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Management of Severely Malnourished Children Aged 6 - 59 Months Hospitalized in the Pediatric Ward of Kayanza Hospital/Burundi

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Open Journal of Pediatrics 2024年第1期14卷 11-21页

作者： michel Baseka Jonathan Niyukuri Alice Ndayishimiye Sedki Az-Eddine Vestine Ntakarutimana Department of Health Nutrition Doctoral School University of Burundi Bujumbura Burundi Food Science and Technology Research Center (CRSTA) Department of Food Science and Technology (STA) Faculty of Agronomy and Bioengineering (FABI) University of Burundi Bujumbura Burundi East African Institute of Nutritional Sciences Bujumbura Burundi Faculty of Medicine University of Burundi Bujumbura Burundi Department of Biology Semlalia Faculty of Science Cadi Ayyad University Marrakech Morocco Centre de recherche en sciences naturelles et environnementales Faculty of Science University of Burundi Bujumbura Burundi

The implementation of WHO guidelines has significantly reduced hospital mortality due to severe malnutrition. Nevertheless, severe acute malnutrition in children under five remains a major public health problem in all low-income countries and is little studied. The study aimed to assess the nutritional status and quality of management of severe acute malnutrition in children aged 06 to 59 months hospitalized in the pediatric ward of Kayanza Hospital. This is a prospective study with descriptive and analytical aims over 6 months from February 10 to July 9, 2023. All children aged 6 to 59 months admitted for severe acute malnutrition are included in this study. The results show that the most affected age group is 12 to 23 months (42.55%). Marasmus is the most common clinical form, at 70.2%. Housewives and mothers from rural areas are the most affected, with rates ranging from 69.14% to 91.49%. The study shows that the reasons for consultation are respectively: edema (29.78%), diarrhea (26.59%), vomiting (19.14%), and fever (14.89%). Dehydration and hypothermia were the main complications observed in 45.74% and 22.34% respectively. Medical treatment was provided by antibiotics (44.68%), artesunate (31.91%), and resomal (21.27%). Nutritional treatment consisted of F75 100% milk and F100 100% milk. Pathologies observed were: anemia 38.29%, malaria 37.23%, urinary tract infection 12.7%, measles 11.7%. The national protocol for integrated management of acute malnutrition (PCIMA) was followed. This study shows that 72.3% of children were successfully treated, with 9.5% dropping out and dying, and 8.5% not responding. We found that malnutrition remains a public health problem, affecting mostly children aged 12 to 24 months. The main complications or pathologies associated with malnutrition are diarrhea, malaria, and fever, and the majority of children suffer from marasmus.

关键词： Severe Acute Malnutrition Child Burundi

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Fatty Acid Composition of Hazelnut Kernel Oil from Coula edulis Collected in the Republic of Congo

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Food and Nutrition Sciences 2024年第4期15卷 290-297页

作者： Josiane Enzonga Yoca Jean Paul Latran Ossoko Yves Okandza michel Didace Mvoula Tsieri Laboratoire de Contrô le et Qualit&#233 des Aliments de l&#8217Ecole Nationale Sup&#233rieure d&#8217Agronomie et de Foresterie Universit&#233 Marien NGOUABI Brazzaville Congo Université Denis Sassou NGUESSO Brazzaville Congo

Coula edulis is non-timber forest product (NTFP) used in Africa for its hazelnuts, which contain edible seeds with a demonstrated nutritional potential. However, there have been very few scientific studies of this species in the Republic of Congo. Thus, the aim of the current study was therefore to determine the fatty acid composition of the oil extracted from Coula edulis hazelnut seeds collected at random in the Republic of Congo. The oil was extracted using the Soxhlet method and its fatty acid composition was determined by gas chromatography. The extracted oil from Coula edulis hazelnut kernels is rich in monounsaturated fatty acids (95.28%), particularly oleic acid (94.5%), which classifies it as an oleic oil and gives it interesting nutritional and therapeutic properties. On the other hand, saturated fatty acids (4.15%) and polyunsaturated fatty acids (0.35%) are not well represented. Its low poly-unsaturated fatty acid content makes it more stable when stored at room temperature.

