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Diversity of wing patterns and abdomen-generated substrate sounds in 3 European scorpionfly species

Insect Science 2015年第4期22卷 521-531页

作者： manfred hartbauer Johannes Gepp Karin Hinteregger Stephan Koblmuller Institute of Zoology KarI-Franzens-University Graz Universitatsplatz 2 8010 Graz Institute for Nature Conservation Herdergasse 3 8010 Graz Austria

In the genus Panorpa （Insecta： Mecoptera）, also known as scorpionflies, pre- mating behavior includes repeated sequences of slow wing movements （waving, fanning, flagging） which are accompanied by rapid abdomen vibrations that generate substantial substrate-borne sound. It is still unknown whether wing patterns or vibratory signals contain information about species identity, sex and/or the quality of potential mating part- ners. Besides species-specific pheromones, these multimodal signals may be of particular importance for the maintenance of reproductive isolation in sympatrically occurring scor- pionfly species. Here, we analyzed phyologenetic relationships among, and the pattern of forewings as well as substrate-borne sound in 3 different sympatric Central-European scorpionfly species （P communis, P germanica, and P alpina）. Divergence time estimates, based on 879 bp of the mitochondrial COI gene, indicate longstanding separate evolu- tionary histories for the studied Panorpa species. Morphological analysis revealed that wing length as an indicator of body size increased in the following order： P alpina 〈 P. germanica 〈 P. communis. Individuals can be assigned to the correct species and sex with high accuracy just by evaluation of the number of dark spots and the proportion of wing pigmentation. Despite high variability of interpulse period at an individual level, across species analysis revealed a positive correlation of average interpulse period as well as mean signal amplitude with forewing length. These results suggest wing patterns, but less likely vibratory signals, to contain information about species identity. Furthermore, receivers may be able to estimate the body size of a signaler solely on the basis of substrate-borne sound.

关键词： courtship signals laser vibrometry phylogeny species recognition substrate-borne sound wing pattern

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Exposure to sublethal concentration of flupyradifurone alters sexual behavior and cuticular hydrocarbon profile in Heriades truncorum,an oligolectic solitary bee

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Insect Science 2024年第3期31卷 859-869页

作者： Samuel Boff manfred Ayasse Institute of Evolutionary Ecology and Conservation Genomics Ulm UniversityUlmGermany

The aboveground oligolectic bee,Heriades truncorum,is a particularly good model for studying the impact of pesticides on sexual communication,since some aspects of its mating behavior have previously been *** have tested(1)the interference of the pesticide flupyradifurone on male precopulatory behavior and male mating partner preferences,(2)the way that the pesticide interferes in male quality assessment by the female,and(3)the effects of the pesticide on the chemical compounds in the female *** exposed bees of both sexes to a sublethal concentration of *** behaviors were registered in a mating arena with two females(one unexposed and one exposed)and one male(either unexposed or exposed).Unexposed males were quicker to attempt to *** also impacted precopulatory behavior and male quality assessment by *** approached unexposed females more quickly than insecticideexposed *** exposed to insecticide produced lower amounts of some cuticular hydrocarbons(sex pheromone candidates)and appeared less choosy than unexposed *** findings suggest that insecticide exposure affects sexual communication,playing a role both in male preference and in male quality assessment by the female.

关键词： courtship display female choice flupyradifurone male partner preference sex communication sublethal effects

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The tri-band high spectral resolution spectrometer with gratings in tandem for the charge-exchange recombination spectroscopy diagnostic system on HL-2A tokamak

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Plasma Science and Technology 2024年第6期26卷 103-110页

作者：刘亮余德良马倩何小斐 Maarten DE BOCK manfred von HELLERMANN Michael WALSH 陈文锦何小雪魏彦玲张能李栋魏会领 the HL-2A Team Southwestern Institute of Physics Chengdu 610041People’s Republic of China College of Physics and Optoelectronic Technology Baoji University of Arts and SciencesBaoji 721000People’s Republic of China ITER Organization Route de Vinon-sur-VerdonCS 90046St.Paul Lez Durance Cedex 13067France Fusion Spectroscopy Markgraf-Albrecht Str.14Berlin 10711Germany

