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An innovative orbital implant positioner for the proper restoration of eye-socket defects

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Bio-Design and Manufacturing 2023年第1期6卷 82-89页

作者： Marco Mandolini Agnese Brunzini manila Caragiuli Alida Mazzoli Mario Pagnoni Department of Industrial Engineering and Mathematical Sciences UniversitàPolitecnica Delle MarcheVia Brecce Bianche 1260131 AnconaItaly Department of Materials Environmental Sciences and Urban PlanningUniversitàPolitecnica Delle MarcheVia Brecce Bianche 1260131 AnconaItaly yourFACE Clinica Ars BiomedicaVia Luigi Bodio 5800191 RomeItaly

Fractures to the orbital walls and floor must be appropriately managed to avoid severe *** results in particularly challenging anatomical *** main issues are the implant’s proper shaping,placement,and orientation onto the eye socket.A new,customized implant-shaping mould has already been developed to shape patient-specific ***,it still does not address the implant positioning in the fractured orbital cavity.

关键词： socket orbital walls

Extrahepatic portal vein thrombosis in children and adolescents:Influence of genetic thrombophilic disorders

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World Journal of Gastroenterology 2010年第48期16卷 6123-6127页

作者： Andrea Pietrobattista Matteo Luciani Juan G Abraldes manila Candusso Simona Pancotti Massimo Soldati Lidia Monti Giuliano Torre Valerio Nobili Liver Unit Research InstituteBambino Gesù Children's Hospital Department of Hematology Bambino Gesù Children's Hospital Hepatic Hemodynamic Laboratory Liver UnitHospital ClínicIDIBAPS and CIBERhedUniversity of Barcelona Department of Laboratory Pediatrics Bambino Gesù Children's Hospital Radiology Department Bambino Gesù Children's Hospital

AIM:To explore the prevalence of local and genetic thrombophilic disorders as risk factors for portal vein thrombosis (PVT) in our series,the largest ever published in pediatric literature. METHODS:We conducted a case-control study enrolling 31 children with PVT and 26 age-matched controls. All were screened for thrombophilia,including genetic disorders,protein C,protein S and homocysteine deficiencies. All coagulation parameters were studied at least 3 mo after the diagnosis of portal vein ***:In our study we showed that most pediatric patients with PVT have local prothrombotic risk factors,which are probably the most important factors leading to PVT. However,there is a clear association between the presence of prothrombotic disorders and PVT,suggesting that these increase the risk of thrombosis in patients with local factors such as perinatal umbilical vein catheterization or sepsis. CONCLUSION:Patients with PVT should be screened for inherited prothrombotic disorders regardless of a history of an obvious local risk factor.

关键词： Portal vein thrombosis Children Thrombophilic disorders Protein C Protein S

The Time Horizon in the Evaluation of Sustainable Development

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Journal of Civil Engineering and Architecture 2012年第3期6卷 334-343页

作者： manila De Iuliis Peter Brandon Building and Planning Office Town Hall Lungomare D 'Albertis 4 Santo Stefano al Mare Imperia Italy School of the Built Environment University of Salford UK

Current methods of evaluating long term Sustainable Development seldom take into account the time period over which an evaluation is made except through simplistic economic models which heavily discount the future. If sustainable development is to be a serious issue then the impact on the future of decisions made today must be properly assessed and evaluated. This requires a new understanding of time as a key feature of the Sustainability debate and new models of how this new understanding can be brought into the evaluation process. This was at the heart of the Torino declaration signed by the University organisations of the G8, G20 and developing nations in April 2009. Time is a critical part of the sustainability debate and is seldom addressed directly. This paper will provide a possible solution based on a strong theoretical and philosophical framework of how this difficult subject can be approached and applied to sustainable urban planning. The work presented is based on a philosophical model of the cosmos which has both internal and external credibility. It forms the basis ofa PhD study and has been applied to small case studies in Italy and elsewhere. These will be presented to encourage further study into this important area within the evaluation and assessment of sustainable development.

关键词： Time sustainable development sustainable urban planning temporal analysis.

Therapeutic molecules for multiple human diseases identified from pigeon pea(Cajanus cajan ***.)through GC–MS and molecular docking

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Food Science and Human Wellness 2017年第4期6卷 202-216页

作者： Deepu Mathew Lidiya John P. manila T.M. Divyasree P. Sandhya Rajan V.T.K. Finishing School in Biotechnology Centre for Plant Biotechnology and Molecular BiologyKerala Agricultural UniversityThrissurKerala 680656India

Molecular mechanism behind the therapeutic potential of pigeon pea over the human diseases such as rheumatoid arthritis,breast cancer,type II diabetes,malaria,measles and sickle cell disease were revealed through docking of GC–MS identified phyto-compound ligands with candidate disease *** the 242 ligands,three dimensional structures of 47 compounds had to be drawn using ChemSketch and the remaining structures were retrieved from PubChem and docked with the active sites of candidate *** molecules identified through docking were further subjected to ADMET analysis and promising drug candidates were identified for each *** paper presents a precise account of the chemoprofile of pigeon pea leaves,stems and seeds,interaction of these molecules with target proteins and suggests 26 highly potential molecules which are drug candidates for multiple human *** pea seeds are especially proven as invaluable source for therapeutic molecules.