关键词： Coula edulis Fatty Acids Oil Seeds Hazelnuts Republic of Congo NTFP

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Investigation of Carbonation of Concrete Based on Crushed Sand and Admixtures

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Journal of Minerals and Materials Characterization and Engineering 2024年第5期12卷 247-264页

作者： Jacques Herve Koung à Bediang Emmanuel Elat Assoua Moukete Paul Djomou Djonga michel Mbessa Laboratory of Civil and Mechanical Engineering Department of Civil Engineering National Advanced School of Engineering of Yaounde 1 Yaounde Cameroon Laboratory of Mechanics and Materials of Civil Engineering Department of Civil Engineering CY Cergy Paris University Paris France Department of Textile and Leather Engineering National Advanced School of Engineering of Maroua Maroua Cameroon Department of Civil Engineering National Advanced School of Public Works National Advanced School of Engineering of Yaounde 1 Yaounde Cameroon

Carbonation is a natural aging process that occurs in all types of concrete. One of its primary implications is the acceleration of steel corrosion caused by the phenomena of depassivation. The goal of this research is to investigate the carbonation of quarry sand-based concrete. The concrete is made of 100% crushed sand 0/6.3, gravel 8/15, and 15/25 from the Arab Contractor quarry in Nomayos, Cameroon, with CEM II B-P 42.5 R from CIMENCAM (Cimenteries du Cameroun). The study employed two admixtures: one with a dual superplasticizing and reducing action (Sikamen) and another with a water-repellent effect (Sika liquid). Carbonation was performed on concrete samples at the following dates: 0, 7, 14, 28, 56, 90, 180 days, one year, and six months. Carbonated concrete (CC) and non-carbonated concrete (NCC) samples are compared in terms of their physical attributes and mineralogical characteristics. The results of this investigation reveal that after more than a year and six months of carbonation, porosity decreases and permeability increases. Despite the high fineness modulus of quarry sand, the compressive strength of quarry sand-based concrete is satisfactory. Carbonation depth is relatively high on some dates, exceeding the minimal cover value for concrete reinforcement. Sikament additive increases concrete compactness and durability while decreasing permeability. Sika water repellant mixes with the lime in cement to generate complimentary crystallizations that block the mortar’s capillaries, making it watertight.

关键词： Carbonation Concrete Crushed Sand Sikamant Water-Repellent

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RANKL inhibition reduces lesional cellularity and Gαs variant expression and enables osteogenic maturation in fibrous dysplasia

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Bone Research 2024年第1期12卷 165-179页

作者： Luis F.de Castro Jarred M.Whitlock Zachary michel Kristen Pan Jocelyn Taylor Vivian Szymczuk Brendan Boyce Daniel Martin Vardit Kram Rebeca Galisteo Kamran Melikov Leonid V.Chernomordik Michael T.Collins Alison M.Boyce Skeletal Disorders and Mineral Homeostasis Section National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Section on Membrane Biology Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaMDUSA Metabolic Bone Disorders Unit National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Department of Plastic and Reconstructive Surgery The Johns Hopkins Medical InstitutionsBaltimoreMDUSA Department of Pathology and Laboratory Medicine University of Rochester Medical CenterRochesterNYUSA NIDCR Genomics and Computational Biology Core National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA

Fibrous dysplasia(FD)is a rare,disabling skeletal disease for which there are no established *** evidence supports inhibiting the osteoclastogenic factor receptor activator of nuclear kappa-B ligand(RANKL)as a potential treatment *** this study,we investigated the mechanisms underlying RANKL inhibition in FD tissue and its likely indirect effects on osteoprogenitors by evaluating human FD tissue pre-and post-treatment in a phase 2 clinical trial of denosumab(NCT03571191)and in murine in vivo and ex vivo preclinical *** analysis of human and mouse tissue demonstrated increased osteogenic maturation,reduced cellularity,and reduced expression of the pathogenic Gαs variant in FD lesions after RANKL *** sequencing of human and mouse tissue supported these *** interaction between osteoclasts and mutant osteoprogenitors was further assessed in an ex vivo lesion model,which indicated that the proliferation of abnormal FD osteoprogenitors was dependent on *** results from this study demonstrated that,in addition to its expected antiosteoclastic effect,denosumab reduces FD lesion activity by decreasing FD cell proliferation and increasing osteogenic maturation,leading to increased bone formation within *** findings highlight the unappreciated role of cellular crosstalk between osteoclasts and preosteoblasts/osteoblasts as a driver of FD pathology and demonstrate a novel mechanism of action of denosumab in the treatment of bone disease.

关键词： dysplasia treatment finding

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Nutritional and Antioxidant Evaluation and Effect of Eggplant Consumption on Anthropometric and Hematologic Parameters in Wistar Rats

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Food and Nutrition Sciences 2024年第4期15卷 245-262页

作者： Elenga michel Nkouka Rhode Gouollaly Tsiba Wossolo Stephane Itoua Okouango Yvon Simplice Mananga Vital Multi-field Team of Research in Feeding and Nutrition (Eprancongo) Faculty of Sciences and Technology Marien Ngouabi University Brazzaville Republic of the Congo Laboratory of Human Nutrition and Feeding (LaNAH) Faculty of Sciences and Technology Marien Ngouabi University Brazzaville Republic of the Congo Department of Pharmacopeia and Traditional Medicine National Institute of Health Science & Research (IRSSA) Scientific City of Brazzaville Brazzaville Republic of the Congo Laboratory of Pharmacodynamics and Experimental Pathophysiology (L2PE) Faculty of Sciences and Technology Marien Ngouabi University Brazzaville Republic of the Congo

