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Impact of vericiguat on heart failure with reduced ejection fraction:a review

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Global Health Journal 2023年第3期7卷 123-129页

作者： manisha Vohra Mohammad Amir Ian Osoro Amit Sharma Ranjeet Kumar Department of Pharmacy Practice ISF College of PharmacyMogaPunjab 142001India

Introduction:Heart failure is a major public health issue with a prevalence of about 26 million people *** nitric oxide availability,lower soluble guanylate cyclase(sGC)activity,and decreased cyclic guanosine monophosphate(cGMP)production are the causes of HF's *** prescribed under the brand name Verquvo was approved by *** and Drug Administration(FDA)in January *** is a novel agent and the first sGC stimulator which helps to treat patients suffering from heart failure with reduced ejection fraction(HFrEF).Objective:The mechanism of action(cGMP pathway)of vericiguat,its clinical trials,its use in the treatment of heart failure,and its possible future aspects in therapeutic recommendations are all covered in this *** will also raise awareness amongst healthcare professionals about the pharmacokinetic and pharmacodynamic parameters,dosing,administration,and drug-related problems of this new ***:Various databases for drug review were used in this review like PubMed,Medline,Google scholar,Drug bank,***,Medscape,and European society of cardiology guidelines.A total of 58 articles were screened out of which 39 articles were included in this ***:This review discusses vericiguat's mechanism of action(cGMP pathway),clinical studies,application in the treatment of heart failure,and potential future considerations in therapeutic *** will also educate healthcare professionals about the new drug's pharmacokinetics and pharmacodynamics,dose,administration,and drug-related ***:After hospitalization for HFrEF,the 5-year survival rate is just 25%,and disease morbidity and death are stil *** adjunctive therapy for individuals with heart failure and a low ejection fraction,vericiguat has a moderate level of ***'s efficacy as an adjunct therapy to different drugs used to cure HF has to be further ***'s safety and dosage in patients w

关键词： Vericiguat Heart failure with reduced ejection fraction Soluble guanylate cyclase stimulator Nitric oxide Cyclicguanosinemonophosphate

A therapeutic potentiality and toxicity concern of nutrient plant Annona squamosa Linn.

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Traditional Medicine Research 2024年第3期9卷 52-65页

作者： manisha Chandrakar Khomendra Kumar Sarwa Vijendra Kumar Suryawanshi Kumari Pramila University College of Pharmacy Raipur Chhattisgarh Swami Vivekanand Technical University BhilaiChhattisgarh 492001India Department of Pharmacy Government Girls PolytechnicRaipurChhattisgarh 492001India Bharti College of Pharmacy Bharti UniversityDurgChhattisgarh 491001India Faculty of Pharmacy M J College BhilaiDurgChhattisgarh 490023India

Annona squamosa *** is famous for its nutritional value with a long history of medicinal benefits due to the presence of many phytochemicals,including alkaloids,diterpenes,essential oil,phytopeptides,*** studies envisaged that Annona squamosa possesses cytotoxic,diuretic,antiurolithiatic,antitumor,anti-psoriatic,antioxidant,and hepatoprotective *** plant is traditionally used for the treatment of wound infection,dysentery,seizure,tumors,fever,vomiting,parasitic infections,hypertension,thyroid,toothache,acne,heart disease,inflammation,diabetes,hair loss,dandruff,hemorrhage,maggot-infected sores,abortifacient,and ***,some chemical constituents isolated from the plant have shown specific toxic effects in human and animal models,such as acute oral toxic effects,genotoxic,neurotoxic,and ocular *** plant has diverse pharmacological actions,the seeds of this plant possess a genotoxic effect but on the contrary,the bark of the plant shows genoprotective activity.A large number of ethnobotanical studies reported the seed of this plant is used to induce abortion in humans,but a scientific study carried out in pregnant rats reported aqueous seed extract of the plant did not interfere with reproductive *** presented review summarized the traditional uses,pharmacological,and toxicological activities of the isolated compounds from this ***,some patents and commercial products related to Annona squamosa are also brought up in this article to explore its application which would attract the scientific community to search out its hidden side.

