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MicroRNA: a new and promising potential biomarker for diagnosis and prognosis of ovarian cancer

Cancer Biology & Medicine 2015年第4期12卷 328-341页

作者： manish k.pal Shyam P.Jaiswar Vinaya N.Dwivedi Amit k.Tripathi Ashish Dwivedi Pushplata Sankhwar Department of Obstetrics and Gynecology King George Medical University Biochemistry and Molecular Biology Laboratory Center for Advanced Study in Zoology Department of Zoology Banaras Hindu University Endocrinology Division Central Drug Research Institute Photobiology Division Indian Institute of Toxicology Research

Epithelial ovarian cancer(EOC) is the leading cause of death among all gynecological malignancies. Despite the technological and medical advances over the past four decades, such as the development of several biological markers(mRNA and proteins biomarkers), the mortality rate of ovarian cancer remains a challenge because of its late diagnosis, which is specifically attributed to low specificities and sensitivities. Under this compulsive scenario, recent advances in expression biology have shifted in identifying and developing specific and sensitive biomarkers, such as micro RNAs(miRNAs) for cancer diagnosis and prognosis. MiRNAs are a novel class of small non-coding RNAs that deregulate gene expression at the posttranscriptional level, either by translational repression or by mRNA degradation. These mechanisms may be involved in a complex cascade of cellular events associated with the pathophysiology of many types of cancer. MiRNAs are easily detectable in tissue and blood samples of cancer patients. Therefore, miRNAs hold good promise as potential biomarkers in ovarian cancer. In this review, we attempted to provide a comprehensive profile of key miRNAs involved in ovarian carcinoma to establish mi RNAs as more reliable non-invasive clinical biomarkers for early detection of ovarian cancer compared with protein and DNA biomarkers.

关键词： Micro RNAs(miRNA) biomarker chemoresistance detection RT-PCR

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Machine Learning-based Electric Load Forecasting for Peak Demand Control in Smart Grid

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Computers, Materials & Continua 2023年第3期74卷 4785-4799页

作者： manish kumar Nitai pal Department of Electrical Engineering Indian Institute of Technology(ISM)Dhanbad826004India Department of Nuclear Science&Technology Pandit Deendayal Energy UniversityGandhinagarIndia

Increasing energy demands due to factors such as population,globalization,and industrialization has led to increased challenges for existing energy *** ways of energy generation and energy consumption like smart grids and smart homes are implemented to face these challenges with reliable,cheap,and easily available sources of *** integration of renewable energy and other clean distributed generation is increasing continuously to reduce carbon and other air pollutants *** the integration of distributed energy sources and increase in electric demand enhance instability in the ***-term electrical load forecasting reduces the grid fluctuation and enhances the robustness and power quality of the *** load forecasting in advance on the basic historical data modelling plays a crucial role in peak electrical demand control,reinforcement of the grid demand,and generation balancing with cost *** accurate forecasting of electrical data is a very challenging task due to the nonstationary and nonlinearly nature of the *** learning and artificial intelligence have recognized more accurate and reliable load forecastingmethods based on historical load *** purpose of this study is to model the electrical load of Jajpur,Orissa Grid for forecasting of load using regression type machine learning algorithms Gaussian process regression(GPR).The historical electrical data and whether data of Jajpur is taken for modelling and simulation and the data is decided in such a way that the model will be considered to learn the connection among past,current,and future dependent variables,factors,and the relationship among *** on this modelling of data the network will be able to forecast the peak load of the electric grid one day *** study is very helpful in grid stability and peak load control management.

关键词： Artificial intelligence electric load forecasting machine learning peak-load control renewable energy smart grids

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Synergism of co-delivered nanosized antioxidants displayed enhanced anticancer efficacy in human colon cancer cell lines

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Bioactive Materials 2017年第2期2卷 82-95页

作者： Lipika Ray manish kumar pal Ratan Singh Ray CSIR-Indian Institute of Toxicology Research P.O.Box No.80M.G.MargLucknowUP226001India Academy of Scientific and Innovative Research New Delhi 110001India

Combination of chemopreventive and/or therapeutic agents is the imminent smart approach to cope upwith cancer because it may act on multiple targets through different pathways. In the present study, wehave synthesized multiple chemopreventive and/or therapeutic agents (Curcumin, Quercetin andAspirin) loaded nanoparticles by simple cation-anion interaction among the amine groups of chitosan(CS) and phosphate groups of sodium hexametaphosphate (SHMP). These nanosized bioactive materials(CS-SHMP-CQA-NPs) were well characterized and found most effective in colon cancer cell line (HCT-116)compared to other cancer cell lines. Triplex chemopreventive and/or therapeutic agents-loaded NPs weresynergistically inducing apoptosis in HCT-116 cells compared to two-chemopreventive agents-loadedNPs as evident by an increase in sub-G1 cells (percent), and chromatin condensation along with thedecrease in mitochondrial membrane potential (MMP). Interestingly, ChoueTalalay analysis revealedthat CS-SHMP-CQA-NPs showed strong synergistic effect in its all doses. Thus, our study demonstratesthat nanoparticles based bioactive materials significantly inhibit the growth of HCT-116 cells and thuscould be a promising approach for colon cancer chemoprevention.

