检索结果-南通市图书馆

Synergism of co-delivered nanosized antioxidants displayed enhanced anticancer efficacy in human colon cancer cell lines

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2017年第2期2卷 82-95页

作者： Lipika Ray manish kumar Pal Ratan Singh Ray CSIR-Indian Institute of Toxicology Research P.O.Box No.80M.G.MargLucknowUP226001India Academy of Scientific and Innovative Research New Delhi 110001India

Combination of chemopreventive and/or therapeutic agents is the imminent smart approach to cope upwith cancer because it may act on multiple targets through different pathways. In the present study, wehave synthesized multiple chemopreventive and/or therapeutic agents (Curcumin, Quercetin andAspirin) loaded nanoparticles by simple cation-anion interaction among the amine groups of chitosan(CS) and phosphate groups of sodium hexametaphosphate (SHMP). These nanosized bioactive materials(CS-SHMP-CQA-NPs) were well characterized and found most effective in colon cancer cell line (HCT-116)compared to other cancer cell lines. Triplex chemopreventive and/or therapeutic agents-loaded NPs weresynergistically inducing apoptosis in HCT-116 cells compared to two-chemopreventive agents-loadedNPs as evident by an increase in sub-G1 cells (percent), and chromatin condensation along with thedecrease in mitochondrial membrane potential (MMP). Interestingly, ChoueTalalay analysis revealedthat CS-SHMP-CQA-NPs showed strong synergistic effect in its all doses. Thus, our study demonstratesthat nanoparticles based bioactive materials significantly inhibit the growth of HCT-116 cells and thuscould be a promising approach for colon cancer chemoprevention.

关键词： Chemoprevention Therapeutic agent Colon cancer Synergistic effect Apoptosis

Oxygen isotope-salinity relation in an Arctic fjord(Kongsfjorden):Implications to hydrographic variability

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geoscience Frontiers 2018年第6期9卷 1937-1943页

作者： manish Tiwari Siddhesh Nagoji Vikash kumar Shubham Tripathi Padmasini Behera National Centre for Polar&Ocean Research Vasco-da-GamaGoa 403804India

The global warming leads to a large freshwater influx into the Arctic Ocean, which has adverse implications to the sea-ice dynamics, ocean circulation, and acidification. The relationship between oxygen isotope ratio(δ^(18)O) and salinity(S) is helpful in exploring various hydrographic processes related to the freshwater influx and is also required to accurately determine past salinity variability using oxygen isotope ratio of the carbonates. In view of this, systematic measurements of δ^(18)O and salinity of water from an Arctic fjord(Kongsfjorden) were carried out during the summer season of 2013. Until now, the relationships between δ^(18)O and salinity from such fjords were based on a limited number of samples collected during a very short span of time and thus may not accurately represent the long-term conditions prevailing in the fjord. The present study determines a more representative δ^(18)O-salinity relationship as water samples from different depths and location over a long period were systematically collected. The water samples were collected from four different locations at different depths along the axis of the fjord representing the inner and outer fjords. The inner stations(1-8 and 1-6) exhibit lowerδ^(18)O values than the outer stations(1-1 and 1-3), which indicate the higher influence of freshwater from glacial melting in the inner stations. The δ^(18)O-salinity relationship from the inner and outer fjords yield a slope of 0.54(r^2 = 0.67, n = 56) and 0.39(r^2 = 0.66, n = 68), respectively. The δ^(18)O of freshwater influx in the fjord is estimated at-18.4‰, which is close to the widely accepted freshwater-δ^(18)O value of the Arctic basin. The δ^(18)O of glacial discharge, which is the largest source of freshwater influx to the fjord, is estimated at ca.-21.0‰, which will be useful for future freshwater budget calculations.