The aim of the present study was to evaluate the nutritional quality of green and purple eggplant, their antioxidant activity and their nutritional efficacy on Wistar rats. For nutritional quality, the parameters measured are dry matter, protein, lipid, ash, carbohydrate, iron, phosphorus, calcium, magnesium and energy content. For antioxidant activity, the parameters measured are 50% DDPH free radical inhibition concentration and total polyphenol content. Nutritional efficacy was evaluated in rats fed the control diet and in rats fed the three treated diets containing eggplant meal obtained by replacing 5%, 10%, and 15% of the control diet. The parameters measured are the amount consumed, the weight of the animal and target organs, and hematologic parameters. The results of the nutritional analysis show the following values: 13.31% protein, 2.66% lipids, 0.84% calcium, 0.12% magnesium, 0.43% phosphorus for the Solanum aethiopicum L. species and 13.47% protein, 3.66% lipids, 0.36% calcium, 0.22% magnesium, 0.35% phosphorus for the Solanum melongena L. species. In terms of antioxidant activity, we obtained DDPH inhibition percentages of 40.28 mg/ml for Solanum aethiopicum L. and 12.42 mg/ml for Solanum melongena L., respectively. Finally, hematologic and anthropometric tests showed that for the different diets used, weight loss and an increase in hematologic parameters were observed in the rats tested. This study showed that eggplant has interesting nutritional characteristics and antioxidant activity, contributing to an increase in weight and anthropometric parameters.

关键词： Fruit Vegetables Eggplant Solanum aethiopicum L. Solanum melongena L. Antioxidants Polyphenols

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自动化:撬动灵活生产的杠杆

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现代制造 2024年第2期 37-38页

作者： Stefanie michel 不详

第41届国际装配自动化展览会的展示核心是从零部件到组件和子系统直至完整的全套系统。工厂企业的设计师、决策者和采购人员都可以在这一会展中找到符合自己需求的最佳解决方案。2023年10月10~13日,著名的国际生产和装配自动化技术展Mo... 详细信息

第41届国际装配自动化展览会的展示核心是从零部件到组件和子系统直至完整的全套系统。工厂企业的设计师、决策者和采购人员都可以在这一会展中找到符合自己需求的最佳解决方案。2023年10月10~13日,著名的国际生产和装配自动化技术展Motek会展与国际粘合剂及密封技术博览会Bondexpo会展同时拉开帷幕。

关键词：装配自动化最佳解决方案采购人员密封技术会展粘合剂博览会

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精确运动控制的驱动系统

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现代制造 2024年第5期 42-43页

作者： Stefanie michel 不详

作为一个系统来讲,电动机和运动控制器不仅仅是一系列元器件的总和。Faulhaber公司就用自己的产品展示了只有使用合适的运动控制器才能可靠地驱动小型电动机实现自动化。在自动化控制领域中,机械设备的运动通常都要精确地、动态地和灵... 详细信息

作为一个系统来讲,电动机和运动控制器不仅仅是一系列元器件的总和。Faulhaber公司就用自己的产品展示了只有使用合适的运动控制器才能可靠地驱动小型电动机实现自动化。在自动化控制领域中,机械设备的运动通常都要精确地、动态地和灵活地予以控制。例如,没有人愿意让不安全的机器人给自己做微创手术。即便是在CNC数控机床加工过程中数控机床的刀具和材料供给也都必须做到非常精确,只有这样才能确保零件的加工精度。但如果没有合适的驱动装置就无法完成此类任务。

关键词：运动控制器 CNC数控机床小型电动机产品展示零件的加工加工过程驱动装置机械设备

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不“只是”CAM软件

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现代制造 2024年第7期 38-39页

作者： Stefanie michel 不详

近几年来,Delcam公司的产品已经成为了Autodesk公司软件中的一部分。数控加工编程软件Powermill是如何发展成为CAM计算机辅助制造软件的?为什么CAM也可以在Autodesk Fusion计算机绘图软件中使用?本文采访了Autodesk公司软件产品管理和... 详细信息

近几年来,Delcam公司的产品已经成为了Autodesk公司软件中的一部分。数控加工编程软件Powermill是如何发展成为CAM计算机辅助制造软件的?为什么CAM也可以在Autodesk Fusion计算机绘图软件中使用?本文采访了Autodesk公司软件产品管理和营销经理Clinton Perry先生。

关键词：计算机辅助制造计算机绘图软件 CAM软件 Autodesk 营销经理软件产品数控加工编程 Fusion

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Progress of International Meridian Circle Program