Charge-exchange(CX) recombination spectroscopy is a powerful tool monitoring ion temperature and plasma rotation with good temporal and spatial resolutions. A compact, new design for a high-throughput, tri-band high spectral resolution spectrometer has been developed for the charge-exchange recombination spectroscopy measurement on the HL-2A tokamak. The simultaneous measurements of He II(468.57 nm), C VI(529.1 nm), and Dα(656.1 nm accompanied by beam emission spectra) with an acquisition frequency up to 400 Hz are achieved by vertically binning the spectrum from each fiber in experiments. Initial results indicate that the system can provide radial profiles of not only ion temperature and rotation velocity,but also concentration of carbon. For the case of helium, the measurements for the ion temperature and rotation velocity are straightforward but the apparent concentration associated with the observed CX intensity is obviously too high. Modeling of the active He II CX feature including plume contributions needs to be carried out to extract the true helium *** spectrometer could become a prototype for the ITER charge-exchange recombination spectroscopy diagnostic and the pilot experiments, as presented here, demonstrate the possibility of impurity concentrations measurements based on the combined measurement of local beam emission and charge-exchange recombination spectroscopy spectra.

关键词： CXRS ion temperature plasma rotation impurity concentration

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Next Generation Sequencing in Oncological Diagnostics: Hype or Hope?

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Journal of Biosciences and Medicines 2024年第2期12卷 244-256页

作者： Rana Hallak manfred Kuepper Amer Al Chikh Youssef Department of Biochemistry Faculty of Pharmacy Al Rasheed University Ghabareb Syria Rana Hallak Clinical Laboratory Damascus Kafar Sousseh Syria Department of Biochemistry Faculty of Pharmacy Arab International University Ghabareb Syria Doctors Cancer Care Center Damascus Damascus Syria

The understanding of how genetic and epigenetic factors influence tumorigenesis, progression and invasion, is vastly growing since new technologies allow the analysis of the functional genome namely the exome, the transcriptome and the epigenome, besides enabling genome-wide assessment of genetic variations. With the advent of new drugs that are indicated tissue agnostic, depending on certain mutations, there is a growing demand for fast and cost-effective genetic diagnosis. The method in focus that already became an indispensable tool in viral diagnosis is next-generation sequencing (NGS). This approach allows sequencing of literally every DNA molecule in the sample and can either be used to assess numerous genetic markers of one patient at a time, or to assess fewer markers of many patients in parallel, which reduces costs. We submitted 23 samples of different tumor entities to four diagnostic companies with different analysis profiles. The results as disclosed and discussed in this report indicate that so far, the main application of NGS is rather in cancer research than in diagnosis, as none of the reports had a real impact on the therapeutic scheme. We are perfectly aware that such a small cohort cannot be generalized, but considering the costs vs. benefits, NGS should be engaged upon a very stringent evaluation only. However, in cases where obtaining a tissue biopsy is impossible or unfavorable, analysis of liquid biopsy by NGS provides a vital alternative.

关键词： Oncology Next Generation Sequencing Tumor Diagnosis Personalized Medicine

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Nonlinear Rydberg exciton-polaritons in Cu2O microcavities

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Light(Science & Applications) 2024年第4期13卷 619-627页

作者： Maxim Makhonin Anthonin Delphan Kok Wee Song Paul Walker Tommi Isoniemi Peter Claronino Konstantinos Orfanakis Sai Kiran Rajendran Hamid Ohadi Julian Heckötter Marc Assmann manfred Bayer Alexander Tartakovskii Maurice Skolnick Oleksandr Kyriienko Dmitry Krizhanovskii Department of Physics and Astronomy University of SheffieldSheffield S37RHUK. Department of Physics and Astronomy University of ExeterStocker RoadExeter EX44PYUK. SUPA School of Physics and AstronomyUniversity of St AndrewsSt Andrews KY169SSUK. Fakultät Physik TU DortmundAugust-Schmidt-Straße 444227 DortmundGermany

