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Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors

Acta Pharmaceutica Sinica B 2024年第7期14卷 3009-3026页

作者： Saini Setua Shabia Shabir Poornima Shaji Ana Martinez Bulnes Anupam Dhasmana Swathi Holla Nivesh k.Mittal Nirakar Sahoo Tripti Saini Francesco Giorgianni Mohammad Sikander Andrew E.Massey Bilal B.Hafeez manish k.tripathi Vincent P.Diego Meena Jaggi Junming Yue Nadeem Zafar Murali M.Yallapu Stephen W.Behrman Sheema khan Subhash C.Chauhan Department of Pharmaceutical Sciences College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA Department of Computer Science Islamic University of Science and TechnologyAwantiporaJ&K 192122India Department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Texas Center of Excellence in Cancer Research School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA Himalayan School of Biosciences and Cancer Research Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India Plough Center for Sterile Drug Delivery Solutions UTHSCMemphisTN 38104USA Department of Biology College of SciencesUTRGVMcAllenTX 78539USA National Institute of Biomedical Imaging and Bioengineering(NIBIB) National Institutes of HealthBethesdaMD 20892USA South Texas Diabetes and Obesity Institute UTRGVMcAllenTX 78504USA Dept.of Laboratory Medicine&Pathology University of WashingtonSeattleWA 98195USA Department of Surgery Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA Baptist Health Sciences University MemphisTN 38104USA

The application of extracellular vesicles,particularly exosomes(EXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological *** study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAF-EXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ***,we show that exosomes(EXs)derived from NAFs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of ***-derived EXs(NAF-EXs)were used for loading ormeloxifene(ORM),a potent anti-cancer and desmoplasia inhibitor as a model *** found that ORM maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a CAF-like phenotype,which may be due to regulation of Ca^(2+) influx in fibroblast ***-EXs-ORM effectively blocked oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(EMT)and repressed tumor growth in xenograft mouse *** conclusion,our data suggests preferential tropism of NAF-EXs for PDAC tumors,thus imply feasibility of developing a novel personalized medicine for PDAC patients using autologous NAF-EXs for improved therapeutic outcome of anti-cancer ***,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.

关键词： Pancreatic cancer Tumor adjacent normal tissue fibroblasts(NAF) Desmoplasia Extracellular vesicles Exosomes Tumor targeting Ormeloxifene Personalized medicine

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Recent advances on the role of long non-coding RNAs in Alzheimer’s disease

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Neural Regeneration Research 2020年第12期15卷 2253-2254页

作者： kyle Doxtater manish k.tripathi Mohammad Moshahid khan Department of Pharmaceutical Sciences University of Tennessee Health Science CenterMemphisTNUSA Department of immunology and Microbiology University of Texas Rio Grande ValleyMcAllenTXUSA Department of Neurology College of MedicineDivision of Rehabilitation Sciences and Department of Physical TherapyCollege of Health ProfessionsUniversity of Tennessee Health Science CenterMemphisTNUSA

Dementia is a progressive cognitive impairment that affects the activities of daily ***’s disease (AD) is the most common form of the dementia worldwide accounting for 60-80%of all dementia *** an estimated cost exceeding$290 billion in the USA,understanding and development of future therapeutic strategies is *** this perspective,we will be examining the current thinking of AD research and therapeutic strategies,while proposing a possible new direction for diagnosis,understanding,and treatment targets.

关键词： Alzheimer diagnosis exceeding

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MicroRNA: a new and promising potential biomarker for diagnosis and prognosis of ovarian cancer

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Cancer Biology & Medicine 2015年第4期12卷 328-341页

作者： manish k.Pal Shyam P.Jaiswar Vinaya N.Dwivedi Amit k.tripathi Ashish Dwivedi Pushplata Sankhwar Department of Obstetrics and Gynecology King George Medical University Biochemistry and Molecular Biology Laboratory Center for Advanced Study in Zoology Department of Zoology Banaras Hindu University Endocrinology Division Central Drug Research Institute Photobiology Division Indian Institute of Toxicology Research

Epithelial ovarian cancer(EOC) is the leading cause of death among all gynecological malignancies. Despite the technological and medical advances over the past four decades, such as the development of several biological markers(mRNA and proteins biomarkers), the mortality rate of ovarian cancer remains a challenge because of its late diagnosis, which is specifically attributed to low specificities and sensitivities. Under this compulsive scenario, recent advances in expression biology have shifted in identifying and developing specific and sensitive biomarkers, such as micro RNAs(miRNAs) for cancer diagnosis and prognosis. MiRNAs are a novel class of small non-coding RNAs that deregulate gene expression at the posttranscriptional level, either by translational repression or by mRNA degradation. These mechanisms may be involved in a complex cascade of cellular events associated with the pathophysiology of many types of cancer. MiRNAs are easily detectable in tissue and blood samples of cancer patients. Therefore, miRNAs hold good promise as potential biomarkers in ovarian cancer. In this review, we attempted to provide a comprehensive profile of key miRNAs involved in ovarian carcinoma to establish mi RNAs as more reliable non-invasive clinical biomarkers for early detection of ovarian cancer compared with protein and DNA biomarkers.