关键词： Annona squamosa cytotoxicity cancer abortifacient genotoxicity isosquamocin annonacin neurotoxicity ocular toxicity

Circulatory and hepatic failure at admission predicts mortality of severe scrub typhus patients: A prospective cohort study

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Asian Pacific Journal of Tropical Medicine 2021年第5期14卷 209-213页

作者： Ashok Kumar Pannu Atul Saroch Saurabh Chandrabhan Sharda Manoj Kumar Debnath manisha Biswal Navneet Sharma Department of Internal Medicine Postgraduate Institute of Medical Education and ResearchChandigarhIndia Department of Medical Microbiology Postgraduate Institute of Medical Education and ResearchChandigarhIndia

Objective:To study the spectrum and outcome of severe scrub typhus in adult patients and to predict the hospital mortality by organ failure on ***:This was a prospective observational cohort study conducted between July 2017 and October 2020 at the medical emergency centre of PGIMER,Chandigarh,*** hundred and twenty-six patients aged≥13 years were diagnosed with scrub *** disease was defined as the presence of organ failure based on the Sequential Organ Failure Assessment(SOFA)score on ***:About two-thirds of the patients were from geographic regions outside the endemic sub-Himalayan ***(99.21%)and dyspnea(79.36%)were the most frequent *** failure(81.75%)was the most common organ failure,followed by hepatic(52.38%),coagulative(47.62%),circulatory(33.33%),renal(21.43%),and cerebral dysfunction(13.49%).The median(Q1,Q3)SOFA score was 8(6,9),and 48.41%of the patients had a quick-SOFA score≥*** supports with invasive ventilation(40.48%),vasopressors(36.51%),and renal replacement therapy(7.14%)were frequently *** in-hospital mortality was 11.90% and was independently predicted by circulatory and hepatic failures on multivariate logistic regression(OR 11.12,95%CI 1.73-71.31 and OR 8.49,95%CI 1.18-61.41,respectively).Conclusions:Most patients had pulmonary dysfunction;circulatory or hepatic failure on admission strongly predicts death.

关键词： Scrub typhus Orientia tsutsugamushi Organ failure Mortality Prognosis

Audiovestibular functioning of post-menopausal females with osteoporosis and osteopenia

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Journal of Otology 2021年第1期16卷 27-33页

作者： manisha K.Juneja Sanjay Munjal Anuradha Sharma Ashok K.Gupta Sanjay Bhadada Speech and Hearing Unit ENT DepartmentGMCHSec-32ChandigarhIndia Speech&Hearing Unit Dept.of OtolaryngologyPGIMERChandigarhIndia Dept.of Otolaryngology PGIMERChandigarhIndia Dept.of Endocrinology PGIMERChandigarhIndia

Introduction:Osteoporosis and osteopenia are progressive disorders characterized by decreased bone mass,especially in postmenopausal *** can be associated with body pain,fractures,hearing loss and balance *** present study aims to evaluate audio-vestibular function in postmenopausal patients with osteopenia or ***:The study included 48 postmenopausal women(new subjects)diagnosed with osteoporosis(n=23)or osteopenia(n=25)in the age range of 50e66 years,as well as 28 normal women as *** testing included pure tone audiometry(conventional and extended high-frequency audiometry),speech audiometry,impedance audiometry and otoacoustic emissions,including both transient evoked otoacoustic emissions(TEOAEs)and distortion product otoacoustic emissions(DPOAEs).All subjects also underwent vestibular evoked myogenic potentials testing(both ocular and cervical VEMPs).Results:In the present study,hearing was worse at all frequencies in the osteoporosis group in comparison with the osteopenia and control groups,with worse speech recognition and discrimination scores and *** function was affected in 95.65%of women with osteoporosis and 76%of those with ***:Osteoporosis and osteopenia are risk factors for vestibular dysfunction and hearing deficits in postmenopausal ***,hearing and vestibular function should be monitored by audiological and vestibular testing periodically in these individuals.

关键词： Hearing loss Audio-vestibular testing Pure tone audiometry(PTA) OAE’S Speech audiometry VEMP Sensorineural hearing

Returning China-India Relations to Normal

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中印对话（英文版） 2022年第1期 8-11页

作者： manisha Chakraborty 不详

No one can dispute that the unfortu-nate bloodshed in the 2020 Galwan Valleyclashbetween the IndianandChineseborder troops at the Line of Actual Control(LAC)in the Ladakh region decimated the China-India *** border conflict at icy heights has been tearing both countries apart,significantlyaffecting the socio-economic fields of the people living on both sides of the Himalayas.

