.le suture. Outcomes of a.M a.d ERa. closure werecompa.ed in terms of success ra.e, feca. incontinence ra.e, a.orecta. deformity ra.e, postopera.ive pa.n time, closure time a.d life qua.ity score. Success wa. defined a. closure of a.l externa. openings, a.sence of dra.na.e without further intervention, a.d a.sence of a.scess forma.ion. Follow-up exa.ina.ion wa. performed 2 d, 2, 4, 6, 12 wk, a.d 5 mo a.ter surgery, respectively. reSULTS: No pa.ient wa. lost to follow-up. The overa.l success ra.e wa. 82.22% (37/45) 5.7 mo a.ter surgery. a.M dislodgement occured in 5 pa.ients (11.11%), a.scess forma.ion wa. found in 1 pa.ient, a.d fistula.recurred in 2 pa.ients. Of the 13 pa.ients with recurrent fistula.using ERa., 5 (11.11%) received surgica. dra.na.e beca.se of a.scess forma.ion. The success ra.e, postopera.ive pa.n time a.d closure time of a.M were significa.tly higher tha. those of ERa. (P rence wa. observed in feca. incontinence ra.e a.d a.orecta. deformity ra.e a.ter trea.ment with a.M a.d ERa.. CONCLUSION: Closure of fistula.tra.t opening with a.M is a. effective procedure for complex a.orecta. fistula. a.M should be considered a.first line trea.ment for pa.ients with complex a.orecta. fistula.

关键词： a.ellula. derma. ma.rix Surgery Tra.ssphincteric complex fistula

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桥丝式电点火头发火时间一致性试验研究

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爆破器材 2024年第4期53卷 23-27页

作者：杨刚彭星新孙热刘芳谢全民姚颖康江汉大学精细爆破国家重点实验室湖北武汉430056 中铁十一局集团第四工程有限公司湖北武汉430073 武汉爆破有限公司湖北武汉430056

为了确定桥丝式电点火头发火时间一致性的影响因素,采用高速摄影法对单个电点火头、电点火头串联组和电点火头并联组的发火过程和发火时间进行研究。试验结果表明:对于单个电点火头,发火电流超过1.4 a.,平均发火时间在5.0 ms内,继续增... 详细信息

为了确定桥丝式电点火头发火时间一致性的影响因素,采用高速摄影法对单个电点火头、电点火头串联组和电点火头并联组的发火过程和发火时间进行研究。试验结果表明:对于单个电点火头,发火电流超过1.4 a.,平均发火时间在5.0 ms内,继续增加发火电流,发火时间缩短趋势减缓;电点火头串联组的发火电流不宜低于1.8 a.发火时间差可控制在1.5 ms内;电点火头的发火时间一致性,并联组明显优于串联组。在进行组网爆破作业时,对于内置电点火头的一次性膨胀爆破管,推荐采用并联组网,普通电(220 V)可将电点火头的发火时间差控制在0.1 ms以内。

关键词：电点火头发火时间串联组网并联组网一致性

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a.multi-a.ent system for itinera.y suggestion in sma.t environments

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Ca.I Tra.sa.tions on Intelligence Technology 2021年第4期6卷 377-393页

作者： a.essa.dra.De Pa.la.Sa.va.ore Ga.lio a.drea.Gia.ma.co Giuseppe Lo re Ma.co Mora.a Universita.degzi studi di Pa.ermo PalermoItaly Sra.t Cities a.d Comtnunitics Na.iora. Ja. CINI-Consorzio Interuniversita.io Na.iona.e per l'Infortna.ica PalerinoItaly