关键词： Arctic Fjord Oxygen isotopes Salinity Freshwater Melting

Preoperative therapy in locally advanced esophageal cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第39期22卷 8750-8759页

作者： Pankaj kumar Garg Jyoti Sharma Ashish Jakhetiya Aakanksha Goel manish kumar Gaur Department of Surgery University College of Medical Sciences and Guru Teg Bahadur Hospital University of Delhi Department of Surgical Oncology Sawai Man Singh Medical College Department of Surgical Oncology Dr BRA Institute Rotary Cancer Hospital All India Institute of Medical Sciences

Esophageal cancer is an aggressive malignancy associated with dismal treatment outcomes. Presence of two distinct histopathological types distinguishes it from other gastrointestinal tract malignancies. Surgery is the cornerstone of treatment in locally advanced esophageal cancer(T2 or greater or node positive); however, a high rate of disease recurrence(systemic and loco-regional) and poor survival justifies a continued search for optimal therapy. Various combinations of multimodality treatment(preoperative/perioperative, or postoperative; radiotherapy, chemotherapy, or chemoradiotherapy) are being explored to lower disease recurrence and improve survival. Preoperative therapy followed by surgery is presently considered the standard of care in resectable locally advanced esophageal cancer as postoperative treatment may not be feasible for all the patients due to the morbidity of esophagectomy and prolonged recovery time limiting the tolerance of patient. There are wide variations in the preoperative therapy practiced across the centres depending upon the institutional practices, availability of facilities and personal experiences. There is paucity of literature to standardize the preoperative therapy. Broadly, chemoradiotherapy is the preferred neo-adjuvant modality in western countries whereas chemotherapy alone is considered optimal in the far East. The present review highlights the significant studies to assist in opting for the best evidence based preoperative therapy(radiotherapy, chemotherapy or chemoradiotherapy) for locally advanced esophageal cancer.

关键词：食道的癌症外科手术前的治疗 Multimodality 治疗化疗放射疗法 Chemoradiotherapy

Review and insight on the behavioral aspects of cybersecurity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cybersecurity 2018年第1期1卷 749-766页

作者： Rachid Ait Maalem Lahcen Bruce Caulkins Ram Mohapatra manish kumar University of Central Florida Mathematics DepartmentOrlandoFL 32816USA Institute for Simulation and Training 3100 Technology PkwyOrlandoFL 32826USA Birla Institute of Technology and Sciences-Pilani Hyderabad CampusHyderabad 500078TelanganaIndia

Stories of cyber attacks are becoming a routine in which cyber attackers show new levels of intention by sophisticated attacks on ***,cybercriminals have figured out profitable business models and they take advantage of the online anonymity.A serious situation that needs to improve for networks’***,a paradigm shift is essential to the effectiveness of current techniques and *** the majority of cyber incidents are human enabled,this shift requires expanding research to underexplored areas such as behavioral aspects of *** is more vital to focus on social and behavioral issues to improve the current *** paper is an effort to provide a review of relevant theories and principles,and gives insights including an interdisciplinary framework that combines behavioral cybersecurity,human factors,and modeling and simulation.

关键词： Cybersecurity Behavioral aspects Human factors Crime theories

An Efficient Class of Estimators for the Mean of a Finite Population in Two-Phase Sampling Using Multi-Auxiliary Variates

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Mathematics and Statistics 2015年第4期3卷 477-489页

作者： Gajendra K.Vishwakarma manish kumar Department of Applied Mathematics Indian School of MinesDhanbadJharkhand 826004India

This paper presents an efficient class of estimators for estimating the population mean of the variate under study in two-phase sampling using information on several auxiliary *** expressions for bias and mean square error(MSE)of the proposed class have been obtained using Taylor series *** addition,the minimum attainableMSE of the proposed class is obtained to the first order of *** proposed class encompasses a wide range of estimators of the sampling *** comparison has been made for demonstrating the performance of the proposed *** attempt has been made to find optimum sample sizes under a known fixed cost *** illustrations are given in support of theoretical findings.

