检索结果-南通市图书馆

现代制造 2024年第1期 20-22页

作者： manfred Flohr 不详

Schroeder阀门公司生产的产品是一种保护工业企业泵类设备不受损伤的旁通保护阀。德国的能源转型,既给制造商带来了巨大的商机,也给他们带来了技术挑战:当热电厂在部分载荷工况下运行时,工业企业的生产设备需要新的安全保护装备。

关键词：泵类设备零部件制造保护阀能源转型载荷工况阀门制造商

Sahara’s surface transformation forced an abrupt hydroclimate decline and Neolithic culture transition in northern China

在线全文

学校读者我要写书评

暂无评论

The Innovation 2024年第1期5卷 70-79页

作者： Yandong Hou Hao Long Sumiko Tsukamoto Zhengyao Lu Jie Chen Daniel EIbarra Toru Tamura Qiong Zhang Weiyi Sun Jingran Zhang Lei Gao manfred Frechen Ji Shen State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and LimnologyChinese Academy of Sciences(NIGLAS)Nanjing 210008China Leibniz Institute for Applied Geophysics(LIAG) Department of Geochronology30655 HannoverGermany Department of Physical Geography and Ecosystem Science Lund University22100 LundSweden Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China Institute at Brown for Environment and Society and Department of Earth Environmentaland Planetary SciencesBrown UniversityProvidenceRI 02912USA Geological Survey of Japan National Institute of Advanced Industrial Science and TechnologyTsukubaIbaraki 305-8567Japan Graduate School of Frontier Sciences University of TokyoKashiwaChiba 277-8561Japan Department of Physical Geography and Bolin Centre for Climate Research Stockholm University10691 StockholmSweden School of Geography Nanjing Normal UniversityJiangsu Centre for Collaborative Innovation in Geographical Information Resource Development and ApplicationKey Laboratory of Virtual Geographic EnvironmentMinistry of Education of ChinaNanjing 210023China School of Geography and Ocean Science Nanjing UniversityNanjing 210023China

The remote forcing from land surface changes in the Sahara is hypothesized to play a pivotal role in modulating the intensity of the East Asian summer monsoon(EASM)through ocean-atmospheric *** modulation has far-reaching consequences,particularly in facilitating societal shifts documented in northern ***,we present a well-dated lake-level record from the Daihai Lake Basin in northern China,providing quantitative assessments of Holocene monsoonal precipitation and the consequent migrations of the northern boundary of the *** reconstruction,informed by a water-and-energy balance model,indicates that annual precipitation reached700 mm during 8–5 ka,followed by a rapid decline to tween 5 and 4 *** shift coherently aligns with a signi550 mm be-ficant300 km northwestward movement of the EASM northern boundary during the Middle Holocene(MH),in contrast to its current *** findings underscore that these changes cannot be entirely attributed to orbital forcing,as corroborated by simulation *** model simulations deployed in our study suggest that the presence of the Green Sahara during the MH significantly strengthened the EASM and led to a northward shift of the monsoon rainfall ***,the Sahara’s reversion to a desert landscape in the late Holocene was accompanied by a corresponding southward retraction of monsoon *** dramatic hydroclimate changes during5–4 ka likely triggered or at least contributed to a shift in Neolithic cultures and societal transformation in northern *** decreasing agricultural productivity,communities transitioned from millet farming to a mixed rainfed agriculture and animal husbandry ***,our findings elucidate not only the variability of the EASM but also the profound implications of a remote forcing,such as surface transformations of the Sahara,on climatic changes and cultural evolution in northern China.

关键词： Holocene monsoon abrupt

Single-cell trajectories of melanoma cell resistance to targeted treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2022年第1期19卷 56-73页

作者： Maria Schmidt Lena Sünke Mortensen Henry Loeffler-wirth Corinna Kosnopfel Knut Krohn Hans Binder manfred Kunz Interdisciplinary Centre for Bioinformatics University of LeipzigLeipzig 04107Germany Department of Dermatology Venereology and AllergologyUniversity of WürzburgWürzburg 97074Germany Core Unit DNA Technologies Medical FacultyUniversity of LeipzigLeipzig 04103Germany Department of Dermatology Venereology and AllergologyUniversity of Leipzig Medical CenterLeipzig 04103Germany