关键词： Chemoprevention Therapeutic agent Colon cancer Synergistic effect Apoptosis

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Recognition of newspaper printed in Gurumukhi script

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Journal of Central South University 2019年第9期26卷 2495-2503页

作者： Rupinder pal kaur manish kumar Jindal Munish kumar Post Graduate Department of Computer Science Guru Nanak College for GirlsSri Muktsar SahibPunjabIndia Department of Computer Science&Applications Panjab University Regional CentreSri Muktsar SahibPunjabIndia Department of Computational Sciences Maharaja Ranjit Singh Punjab Technical UniversityBathindaPunjabIndia

In this work,a system for recognition of newspaper printed in Gurumukhi script is *** feature extraction techniques,namely,zoning features,diagonal features,parabola curve fitting based features,and power curve fitting based features are considered for extracting the statistical properties of the characters printed in the *** combinations of these features are also applied to improve the recognition *** recognition,four classification techniques,namely,k-NN,linear-SVM,decision tree,and random forest are used.A database for the experiments is collected from three major Gurumukhi script newspapers which are Ajit,Jagbani and Punjabi *** 5-fold cross validation and random forest classifier,a recognition accuracy of 96.19%with a combination of zoning features,diagonal features and parabola curve fitting based features has been reported.A recognition accuracy of 95.21%with a partitioning strategy of data set(70%data as training data and remaining 30%data as testing data)has been achieved.

关键词： newspaper recognition feature extraction classification Gurumukhi script random forest

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Spondyloptosis of C6-C7： a rare case report

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Chinese Journal of Traumatology 2010年第6期13卷 377-379页

作者： manish Chadha Ajay pal Singh Arun pal Singh Department of Orthopaedics Guru Teg Bahadur Hospital University College of Medical Sciences University of Delhi New Delhi 110095 India Department of Orthopaedics and Joint Replacement Indraprastha Apollo Hospital New Delhi 110095 India

A 35 years old female presented to us after falling from a height. She complained of a neck pain and a complete quadriplegia and was diagnosed as having spondyloptosis of the C6-C7. Skeletal traction was performed on her. CT scan showed fractures of the C5, C6, and C7 vertebral body. The patient underwent anterior approach partial corpectomy with anterior cervical locking plate and strut grafting from ipsilateral iliac crest. Intraoperatively it was found that the disc was completely ruptured and there was a dural tear and cerebrospinal fluid leak. Her postoperative period was complicated by cerebrospinal fluid collection and posterior instrumentation was not performed due to the poor general condition. She had no neural recovery at the last follow-up. Spondyloptosis is a severe and highly unstable injury with a three column ligamentous disruption and may be complicated, as in our case, with a dural *** of these cases is fraught with complications,and prognosis for neural recovery is dismal.

关键词： Spondylolisthesis Spine Spinal injuries

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Adansonia digitata L.(baobab):a review of traditional information and taxonomic description

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Asian Pacific Journal of Tropical Biomedicine 2015年第1期5卷 79-84页

作者： Jitin Rahul manish kumar Jain Shishu pal Singh Rakesh kant kama Anuradha Aliya Naz Anup kumar Gupta Sujeet kumar Mrityunjay Centre of Mining Environment Department of Environmental Science&EngineeringIndian School of Mines Department of Botany Dayanand Brajendra Swarup College Centre of Mining Environment Department of Environmental Science&EngineeringIndian School of MinesDhanbad-826004JharkhandIndia

Adansonia digitata L.(Malvaceae) is commonly known as baobab tree native to *** is a multi-purpose tree which offers protection and provides food,clothing and medicine as well as raw material for many useful *** fruit pulp,seeds,leaves,***,and bark of baobab are edible and they have been studied by scientists for their useful *** fruit pulp have very high vitamin ***,phosphorus,carbohydrates,fibers,potassium,proteins and lipids content,which can be used in seasoning as an appetizer and also make *** contain appreciable quantities of phosphorus,magnesium,zinc,sodium,iron,manganese,whereas they have high levels of lysine,thiamine,calcium and *** has numerous biological properties including antimicrobial,anti-malarial,diarrhoea,anaemia,asthma,antiviral,anti-oxidant and anti-inflammatory activities amongst *** investigation revealed the presence of *** acids,fatty acids,vitamins and *** review summarizes the information on various aspects of traditional information,taxonomic description,medicinal properties and importantly nutritional value.

关键词： Adansonia digitata Baobab Traditional information Taxonomic description

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Rectangular Microstrip Patch Antenna Using Air as Substrate for S-Band Communication

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Journal of Electromagnetic Analysis and Applications 2014年第3期6卷 38-41页

作者： manish Gupta Saurabh Sachdeva N. kumar Swamy Inder pal Singh Department of EECE ITM University Gurgaon India Departmentof Electrical and Electronics Engineering ITM University Gur- gaon & Raipur India Departmentof Mechanical Engineering Shinas College of Technology Shinas Oman.

A Rectangular Microstrip Patch Antenna model is proposed using air as a substrate to study the characteristics of designed antenna. The dimensions of designed antenna are 17 mm × 16.66 mm with substrate at frequency 3.525 GHz. In this paper, the simulation is performed by using software Computer Simulation Technology (CST) Microwave studio based on finite difference time domain technique. The characterization of the designed antenna was analyzed in terms of return loss, bandwidth, directivity, gain, radiation pattern, VSWR.

关键词： Rectangular Microstrip Patch Antenna Air Substrate Directivity

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