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World Journal of Clinical Cases 2022年第14期10卷 4502-4508页

作者： Marc Huguenot Anne-Catherine Bruhm manfred essig Department of Gastroenterology and Internal Medicine Tiefenau HospitalBern 3004Switzerland

BACKGROUND Benralizumab is a monoclonal antibody targeting the IL-5 receptor used in the treatment of *** use of benralizumab in other conditions is only emerging and could represent a therapeutic option for other eosinophil-associated ***,we report the case of a patient suffering from eosinophilic esophagitis and asthma who achieved histological remission of eosinophilic esophagitis(EoE)under benralizumab treatment for his *** SUMMARY Our patient was a 56-year-old white male with a history of eosinophilic esophagitis and severe *** years of usual treatments,including topical steroids,biological treatment with mepolizumab,and standard asthma treatment,only poor control of both conditions was obtained.A control gastroscopy after the initiation of benralizumab showed complete histological remission of his *** Our case shows the effects of therapy with a novel agent not yet approved for this condition but for other diseases,with histological resolution of EoE after *** clinical remission was not observed,which exemplifies the complex nature of EoE,its associated psychosomatic burden,and the chronification of the ***,monoclonal antibodies targeting the Th2 response and,in our case,an IL5 receptor antagonist,achieved complete histological remission,which was not the case with an antibody against IL-5,which was also initiated to treat asthma.

关键词： Eosinophilic esophagitis Benralizumab,Eosinophilic asthma Case report

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搜寻小质量暗物质

物理 2021年第3期50卷 197-198页

作者：徐仁新(编译) Rouven essig 北京大学

人们传统上依赖大型设备来搜寻比质子还重的暗物质粒子,但最近正将目光转向对轻质量粒子敏感的小型实验。依据暗物质粒子与各种材料中电子或原子核之间的非弹性碰撞,新的探测方案拟搜寻所谓的亚GeV暗物质,其质量可低于质子质量的百万分... 详细信息

人们传统上依赖大型设备来搜寻比质子还重的暗物质粒子,但最近正将目光转向对轻质量粒子敏感的小型实验。依据暗物质粒子与各种材料中电子或原子核之间的非弹性碰撞,新的探测方案拟搜寻所谓的亚GeV暗物质,其质量可低于质子质量的百万分之一。

关键词：暗物质非弹性碰撞大型设备小型实验搜寻质子轻质量原子核

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Anti-hepatitis C virus drugs and kidney

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World Journal of Hepatology 2016年第32期8卷 1343-1353页

作者： Paul Carrier Marie essig Marilyne Debette-Gratien Denis Sautereau Annick Rousseau Pierre Marquet Jérémie Jacques Véronique Loustaud-Ratti U850 INSERM Université de Limoges Service d’Hépato-gastroentérologie CHU Limoges

Hepatitis C virus(HCV) mainly targets the liver but can also induce extrahepatic manifestations. The kidney may be impacted via an immune mediated mechanism or a cytopathic effect. HCV patients are clearly at a greater risk of chronic kidney disease(CKD) than uninfected patients are, and the presence of CKD increases mortality. Interferon-based therapies and ribavirin are difficult to manage and are poorly effective in endstage renal disease and hemodialysis. These patients should be given priority treatment with new direct anti-viral agents(DAAs) while avoiding peginterferon and ribavirin. The first results were convincing. To aid in the correct use of these drugs in patients with renal insufficiency, their pharmacokinetic properties and potential renal toxicity must be known. The renal toxicity of these new drugs was not a safety signal in clinical trials, and the drugs are generally efficient in these frail populations. These drugs are usually well tolerated, but recent cohort studies have demonstrated that these new regimens may be associated with renal side effects, especially when using sofosbuvir combinations. HCV, renal diseases and comorbidities are intimately linked. The close monitoring of renal function is required, particularly for at-risk patients(transplanted, HIV-coinfected, CKD, hypertensive or diabetic patients). New DAA regimens, which will soon be approved, will probably change the landscape.