关键词：生物标志物肿瘤诊断卵巢癌预后 miRNAs 开发基因表达癌症患者

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Oxygen isotope-salinity relation in an Arctic fjord(kongsfjorden):Implications to hydrographic variability

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Geoscience Frontiers 2018年第6期9卷 1937-1943页

作者： manish Tiwari Siddhesh Nagoji Vikash kumar Shubham tripathi Padmasini Behera National Centre for Polar&Ocean Research Vasco-da-GamaGoa 403804India

The global warming leads to a large freshwater influx into the Arctic Ocean, which has adverse implications to the sea-ice dynamics, ocean circulation, and acidification. The relationship between oxygen isotope ratio(δ^(18)O) and salinity(S) is helpful in exploring various hydrographic processes related to the freshwater influx and is also required to accurately determine past salinity variability using oxygen isotope ratio of the carbonates. In view of this, systematic measurements of δ^(18)O and salinity of water from an Arctic fjord(kongsfjorden) were carried out during the summer season of 2013. Until now, the relationships between δ^(18)O and salinity from such fjords were based on a limited number of samples collected during a very short span of time and thus may not accurately represent the long-term conditions prevailing in the fjord. The present study determines a more representative δ^(18)O-salinity relationship as water samples from different depths and location over a long period were systematically collected. The water samples were collected from four different locations at different depths along the axis of the fjord representing the inner and outer fjords. The inner stations(1-8 and 1-6) exhibit lowerδ^(18)O values than the outer stations(1-1 and 1-3), which indicate the higher influence of freshwater from glacial melting in the inner stations. The δ^(18)O-salinity relationship from the inner and outer fjords yield a slope of 0.54(r^2 = 0.67, n = 56) and 0.39(r^2 = 0.66, n = 68), respectively. The δ^(18)O of freshwater influx in the fjord is estimated at-18.4‰, which is close to the widely accepted freshwater-δ^(18)O value of the Arctic basin. The δ^(18)O of glacial discharge, which is the largest source of freshwater influx to the fjord, is estimated at ca.-21.0‰, which will be useful for future freshwater budget calculations.

关键词： Arctic Fjord Oxygen isotopes Salinity Freshwater Melting

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Carbon and water footprints of major crop production in India

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Pedosphere 2023年第3期33卷 448-462页

作者： Amaresh kumar NAYAk Rahul tripathi manish DEBNATH Chinmaya kumar SWAIN Biswaranjan DHAL Shanmugam VIJAYkUMAR Anshuman Debasis NAYAk Sangita MOHANTY Mohammad SHAHID Anjani kUMAR Manoj RAJAk khitish Chandra MOHARANA Dibyendu CHATTERJEE Susmita MUNDA Pravat GURU Rubina kHANAM Banwari LAL Priyanka GAUTAM Suschismita PATTANAIk Arvind kumar SHUkLA Nuala FITTON Pete SMITH Himanshu PATHAk Indian Council of Agriculture Research(ICAR)-National Rice Research Institute Cuttack 753006(India) ICAR-Central Sheep and Wool Research Institute Avikanagar 304501(India) ICAR-National Research Centre on Camel Bikaner 304001(India) ICAR-Indian Institute of Soil Science Bhopal 462038(India) Institute of Biological and Environmental Sciences University of Aberdeen23St Machar DriveAberdeen AB243UU(UK)

Scarcity of water and emission of greenhouse gases(GHGs)are the two key environmental issues affecting crop production in *** the carbon footprint(CF)and water footprint(WF)of crop production can help to mitigate the environmental hazards that stem from GHG emissions and water *** CFs and WFs of three major cereal crops,rice,wheat,and maize,were estimated for the year 2014 under the environmental conditions in India,based on national statistics and other data *** CFs(TCFs)of rice,wheat,and maize in India were estimated to be 2.44,1.27,and 0.80 t CO_(2)equivalent ha-1,respectively,and product WFs for rice,wheat,and maize in India were 3.52,1.59,and 2.06 m3 kg^(-1),*** WF was found to be the highest in West India for rice and in South India for both wheat and maize,with the highest irrigation water use in these *** was a positive correlation between TCF and total WF,and hence mitigation of both was possibly simultaneous in various regions in *** measures for mitigating GHG emissions and optimizing water use for rice,wheat,and maize production in India are recommended in this paper.

关键词： cereal crop crop planning green water footprint greenhouse gas emission water productivity water use

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