关键词： Auxiliary variate Study variate Two-phase sampling Bias MSE

Prevalence of excessive internet use and its correlation with associated psychopathology in 11th and 12th grade students

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

General Psychiatry 2019年第2期32卷 84-91页

作者： Nitin kumar Arvind kumar Subodh kumar Mahto manish Kandpal Smita Neelkanth Deshpande Parul Tanwar Department of Psychiatry Dr Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education and Research New Delhi India Department of Medicine Dr Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education and Research New Delhi India Vardhman Mahavir Medical College and Safdarjung Hospital New Delhi India

Background Globally, the number of internet users has crossed the three-billion mark, while in India users grew over 17% in the first 6 months of 2015 to 354 million. This study presented a background on internet use and the existence of excessive internet use. Aim To study the extent of internet use in 11th and 12th grade students and the psychopathology, if any, associated with excessive internet use. Methods 426 students who met the inclusion criteria were recruited from 11 th and 12th grade classes from Kendriya Vidyalaya, New Delhi, India, and were assessed by Young's Internet Addiction Test and the Strength and Difficulties Questionnaire. Results Among the 426 students, the mean internet addiction total score was 36.63 (20.78), which indicated mild level of internet addiction. 1.41%(six students) was diagnosed as excessive internet users, while 30.28% and 23.94% were classified as moderate and mild internet users, respectively. The prevalence of internet addiction between gender was 58.22% in males and 41.78% in females. While both positive (prosocial) and negative (hyperactivity, emotional, conduct and peer problem) impacts of internet use were reported by students, in the current study excessive use of internet had a negative impact on students' lives as compared with positive impact, which was statistically significant (p<0.0001). Conclusion Excessive internet use led to abnormal behaviours which cause negative consequences to users. Early diagnosis of risk factors related to excessive internet use, provides education about responsible use and supervision of students by family members.

关键词： internet psychopathology inclusion criteria

Biodiversity,current developments and potential biotechnological applications of phosphorus-solubilizing and-mobilizing microbes:A review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pedosphere 2021年第1期31卷 43-75页

作者： Divjot KOUR Kusam Lata RANA Tanvir KAUR Neelam YADAV Ajar Nath YADAV manish kumar Vinod kumar Harcharan Singh DHALIWAL Anil kumar SAXENA Department of Biotechnology Dr.Khem Singh Gill Akal College of AgricultureEternal UniversityBaru SahibSirmour 173101(India Gopi Nath P.G.College Veer Bahadur Singh Purvanchal UniversityGhazipur 275201(India Amity Institute of Biotechnology Amity UniversityGwalior 474005(India Biochemistry Forage SectionCollege of AgricultureCCS Agricultural UniversityHaryana 125004India ICAR-National Bureau of Agriculturally Important Microorganisms Kusmaur 275103(India)

As one of the most important and essential macronutrients next to nitrogen,phosphorus(P)is important for plant development,but it is the least mobile nutrient element in plant and ***,P is mined from geological sediments and added to agricultural soils so as to meet the critical requirements of crop plants for agronomic *** exists in soil in both organic and inorganic *** various inorganic forms of the element in soil are salts with calcium,iron,and aluminum,whereas the organic forms come from decaying vegetation and microbial *** is a huge diversity of plant microbiomes(epiphytic,endophytic,and rhizospheric)and soil microbiomes that have the capability to solubilize the insoluble P and make it available to *** main mechanism for the solubilization of inorganic P is by the production of organic acids,which lowers soil pH,or by the production of acid and alkaline phosphatases,which causes the mineralization of organic *** P-solubilizing and-mobilizing microorganisms belong to all three domains,comprising archaea,bacteria,and *** strains belonging to the genera Arthrobacter,Bacillus,Burkholderia,Natrinema,Pseudomonas,Rhizobium,and Serratia have been reported as efficient and potential P *** use of P solubilizers,alone or in combination with other plant growth-promoting microbes as an eco-friendly microbial consortium,could increase the P uptake of crops,increasing their yields for agricultural and environmental sustainability.