关键词： Nephrotoxicity Hepatitis C Direct anti-viral agents Kidney End-stage renal disease

Iohexol plasma and urinary concentrations in cirrhotic patients:A pilot study

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World Journal of Hepatology 2022年第8期14卷 1621-1632页

作者： Paul Carrier Alexandre Destere Baptiste Giguet Marilyne Debette-Gratien Marie essig Caroline Monchaud Jean-Baptiste Woillard Véronique Loustaud-Ratti Department of Liver Disease Limoges University Hospital CenterU1248INSERMF-87000LimogesFrance Department of Pharmacology Toxicology and Centre of PharmacovigilanceLimoges University Hospital CenterU1248INSERMF-87000LimogesFrance

BACKGROUND Renal failure is an independent prognostic factor for survival in patients with *** to calculate serum creatinine significantly overestimate the glomerular filtration rate(GFR).Plasma clearance of direct biomarkers has been used to improve the accuracy of evaluations of GFR in this population,but no study has simultaneously measured plasma and urinary clearance,which is the gold *** To study calculated plasma and urinary concentrations of iohexol,based on the kinetics of samples collected over 24 h from cirrhotic patients with three different grades of *** One dose of iohexol(5 mL)was injected intravenously and plasma concentrations were measured 11 times over 24 h in nine cirrhotic *** urinary concentration of iohexol was also measured,in urine collected at 4,8,12 and 24 *** The plasma and urinary curves of iohexol were similar;however,incomplete urinary excretion was detected at 24 *** the estimated GFR limits of our population(>30 and<120 mL/min/1.73 m^(2)),the median measured GFR(m GFR)was 63.7 mL/min/1.73 m^(2)(range:41.3–111.3 mL/min/1.73 m^(2)),which was an accurate reflection of the actual ***-based formulas for estimatingGFR showed significant bias and imprecision,while the Brochner–Mortensen(BM)equation accurately estimated the m GFR(r=0.93).CONCLUSION Plasma clearance of iohexol seems useful for determining GFR regardless of the ascites *** will secondly devise a pharmacokinetics model requiring fewer samples andvalidate the BM equation.

关键词： Cirrhosis Glomerular filtration Rate Iohexol Pharmacokinetics Brochner-Mortensen

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通过降低柴油机机油的消耗减少有害排放

柴油机设计与制造 1993年第1期2卷 17-24页

作者： essig,G 牟黎明

维生素A过多症——少年足球运动员的病例报告(摘译)

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天津体育学院学报 1984年第4期 50-51页

作者： Robert Mark Fumich,George W.essig,刘金生 MD MD

据《美国运动医学杂志》报导,有一例15岁少年足球运动员在训练期间为获得优异的训练成绩采用“保健膳食”而出现双侧下肢疼痛、骨扫描呈现长骨骨膜炎等征象的维生素A中毒症。病例报告患儿男15岁于入院前四周在训练后始感肌肉疲劳、疼痛... 详细信息

据《美国运动医学杂志》报导,有一例15岁少年足球运动员在训练期间为获得优异的训练成绩采用“保健膳食”而出现双侧下肢疼痛、骨扫描呈现长骨骨膜炎等征象的维生素A中毒症。病例报告患儿男15岁于入院前四周在训练后始感肌肉疲劳、疼痛和僵硬尤以双下肢为著。因右胫骨近端疼痛、肿胀不断进展、体重下降、全身不适、咽疼而来就医。既往体健无任何疾病,但于两个月前曾因每天除食用大量肝、乳制品、黄色蔬菜(胡萝卜等)外还加服六个胶囊鱼肝油和两个胶囊多种维生素。(予计每天食用的上述食品中至少含10万国际单位维生素A)

关键词：少年足球运动员体育工作者维生素病例报告

部分切除脑胶质瘤:磁共振液体衰减反转恢复序列在检测肿瘤进展中的诊断价值

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国际医学放射学杂志 2010年第3期 274-275页

作者：蔡兆诚 M. Winterstein M.W. Münter I. Burkholder M. essig HU. Kauczor MA. Weber Department of Radiology German Cancer Research Center