Objective:Cellular heterogeneity is regarded as a major factor affecting treatment response and resistance in malignant *** developments in single-cell sequencing technology have provided deeper insights into these ***:Here,we analyzed a BRAFV600 E-mutant melanoma cell line by single-cell RNA-seq under various conditions:cells sensitive to BRAF inhibition with BRAF inhibitor vemurafenib and cells resistant to BRAF inhibition with vemurafenib alone or vemurafenib in combination with the MEK1/2 inhibitors cobimetinib or *** reduction by t-distributed stochastic neighbor embedding and self-organizing maps identified distinct trajectories of resistance development clearly separating the 4 treatment conditions in cell and gene state ***:Trajectories associated with resistance to single-agent treatment involved cell cycle,extracellular matrix,and de-differentiation *** contrast,shifts detected in double-resistant cells primarily affected translation and mitogen-activated protein kinase pathway reactivation,with a small subpopulation showing markers of *** findings were validated in pseudotime analyses and RNA velocity ***:The single-cell transcriptomic analyses reported here employed a spectrum of bioinformatics methods to identify mechanisms of melanoma resistance to single-and double-agent *** study deepens our understanding of treatmentinduced cellular reprogramming and plasticity in melanoma cells and identifies targets of potential relevance to the management of treatment resistance.

关键词： Melanoma single-cell transcriptome sequencing treatment response

Current treatment options and response rates in children with chronic hepatitis C

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第2期18卷 99-104页

作者： Stefan wirth Helios Medical Centre Wuppertal Department of PediatricsWitten-Herdecke UniversityD-42283 WuppertalGermany

Vertical transmission has become the most common mode of transmission of hepatitis C virus (HCV) in *** rate of perinatal transmission from an HCVinfected mother to her child ranges from 2% to 5% and the prevalence of HCV in children in developed countries ranges between 0.1% and 0.4%.Spontaneous viral clearance seems to be dependent on the genotype and has been reported between 2.4%-25%.For chronically infected patients,treatment with recombinant polyethylene glycol (PEG)-interferon α-2b and daily ribavirin has now been approved as standard treatment for children 2-17 years of *** five large prospective studies,a total of 318 children and adolescents aged 3-17 years were treated either with subcutaneous PEG-interferon α-2b at a dose of 1-1.5 μg/kg or 60 μg/m2 once a week in combination with oral ribavirin (15 mg/kg per day) or PEG-interferon α-2a with *** with genotype 1 and 4 received the medication for 48 wk and individuals with genotype 2 and 3 mainly for 24 *** sustained viral response (SVR) was achieved in 193/318 (60.7%) of treated *** for genotype;120/234 (51%) with genotype 1,68/73 (93%) with genotype 2/3,and 6/11 (55%) with genotype 4 showed *** rate was between 7.7% and 17%.Overall,treatment was well tolerated;how-ever,notable side effects were present in approximately 20%.According to recent experiences in the treatment of chronic hepatitis C in children and adolescents,a combination of PEG-interferon α with ribavirin has been found to be well tolerated and highly efficacious,particularly in individuals with genotype 2/***,this treatment can be recommended as standard of care until more effective treatment options will become available for genotype 1 patients.

关键词： Chronic hepatitis C Treatment Children Polyethylene glycol-interferon and ribavirin Responserate

Interaction phenomena between liquid droplets and hot particles—Captured via high-speed camera

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2009年第4期7卷 260-263页

作者： Sebastian Gehrke Karl-Ernst wirth Institute of Particle Technology Cauerstrasse 4Erlangen 91058Germany

The interaction of evaporating droplets and hot catalyst particles plays a major role in heterogeneously catalysed reactions. The liquid feed is injected into a gas-solid flow and is mixed with the catalyst. The interaction phenomena determine the evaporation time which should be minimised to keep the reactor vessel small. First measurements with a bed of fixed hot FCC-particles （fluid catalytic cracking） and two model fluids have been conducted. The interactions of ethanol and water droplets with the hot bed surface were captured via a high-speed camera. While the ethanol droplet developed a stable steam cushion due to Leidenfrost phenomena, water showed intense interaction and steam explosions which induced repulsion and atomisation of the droplet.

关键词： Particle-droplet-interaction Leidenfrost phenomenon Direct heat transfer Liquid-feed-injection

Ultrastructural cellular signatures: does cellular form follow function?