关键词： crop improvement gene expression microbial diversity organic acid production P mineralization P solubilizer phosphatase production plant growth-promoting traits

Patients with Cirrhosis of Liver Operated for Non-transplant Surgery: A Retrospective Analysis

在线全文

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2019年第1期7卷 9-14页

作者： Kishore kumar Kuduva Subramanian manish Tandon Chandra Kant Pandey Priyanka Jain Department of Anaesthesiology Institute of Liver and Biliary SciencesNew DelhiIndia Department of Research Institute of Liver&Biliary Sciences(ILBS)New DelhiIndia

Background and Aims:Patients with cirrhosis of the liver have high mortality after *** investigated the mortality in patients with cirrhosis of the liver who underwent surgery other than liver transplant and applied the Mayo clinic model to predict mortality and compare with the observed *** also studied the association of the observed mortality with the Child-Turcotte-Pugh(CTP)class and the model for end-stage liver disease(MELD)and model for end-stage liver disease-sodium(MELD-Na)***:The electronic records database of our hospital was accessed to analyze the data of 133 cirrhotic patients who underwent various surgeries under general anesthesia from October 2009 to June *** Mayo risk score was applied to each and used to calculate predicted mortality;the MELD and MELD-Na scores were also *** interview was performed with the patients and or their relative to ascertain survival or time of death after surgery,when the information was not available from the hospital ***:The all-cause observed mortality rates at postoperative days 30 and 90 and at 1 year were 12%,20.3%and 26.3%*** area under the receiver operating characteristic curve values for the Mayo model as a predictor of 30-day,90-day and 1-year mortality were 0.836,0.828 and 0.744 *** correlation was seen for observed mortality with CTP class and with MELD and MELD-Na ***:The Mayo model for predicting postoperative mortality in patients with cirrhosis of the liver demonstrated good correlation in this *** strength of prediction of mortality by Mayo risk score calculation was similar at postoperative days 30 and 90 but decreased at 1-year after the *** correlation was seen for the observed mortality with MELD,MELD-Na and CTP scores.

关键词： Cirrhosis of the liver Mayo risk model CTP score MELD score

Gurumukhi印刷报纸的文字识别（英文）

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Central South University 2019年第9期26卷 2495-2503页

作者： Rupinder Pal Kaur manish kumar Jindal Munish kumar Post Graduate Department of Computer Science Guru Nanak College for GirlsSri Muktsar SahibPunjabIndia Department of Computer Science&Applications Panjab University Regional CentreSri Muktsar SahibPunjabIndia Department of Computational Sciences Maharaja Ranjit Singh Punjab Technical UniversityBathindaPunjabIndia

本文提出了一种基于Gurumukhi字体的报纸识别系统。采用分区特征、对角线特征、抛物线拟合特征和势曲线拟合特征提取技术对报刊印刷字符的统计特性进行提取。为了提高识别精度,还对这些特征进行了不同的组合。在识别方面,采用了k-神经... 详细信息

本文提出了一种基于Gurumukhi字体的报纸识别系统。采用分区特征、对角线特征、抛物线拟合特征和势曲线拟合特征提取技术对报刊印刷字符的统计特性进行提取。为了提高识别精度,还对这些特征进行了不同的组合。在识别方面,采用了k-神经网络、线性支持向量机、决策树和随机森林四种分类技术。实验数据库是从三家主要的Gurumukhi字体报纸Ajit,Jagbani和Punjabi Tribune收集的。采用五倍交叉验证和随机森林分类器,以及分区特征、对角线特征和抛物线拟合特征相结合的方法,识别准确率达96.19%。采用数据集分割策略(70%的数据作为训练数据,其余的30%的数据作为测试数据),识别准确率达到95.21%。

关键词：报纸识别特征提取分类 Gurumukhi字体随机森林算法