摘要目的本研究旨在评价胶质瘤部分切除术后随访中,术后空腔与脑脊液(CSF)间信号强度(SI)的差异是否有助于预测肿瘤的进展。

关键词：肿瘤进展病人胶质瘤 SI 空腔部分切除 FLAIR

Kimura病伴随毛细血管外肾小球肾炎(法语)

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世界核心医学期刊文摘（皮肤病学分册） 2006年第12期2卷 55-页

作者： Chauvel C. Valeyrie-Allanore L. essig M 王琼 Service de Dermatologie Bichat 46 rue Henri Huchard 75018 Paris

Background. Kimura’s disease is a rare and benign chronic in-flammatory soft-tissue disorder of unknown origin. Most cases involve young Asian males. The typical presentation consists of painless papules or nodules with a predilection for the head and neck region, associated with lymphadenopathy, parotid gland involvement, peripheral blood eosinophilia and raised immunoglobulin E. Patients and methods. A 49-year-old Mauritian man was hospitalized for nephrotic syndrome. Examination revealed a painless 3 cm nodule in the left pre-auricular region and multiple enlarged left cervical lymph nodes. Histopathologic examination of a nodule confirmed the diagnosis of Kimura’s disease, which was associated with necrotic extracapillary glomerulonephritis. Corticosteroids were initiated, resulting in rapid improvement of renal function and partial regression of the patient’s cutaneous nodules and lymph node disorder. Discussion. Renal manifestations are the only visceral localization of Kimura’s disease, and proteinuria is seen in 12%of cases, of which 50%are accompanied by nephrotic syndrome. Many different histologic types of renal involvementmay be observed with potentially severe lesions. To our knowledge, this is the first case of Kimura’s disease associated with extracapillary glomerulonephritis.

关键词：肾病综合征肾变病结节 Kimura

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性病性淋巴肉芽肿:一种中欧少见的生殖器溃疡病因

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世界核心医学期刊文摘（皮肤病学分册） 2005年第3期1卷 7-7页

作者： Rampf J. essig A. Hinrichs R. C. Sunderktter 牛新武 Dept. of Dermatology and Allergology University of Ulm Maienweg 12 DE- 89081 Ulm Germany

Lymphogranuloma inguinale, caused by Chlamydia trachomatis serovar L1 - L3 is rare in patients from western countries but needs yet to be considered in the d ifferential diagnosis of genital ulcers. We report a case of a young male patien t without any eventful travel history who presented with a genital ulcer at the sulcus coronarius and painfully enlarged lymph nodes in the right inguinal area. The typical clinical picture and serum IgM and IgG antibody titers of 1:16 and 1:512, respectively, against C. trachomatis were suggestive of infection with C. trachomatis serovar L1- L3. The diagnosis was confirmed by isolation of the or ganisms from the ulcer ground and subsequent sequence analysis of the omp1 gene which led to identification of C. trachomatis genotype L2 with 99% homology to a reference strain of C. trachomatis serovar L2. The lesion healed rapidly unde r treatment with doxycycline for 3 weeks, and the lymph nodes did not ulcerate. Thus, clinical suspicion was confirmed by genotyping of the isolated strain allo wing timely diagnosis and treatment of lymphogranuloma inguinale.

关键词：生殖器溃疡沙眼衣原体感染腹股沟淋巴结肿大淋巴结疼痛性基因分析可疑病例冠状沟病原微生物基因分型

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蛋白结合型MR对比剂应用于人脑肿瘤成像的初步经验

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国际医学放射学杂志 2010年第2期 195-195页

作者： M.essig M.Rohrer F.Giesel F.Tuttenberg J.Tuttenberg M.A.Weber 李琼 Department of Radiology German Cancer Research CenterINF 28069120 HeidelbergGermany

钆膦维司(Gadofosveset)是一种含钆的蛋白结合型血池对比剂,与传统的钆对比剂相比具有较长的半衰期和更高的弛豫性。目前尚无使用钆膦维司作为细胞外对比剂的经验

关键词：对比剂颅内肿瘤 MR 结合型蛋白