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空间科学学报 2024年第4期44卷 741-745页

作者： WANG Chi BLANC michel ZHANG Shunrong DENARDINI Clezio Marcos LIU William SHEN Xuhui WU Jian XU Jiyao LI Hui ZHANG Qinghe REN Liwen ZHU Yajun LI Guozhu DING Zonghua LIU Zhengkuan YANG Fang National Space Science Center Chinese Academy of SciencesBeijing 100190 IRAP(CNRS-University Toulouse III-CNES) Toulouse 31400 Haystack Observatory Massachusetts Institute of TechnologyMA 01886 Instituto Nacional de Pesquisas Espaciais São Josédos Campos(SP)Brazil 12227-010 China Research Institute of Radio wave Propagation Qingdao 266000 Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100083

In 2024,the Chinese Meridian Project(CMP)completed its construction,deploying 282 instruments across 31 *** achievement not only provides a robust foundation but also serves as a reference template for the International Meridian Circle Program(IMCP).The IMCP aims to integrate and establish a comprehensive network of ground-based monitoring stations designed to track the propagation of space weather events from the Sun to ***,it monitors various disturbances generated within the Earth system that impact *** the past two years,significant progress has been made on the *** particular,the second phase of construction for the China-Brazil Joint Laboratory for Space Weather has been completed,and the North Pole and Southeast Asia networks are under active *** 2024 IMCP joint observation campaign was successfully *** facilitate these developments,the scientific program committee of IMCP was established,following the success of 2023 IMCP workshop and the space weather school,which was co-hosted with the Asia-Pacific Space Cooperation Organization(APSCO)and sponsored by Chinese Academy of Sciences(CAS)and Scientific Committee on Solar-Terrestrial Physics(SCOSTEP).Preparations are now underway for the 2024 workshop in collaboration with the National Institute for Space Research(INPE)in Brazil.

关键词： Chinese Meridian Project(CMP) International Meridian Circle Program(IMCP) China-Brazil Joint Laboratory for Space Weather North Pole and Southeast Asia networks

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Vitamin D, Parathyroid Hormone, Insulin Sensitivity and Islet β-Cell Secretory Function in Diabetic Patients from South Kivu in the Democratic Republic of Congo: Cross-Sectional Study

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Journal of Diabetes Mellitus 2024年第2期14卷 81-94页

作者： Dieudonne Masemo Bihehe Ahadi Birindwa Bwihangane Jean-Paulin Mukonkole Mbo michel Hermans Philippe Bianga Katchunga Faculté de Médecine H&#244pital Général de Référence de Panzi Université Evangélique en Afrique Bukavu DR Congo Département de Biologie Faculté des Sciences Université Officielle de Bukavu Bukavu DR Congo Département de Médecine Interne Université de Kisangani Kisangani DR Congo Service d’endocrinologie et de Diabétologie Cliniques Universitaires Saint-Luc Université Catholique de Louvain Bruxelles Belgique Département de Médecine Interne Cliniques Universitaires de Bukavu Université Officielle de Bukavu Bukavu DR Congo

Background: The role of vitamin D and parathyroid hormone in the metabolic profile of type 2 diabetes mellitus in sub-Saharan Africa has not been adequately assessed. The aim of this study was to determine the prevalence of low vitamin D level and secondary hyperparathyroidism and their association with insulin sensitivity and β-cell secretory function among Congolese type 2 diabetics. Methodology: Fasting glycaemia, fasting insulin, 25OH D3 and human parathyroid hormone (hPTH) were measured in one hundred and eighty-four type 2 diabetic patients followed as outpatients in South Kivu. Levels of 25OH D3 65 pg/ml defined low vitamin D and elevated parathyroid hormone levels, respectively. The HOMA model was used to measure insulin sensitivity and β-cell secretory function. Results: Medians (IQR) were 25.3 (20.4 - 32.4) ng/ml for 25OH D3 and 53.7 (38.4 - 115.7) pg/ml for hPTH. 58.7% of diabetics had insulin resistance, 126 (68.5%) had low vitamin D and 80 (43.5%) had hyperparathyroidism. In multivariate analysis, hPTH (partial r = −0.28;p = 0.0002) and 25OH D3 (partial r = 0.16;p = 0.03) showed an independent association with insulin sensitivity after adjustment for body mass index and waist circumference. Finally, hPTH (partial r = 0.27;p = 0.0002) was the sole determinant of β-cell secretory function. Conclusions: This study confirms the high prevalence of low vitamin D level and secondary hyperparathyroidism and their association with insulin resistance and impaired islet β-cell secretory function among Congolese with type 2 diabetes mellitus. Vitamin D and calcium supplementation should be envisaged for cases of deficiency in this region.

关键词： Vitamin D Parathyroid Hormone Diabetes Mellitus Insulin Resistance South Kivu

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