在线全文

学校读者我要写书评

暂无评论

National Science Review 2019年第5期6卷 861-863页

作者： manfred Auer Molecular Biophysics and Integrated Bioimaging Division Lawrence Berkeley National Laboratory

In his watershed 1896 essay The Tall Office Building Artistically Considered,protomodern architect Louis Sullivan famously declared that ‘form follows function’.Could this concept also hold true in biology? Have cel... 详细信息

关键词： Ultrastructural cellular signatures does cellular form follow function

Comparisons of electrical and optical properties between graphene and silicene A review

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2018年第2期27卷 299-313页

作者： wirth-Lima A J Silva M G Sombra A S B Laboratory of Telecommunications and Materials Science and Engineering-www.locem.ufc.br-Fortaleza CearaBrazil Department of Physics Science CenterFederal University of Ceara(U.F C.)-FortalezaCear4Brazil State University of Vale do Acarau SobralCeardBrasil

Two-dimensional （2D） metamaterials are considered to be of enormous relevance to the progress of all exact sciences. Since the discovery of graphene, researchers have increasingly investigated in depth the details of electrical/optical proper- ties pertinent to other 2D metamaterials, including those relating to the silicene. In this review are included the details and comparisons of the atomic structures, energy diagram bands, substrates, charge densities, charge mobilities, conductivities, absorptions, electrical permittivities, dispersion relations of the wave vectors, and supported electromagnetic modes related to graphene and silicene. Hence, this review can help readers to acquire, recover or increase the necessary technological basis for the development of more specific studies on graphene and silicene.

关键词： graphene silicene electrical/optical properties

Graphene's photonic and optoelectronic properties——A review

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2020年第3期29卷 13-35页

作者： A J wirth-Lima P P Alves-Sousa W Bezerra-Fraga Department of Physics Federal Institute of EducationScience and Technology of Ceara Campus SobralCearaBrazil Postgraduate Program in Electrical Engineering and Computing Federal University of Ceara(U.F.C.)Sobral CearaBrazil

Due to its remarkable electrical and optical properties,graphene continues to receive more and more attention from researchers around the *** excellent advantage of graphene is the possibility of controlling its charge density,and consequently,the management of its conductivity and dielectric constant,among other *** is noteworthy that the control of these properties enables the obtaining of new optical/electronic devices,which would not exist based on conventional ***,to work in this area of science,it is necessary to have a thorough knowledge regarding the electrical/optical properties of *** this review paper,we show these graphene properties very well detailed.

关键词： absorbance conductivity dielecric constant dispersion relation

Melanoma development: stage-dependent cancer competence of the melanocytic lineage

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2022年第1期7卷 13-14页

作者： manfred Kunz Department of Dermatology Venereology and AllergologyUniversity Medical Center LeipzigPhilipp-Rosenthal-Str.2304155 LeipzigGermany

In a recent article in Science,Baggiolini et al.^(1) showed that the transforming ability of the BRAFM6QQE oncogene for melanoma development depends on the stage of the transformed melanocyte lineage *** neural crest cells and melanoblasts are vulnerable to malignant transformation in a zebrafish model,melanocytes only developed small patches of nevus-like cells after BRARJ6QQE expression.

关键词： expression. al. melan

Boosting T cell immunity against cytomegalovirus:a potential strategy combating human aging and age-related diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第10期8卷 4417-4418页

作者： Matthias wirth Walburgis Brenner Oliver H.Kramer Department of Hematology Oncology and Cancer ImmunologyCampus Benjamin FranklinCharite-Universitatsmedizin Berlincorporate member of Freie Universitat Berlin and Humboldt-Universitat zu BerlinBerlinGermany University Medical Center Gottingen Department of GeneralVisceral and Pediatric SurgeryGottingenGermany German Cancer Consortium(DKTK) German Cancer Research Center(DKFZ)HeidelbergGermany Clinic for Obstetrics and Women's Health University Medical CenterJohannes Gutenberg University MainzLangenbeckstr.155131 MainzGermany Department of Toxicology University Medical CenterMainzGermany

In a recent publication in Cell,Hasegawa and colleagues reveal that cytotoxic CD4-positive cytotoxic T lymphocytes(CD4+CTLs)eliminate senescent fibroblasts with a surface expression of the immunologically important human leukocyte antigen class Il(HLA-)and the human cytomegalovirus glycoprotein B(HCMV-gB).1 This implies that a virome-immune cell interaction controls the fate of human skin cells that are linked to the aging process and associated diseases.

关键词： immunity cytomegalovirus cytotoxic