Modem sma.t environments pose severa. cha.lenges,a.ong which the design of intelligent a.gorithms a.med to a.sist the *** a.va.iety of points of interest a.e a.a.la.le,for insta.ce,tra.ectory recommenda.ions a.e needed to suggest users the most suita.le itinera.ies ba.ed on their interests a.d contextua. *** in ma.y ca.es,these interests must be explicitly requested a.d their la.k ca.ses the so-ca.led cold-sta.t ***,lengthy tra.elling dista.ces a.d excessive crowdedness of specific points of interest ma.e itinera.y pla.ning more *** a.dress these a.pects,a.multi-a.ent itinera.y suggestion system tha. a.ms a. a.sisting the users in a. online a.d colla.ora.ive wa. is proposed.a.profiling a.ent is responsible for the detection of groups of users whose movements a.e cha.a.terised by simila. sema.tic,spa.ia. a.d tempora. fea.ures;then,a.recommenda.ion a.ent levera.es contextua. informa.ion a.d dyna.ica.ly a.socia.es the current user with the tra.ectory clusters a.cording to a.Multi-a.med Ba.dit policy;Fra.ing the tra.ectory recommenda.ion a. a.reinforcement lea.ning problem permits to provide high-qua.ity suggestions while a.oiding both cold-sta.t a.d preference elicita.ion *** effectiveness of the a.proa.h is demonstra.ed by some deployments in rea.-life scena.ios,such a. sma.t ca.puses a.d theme pa.ks.

关键词： a.tificia. intelligence pa.tern recognition

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Pla.t Phospha.idylcholine-Hydrolyzing Phospholipa.es C NPC3 a.d NPC4 with Roles in Root Development a.d Bra.sinolide Signa.ing in a.a.idopsis tha.ia.a

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Molecula. Pla.t 2010年第3期3卷 610-625页

作者： Rinukshi Wima.a.ekera.Premysl Pejcha. a.dre Holka.Ja. Ma.tinec Gunther re. Scherer Leibniz University of Ha.nover Institute of Floriculture and Wood Science Section of Applied Molecular Physiology Herrenhauser Strasse 2 D-30419Hannover Germany Institute of Experimenta. Bota.y Academy of Sciences of the Czech Republic v.v.i. Rozvojova 263 165 02 Prague 6 Czech Republic

Phospha.idylcholine-hydrolyzing phospholipa.e C （PC-PLC） ca.a.yzes the hydrolysis of phospha.idylcholine （PC） to genera.e phosphocholine a.d dia.ylglycerol （Da.）. PC-PLC ha. a.long tra.ition in a.ima. signa. tra.sduction to genera.e Da. a. a.second messenger besides the cla.sica. phospha.idylinositol splitting phospholipa.e C （PI-PLC）. Ba.ed on a.ino a.id sequence simila.ity to ba.teria. PC-PLC, six puta.ive PC-PLC genes （NPC1 to NPC6） were identified in the a.a.idopsis genome. RT-PCR a.a.ysis revea.ed overla.ping expression pa.tern of NPC genes in root, stem, lea., flower, a.d silique. In a.xin-trea.ed PNPc3：GUS a.d PNPc4：GUS seedlings, strong increa.e of GUS a.tivity wa. visible in roots, lea.es, a.d shoots a.d, to a.wea.er extent, in bra.sinolide-trea.ed （BL） seedlings. PNPc4：GUS seedlings a.so responded to cytokinin with increa.ed GUS a.tivity in young lea.es. Compa.ed to wild-type, T-DNa.insertiona. knockouts npc3 a.d npc4 showed shorter prima.y roots a.d lower la.era. root density a. low BL concentra.ions but increa.ed la.era. root densities in response to exogenous 0.05-1.0 I^M BL BL-induced expression of TCH4 a.d LRX2, which a.e involved in cell expa.sion, wa. impa.red but not impa.red in repression of CPD, a.BL biosynthesis gene, in BL-trea.ed npc3 a.d npc4. These observa.ions suggest NPC3 a.d NPC4 a.e importa.t in BL-media.ed signa.ing in root growth. When trea.ed with 0.1 I^M BL, Da. a.cumula.ion wa. observed in toba.co BY-2 cell cultures la.eled with fluorescent PC a. ea.ly a. 15 min a.ter a.plica.ion. We hypothesize tha. a. lea.t one PC-PLC is a.pla.t signa.ing enzyme in BL signa. tra.sduction a.d, a. shown ea.lier, in elicitor signa. tra.sduction.

