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MUTAGEN SENSITIVITY AND DNA REPAIR CAPACITY (DRC) AS RISK FACTORS FOR NON-SMALL CELL LUNG CANCER

癌变．畸变．突变 2001年第4期13卷 207-208页

作者： P.Schmezer N.Rajaee-behbahani A.Risch S.Thiel W.Rittgen K.Kayser H.Dienemann V.Schulz P.Drings H.Bartsch GermanCancerResearchCenter D-69120HeidelbergandThoraxklinikHeidelberg-RohrbachD-69126Heid

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Hepatitis B virus genotypes in southwest Iran: Molecular, serological and clinical outcomes

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World Journal of Gastroenterology 2008年第10期14卷 1510-1513页

作者： Anahita Mojiri Abbas Behzad-behbahani Mehdei Saberifirozi Maryam Ardabili Mahmood Beheshti Marjan Rahsaz Mehrdad Banihashemi Negar Azarpira Bita Geramizadeh Baharak Khadang Afsaneh Moaddeb Mojgan Ghaedi Tahereh Heidari Ardeshir Torab Alireza Salah Saeid Amirzadeh Zahra Jowkar Davood Mehrabani Samad Amini-Bavil-Olyaee Mohammad Ali Dehyadegari Gastroenterology and Hepatology Research Center Namazi Hospital Shiraz University of Medical Sciences Shiraz Iran Organ Transplant Research Center Namazi Hospital Shiraz University of Medical Sciences Shiraz Iran Department of Microbiology School of Medicine Shiraz University of Medical Sciences Shiraz Iran Iranian Blood Transfusion Organization Shiraz Iran Biotechnology Department PasteurInstitute of Iran Tehran Iran Professor Alborzi Clinical Microbiology Research Center Shiraz University of Medical Sciences Shiraz Iran

AIM: To investigate the associations of hepatitis B virus (HBV) genotype with HBeAg and anti-HBe status, alanine aminotransferase (ALT) levels and HBV-DNA detection in different groups of HBV-infected patients in southwest Iran. METHODS: A total of 89 HBsAg-positive serum samples were collected from the same number of patients. All sera were then investigated to determine HBV DNA and serological markers. For all the polymerase chain reaction (PCR)-positive samples, biochemical, histopathological assays and genotyping were also performed. RESULTS: Genotype D was the only type of HBV foundin different clinical forms of acute and chronic infections. There was a high prevalence of HBeAg-negative HBV- infected patients with chronic hepatitis (52.7%). Out of 55 patients with chronic hepatitis, seven (12.7%) were diagnosed with cirrhosis. A significant association between the presence of anti-HBe antibody and an increase in ALT level, among either HBeAg-negative (P = 0.01) or HBeAg-positive (P = 0.026) patients, was demonstrated. No significant differences were observed between the clinical outcomes of HBeAg-positive and -negative individuals (P = 0.24). CONCLUSION: Genotype D has been recognized as the only type of HBV found in different clinical forms of HBV infections, including cirrhosis, among the residents of southwest Iran. Anti-HBe possibly plays a role in disease progression in some patients with chronic hepatitis, at least for a period of disease.

关键词： Hepatitis B virus-D Cirrhosis Iran Anti-HBe Polymerase chain reaction

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