Rydberg excitons(analogues of Rydberg atoms in condensed matter systems)are highly excited bound electron-hole states with large Bohr *** interaction between them as well as exciton coupling to light may lead to strong optical nonlinearity,with applications in sensing and quantum information ***,we achieve strong effective photon–photon interactions(Kerr-like optical nonlinearity)via the Rydberg blockade phenomenon and the hybridisation of excitons and photons forming polaritons in a Cu2O-filled *** pulsed resonant excitation polariton resonance frequencies are renormalised due to the reduction of the photon-exciton coupling with increasing exciton *** analysis shows that the Rydberg blockade plays a major role in the experimentally observed scaling of the polariton nonlinearity coefficient as∝n4.4±1.8 for principal quantum numbers up to n=*** high principal quantum numbers studied in a polariton system for the first time are essential for realisation of high Rydberg optical nonlinearities,which paves the way towards quantum optical applications and fundamental studies of strongly correlated photonic(polaritonic)states in a solid state system.

关键词： density Rydberg polar

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Sahara’s surface transformation forced an abrupt hydroclimate decline and Neolithic culture transition in northern China

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The Innovation 2024年第1期5卷 70-79页

作者： Yandong Hou Hao Long Sumiko Tsukamoto Zhengyao Lu Jie Chen Daniel EIbarra Toru Tamura Qiong Zhang Weiyi Sun Jingran Zhang Lei Gao manfred Frechen Ji Shen State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and LimnologyChinese Academy of Sciences(NIGLAS)Nanjing 210008China Leibniz Institute for Applied Geophysics(LIAG) Department of Geochronology30655 HannoverGermany Department of Physical Geography and Ecosystem Science Lund University22100 LundSweden Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China Institute at Brown for Environment and Society and Department of Earth Environmentaland Planetary SciencesBrown UniversityProvidenceRI 02912USA Geological Survey of Japan National Institute of Advanced Industrial Science and TechnologyTsukubaIbaraki 305-8567Japan Graduate School of Frontier Sciences University of TokyoKashiwaChiba 277-8561Japan Department of Physical Geography and Bolin Centre for Climate Research Stockholm University10691 StockholmSweden School of Geography Nanjing Normal UniversityJiangsu Centre for Collaborative Innovation in Geographical Information Resource Development and ApplicationKey Laboratory of Virtual Geographic EnvironmentMinistry of Education of ChinaNanjing 210023China School of Geography and Ocean Science Nanjing UniversityNanjing 210023China

The remote forcing from land surface changes in the Sahara is hypothesized to play a pivotal role in modulating the intensity of the East Asian summer monsoon(EASM)through ocean-atmospheric *** modulation has far-reaching consequences,particularly in facilitating societal shifts documented in northern ***,we present a well-dated lake-level record from the Daihai Lake Basin in northern China,providing quantitative assessments of Holocene monsoonal precipitation and the consequent migrations of the northern boundary of the *** reconstruction,informed by a water-and-energy balance model,indicates that annual precipitation reached700 mm during 8–5 ka,followed by a rapid decline to tween 5 and 4 *** shift coherently aligns with a signi550 mm be-ficant300 km northwestward movement of the EASM northern boundary during the Middle Holocene(MH),in contrast to its current *** findings underscore that these changes cannot be entirely attributed to orbital forcing,as corroborated by simulation *** model simulations deployed in our study suggest that the presence of the Green Sahara during the MH significantly strengthened the EASM and led to a northward shift of the monsoon rainfall ***,the Sahara’s reversion to a desert landscape in the late Holocene was accompanied by a corresponding southward retraction of monsoon *** dramatic hydroclimate changes during5–4 ka likely triggered or at least contributed to a shift in Neolithic cultures and societal transformation in northern *** decreasing agricultural productivity,communities transitioned from millet farming to a mixed rainfed agriculture and animal husbandry ***,our findings elucidate not only the variability of the EASM but also the profound implications of a remote forcing,such as surface transformations of the Sahara,on climatic changes and cultural evolution in northern China.