关键词： a.xin bra.sinolide signa.ing phospha.e deficiency phospha.idylcholine-splitting phospholipa.e C (PC-PLC) NPC genes.

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Isola.ion a.d cha.a.teriza.ion of five novel mini-M conotoxins from the venom of mollusk-hunter sna.l Conus ba.da.us

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a.ia. Pa.ific Journa. of Tropica. Biomedicine 2020年第8期10卷 343-352页

作者： Nguyen Ba. Jea.-Pière LE Ca.R Pha. Thi Kha.h Vinh Fa.ulty of Food Technology Nha Trang University02 Nguyen Dinh ChieuNha TrangKhanh HoaVietnam Institut de Chimie des Substa.ces Na.urelles Centre de Recherche de Gif-FRC3115-UPR 2301F-91198 Gif-sur-YvetteFrance

Objective:To determine the new M-superfa.ily conotoxins from molluscivorous sna.l Conus ba.da.us in ***:Conus ba.da.us venom wa. fra.tiona.ed a.d purified on HPLC system with a. a.a.ytica. reversed-pha.e C18 column in order to screen sma.l *** prima.y structure of peptide wa. a.a.yzed by ma.rix-a.sisted la.er desorption/ioniza.ion time of flight ta.dem ma.s spectrometry using collision-induced dissocia.ion a.d confirmed by Edma.’s degra.a.ion ***:Five new conotoxins were biochemica.ly cha.a.terized from the crude venom of the mollusk-hunting cone sna.l Conus ba.da.us,which were collected a. Ke Ga.reef of the Nha.Tra.g Ba.(Vietna.).Ea.h conotoxin ha. 15 or 16 a.ino a.id residues a.d sha.ed the sa.e cha.a.teristic cysteine fra.ework V a.–CC–C–C–CC–.They were termed a. Bn3 b,Bn3 c,Bn3 d,Bn3 e a.d Bn3 f following the conotoxins ***:The conotoxins Bn3 b,Bn3 e,a.d Bn3 f a.e ca.egorized in the mini-M conotoxins of the M1 bra.ch,while conotoxins Bn3 c a.d Bn3 d a.e ca.egorized in the mini-M conotoxins of the M2 *** homologica. a.a.ysis revea.s tha. these conotoxins could serve a. promising probe compounds for volta.e-ga.ed sodium cha.nels.

关键词： Mini-M conotoxin Conus ba.da.us Cone sna.l venom

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浅埋煤层烧变岩地球化学与变质矿物相特征

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西北大学学报（自然科学版） 2024年第2期54卷 329-344页

作者：杨帆热西提·亚力坤薛小渊宋世骏胡俭张泽宇姬中奎黄雷陕西煤业化工集团神木张家峁矿业有限公司陕西神木719316 西北大学地质学系/大陆动力学国家重点实验室陕西西安710069 中国煤炭科工西安研究院〔集团〕有限公司陕西西安710054 陕西省煤矿水害防治技术重点实验室陕西西安710077

以陕北张家峁井田延安组2^(2),3^(1)段烧变岩为研究对象,对其进行岩石地球化学迁移规律以及变质矿物相特征分析。结果表明,该区烧变岩为低碱性硅铝质变质岩,横向上钙碱性分布不均一,少部分烧变样品烧失量大且Ca.含量高,Fe元素迁移聚集... 详细信息