关键词： Breast cancer Drug discovery Herbal medicine In silico Malaria Measles Phyto-compounds Rheumatoid arthritis Sickle cell disease Type II diabetes

不同来源紫苏酚类和挥发油的成分分析及活性比较

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不同来源紫苏酚类和挥发油的成分分析及活性比较

作者： manila Vorlasan 重庆医科大学

学位级别：硕士

紫苏为唇形科紫苏属草本植物,在包括中国在内的亚洲多国具有丰富的种植资源,叶、梗、种子均可入药,已被收入《中国药典》。紫苏叶也具有食用价值,在中国被列入食、药两用植物来源,早在2000年前便已有栽培种植。紫苏全草具有芳香气味,紫... 详细信息

紫苏为唇形科紫苏属草本植物,在包括中国在内的亚洲多国具有丰富的种植资源,叶、梗、种子均可入药,已被收入《中国药典》。紫苏叶也具有食用价值,在中国被列入食、药两用植物来源,早在2000年前便已有栽培种植。紫苏全草具有芳香气味,紫苏子含油丰富,因此紫苏还在香料和油品产业中发展势头强劲。紫苏在中药中为解表药,现代研究也表明其具有抗炎、抗氧化、抗菌、抗血栓、降血脂和抗肿瘤等多种药理作用。紫苏化学成分丰富,主要活性物质包括酚酸、黄酮类、挥发油、脂肪酸等成分。由于紫苏种植地繁多,来源复杂,无法保证入药时的临床效果;国内外大多研究者聚焦于紫苏的叶、梗以及紫苏子,而紫苏的花以及花序极少得以充分研究并加以利用,因此,有必要以紫苏中的药效物质和生物活性为评价指标,对紫苏各来源以及各个部位进行评价和比较,从而优化紫苏资源的利用,并促进其相关产品业的发展。一、不同来源、部位紫苏酚类物质成分分析及抗氧化活性比较本章将对5个不同来源紫苏的叶、穗、梗三个植物部位的酚酸、黄酮类成分组成,总含量以及抗氧化活性进行测定比较以评价紫苏中较优的来源以及部位。采用液-质联用方法,从紫苏的三个部位中一共鉴定出包括木犀草素-7-氧-二葡萄糖醛酸苷在内的30个酚类成分。同时采用化学显色法对总酚酸、总黄酮进行含量测定,结果表明叶的含量最高,穗次之,梗最低。通过体外抗氧化试验,我们对各样品潜在的生物活性进行了评价,皮尔森相关系数计算表明抗氧化能力与酚酸、黄酮类物质具有显著的相关性。最后,我们采用系统聚类分析法对样品分类,结果表明各来源紫苏叶与来源2的穗的质量总体较好,可暂定为较优的用药来源。二、紫苏不同部位挥发油成分种类比较及紫苏穗挥发油抑菌活性评价本章以紫苏的挥发油为研究对象,探究了挥发油的最佳提取工艺,并将提取得到的挥发油以气-质联用仪进行成分分析,最后将紫苏穗挥发油用以体外抗氧化活性评价。成分分析结果表明各来源紫苏的成分种类差异较大,各部位之间以紫苏穗中成分最多,叶次之,梗最少。在抗氧化活性评价实验中,来源2紫苏穗挥发油与其叶挥发油清除DPPH、ABTS自由基的能力无差异,来源1紫苏穗挥发油与其叶挥发油的还原能力无差异。紫苏穗挥发油表现出较好的抗氧化活性,因此认为该部位可能为潜在的药用部位。

关键词：紫苏来源部位酚类成分挥发油

A Case of Adverse Reaction to Booster Dose of COVID-19 Vaccination: Could D-Dimer Elevation Suggest Increased Clotting Risk?

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Health 2022年第2期14卷 204-208页

作者： Serafino Fazio manila Vaccariello Flora Affuso University Federico II Naples Italy Barletta Italy Gallipoli Italy

We report the clinical case of a 40-year-old Italian woman, who soon after her booster vaccination with mRNA-1273 after the two previous vaccinations with BNT162b2, developed severe headache, high fever, and Musculo-skeletal pain. She went to the emergency department, where computerized tomography (CT) scans of chest and brain were performed, resulting in both negative for pathologic findings. On the contrary, white blood count was strongly lowered and D-dimer severely elevated. She improved after treatment with enoxaparin and the blood analyses returned in the normal range after ten days. This case supports the hypothesis that COVID-19 vaccines could increase blood clotting in some predisposed subjects. Therefore, we believe that robust and well-designed clinical trials, considering the evaluation of D-dimer levels, should be performed to eliminate any doubts on this issue.