关键词： Holocene monsoon abrupt

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缩短切削加工时间的“秘诀”

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现代制造 2024年第4期 32-33页

作者： manfred Lerch 不详

Oskar Frech公司过去使用的是卧式四轴加工中心。在使用了五轴加工中心之后,同样零件的切削加工时间可缩短20%;随着经验的积累,切削加工的时间甚至缩短30%。一直以来,Oskar Frech公司被视为热芯盒和冷芯盒压铸技术领域中的市场领导者。

关键词：切削加工五轴加工中心压铸技术卧式四轴加工中心冷芯盒热芯盒市场领导者缩短

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阀门零部件制造的高精密加工

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现代制造 2024年第1期 20-22页

作者： manfred Flohr 不详

Schroeder阀门公司生产的产品是一种保护工业企业泵类设备不受损伤的旁通保护阀。德国的能源转型,既给制造商带来了巨大的商机,也给他们带来了技术挑战:当热电厂在部分载荷工况下运行时,工业企业的生产设备需要新的安全保护装备。

关键词：泵类设备零部件制造保护阀能源转型载荷工况阀门制造商

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Melanoma development: stage-dependent cancer competence of the melanocytic lineage

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Signal Transduction and Targeted Therapy 2022年第1期7卷 13-14页

作者： manfred Kunz Department of Dermatology Venereology and AllergologyUniversity Medical Center LeipzigPhilipp-Rosenthal-Str.2304155 LeipzigGermany

In a recent article in Science,Baggiolini et al.^(1) showed that the transforming ability of the BRAFM6QQE oncogene for melanoma development depends on the stage of the transformed melanocyte lineage *** neural crest cells and melanoblasts are vulnerable to malignant transformation in a zebrafish model,melanocytes only developed small patches of nevus-like cells after BRARJ6QQE expression.

关键词： expression. al. melan

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13C analysis of cow tail hair and farm slurry can be used to implicitly distinguish between different dairy production systems

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Ecological Processes 2023年第1期12卷 100-111页

作者： Friederike Sieve Johannes Isselstein manfred Kayser Department of Crop Science Grassland Science Georg-August University G?ttingen Geo-Lab University of Vechta

Background Public interest in the way food is produced on the farm and processed along the food-production chain is increasing. The analysis of isotopic signatures(13C) in cow tail hair provides a method to reconstruct the dietary proportion of maize in cow diets. Based on this, we further investigated whether there is a relationship between isotopic signatures in cow tail hair or farm slurry and the proportion of maize of the total utilized agricultural area per farm [%]. We did an on-farm survey on 17 dairy farms in coastal Northwest Germany and collected cow tail hair from dairy cows and slurry samples on each farm. The farms differed in their feeding regime（C3vs. C4plants）, their site conditions（sandy soil = ‘Geestland'; organic soil = ‘Peatland'; clayey soil = ‘Marshland'）, and in the area cultivated with maize as a proportion of the total utilized agricultural area per *** We found a positive relationship between δ13C values in both cow tail hair and slurry and the annual dietary proportion of maize（R2= 0.67; and R2= 0.63）. Furthermore, we confirmed that there was a relationship between δ13C values in cow tail hair and area of maize as a proportion of the total utilized agricultural area per farm（R2= 0.69）.Conclusion Our findings suggest a general applicability of using isotopic signatures(13C) along a wide gradient of site conditions and productions systems in practice.

关键词： Stable isotopes Natural 13 C abundance Environmental indicator Maize Dietary composition Traceability

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