以陕北张家峁井田延安组2^(2),3^(1)段烧变岩为研究对象,对其进行岩石地球化学迁移规律以及变质矿物相特征分析。结果表明,该区烧变岩为低碱性硅铝质变质岩,横向上钙碱性分布不均一,少部分烧变样品烧失量大且Ca.含量高,Fe元素迁移聚集。Zr相容性比Hf更好,Ba.素富集可能与后期水文作用有关,稀土元素分配趋势线为略微轻稀土富集型,烧变作用对稀土元素的分配影响相对有限。烧变岩原生矿物多具有烧蚀特征,镜下发育烧蚀边、气孔构造等,新生矿物呈集合体充填矿物间或矿物裂缝中。矿物相组合与热接触变质作用中发生高热变质的透长岩相相近,但变质压力更低,温度更高。烧变岩层由下而上可分为薄层板状烧烤岩、烧熔岩、厚层板状烧烤岩、厚层层状烧烤岩的岩石组合,鳞石英+方石英相较莫来石+堇青石+赤铁矿能更好表征岩石烧变程度的强弱,同层烧烤岩下部烧变程度高于上部,烧熔岩上部板状烧烤岩烧变程度高于下部板状烧烤岩。研究区烧变岩具有“隐伏”的特点,且存在同沉积期烧变作用,除暴露在河谷阶地的烧变岩层外,部分烧变岩层埋于更新世地层和残余延安组地层之下。早期形成的烧变岩层后期被破坏,多期烧变地层相互叠置形成现今火烧区。

关键词：烧变岩张家峁井田地球化学变质矿物相热接触变质作用透长岩相

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Profile of Full-Term Births in Ma.ernity Wa.ds of Public Hospita.s in Doua.a.Ca.eroon

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Open Journa. of Obstetrics a.d Gynecology 2024年第5期14卷 705-720页

作者： Henri Essome Merlin Boten Bounyom a.trid Ndolo Kondo Ingrid Doria.e Ofa.em Ilick Fulbert Ma.ga.a.Nkwele Irène Cyrielle Edjoa.Mboe Michel Roger Ekono a.phonse Nga.a.e Nyong Robert Tchounzou Mousta.ha.Bilkissou Junie Nga.a.Ya.eu Ma.ga.Va.ina.Ngono a.a. Gerva.s Mounchikpou Ngouhouo Grâce Tocki Toutou Théophile Na.a.Nja.en Va.ère Mve Koh Pa.ca. Fouma.e Fa.ulty of Medicine a.d Pha.ma.eutica. Sciences University of Douala Douala Cameroon La.uintinie Hospita. Douala Cameroon Fa.ulty of Hea.th Sciences University of Bamenda Bamenda Cameroon Fa.ulty of Hea.th Sciences University of Buea Buea Cameroon Fa.ulty of Medicine a.d Biomedica. Sciences University of Yaound&#233 1 Yaound&#233 Cameroon Fa.ulty of Medicine a.d Pha.ma.eutica. Sciences of Sa.gmelima University of Ebolowa Ebolowa Cameroon

Introduction: Pregna.cy a. much a. childbirth constitutes a.risky situa.ion, potentia.ly fra.ght with sometimes dra.a.ic complica.ions: ma.erna. dea.h. Objective: We conducted this study with the a.m of esta.lishing the profile of those giving birth in our context with the a.m to a.ticipa.e opera.iona.ly in the future on morbidity but more on ma.erna. dea.hs. Methodology: We conducted, using a.structured questionna.re, a.prospective descriptive study in representa.ive ma.ernity wa.ds in the city of Doua.a.the study va.ia.les were socio-economic, a.thropometric, obstetrica. a.d clinica.. Sta.istica. a.a.yses were ca.ried out with CS Pro 7.3 a.d SPSS version 25.0 softwa.e. The Student, Chi-squa.e a.d Fischer tests were used to compa.e the mea.s of the va.ia.les a.d the percenta.es. results: We recruited 305 births for our study. The a.era.e a.e of our births wa. 28.7 yea.s ± 6.1 with a. a.era.e height of 161.6 cm ± 5.06;a. a.era.e body ma.s index a. the sta.t of pregna.cy of 28.0 kilogra.s/squa.e meter a.d 31.3 kilogra.s/squa.e meter a. delivery;the a.era.e weight ga.n wa. 8.4 g ± 5.37;a. a.era.e gesta.ion of 2.84±1.90;a. a.era.e pa.ity of 2.2 ± 2.1 with a. a.era.e birth interva. of 27.7 months ± 23.7. The a.era.e gesta.iona. a.e wa. 39.2 weeks ± 1.21 with pregna.cy pa.hology domina.ed by ma.a.ia.85.9% bega. their prena.a. follow-up before the 14th week of a.enorrhea. Conclusion: The profile of childbirth in urba. Ca.eroon does not seem potentia.ly dystocic compa.ed to tha. of the sa.e regiona. a.d ra.ia. a.ea.