关键词： Adverse Reaction COVID-19 Vaccination Blood Clotting

What Causes Some People to be Left-handed,and Why Are Fewer People Left-handed than Right-handed?

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当代外语研究 2004年第12期 9-10页

作者： J.Tan manila Philippines 李伟

为什么右手成为大多数人的优势手?为什么左撇子虽然是少数,但依然存在呢?一项医学研究显示,在双亲均为左撇子的家庭,子女是左撇子的机率为50％。另一个证据是,左撇子的比例在某些家族中明显高于一般家族,说明用手的偏爱与遗传直接相关。

关键词： What Causes Some People to be Left-handed,and Why Are Fewer People Left-handed than Right-handed

Combined endovascular-surgical treatment for complex congenital intrahepatic arterioportal fistula: A case report and review of the literature

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World Journal of Hepatology 2020年第4期12卷 160-169页

作者： Roberta Angelico Guglielmo Paolantonio Monica Paoletti Chiara Grimaldi Maria Cristina Saffioti Lidia Monti manila Candusso Massimo Rollo Marco Spada Department of Abdominal Transplantation and Hepatobiliary and Pancreatic Surgery Bambino GesùChildren’s Hospital IRCCSRome 00165Italy Department of Surgery Hepato-bilio-pancreatic Surgery and Transplant UnitUniversity of Rome Tor VergataFondazione PVTRome 00133Italy Interventional Radiology Unit Department of ImagingBambino GesùChildren’s Hospital IRCCSRome 00165Italy Department of Imaging Bambino GesùChildren’s Hospital IRCCSRome 00165Italy Division of Hepatogastroenterology Bambino GesùChildren’s Hospital IRCCSRome 00165Italy

BACKGROUND Congenital intrahepatic arterioportal fistula(IAPF) is a rare vascular malformation in infants that causes severe portal hypertension(PH) with poor prognosis if untreated. Currently, radiological embolisation is considered the first-line therapy for simple IAPF; however, it might be not resolutive for complex hepatic vascular lesions. When endovascular embolization is not sufficient to completely obliterate the IAPF, surgical intervention is needed, but it has been associated with severe morbidity and mortality in small ***, indications are not *** SUMMARY We present the first case of a 6-month-old girl with trisomy 21 affected by a complex congenital IAFP, which caused severe PH, successfully treated with an endovascular-surgical hybrid procedure. The novel technique comprised a multistep endovascular embolisation, including a superselective transarterial embolisation of the afferent vessels and a direct transhepatic embolisation of the dilated portal vein segment, combined with selective surgical ligation of the arterial branches that supply the fistula, which were too small to be *** complex IAPF was also associated with severe cholestasis and intra/extrahepatic biliary tree dilatation, which was successfully treated by a temporary biliary drainage. At 24-mo follow-up, the hybrid endovascularsurgical procedure achieved complete occlusion of the complex IAPF and resolution of the PH. A comprehensive review of the literature on congenital IAPF management, focussed on alternative treatment strategies, is also *** The combined radiological-surgical approach is a safe and effective treatment option for complex IAPF and avoids major invasive surgery.

关键词： Liver Intrahepatic arterioportal fistula Congenital malformation Portal hypertension Radiological embolization Hepatic surgery Case report

柬埔寨护士护理程序应用能力问卷的编制及信效度检验

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International Journal of Nursing Sciences 2023年第2期10卷 245-250页

作者： Virya Koy Jintana Yunibhand Andrew Rauth Nicholas Bircher manila Prak Richard Henker Faculty of Nursing Chulalongkorn UniversityBangkokThailand Department of Hospital Services Ministry of HealthPhnom PenhCambodia School of Nursing University of PittsburghPittsburghPAUSA Cambodian Association of Nurses Phnom PenhCambodia

目的旨在编制柬埔寨注册护士护理程序应用能力问卷.方法以护理程序理论为理论基础,结合焦点小组讨论、文献回顾法和专家咨询编制初始问卷.于2022年1-2月采用便利抽样法,对柬埔寨5个区域的不同级别医院260名护士进行网络调查,验证问卷... 详细信息

目的旨在编制柬埔寨注册护士护理程序应用能力问卷.方法以护理程序理论为理论基础,结合焦点小组讨论、文献回顾法和专家咨询编制初始问卷.于2022年1-2月采用便利抽样法,对柬埔寨5个区域的不同级别医院260名护士进行网络调查,验证问卷的信度和效度.结果问卷内容效度指数为1.00,Cron-bach's α系数为0.963,5个维度的Cronbach's α系数范围0.963~0.964,重测信度为0.769.探索性因子分析提取出5个公因子,为护理评估、诊断、计划、实施及评价,共24个条目,累计方差贡献率为70.08%.结论问卷的信度和效度较好,有助于护士评估自己的护理程序应用能力,并为护理管理者制订相关政策提供依据.

关键词：柬埔寨护士护理程序问卷信度效度