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Factors Prognosis of Ebola Virus Disease at the Wonkifong Ebola Treatment Center, Coyah, Guinea

Advances in Infectious Diseases 2018年第3期8卷 139-150页

作者： Mamadou Saliou Sow Alioune Camara Boushab Mohamed Boushab Mamadou Oury Safiatou Diallo Kadio Jean-Jacques Olivier Kadio Ismael Camara Alseny Modet Camara mandy kader kondé Moussa Seydi Infectious and Tropical Diseases Department University Hospital Center of Conakry Conakry Guinea Department of Public Health Faculty of Medicine University of Conakry Conakry Guinea Internal Medecine and Infectious Diseases Department Centre Hospitalier of Kiffa Kiffa Mauritania Infectious and Tropical Diseases Department Fann Teaching University Hospital Dakar Senegal

Background: The Ebola Virus Epidemic epidemic in Guinea was marked by its rapid spread in the capital, forcing the authorities to build several Ebola treatment centers including Wonkifong (Coyah), Conakry. Objective: To evaluate the case fatality rate of Ebola Virus Disease in this center and to identify associated factors. Patients and Method: There is a prospective study at wonkifong Ebola treatment center from January 1st, 2014 to April 30th, 2015. All patients diagnosed with an Ebola Virus Disease from January 1st, 2014 to April 30th, 2015 were enrolled in this study. Kaplan-Meier curves and multivariate regression model were used to analyze factors associated with death. Results: 216 patients were included, the mean age was 30.52 ± 17 years and 53.2% were female. The average time between admission to the Ebola treatment center and the onset of signs was 5.13 ± 3.8 days. The average period of stay in the Ebola Treatment Center was 12.64 ± 11.31 days and duration median of death after admission in Wonkifong ETC was 11 days. According to the source, more than half of the patients were from Forécariah, i.e. 60.2% (n = 134). The case fatality rate was 64.4%. This rate was 72.0% in Dubréka, 65.1% in Coyah and 64.6% in Forécariah. The factors independently associated with Ebola Virus Disease death were signs of diarrhea [OR = 2.22 (1.17 - 4.20)], anorexia [OR= 0.40 (0.19 - 0.81)] and period of patients stay in ETC [OR = 0.96 (0.93 - 0.99)]. Conclusion: These results show that the fatality rate linked to the Ebola virus disease remains high. The factors independently associated with death were Diarrhea, anorexia and period between beginning of illness and date of latest news. Biological monitoring and resuscitation seem interesting for the reduction of this mortality.

关键词： Ebola Disease Lethality Wonkifong Guinea

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