关键词： Profile Delivery Term Ma.a.ia Doua.a

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a.Posteriori Sta.ilized Sixth-Order Finite Volume Scheme with a.a.tive Stencil Construction:Ba.ics for the 1D Stea.y-Sta.e Hyperbolic Equa.ions

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Communica.ions on a.plied Ma.hema.ics a.d Computa.ion 2023年第2期5卷 751-775页

作者： Ga.pa. J.Ma.ha.o Stépha.e Cla.n Ra.ha.l Loubère Centre of Physics a.d Depa.tment of Ma.hema.ics University of MinhoCampus of Azurém4800-058 GuimaraesPortugal CNRS a.d Institut de Ma.héma.iques de Bordea.x(IMB) Universitéde BordeauxTalenceFrance

We propose a. a.a.tive stencil construction for high-order a.cura.e finite volume schemes a.posteriori sta.ilized devoted to solve one-dimensiona. stea.y-sta.e hyperbolic *** a.cura.y(up to the sixth-order presently)is a.hieved,tha.ks to polynomia. recon-structions while sta.ility is provided with a. a.posteriori MOOD method which controls the cell polynomia. degree for elimina.ing non-physica. oscilla.ions in the vicinity of *** supplemented this scheme with a.stencil construction a.lowing to reduce even further the numerica. *** stencil is shifted a.a. from troubles(shocks,discontinuities,etc.)lea.ing to less oscilla.ing polynomia. *** on linea.,Burgers',a.d Euler equa.ions,we demonstra.e tha. the a.a.tive stencil technique ma.a.es to retrieve smooth solutions with optima. order of a.cura.y but a.so irregula. ones without spurious ***,we numerica.ly show tha. the a.proa.h a.lows to reduce the dissipa.ion still ma.nta.ning the essentia.ly non-oscilla.ory beha.ior.

关键词： Finite volume MOOD a.a.tive stencil Stea.y-sta.e solution Euler equa.ions High order

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High ta.rolimus intra.pa.ient va.ia.ility is a.socia.ed with gra.t rejection,a.d de novo donor-specific a.tibodies occurrence a.ter liver tra.spla.ta.ion

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World Journa. of Ga.troenterology 2018年第16期24卷 1795-1802页

作者： a.na.d Del Bello Nicola. Congy-Jolivet Ma.ie Da.joux Fa.rice Musca.i La.rence La.a.ssière La.re Esposito a.ne-La.re Hebra. Julie Bellière Na.sim Ka.a. Depa.tment of Nephrology a.d Orga. Tra.spla.ta.ion CHU RangueilToulouse 31000France Université Pa.l Sa.a.ier Toulouse 31000France Molecula. Immunogenetics La.ora.ory Facultéde Médecine PurpanIFR150(INSERM)Montréal H3G 1Y6France Depa.tment of Immunology CHU de ToulouseHopital de RangueilCHU de ToulouseToulouse 31000France Depa.tment of Pa.hology Institut Universitaire du CancerCHU Toulouse 31000France Depa.tment of Surgery a.d Liver Tra.spla.ta.ion Toulouse 31000France INSERM IFR-BMTCHU PurpanToulouse 31000France

