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Saliva as a diagnostic specimen for detection of SARS-CoV-2 in suspected patients: a scoping review

Infectious Diseases of Poverty 2020年第4期9卷 3-9页

作者： Omid Fakheran mandana dehghannejad Abbasali Khademi Dental research center Department of PeriodonticsDental Research InstituteIsfahan University of Medical sciencesIsfahanIran Dental Research Center Dental Research InstituteIsfahan University of Medical sciencesIsfahanIran Dental Research Center Department of EndodonticsFaculty of DentistryDental Research InstituteIsfahan University of Medical SciencesIsfahanIran

Background:From the begging months of 2020 a severe acute respiratory syndrome coronavirus(SARS-CoV-2,also called 2019-nCoV)caused a devastating global *** present,the diagnosis of coronavirus disease 2019(COVlD-19)is made through a nasopharyngeal swab based on reverse transcription polymerase chain reaction(RT-PCR)***,some recent studies suggested the possible role of oral fluids and saliva in the detection of *** purpose of this scoping review is evaluating the available evidence regarding the efficacy of saliva as a diagnostic specimen in COVID-19 ***:A systematic literature review of six databases(PubMed,Scopus,The Cochrane Central Register of Controlled Trials[CENTRAL],Science Direct,Web of Science and Google scholar)was carried out without any restrictions on date of publication to identify the reliability of saliva as a diagnostic specimen for detection of SARS-CoV-2 in suspected ***:Nine eligible articles were included in this review based on our described *** the included studies are based on clinical surveys among patients with confirmed SARS-CoV-2 *** of studies included in this review,reported that there is no statistically significant difference between nasopharyngeal or sputum specimens and saliva samples regarding viral ***:Despite limitations of this study,the findings of this review suggest that the use of self-collected saliva as a non-invasive specimen has proper accuracy and reliability regarding detection of SARS-CoV-2 based on RT-PCR technique.

关键词： COVID-19 SARS-CoV-2 2019-nCoV Saliva PCR Review

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