关键词： relationship. dispute India

Soil phyllosilicate and iron oxide inhibit the quorum sensing of Chromobacterium violaceum

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Soil Ecology Letters 2021年第1期3卷 22-31页

作者： Shanshan Yang Chenchen Qu manisha Mukherjee Yichao Wu Qiaoyun Huang Peng Cai State Key Laboratory of Agricultural Microbiology College of Resources and EnvironmentHuazhong Agricultural UniversityWuhan 430070China Singapore Centre for Environmental Life Sciences Engineering Nanyang Techological UniversitySingaporeSingapore 637551 School of Civil and Environmental Engineering Nanyang Technological UniversitySingaporeSingapore 639798

Microorganisms respond to various adverse environmental conditions and regulate different physiological functions by secreting and sensing signal molecules through quorum sensing(QS)*** and iron oxides present in soils and sediments may have substantial impact on bacterial activity and QS due to their unique reactivity and close association with *** research explored the effect of goethite,montmorillonite and kaolinite(0.05–2gL^(–1))on the growth and QS of a bacterial model,Chromobacterium *** results showed that kaolinite and goethite caused cellular damage at low mineral *** capacity for violacein production and biofilm formation of *** were inhibited by the minerals in the order of kaolinite>goethite>*** possible underlying mechanisms for QS inhibition by different minerals were ***,kaolinite repressed QS function through downregulation the expression of signal molecules synthesis gene *** and montmorillonite interfered with QS by adsorption of extracellular signal *** work provides a better understanding of the interactions between bacteria and minerals and proposed that the inhibition of QS system is an ignored mechanism for bacterial toxicity by phyllosilicates and iron oxides.

关键词： Violacein Quorum sensing Signal molecule Soil mineral

Working for Humanity's Future

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中印对话（英文版） 2023年第3期 31-33页

作者： manisha Chakraborty 不详

The aim of all these people-centered initiatives is to build a community of common goals for mankind and create a beautiful future while upholding world peace and promoting common development.

关键词： peace development. beautiful

Comparison of conventional and Hang-back methods of inferior oblique recession in V-pattern strabismus with inferior oblique overaction

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International Journal of Ophthalmology(English edition) 2020年第6期13卷 985-990页

作者： Kamlesh AnAND Ankita Bharadwaj Shweta Dhiman Yashpal Goel Anju Rastogi Richa Agarwal manisha Misthra Prateek Kumar Department of Ophthalmology Guru Nanak Eye CentreMaulana Azad Medical CollegeNew Delhi 110002India

AIM:To compare outcomes of conventional and Hangback methods of inferior oblique(IO)recession in V-pattern strabismus with inferior oblique overaction(IOOA).METHODS:Comparative randomized study was conducted consisting of 50 patients,age 6 to 35 y having V-pattern strabismus[>15 prism diopter(PD)]with *** were divided equally in two groups and underwent IO recession,group A by conventional method and group B by Hang-back *** evaluated were reduction in V-pattern and IOOA,shift in torsion,improvement in binocular *** was a residual V-pattern of less than 10 PD at 1 y of follow ***:The mean V-pattern preoperatively and postoperatively at 1 y was 24±5.4 PD and 4.2±3.51 PD in group A and 23.44±6.44 PD and 5.76±3.8 PD in group B *** mean reduction in V-pattern was 20±6.78 PD in group A and 18.2±5.48 PD in group *** mean correction of IOOA was 18.48±3.13 PD in group A and 16±2.93 PD in group *** shift in extorsion was 3.08±1.8 degree in group A and 3.72±2.14 degree in group ***:Both the procedures achieve a significant and comparable reduction in V-pattern and ***-back recession being a landmark free surgery eliminates the need for intrascleral suturing thereby reducing the risk of scleral perforation with possible postoperative adjustment of *** may be considered as a good alternative for IO recession in patients of V-pattern strabismus with mild to moderate amount of IOOA.

关键词： V-pattern inferior oblique overaction Hang-back recession conventional recession

SRS and XPM Impairments on Different Optical Fibers

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International Journal of Intelligence Science 2016年第2期6卷 11-15页

作者： Ravi Gupta manisha Department of ECE Government Engineering College of Bharatpur Bharatpur India

In this paper, the analysis of crosstalk induced by stimulated Raman scattering has been discussed. The expression for SRS induced crosstalk has been observed at different fiber types, such as single mode fiber, DCF, NZDF and NZDSF with the variation of modulation frequency, transmission length and the input power. It has been observed that as an increase in the modulation frequency, the crosstalk decreases.

关键词： SRS DCF NZDF NZDSF Modulation Frequency Transmission Length