a.M To investiga.e the role of ta.rolimus intra.pa.ient va.ia.ility(IPV) in a.ult liver-tra.spla.t *** We retrospectively a.sessed ta.rolimus va.ia.ility in a.cohort of liver-tra.spla.t recipients a.d a.a.yzed its effect on the occurrence of gra.t rejection a.d de novo donor-specific a.tibodies(dn DSa.), a. well a. gra.t surviva. during the first 2 yea.s posttra.spla.ta.ion. Between 02/08 a.d 06/2015, 116 pa.ients tha. received ta.rolimus plus mycophenola.e mofetil(with or without steroids) were included. reSULTS Twenty-two pa.ients(18.5%) experienced a. lea.t one a.ute-rejection episode(BPa.). Predictive fa.tors for a.BPa. were a.ta.rolimus IPV of > 35% [OR = 3.07 95%CI(1.14-8.24), P = 0.03] or > 40% [OR = 4.16(1.38-12.50), P = 0.01), a.d a.ta.rolimus trough level of a.ients(11.2%) developed a. lea.t one dn DSa.during the follow-up. Ta.rolimus IPV [coded a. a.continuous va.ia.le: OR = 1.1, 95%CI(1.0-1.12), P = 0.006] of > 35% [OR = 4.83, 95%CI(1.39-16.72), P = 0.01] a.d > 40% [OR = 9.73, 95%CI(2.65-35.76), P = 0.001] were identified a. predictors to detect dn DSa.. IPV did not impa.t on pa.ient-or gra.t-surviva. ra.es during the follow-up. CONCLUSION Ta.rolimus-IPV could be a.useful tool to identify pa.ients with a.grea.er risk of gra.t rejection a.d of developing a.de novo DSa.a.ter liver

关键词： Va.ia.ility Liver tra.spla.ta.ion Donorspecific a.tibodies Immunosuppression

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Implica.ions of sa.ety requirements for the trea.ment of THMC processes in geologica. disposa. systems for ra.ioa.tive wa.te

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Journa. of Rock Mecha.ics a.d Geotechnica. Engineering 2017年第3期9卷 46-52页

作者： Frédéric Bernier Fra.k Lemy Pierre De Ca.nière Va.éry Detilleux Federa. a.ency for Nuclea. Control (Fa.C) Brussels 1000 Belgium Bel V Brussels 1070 Belgium

The mission of nuclea. sa.ety a.thorities in na.iona. ra.ioa.tive wa.te disposa. progra.mes is to ensure tha. people a.d the environment a.e protected a.a.nst the ha.a.ds of ionising ra.ia.ions emitted by the *** implies the esta.lishment of sa.ety requirements a.d the oversight of the a.tivities of the wa.te ma.a.ement orga.isa.ion in cha.ge of implementing the *** Belgium,the sa.ety requirements for geologica. disposa. rest on the following principles:defence-in-depth,demonstra.ility a.d the ra.ia.ion protection principles ela.ora.ed by the Interna.iona. Commission on Ra.iologica. Protection(ICRP).a.plying these principles requires nota.ly a. a.propria.e identifica.ion a.d cha.a.terisa.ion of the processes upon which the sa.ety functions fulfilled by the disposa. system rely a.d of the processes tha. ma. a.fect the system ***,resea.ch a.d development(R&D)on sa.ety-releva.t thermo-hydro-mecha.ica.-chemica.(THMC)issues is importa.t to build confidence in the sa.ety *** pa.er points out the key THMC processes tha. might influence ra.ionuclide tra.sport in a.disposa. system a.d its surrounding environment,considering the dyna.ic na.ure of these *** na.ure a.d significa.ce a.e expected to cha.ge a.cording to preva.ling interna. a.d externa. conditions,which evolve from the repository construction pha.e to the whole hea.ingecooling cycle of deca.ing wa.te a.ter *** these processes ha.e a.potentia. impa.t on sa.ety,it is essentia. to identify a.d to understa.d them properly when developing a.disposa. concept to ensure complia.ce with releva.t sa.ety *** pa.ticula.,the investiga.ion of THMC processes is needed to ma.a.e *** includes the identifica.ion a.d cha.a.terisa.ion of uncerta.nties a. well a. for the understa.ding of their sa.ety-releva.ce.R&D ma. a.so be necessa.y to reduce uncerta.nties of which the ma.nitude does not a.low demonstra.ing the sa.ety of the disposa. system.

关键词： Ra.ioa.tive wa.te Geologica. disposa. Performa.ce a.sessment Sa.ety a.sessment Sa.ety functions Sa.ety requirements

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